{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:48:02Z","timestamp":1759160882006,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (CN)","doi-asserted-by":"publisher","award":["81071537","81471862"],"award-info":[{"award-number":["81071537","81471862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Huimin project of Chongqing Science and Technology","award":["CSTC\\2013jcsfC10001-4"],"award-info":[{"award-number":["CSTC\\2013jcsfC10001-4"]}]},{"name":"Clinical Innovative Foundation of The Third Military Medical University","award":["SWH2013LC11"],"award-info":[{"award-number":["SWH2013LC11"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s10529-016-2172-6","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T11:22:42Z","timestamp":1468581762000},"page":"1867-1873","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Screening, tandem expression and immune activity appraisal of Deinagkistrodon acutus (pit viper) venom mimotopes from a phage display 12-mer peptide library"],"prefix":"10.1007","volume":"38","author":[{"given":"Guoning","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Gou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"2172_CR1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/15563650701647405","volume":"46","author":"VA Abreu De","year":"2008","unstructured":"De Abreu VA, Leite GB, Oliveira CB, Hyslop S, Furtado Mde F, Simioni LR (2008) Neurotoxicity of Micrurusaltirostris (Uruguayan coral snake) venom and its neutralization by commercial coral snake antivenom and specific antiserum raised in rabbits. Clin Toxicol 46:519\u2013527","journal-title":"Clin Toxicol"},{"key":"2172_CR2","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1046\/j.1432-1327.2000.01244.x","volume":"267","author":"C Demangel","year":"2000","unstructured":"Demangel C, Maroun RC, Rouyre S, Bon C, Mazie JC, Choumet V (2000) Combining phage display and molecular modeling to map the epitope of a neutralizing antitoxin antibody. Eur J Biochem 267:2345\u20132353","journal-title":"Eur J Biochem"},{"key":"2172_CR3","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.toxicon.2005.02.012","volume":"45","author":"JW Fox","year":"2005","unstructured":"Fox JW, Serrano SM (2005) Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases. Toxicon 45:969\u2013985","journal-title":"Toxicon"},{"key":"2172_CR4","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.toxicon.2005.02.029","volume":"45","author":"JM Gutierrez","year":"2005","unstructured":"Gutierrez JM, Rucavado A, Escalante T, Diaz C (2005) Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage. Toxicon 45:997\u20131011","journal-title":"Toxicon"},{"key":"2172_CR5","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1016\/j.vaccine.2005.04.009","volume":"23","author":"B Hardy","year":"2005","unstructured":"Hardy B, Raiter A (2005) Amimotope peptide-based anti-cancer vaccine selected by BAT monoclonal antibody. Vaccine 23:4283\u20134291","journal-title":"Vaccine"},{"key":"2172_CR6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1074-5521(00)90063-2","volume":"8","author":"R Kasher","year":"2001","unstructured":"Kasher R, Balass M, Scherf T, Fridkin M, Fuchs S, Katchalski-Katzir E (2001) Design and synthesis of peptides that bind alpha-bungarotoxin with high affinity. Chem Biol 8:147\u2013155","journal-title":"Chem Biol"},{"key":"2172_CR7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/187152811797200605","volume":"10","author":"G Leon","year":"2011","unstructured":"Leon G et al (2011) Immune response towards snake venoms. Inflamm Aller Drug Targ 10:381\u2013398","journal-title":"Inflamm Aller Drug Targ"},{"key":"2172_CR8","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0264-410X(00)00397-2","volume":"19","author":"GB Lesinski","year":"2001","unstructured":"Lesinski GB, Smithson SL, Srivastava N, Chen D, Widera G, Westerink MA (2001) A DNA vaccine encoding a peptide mimic of Streptococcus pneumoniae serotype 4 capsular polysaccharide induces specific anti-carbohydrate antibodies in Balb\/c mice. Vaccine 19:1717\u20131726","journal-title":"Vaccine"},{"key":"2172_CR9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-4939-2742-5_5","volume":"1318","author":"AV Lin","year":"2015","unstructured":"Lin AV (2015) Direct ELISA. Methos Mol Biol 1318:51\u201359","journal-title":"Methos Mol Biol"},{"key":"2172_CR10","first-page":"949","volume":"61","author":"RD Theakston","year":"1983","unstructured":"Theakston RD, Reid HA (1983) Development of simple standard assay procedures for the characterization of snake venom. Bull World Health Organ 61:949\u2013956","journal-title":"Bull World Health Organ"},{"key":"2172_CR11","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","volume":"76","author":"H Towbin","year":"1979","unstructured":"Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350\u20134354","journal-title":"Proc Natl Acad Sci USA"},{"key":"2172_CR12","doi-asserted-by":"crossref","first-page":"e184","DOI":"10.1371\/journal.pmed.0030184","volume":"3","author":"SC Wagstaff","year":"2006","unstructured":"Wagstaff SC, Laing GD, Theakston RD, Papaspyridis C, Harrison RA (2006) Bioinformatics and multiepitope DNA immunization to design rational snake antivenom. PLoS Med 3:e184","journal-title":"PLoS Med"},{"key":"2172_CR13","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1021\/jp808182y","volume":"113","author":"EL Wu","year":"2009","unstructured":"Wu EL, Wong KY, Zhang X, Han K, Gao J (2009) Determination of the structure form of the fourth ligand of zinc in Acutolysin A using combined quantum mechanical and molecular mechanical simulation. J Phys Chem B 113:2477\u20132485","journal-title":"J Phys Chem B"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-016-2172-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10529-016-2172-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-016-2172-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T14:29:32Z","timestamp":1498314572000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10529-016-2172-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["2172"],"URL":"https:\/\/doi.org\/10.1007\/s10529-016-2172-6","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"type":"print","value":"0141-5492"},{"type":"electronic","value":"1573-6776"}],"subject":[],"published":{"date-parts":[[2016,7,15]]}}}