{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:50:19Z","timestamp":1780321819333,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401181"],"award-info":[{"award-number":["31401181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["81771336, U1704186"],"award-info":[{"award-number":["81771336, U1704186"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10529-020-02818-z","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T08:02:31Z","timestamp":1580112151000},"page":"657-668","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Biglycan protects human neuroblastoma cells from nitric oxide-induced death by inhibiting AMPK-mTOR mediated autophagy and intracellular ROS level"],"prefix":"10.1007","volume":"42","author":[{"given":"Sujuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"2818_CR1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","volume":"452","author":"G Bj\u00f8rk\u00f8y","year":"2009","unstructured":"Bj\u00f8rk\u00f8y G, Lamark T, Pankiv S, \u00d8vervatn A, Brech A, Johansen T (2009) Monitoring autophagic degradation of p62\/SQSTM1. Methods Enzymol 452:181\u2013197","journal-title":"Methods Enzymol"},{"key":"2818_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ceb.2017.01.005","volume":"45","author":"D Carling","year":"2017","unstructured":"Carling D (2017) AMPK signalling in health and disease. Curr Opin Cell Biol 45:31\u201337","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"2818_CR3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s12031-018-1151-x","volume":"66","author":"S Chen","year":"2018","unstructured":"Chen S, Guo D, Zhang W, Xie Y, Yang H, Cheng B, Wang L, Yang R, Bi J, Feng Z (2018) Biglycan, a nitric oxide-downregulated proteoglycan, prevents nitric oxide-induced neuronal cell apoptosis via targeting Erk1\/2 and p38 signaling pathways. J Mol Neurosci 66(1):68\u201376","journal-title":"J Mol Neurosci"},{"issue":"3","key":"2818_CR4","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3390\/ijms18030545","volume":"18","author":"SD Chen","year":"2017","unstructured":"Chen SD, Wu CL, Hwang WC, Yang DI (2017) More insight into BDNF against neurodegeneration: anti-apoptosis, anti-oxidation, and suppression of autophagy. Int J Mol Sci 18(3):545","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2818_CR5","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1007\/s12035-017-0513-7","volume":"55","author":"CM Chong","year":"2018","unstructured":"Chong CM, Ai N, Ke M, Tan Y, Huang Z, Li Y, Lu JH, Ge W, Su H (2018) Roles of nitric oxide synthase isoforms in neurogenesis. Mol Neurobiol 55(3):2645\u20132652","journal-title":"Mol Neurobiol"},{"key":"2818_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.nbd.2018.05.012","volume":"122","author":"CJ Cortes","year":"2019","unstructured":"Cortes CJ, La Spada AR (2019) TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities. Neurobiol Dis 122:83\u201393","journal-title":"Neurobiol Dis"},{"issue":"4","key":"2818_CR7","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.yjmcc.2010.01.013","volume":"48","author":"T Csont","year":"2010","unstructured":"Csont T, G\u00f6rbe A, Bereczki E, Szunyog A, Aypar E, T\u00f3th ME, Varga ZV, Csonka C, F\u00fcl\u00f6p F, S\u00e1ntha M, Ferdinandy P (2010) Biglycan protects cardiomyocytes against hypoxia\/reoxygenation injury: role of nitric oxide. J Mol Cell Cardiol 48(4):649\u2013652","journal-title":"J Mol Cell Cardiol"},{"issue":"5","key":"2818_CR8","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/ar4295","volume":"15","author":"MC de Andr\u00e9s","year":"2013","unstructured":"de Andr\u00e9s MC, Maneiro E, Mart\u00edn MA, Arenas J, Blanco FJ (2013) Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism. Arthritis Res Ther 15(5):R115","journal-title":"Arthritis Res Ther"},{"key":"2818_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/bs.apcsb.2018.12.001","volume":"116","author":"M D\u00ebrmaku-Sopjani","year":"2019","unstructured":"D\u00ebrmaku-Sopjani M, Sopjani M (2019) Intracellular signaling of the AMP-activated protein kinase. Adv Protein Chem Struct Biol 116:171\u2013207","journal-title":"Adv Protein Chem Struct Biol"},{"key":"2818_CR10","first-page":"8495160","volume":"2017","author":"C Fang","year":"2017","unstructured":"Fang C, Gu L, Smerin D, Mao S, Xiong X (2017) The interrelation between reactive oxygen species and autophagy in neurological disorders. Oxid Mcellsed Cell Longev 2017:8495160","journal-title":"Oxid Mcellsed Cell Longev"},{"issue":"9","key":"2818_CR11","doi-asserted-by":"publisher","first-page":"6594","DOI":"10.1007\/s12035-019-1546-x","volume":"56","author":"C Ger\u00f3nimo-Olvera","year":"2019","unstructured":"Ger\u00f3nimo-Olvera C, Massieu L (2019) Autophagy as a homeostatic mechanism in response to stress conditions in the central nervous system. Mol Neurobiol 56(9):6594\u20136608","journal-title":"Mol Neurobiol"},{"issue":"7","key":"2818_CR12","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1002\/jor.22331","volume":"31","author":"R G\u00f3mez","year":"2013","unstructured":"G\u00f3mez R, Scotece M, Conde J, Lopez V, Pino J, Lago F, G\u00f3mez-Reino JJ, Gualillo O (2013) Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes. J Orthop Res 31(7):1046\u20131052","journal-title":"J Orthop Res"},{"issue":"1","key":"2818_CR13","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00441-018-2872-4","volume":"375","author":"D Hagiwara","year":"2019","unstructured":"Hagiwara D, Grinevich V, Arima H (2019) A novel mechanism of autophagy-associated cell death of vasopressin neurons in familial neurohypophysial diabetes insipidus. Cell Tissue Res 375(1):259\u2013266","journal-title":"Cell Tissue Res"},{"key":"2818_CR14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.matbio.2015.12.005","volume":"49","author":"LT Hsieh","year":"2016","unstructured":"Hsieh LT, Frey H, Nastase MV, Tredup C, Hoffmann A, Poluzzi C, Zeng-Brouwers J, Manon-Jensen T, Schr\u00f6der K, Brandes RP, Iozzo RV, Schaefer L (2016) Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1\u03b2 synthesis. Matrix Biol 49:61\u201381","journal-title":"Matrix Biol"},{"issue":"1","key":"2818_CR15","first-page":"499","volume":"36","author":"J Jiang","year":"2019","unstructured":"Jiang J, Chen S, Li K, Zhang C, Tan Y, Deng Q, Chai Y, Wang X, Chen G, Feng K, Zhang L, Xie CM, Ma K (2019) Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma. Int J Hyperth 36(1):499\u2013510","journal-title":"Int J Hyperth"},{"issue":"11","key":"2818_CR16","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1111\/liv.13476","volume":"7","author":"L Jin","year":"2017","unstructured":"Jin L, Gao H, Wang J, Yang S, Wang J, Liu J, Yang Y, Yan T, Chen T, Zhao Y, He Y (2017) Role and regulation of autophagy and apoptosis by nitric oxide in hepatic stellate cells during acute liver failure. Liver Int 7(11):1651\u20131659","journal-title":"Liver Int"},{"issue":"3","key":"2818_CR17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1615\/CritRevEukaryotGeneExpr.v14.i3.40","volume":"14","author":"MG Kinsella","year":"2004","unstructured":"Kinsella MG, Bressler SL, Wight TN (2004) The regulated synthesis of versican, decorin, and biglycan: extracellular matrix proteoglycans that influence cellular phenotype. Crit Rev Eukaryot Gene Expr 14(3):203\u2013234","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"9","key":"2818_CR18","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.intimp.2011.04.004","volume":"11","author":"SR Lee","year":"2011","unstructured":"Lee SR, Kwak JH, Park DS, Pyo S (2011) Protective effect of kobophenol A on nitric oxide-induced cell apoptosis in human osteoblast-like MG-63 cells: involvement of JNK, NF-\u03baB and AP-1 pathways. Int Immunopharmacol 11(9):1251\u20131259","journal-title":"Int Immunopharmacol"},{"issue":"28","key":"2818_CR19","doi-asserted-by":"publisher","first-page":"20351","DOI":"10.1074\/jbc.M702182200","volume":"282","author":"YC Levine","year":"2007","unstructured":"Levine YC, Li GK, Michel T (2007) Agonist-modulated regulation of AMK-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK-&gt; Rac1-&gt; Akt-&gt; endothelial nitric-oxide synthase pathway. J Biol Chem 282(28):20351\u201320364","journal-title":"J Biol Chem"},{"key":"2818_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.nbd.2018.04.017","volume":"122","author":"OJ Lieberman","year":"2019","unstructured":"Lieberman OJ, McGuirt AF, Tang G, Sulzer D (2019) Roles for neuronal and glial autophagy in synaptic pruning during development. Neurobiol Dis 122:49\u201363","journal-title":"Neurobiol Dis"},{"key":"2818_CR21","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.freeradbiomed.2017.04.026","volume":"108","author":"CF Louren\u00e7o","year":"2017","unstructured":"Louren\u00e7o CF, Ledo A, Barbosa RM, Laranjinha J (2017) Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration. Free Radic Biol Med 108:668\u2013682","journal-title":"Free Radic Biol Med"},{"key":"2818_CR22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-3-319-60733-7_5","volume":"1007","author":"A Maher","year":"2017","unstructured":"Maher A, Abdel Rahman MF, Gad MZ (2017) The role of nitric oxide from neurological disease to cancer. Adv Exp Med Biol 1007:71\u201388","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"2818_CR23","first-page":"92","volume":"29","author":"W Manucha","year":"2017","unstructured":"Manucha W (2017) Mitochondrial dysfunction associated with nitric oxide pathways in glutamate neurotoxicity. Clin Investig Arterioscler 29(2):92\u201397","journal-title":"Clin Investig Arterioscler"},{"issue":"10","key":"2818_CR24","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1096\/fj.05-5124fje","volume":"20","author":"ML Mercado","year":"2006","unstructured":"Mercado ML, Amenta AR, Hagiwara H, Rafil MS, Lechner BE, Owens RT, McQuillan DJ, Froehner SC, Fallon JR (2006) Biglycan regulates the expression and sarcolemmal localizalitin of dystrobrevin, syntrophin, and nNOS. FASEB J 20(10):1724\u20131726","journal-title":"FASEB J"},{"issue":"5","key":"2818_CR25","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1750-3639.2010.00399.x","volume":"20","author":"H Mohan","year":"2010","unstructured":"Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt M, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E (2010) Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathol 20(5):966\u2013975","journal-title":"Brain Pathol"},{"key":"2818_CR26","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.matbio.2016.03.008","volume":"52\u201354","author":"M Myren","year":"2016","unstructured":"Myren M, Kirby DJ, Noonan ML, Maeda A, Owens RT, Ricard-Blum S, Kram V, Kilts TM, Young MF (2016) Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin. Matrix Biol 52\u201354:141\u2013150","journal-title":"Matrix Biol"},{"key":"2818_CR27","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1111\/febs.14791","volume":"15","author":"H Roedig","year":"2019","unstructured":"Roedig H, Nastase MV, Wygrecka M, Schaefer L (2019) Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J 15:2965\u20132979","journal-title":"FEBS J"},{"issue":"1","key":"2818_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/febs.13963","volume":"284","author":"L Schaefer","year":"2017","unstructured":"Schaefer L, Tredup C, Gubbiotti MA, Iozzo RV (2017) Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J 284(1):10\u201326","journal-title":"FEBS J"},{"issue":"9","key":"2818_CR29","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/PHM.0000000000000460","volume":"95","author":"P Shi","year":"2016","unstructured":"Shi P, Chen EY, Cs-Szabo G, Chee A, Tannoury C, Qin L, Lin H, An S, An HS, Zhang Y (2016) Biglycan inhibits capsaicin-induced substance P release by cultured dorsal root ganglion neurons. Am J Phys Med Rehabil 95(9):656\u2013662","journal-title":"Am J Phys Med Rehabil"},{"issue":"7","key":"2818_CR30","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1021\/acschemneuro.7b00176","volume":"8","author":"JKY Tse","year":"2017","unstructured":"Tse JKY (2017) Gut microbiota, nitric oxide, and microglia as prerequisites for neurodegenerative disorders. ACS Chem Neurosci 8(7):1438\u20131447","journal-title":"ACS Chem Neurosci"},{"issue":"3","key":"2818_CR31","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/iej.12616","volume":"50","author":"SY Park","year":"2017","unstructured":"Park SY, Park MY, Park HG, Lee KJ, Kook MS, Kim WJ, Jung JY (2017) Nitric oxide-induced autophagy and the activation of activated protein kinase pathway protect against apoptosis in human dental pulp cells. Int Endod J 50(3):260\u2013270","journal-title":"Int Endod J"},{"issue":"4","key":"2818_CR32","doi-asserted-by":"publisher","first-page":"582","DOI":"10.4103\/1673-5374.247441","volume":"14","author":"E Piscianz","year":"2019","unstructured":"Piscianz E, Vecchi Brumatti L, Tommasini A, Marcuzzi A (2019) Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism? Neural Regener Res 14(4):582\u2013587","journal-title":"Neural Regener Res"},{"issue":"3","key":"2818_CR33","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.kint.2018.10.037","volume":"95","author":"C Poluzzi","year":"2019","unstructured":"Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y (2019) Biglycan\u2002evokes\u2002autophagy\u2002in macrophages via a\u2002novel CD44\/Toll-like receptor 4 signaling axis\u2002in\u2002ischemia\/reperfusion injury. Kidney Int 95(3):540\u2013562","journal-title":"Kidney Int"},{"issue":"9","key":"2818_CR34","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1177\/1535370219847941","volume":"244","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zhang Y, Bo J, Wang X, Zhu J (2019) Hydrogen-rich saline ameliorated LPS-inducd acute lung injury via autophagy inhibition through the ROS\/AMPK\/mTOR pathway in mice. Exp Biol Med 244(9):721\u2013727","journal-title":"Exp Biol Med"},{"key":"2818_CR35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.lfs.2016.04.004","volume":"153","author":"H Xue","year":"2016","unstructured":"Xue H, Ji Y, Wei S, Yu Y, Yan X, Liu S, Zhang M, Yao F, Lan X, Chen L (2016) HGSD attenuates neuronal apoptosis through enhancing neuronal autophagy in the brain of diabetic mice: the role of AMP-activated protein kinase. Life Sci 153:23\u201334","journal-title":"Life Sci"},{"issue":"6","key":"2818_CR36","doi-asserted-by":"publisher","first-page":"507","DOI":"10.4196\/kjpp.2015.19.6.507","volume":"19","author":"JY Yang","year":"2015","unstructured":"Yang JY, Park MY, Park SY, Yoo HI, Kim MS, Kim JH, Kim WJ, Jung JY (2015) Nitric oxide-induced autophagy in MC3T3-E1 cells is associated with cytoprotection via AMPK activation. Korean J Physiol Pharmacol 19(6):507\u2013514","journal-title":"Korean J Physiol Pharmacol"},{"issue":"12","key":"2818_CR37","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1016\/j.bbadis.2018.10.002","volume":"1864","author":"Z Ying","year":"2018","unstructured":"Ying Z, Byun HR, Meng Q, Noble E, Zhang G, Yang X, Gomez-Pinilla F (2018) Biglycan gene connects metabolic dysfunction with brain disorder. Biochim Biophys Acta Mol Basis Dis 1864(12):3679\u20133687","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"10","key":"2818_CR38","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.3109\/10715762.2012.700515","volume":"46","author":"L Zang","year":"2012","unstructured":"Zang L, He H, Ye Y, Liu W, Fan S, Tashiro S, Onodera S, Ikejima T (2012) Nitric oxide augments oridonin-induced effff erocytosis by human histocytic lymphoma U937 cells via autophagy and the NF- \u03ba B-COX-2-IL-1 \u03b2 pathway. Free Radic Res 46(10):1207\u20131219","journal-title":"Free Radic Res"},{"key":"2818_CR39","doi-asserted-by":"publisher","first-page":"40461","DOI":"10.1074\/jbc.M110.164046","volume":"285","author":"WB Zhang","year":"2010","unstructured":"Zhang WB, Wang Z, Shu F, Jin YH, Liu HY, Wang QJ, Yang Y (2010) Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. J Biol Chem 285:40461\u201340471","journal-title":"J Biol Chem"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-020-02818-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10529-020-02818-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-020-02818-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T18:46:26Z","timestamp":1722365186000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10529-020-02818-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,27]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["2818"],"URL":"https:\/\/doi.org\/10.1007\/s10529-020-02818-z","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,27]]},"assertion":[{"value":"10 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}