{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:02:19Z","timestamp":1782230539638,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s10529-017-2488-x","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T05:19:35Z","timestamp":1513833575000},"page":"437-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["p70S6K activation promotes the transdifferentiation of fibroblasts to myofibroblasts in pterygium tissue growth on the cornea"],"prefix":"10.1007","volume":"40","author":[{"given":"Xin-Rong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Tao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Tian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"2488_CR1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0161-6420(83)34594-2","volume":"90","author":"P Austin","year":"1983","unstructured":"Austin P, Jakobiec FA, Iwamoto T (1983) Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula. Ophthalmology 90:96\u2013109","journal-title":"Ophthalmology"},{"key":"2488_CR2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1167\/iovs.12-10469","volume":"54","author":"SC Chao","year":"2013","unstructured":"Chao SC, Hu DN, Yang PY, Lin CY, Nien CW, Yang SF, Roberts JE (2013) Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways. Invest Ophthalmol Vis Sci 54:999\u20131007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2488_CR3","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1136\/bjo.86.12.1341","volume":"86","author":"G Gazzard","year":"2002","unstructured":"Gazzard G, Saw SM, Farook M, Koh D, Widjaja D, Chia SE, Hong CY, Tan DT (2002) Pterygium in Indonesia: prevalence, severity and risk factors. Br J Ophthalmol 86:1341\u20131346","journal-title":"Br J Ophthalmol"},{"key":"2488_CR4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm0202-128","volume":"8","author":"M Guba","year":"2002","unstructured":"Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK (2002) Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 8:128\u2013135","journal-title":"Nat Med"},{"key":"2488_CR5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jdermsci.2015.06.002","volume":"79","author":"H Huang","year":"2015","unstructured":"Huang H, Cui W, Qiu W, Zhu M et al (2015) Impaired wound healing results from the dysfunction of the Akt\/mTOR pathway in diabetic rats. J Dermatol Sci 79:241\u2013251","journal-title":"J Dermatol Sci"},{"key":"2488_CR6","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1167\/iovs.13-12141","volume":"54","author":"KW Kim","year":"2013","unstructured":"Kim KW, Park SH, Wee SW, Kim JC (2013) Overexpression of angiogenin in pterygium body fibroblasts and its association with proliferative potency. Invest Ophthalmol Vis Sci 54:6355\u20136362","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2488_CR7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exer.2015.01.010","volume":"142","author":"KW Kim","year":"2016","unstructured":"Kim KW, Park SH, Kim JC (2016) Fibroblast biology in pterygia. Exp Eye Res 142:32\u201339","journal-title":"Exp Eye Res"},{"key":"2488_CR8","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2005.05.025","volume":"43","author":"H Pabic Le","year":"2005","unstructured":"Le Pabic H, L\u2019Helgoualc\u2019h A, Coutant A, Wewer UM, Baffet G, Cl\u00e9ment B, Th\u00e9ret N (2005) Coutant a involvement of the serine\/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. J Hepatol 43:1038\u20131044","journal-title":"J Hepatol"},{"key":"2488_CR9","doi-asserted-by":"crossref","first-page":"L175","DOI":"10.1152\/ajplung.00063.2015","volume":"310","author":"SK Madala","year":"2016","unstructured":"Madala SK, Thomas G, Edukulla R (2016) p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-\u03b1 expression in the lung. Am J Physiol Lung Cell Mol Physiol 310:L175\u2013L186","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2488_CR10","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.1167\/iovs.13-12674","volume":"54","author":"BY Milani","year":"2013","unstructured":"Milani BY, Milani FY, Park DW, Namavari A, Shah J, Amirjamshidi H, Ying H, Djalilian AR (2013) Rapamycin Inhibits the production of myofibroblasts and reduces corneal scarring after photorefractive keratectomy. Invest Ophthalmol Vis Sci 54:7424\u20137430","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2488_CR11","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1093\/emboj\/17.22.6649","volume":"17","author":"H Shima","year":"1998","unstructured":"Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC (1998) Disruption of the p70(s6k)\/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J 17:6649\u20136659","journal-title":"EMBO J"},{"key":"2488_CR12","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/archopht.1997.01100160405001","volume":"115","author":"DT Tan","year":"1997","unstructured":"Tan DT, Chee SP, Dear KB, Lim AS (1997) Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision. Arch Ophthalmol 115:1235\u20131240","journal-title":"Arch Ophthalmol"},{"key":"2488_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2015.03.001","volume":"131","author":"MR Tavares","year":"2015","unstructured":"Tavares MR, Pavan IC, Amaral CL, Meneguello L, Luchessi AD, Simabuco FM (2015) The S6K protein family in health and disease. Life Sci 131:1\u201310","journal-title":"Life Sci"},{"key":"2488_CR14","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1074\/jbc.M115.672170","volume":"291","author":"NM Walker","year":"2016","unstructured":"Walker NM, Belloli EA, Stuckey L, Chan KM, Lin J, Lynch W, Chang A, Mazzoni SM, Fingar DC, Lama VN (2016) Mechanistic target of rapamycin complex1 (mTORC1) and mTORC2 as key signaling intermediates in mesenchymal cell activation. J Biol Chem 291:6262\u20136271","journal-title":"J Biol Chem"},{"key":"2488_CR15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.exer.2017.03.012","volume":"159","author":"MC Wojciechowski","year":"2017","unstructured":"Wojciechowski MC, Mahmutovic L, Shu DY, Lovicu FJ (2017) ERK1\/2 signaling is required for the initiation but not progression of TGF\u03b2-induced lens epithelial to mesenchymal transition (EMT). Exp Eye Res 159:98\u2013113","journal-title":"Exp Eye Res"},{"key":"2488_CR16","doi-asserted-by":"crossref","first-page":"36539","DOI":"10.18632\/oncotarget.9282","volume":"7","author":"D Wu","year":"2016","unstructured":"Wu D, Cheng J, Sun G, Wu S, Li M, Gao Z, Zhai S, Li P, Su D, Wang X (2016) p70S6K promotes IL-6-induced epithelial-mesenchymal transition and metastasis of head and neck squamous cell carcinoma. Oncotarget 7:36539\u201336550","journal-title":"Oncotarget"},{"key":"2488_CR17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jdermsci.2015.03.016","volume":"79","author":"W Xing","year":"2015","unstructured":"Xing W, Guo W, Zou CH et al (2015) Acemannan accelerates cell proliferation and skin wound healing through AKT\/mTOR signaling pathway. J Dermatol Sci 79:101\u2013109","journal-title":"J Dermatol Sci"},{"key":"2488_CR18","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000985","author":"XR Zhao","year":"2017","unstructured":"Zhao XR, Zhang MC, Xie HT, Ji N, Ma XQ (2017) Expression of mTOR in primary pterygium and its correlation with \u03b1-smooth muscle actin. Eur J Ophthalmol. https:\/\/doi.org\/10.5301\/ejo.5000985","journal-title":"Eur J Ophthalmol"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10529-017-2488-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-017-2488-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-017-2488-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T16:53:10Z","timestamp":1603558390000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10529-017-2488-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,21]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["2488"],"URL":"https:\/\/doi.org\/10.1007\/s10529-017-2488-x","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,21]]}}}