{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:18:42Z","timestamp":1769505522585,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10529-025-03614-3","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:28:44Z","timestamp":1751545724000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High-density heterotrophic cultivation of a cell-wall-deficient Chlamydomonas reinhardtii strain by fed-batch strategy"],"prefix":"10.1007","volume":"47","author":[{"given":"Kaidi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minxi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengxu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenming","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4273-6373","authenticated-orcid":false,"given":"Weiliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"3614_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.biortech.2016.02.112","volume":"213","author":"N Arora","year":"2016","unstructured":"Arora N, Patel A, Pruthi PA et al (2016) Synergistic dynamics of nitrogen and phosphorous influences lipid productivity in Chlorella minutissima for biodiesel production. Biores Technol 213:79\u201387. https:\/\/doi.org\/10.1016\/j.biortech.2016.02.112","journal-title":"Biores Technol"},{"key":"3614_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-019-1496-3","author":"AD Batista","year":"2019","unstructured":"Batista AD, Rosa RM, Machado M et al (2019) Increased urea availability promotes adjustments in C\/N metabolism and lipid content without impacting growth in Chlamydomonas reinhardtii. Metabolomics. https:\/\/doi.org\/10.1007\/s11306-019-1496-3","journal-title":"Metabolomics"},{"issue":"2","key":"3614_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.biotechadv.2006.11.002","volume":"25","author":"EW Becker","year":"2007","unstructured":"Becker EW (2007) Micro-algae as a source of protein. Biotechnol Adv 25(2):207\u2013210. https:\/\/doi.org\/10.1016\/j.biotechadv.2006.11.002","journal-title":"Biotechnol Adv"},{"issue":"4","key":"3614_CR4","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1128\/MCB.11.4.2328","volume":"11","author":"LE Brown","year":"1991","unstructured":"Brown LE, Sprecher SL, Keller LR (1991) Introduction of exogenous DNA into chlamydomonas-reinhardtii by electroporation. Mol Cell Biol 11(4):2328\u20132332. https:\/\/doi.org\/10.1128\/MCB.11.4.2328","journal-title":"Mol Cell Biol"},{"key":"3614_CR5","doi-asserted-by":"publisher","first-page":"01","DOI":"10.3389\/fnut.2024.1456230","volume":"11","author":"G Cao","year":"2024","unstructured":"Cao G, Hu K, Hu ZW et al (2024) Mutagenesis selection and large-scale cultivation of non-green Chlamydomonas reinhardtii for food applications. Front Nutr 11:01\u201309. https:\/\/doi.org\/10.3389\/fnut.2024.1456230","journal-title":"Front Nutr"},{"issue":"4","key":"3614_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0032-9592(94)80064-2","volume":"29","author":"F Chen","year":"1994","unstructured":"Chen F, Johns MR (1994) Substrate inhibition of Chlamydomonas reinhardtii by acetate in heterotrophic culture. Process Biochem 29(4):245\u2013252. https:\/\/doi.org\/10.1016\/0032-9592(94)80064-2","journal-title":"Process Biochem"},{"issue":"1","key":"3614_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/BF00003548","volume":"7","author":"F Chen","year":"1995","unstructured":"Chen F, Johns M (1995) A strategy for high cell density culture of heterotrophic microalgae with inhibitory substrates. J Appl Phycol 7(1):43\u201346. https:\/\/doi.org\/10.1007\/BF00003548","journal-title":"J Appl Phycol"},{"issue":"6","key":"3614_CR8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0032-9592(96)00006-4","volume":"31","author":"F Chen","year":"1996","unstructured":"Chen F, Johns MR (1996) Heterotrophic growth of Chlamydomonas reinhardtii on acetate in chemostat culture. Process Biochem 31(6):601\u2013604. https:\/\/doi.org\/10.1016\/S0032-9592(96)00006-4","journal-title":"Process Biochem"},{"key":"3614_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2024.1407915","author":"J Chen","year":"2024","unstructured":"Chen J, Chen YH, He WL et al (2024) Transcriptome analysis reveals the molecular mechanism of differences in growth between photoautotrophy and heterotrophy in Chlamydomonas reinhardtii. Front Plant Sci. https:\/\/doi.org\/10.3389\/fpls.2024.1407915","journal-title":"Front Plant Sci"},{"issue":"19","key":"3614_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/app10196736","volume":"10","author":"R Darwish","year":"2020","unstructured":"Darwish R, Gedi MA, Akepach P et al (2020) Chlamydomonas reinhardtii is a potential food supplement with the capacity to outperform Chlorella and Spirulina. Appl Sci-Basel 10(19):1\u201317. https:\/\/doi.org\/10.3390\/app10196736","journal-title":"Appl Sci-Basel"},{"issue":"1","key":"3614_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1017\/S0016672300012015","volume":"17","author":"DR Davies","year":"1971","unstructured":"Davies DR, Plaskitt A (1971) Genetical and structural analyses of cell-wall formation in Chlamydomonas reinhardi. Genet Res 17(1):33\u201343. https:\/\/doi.org\/10.1017\/S0016672300012015","journal-title":"Genet Res"},{"issue":"1","key":"3614_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1104\/pp.106.1.103","volume":"106","author":"JP Fett","year":"1994","unstructured":"Fett JP, Coleman JR (1994) Regulation of periplasmic carbonic anhydrase expression in Chlamydomonas reinhardtii by acetate and pH. Plant Physiol 106(1):103\u2013108. https:\/\/doi.org\/10.1104\/pp.106.1.103","journal-title":"Plant Physiol"},{"key":"3614_CR13","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.algal.2018.05.006","volume":"33","author":"FJ Fields","year":"2018","unstructured":"Fields FJ, Ostrand JT, Mayfield SP (2018) Fed-batch mixotrophic cultivation of Chlamydomonas reinhardtii for high-density cultures. Algal Res 33:109\u2013117. https:\/\/doi.org\/10.1016\/j.algal.2018.05.006","journal-title":"Algal Res"},{"key":"3614_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103738","volume":"65","author":"FJ Fields","year":"2020","unstructured":"Fields FJ, Lejzerowicz F, Schroeder D et al (2020) Effects of the microalgae Chlamydomonas on gastrointestinal health. J Funct Foods 65:103738. https:\/\/doi.org\/10.1016\/j.jff.2019.103738","journal-title":"J Funct Foods"},{"key":"3614_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.124542","volume":"323","author":"RA Freudenberg","year":"2021","unstructured":"Freudenberg RA, Baier T, Einhaus A et al (2021) High cell density cultivation enables efficient and sustainable recombinant polyamine production in the microalga Chlamydomonas reinhardtii. Biores Technol 323:124542. https:\/\/doi.org\/10.1016\/j.biortech.2020.124542","journal-title":"Biores Technol"},{"issue":"29","key":"3614_CR16","doi-asserted-by":"publisher","first-page":"25983","DOI":"10.1074\/jbc.M202912200","volume":"277","author":"L-H Fu","year":"2002","unstructured":"Fu L-H, Wang X-F, Eyal Y et al (2002) A selenoprotein in the plant kingdom: mass spectrometry confirms that an opalcodon (UGA) encodes selenocysteine in Chlamydomonas reinhardtii glutathione peroxidase. J Biol Chem 277(29):25983\u201325991. https:\/\/doi.org\/10.1074\/jbc.M202912200","journal-title":"J Biol Chem"},{"issue":"1","key":"3614_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13068-019-1458-z","volume":"12","author":"L Fu","year":"2019","unstructured":"Fu L, Li Q, Yan G et al (2019) Hormesis effects of phosphorus on the viability of Chlorella regularis cells under nitrogen limitation. Biotechnol Biofuels 12(1):1\u20139. https:\/\/doi.org\/10.1186\/s13068-019-1458-z","journal-title":"Biotechnol Biofuels"},{"issue":"5","key":"3614_CR18","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0038-0717(99)00203-5","volume":"32","author":"AS Grandy","year":"2000","unstructured":"Grandy AS, Erich MS, Porter GA (2000) Suitability of the anthrone\u2013sulfuric acid reagent for determining water soluble carbohydrates in soil water extracts. Soil Biol Biochem 32(5):725\u2013727. https:\/\/doi.org\/10.1016\/S0038-0717(99)00203-5","journal-title":"Soil Biol Biochem"},{"issue":"3","key":"3614_CR19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2105\/AJPH.56.4.684-a","volume":"56","author":"AE Greenberg","year":"2005","unstructured":"Greenberg AE, Trussell RR, Clesceri LS et al (2005) Standard methods for the examination of water and wastewater\u202f: supplement to the sixteenth edition. Am J Public Health Nations Health 56(3):387. https:\/\/doi.org\/10.2105\/AJPH.56.4.684-a","journal-title":"Am J Public Health Nations Health"},{"key":"3614_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00155487","author":"DV Guebel","year":"1991","unstructured":"Guebel DV, Nudel BC, Giulietti AM (1991) A simple and rapid micro-Kjeldahl method for total nitrogen analysis. Biotechnol Techniques. https:\/\/doi.org\/10.1007\/BF00155487","journal-title":"Biotechnol Techniques"},{"key":"3614_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2021.102626","volume":"62","author":"G Huang","year":"2022","unstructured":"Huang G, Zhao D, Lan C et al (2022) Glucose-assisted trophic conversion of Chlamydomonas reinhardtii by expression of glucose transporter GLUT1. Algal Res 62:102626. https:\/\/doi.org\/10.1016\/j.algal.2021.102626","journal-title":"Algal Res"},{"issue":"2","key":"3614_CR22","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/tpj.13787","volume":"93","author":"J J\u00fcppner","year":"2018","unstructured":"J\u00fcppner J, Mubeen U, Leisse A et al (2018) The target of rapamycin kinase affects biomass accumulation and cell cycle progression by altering carbon\/nitrogen balance in synchronized Chlamydomonas reinhardtii cells. Front Nutr 93(2):355\u2013376. https:\/\/doi.org\/10.1111\/tpj.13787","journal-title":"Front Nutr"},{"issue":"17","key":"3614_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells11172724","volume":"11","author":"N Kato","year":"2022","unstructured":"Kato N, McCuiston C, Szuska KA et al (2022) Chlamydomonas reinhardtii alternates peroxisomal contents in response to trophic conditions. Cells 11(17):1\u201315. https:\/\/doi.org\/10.3390\/cells11172724","journal-title":"Cells"},{"key":"3614_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/plants13091182","author":"TT Le","year":"2024","unstructured":"Le TT, Corato A, Gerards T et al (2024) Heterotrophy compared to photoautotrophy for growth characteristics and pigment compositions in batch cultures of four green microalgae. Plants-Basel. https:\/\/doi.org\/10.3390\/plants13091182","journal-title":"Plants-Basel"},{"key":"3614_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031185","author":"A Masi","year":"2023","unstructured":"Masi A, Leonelli F, Scognamiglio V et al (2023) Chlamydomonas reinhardtii: a factory of nutraceutical and food supplements for human health. Molecules. https:\/\/doi.org\/10.3390\/molecules28031185","journal-title":"Molecules"},{"issue":"4","key":"3614_CR26","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.algal.2013.09.003","volume":"2","author":"M Moon","year":"2013","unstructured":"Moon M, Kim CW, Park WK et al (2013) Mixotrophic growth with acetate or volatile fatty acids maximizes growth and lipid production in Chlamydomonas reinhardtii. Algal Res 2(4):352\u2013357. https:\/\/doi.org\/10.1016\/j.algal.2013.09.003","journal-title":"Algal Res"},{"issue":"13","key":"3614_CR27","doi-asserted-by":"publisher","first-page":"5407","DOI":"10.1007\/s00253-015-6698-7","volume":"99","author":"JH Mussgnug","year":"2015","unstructured":"Mussgnug JH (2015) Genetic tools and techniques for Chlamydomonas reinhardtii. Appl Microbiol Biotechnol 99(13):5407\u20135418. https:\/\/doi.org\/10.1007\/s00253-015-6698-7","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"3614_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.watres.2010.08.037","volume":"45","author":"O Perez-Garcia","year":"2011","unstructured":"Perez-Garcia O, Escalante FME, de Bashan LE et al (2011) Heterotrophic cultures of microalgae: Metabolism and potential products. Water Res 45(1):11\u201336. https:\/\/doi.org\/10.1016\/j.watres.2010.08.037","journal-title":"Water Res"},{"key":"3614_CR29","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.bbabio.2013.06.004","volume":"10","author":"T Roach","year":"1827","unstructured":"Roach T, Sedoud A, Krieger-Liszkay A (1827) (2013) Acetate in mixotrophic growth medium affects photosystem II in Chlamydomonas reinhardtii and protects against photoinhibition. Biochem Biophys Acta 10:1183\u20131190. https:\/\/doi.org\/10.1016\/j.bbabio.2013.06.004","journal-title":"Biochem Biophys Acta"},{"issue":"2","key":"3614_CR30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/BF00194001","volume":"180","author":"ZDG Robinson","year":"1990","unstructured":"Robinson ZDG (1990) Cell-wall synthesis in Chlamydomonas reinhardtii: an immunological study on the wild type and wall-less mutants cw2 and cw15. Planta 180(2):229\u2013236. https:\/\/doi.org\/10.1007\/BF00194001","journal-title":"Planta"},{"key":"3614_CR31","doi-asserted-by":"publisher","first-page":"140685","DOI":"10.1016\/j.bbapap.2021.140685","volume":"10","author":"CL Schmidt","year":"1869","unstructured":"Schmidt CL, Daberger J, Sobek M et al (1869) (2021) Structural and biophysical characterization of the selenoprotein SelW1 from Chlamydomonas reinhardtii. Biochem Biophys Acta 10:140685. https:\/\/doi.org\/10.1016\/j.bbapap.2021.140685","journal-title":"Biochem Biophys Acta"},{"key":"3614_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106457","author":"H Singh","year":"2014","unstructured":"Singh H, Shukla MR, Chary KVR et al (2014) Acetate and bicarbonate assimilation and metabolite formation in Chlamydomonas reinhardtii: a 13C-NMR study. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0106457","journal-title":"PLoS ONE"},{"issue":"6","key":"3614_CR33","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1134\/S1021443719050194","volume":"66","author":"AP Smolov","year":"2019","unstructured":"Smolov AP, Maslov AI, Shirshikova GN et al (2019) Effect of the form of mineral nitrogen on the growth and heterotrophic fixation of 14C-bicarbonate in Chlamydomonas reinhardtii. Russ J Plant Physiol 66(6):976\u2013983. https:\/\/doi.org\/10.1134\/S1021443719050194","journal-title":"Russ J Plant Physiol"},{"issue":"36","key":"3614_CR34","doi-asserted-by":"publisher","first-page":"16029","DOI":"10.1016\/j.ijhydene.2013.10.011","volume":"38","author":"Y Sun","year":"2013","unstructured":"Sun Y, Chen M, Yang H et al (2013) Enhanced H2 photoproduction by down-regulation of ferredoxin-NADP+ reductase (FNR) in the green alga Chlamydomonas reinhardtii. Int J Hydrogen Energy 38(36):16029\u201316037. https:\/\/doi.org\/10.1016\/j.ijhydene.2013.10.011","journal-title":"Int J Hydrogen Energy"},{"key":"3614_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2022.102786","volume":"66","author":"Y Torres-Tiji","year":"2022","unstructured":"Torres-Tiji Y, Fields FJ, Yang Y (2022) Optimized production of a bioactive human recombinant protein from the microalgae Chlamydomonas reinhardtii grown at high density in a fed-batch bioreactor. Algal Res 66:102786. https:\/\/doi.org\/10.1016\/j.algal.2022.102786","journal-title":"Algal Res"},{"key":"3614_CR36","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.4028\/www.scientific.net\/AMR.726-731.1362","volume":"726\u2013731","author":"HZ Wu","year":"2013","unstructured":"Wu HZ, Cao AE (2013) Preparation and adding methods of Nessler\u2019s reagent having effects on determination of water quality ammonia nitrogen. Adv Environ Technolo 726\u2013731:1362\u20131366. https:\/\/doi.org\/10.4028\/www.scientific.net\/AMR.726-731.1362","journal-title":"Adv Environ Technolo"},{"issue":"51","key":"3614_CR37","doi-asserted-by":"publisher","first-page":"111369","DOI":"10.1007\/s11356-023-30231-2","volume":"30","author":"CO Yasar","year":"2023","unstructured":"Yasar CO, Fletcher L, Camargo-Valero MA (2023) Effect of macronutrients (carbon, nitrogen, and phosphorus) on the growth of Chlamydomonas reinhardtii and nutrient recovery under different trophic conditions. Environ Sci Pollution Res 30(51):111369\u2013111381. https:\/\/doi.org\/10.1007\/s11356-023-30231-2","journal-title":"Environ Sci Pollution Res"},{"issue":"16","key":"3614_CR38","doi-asserted-by":"publisher","first-page":"7061","DOI":"10.1007\/s00253-016-7430-y","volume":"100","author":"JAZ Zedler","year":"2016","unstructured":"Zedler JAZ, Gangl D, Guerra T et al (2016) Pilot-scale cultivation of wall-deficient transgenic Chlamydomonas reinhardtii strains expressing recombinant proteins in the chloroplast. Appl Microbiol Biotechnol 100(16):7061\u20137070. https:\/\/doi.org\/10.1007\/s00253-016-7430-y","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3\u20134","key":"3614_CR39","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/s0032-9592(99)00082-5","volume":"35","author":"XW Zhang","year":"1999","unstructured":"Zhang XW, Chen F, Johns MR (1999) Kinetic models for heterotrophic growth of Chlamydomonas reinhardti in batch and fed-batch cultures. Process Biochem 35(3\u20134):385\u2013389. https:\/\/doi.org\/10.1016\/s0032-9592(99)00082-5","journal-title":"Process Biochem"},{"issue":"3","key":"3614_CR40","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s10811-018-1666-0","volume":"31","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Tan Y, Wang W et al (2019) Efficient heterotrophic cultivation of Chlamydomonas reinhardtii. J Appl Phycol 31(3):1545\u20131554. https:\/\/doi.org\/10.1007\/s10811-018-1666-0","journal-title":"J Appl Phycol"},{"key":"3614_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biochi.2020.11.016","volume":"181","author":"M-P Zhang","year":"2021","unstructured":"Zhang M-P, Wang M, Wang C (2021) Nuclear transformation of Chlamydomonas reinhardtii: a review. Biochimie 181:1\u201311. https:\/\/doi.org\/10.1016\/j.biochi.2020.11.016","journal-title":"Biochimie"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-025-03614-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10529-025-03614-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-025-03614-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T06:45:28Z","timestamp":1755672328000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10529-025-03614-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["3614"],"URL":"https:\/\/doi.org\/10.1007\/s10529-025-03614-3","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"1 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"72"}}