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RNA-seq was used to investigate gene expression changes following 3-octanone exposure. While 1-octen-3-ol or 3-octanol inhibited mycelial growth in\n                    <jats:italic>G. lucidum<\/jats:italic>\n                    , 3-octanone promoted it. In total, 590 differentially expressed genes (DEGs), including 162 upregulated and 428 downregulated genes, were identified following 3-octanone exposure. Functional annotation revealed that among the DEGs, 23 genes were related to fungal cell wall biosynthesis and remodeling, whereas 21 genes were involved in plant-derived polysaccharide degradation. Furthermore, significant expression changes were observed in genes related to secondary metabolism. Our results indicate that\n                    <jats:italic>G. lucidum<\/jats:italic>\n                    can use 3-octanone as a signal to recognize other fungi, potentially facilitating the expansion of its own territory within wood in nature.\n                  <\/jats:p>","DOI":"10.1007\/s10529-026-03698-5","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:19:52Z","timestamp":1770286792000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gene expression profiling to elucidate the promotive effects of the volatile organic compound 3-octanone on the mycelial growth of Ganoderma lucidum"],"prefix":"10.1007","volume":"48","author":[{"given":"Shoko","family":"Horikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5281-5453","authenticated-orcid":false,"given":"Ryuka","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-0558","authenticated-orcid":false,"given":"Kiwamu","family":"Umezawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Konuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6318-8109","authenticated-orcid":false,"given":"Makoto","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"3698_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/82_2019_186","volume":"425","author":"SR Ball","year":"2020","unstructured":"Ball SR, Kwan AH, Sunde M (2020) Hydrophobin rodlets on the fungal cell wall. 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