{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:58:04Z","timestamp":1784699884965,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T00:00:00Z","timestamp":1345852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s10529-012-1022-4","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T09:13:26Z","timestamp":1345799606000},"page":"2175-2182","source":"Crossref","is-referenced-by-count":27,"title":["T-5224, a selective inhibitor of c-Fos\/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice"],"prefix":"10.1007","volume":"34","author":[{"given":"Shinichiro","family":"Izuta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahoru","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Shiozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,25]]},"reference":[{"issue":"7","key":"1022_CR1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nbt1412","volume":"26","author":"Y Aikawa","year":"2008","unstructured":"Aikawa Y, Morimoto K, Yamamoto T, Chaki H, Hashiramoto A, Narita H, Hirono S, Shiozawa S (2008) Treatment of arthritis with a selective inhibitor of c-Fos\/activator protein-1. Nat Biotechnol 26(7):817\u2013823","journal-title":"Nat Biotechnol"},{"issue":"4","key":"1022_CR2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/11024150260102807","volume":"168","author":"AJ Aldridge","year":"2002","unstructured":"Aldridge AJ (2002) Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg 168(4):204\u2013214","journal-title":"Eur J Surg"},{"issue":"12","key":"1022_CR3","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.4049\/jimmunol.155.12.5743","volume":"155","author":"T Arai","year":"1995","unstructured":"Arai T, Hiromatsu K, Kobayashi N, Takano M, Ishida H, Nimura Y, Yoshikai Y (1995) IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. J Immunol 155(12):5743\u20135749","journal-title":"J Immunol"},{"issue":"6","key":"1022_CR4","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.4049\/jimmunol.135.6.3972","volume":"135","author":"BA Beutler","year":"1985","unstructured":"Beutler BA, Milsark IW, Cerami A (1985) Cachectin\/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J Immunol 135(6):3972\u20133977","journal-title":"J Immunol"},{"issue":"10","key":"1022_CR5","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd1854","volume":"4","author":"JA Buras","year":"2005","unstructured":"Buras JA, Holzmann B, Sitkovsky M (2005) Animal models of sepsis: setting the stage. Nat Rev Drug Discov 4(10):854\u2013865","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"1022_CR6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00003246-200201000-00048","volume":"30","author":"RN Cooney","year":"2002","unstructured":"Cooney RN, Yumet G (2002) Cytokine signaling in sepsis: redundancy, crosstalk, and regulatory mechanisms. Crit Care Med 30(1):262\u2013263","journal-title":"Crit Care Med"},{"issue":"5","key":"1022_CR7","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.174.5.1209","volume":"174","author":"Malefyt R Waal de","year":"1991","unstructured":"de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE (1991) Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174(5):1209\u20131220","journal-title":"J Exp Med"},{"issue":"2","key":"1022_CR8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1084\/jem.177.2.547","volume":"177","author":"C Gerard","year":"1993","unstructured":"Gerard C, Bruyns C, Marchant A, Abramowicz D, Vandenabeele P, Delvaux A, Fiers W, Goldman M, Velu T (1993) Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 177(2):547\u2013550","journal-title":"J Exp Med"},{"issue":"2","key":"1022_CR9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0168-8278(95)80433-1","volume":"22","author":"P Knolle","year":"1995","unstructured":"Knolle P, Schlaak J, Uhrig A, Kempf P, Meyer zum Buschenfelde KH, Gerken G (1995) Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J Hepatol 22(2):226\u2013229","journal-title":"J Hepatol"},{"issue":"4","key":"1022_CR10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/emm.2007.47","volume":"39","author":"J Krishnan","year":"2007","unstructured":"Krishnan J, Selvarajoo K, Tsuchiya M, Lee G, Choi S (2007) Toll-like receptor signal transduction. Exp Mol Med 39(4):421\u2013438","journal-title":"Exp Mol Med"},{"issue":"4\u20136","key":"1022_CR11","first-page":"217","volume":"7","author":"JM Kyriakis","year":"1999","unstructured":"Kyriakis JM (1999) Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family. Gene Expr 7(4\u20136):217\u2013231","journal-title":"Gene Expr"},{"issue":"1","key":"1022_CR12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/IAI.70.1.192-198.2002","volume":"70","author":"L Liaudet","year":"2002","unstructured":"Liaudet L, Murthy KG, Mabley JG, Pacher P, Soriano FG, Salzman AL, Szabo C (2002) Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Infect Immun 70(1):192\u2013198","journal-title":"Infect Immun"},{"key":"1022_CR13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2334-8-141","volume":"8","author":"CC Moore","year":"2008","unstructured":"Moore CC, Martin EN, Lee GH, Obrig T, Linden J, Scheld WM (2008) An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models. BMC Infect Dis 8:141","journal-title":"BMC Infect Dis"},{"issue":"6","key":"1022_CR14","doi-asserted-by":"crossref","first-page":"G1423","DOI":"10.1152\/ajpgi.2001.281.6.G1423","volume":"281","author":"F Moulin","year":"2001","unstructured":"Moulin F, Copple BL, Ganey PE, Roth RA (2001) Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure. Am J Physiol Gastrointest Liver Physiol 281(6):G1423\u2013G1431","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"25","key":"1022_CR15","doi-asserted-by":"crossref","first-page":"13766","DOI":"10.1073\/pnas.250476497","volume":"97","author":"A Ozinsky","year":"2000","unstructured":"Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 97(25):13766\u201313771","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"1022_CR16","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.intimp.2008.01.033","volume":"8","author":"RD Ramnath","year":"2008","unstructured":"Ramnath RD, Ng SW, Guglielmotti A, Bhatia M (2008) Role of MCP-1 in endotoxemia and sepsis. Int Immunopharmacol 8(6):810\u2013818","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"1022_CR17","first-page":"M9","volume":"1333","author":"T Taniguchi","year":"1997","unstructured":"Taniguchi T, Lamphier MS, Tanaka N (1997) IRF-1: the transcription factor linking the interferon response and oncogenesis. Biochim Biophys Acta 1333(1):M9\u2013M17","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"1022_CR18","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3390\/molecules14051869","volume":"14","author":"C Thippakorn","year":"2009","unstructured":"Thippakorn C, Suksrichavalit T, Nantasenamat C, Tantimongcolwat T, Isarankura-Na-Ayudhya C, Naenna T, Prachayasittikul V (2009) Modeling the LPS neutralization activity of anti-endotoxins. Molecules 14(5):1869\u20131888","journal-title":"Molecules"},{"issue":"6149","key":"1022_CR19","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/330662a0","volume":"330","author":"KJ Tracey","year":"1987","unstructured":"Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A (1987) Anti-cachectin\/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330(6149):662\u2013664","journal-title":"Nature"},{"issue":"1","key":"1022_CR20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1021\/jm050550d","volume":"49","author":"K Tsuchida","year":"2006","unstructured":"Tsuchida K, Chaki H, Takakura T, Kotsubo H, Tanaka T, Aikawa Y, Shiozawa S, Hirono S (2006) Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. J Med Chem 49(1):80\u201391","journal-title":"J Med Chem"},{"issue":"1","key":"1022_CR21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.shk.0000145936.31967.d7","volume":"23","author":"H Tsujimoto","year":"2005","unstructured":"Tsujimoto H, Ono S, Majima T, Kawarabayashi N, Takayama E, Kinoshita M, Seki S, Hiraide H, Moldawer LL, Mochizuki H (2005) Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock 23(1):39\u201344","journal-title":"Shock"},{"issue":"5425","key":"1022_CR22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","volume":"285","author":"H Wang","year":"1999","unstructured":"Wang H (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285(5425):248\u2013251","journal-title":"Science"},{"issue":"10 Pt 1","key":"1022_CR23","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1164\/ajrccm.164.10.2106117","volume":"164","author":"H Wang","year":"2001","unstructured":"Wang H, Yang H, Czura CJ, Sama AE, Tracey KJ (2001) HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med 164(10 Pt 1):1768\u20131773","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"1022_CR24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1179\/096805100101532414","volume":"6","author":"G Zhang","year":"2000","unstructured":"Zhang G, Ghosh S (2000) Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J Endotoxin Res 6(6):453\u2013457","journal-title":"J Endotoxin Res"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-012-1022-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10529-012-1022-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-012-1022-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T12:08:28Z","timestamp":1687694908000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10529-012-1022-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,25]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1022"],"URL":"https:\/\/doi.org\/10.1007\/s10529-012-1022-4","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,25]]}}}