{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:15:54Z","timestamp":1788002154538,"version":"build-2784847793"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Tecnologico de Monterrey","award":["IJUT070-23TE88002"],"award-info":[{"award-number":["IJUT070-23TE88002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10529-026-03765-x","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:33:15Z","timestamp":1786419195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of acetaminophen on the growth kinetics and metabolite production of probiotic lactic acid bacteria"],"prefix":"10.1007","volume":"48","author":[{"given":"Abel","family":"Gutierrez-Vilchis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yocanx\u00f3chitl","family":"Perfecto-Avalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Navarro-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Gonzalez-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Armendariz-Borunda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Garcia-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"3765_CR1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.chom.2012.10.012","volume":"12","author":"F B\u00e4ckhed","year":"2012","unstructured":"B\u00e4ckhed F, Fraser CM, Ringel Y et al (2012) Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell Host Microbe 12:611\u2013622. https:\/\/doi.org\/10.1016\/j.chom.2012.10.012","journal-title":"Cell Host Microbe"},{"key":"3765_CR2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12934-024-02449-3","volume":"23","author":"LG Berm\u00fadez-Humar\u00e1n","year":"2024","unstructured":"Berm\u00fadez-Humar\u00e1n LG, Chassaing B, Langella P (2024) Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism. Microb Cell Fact 23:172. https:\/\/doi.org\/10.1186\/s12934-024-02449-3","journal-title":"Microb Cell Fact"},{"key":"3765_CR3","doi-asserted-by":"publisher","DOI":"10.1128\/jb.00697-18","volume":"201","author":"RL Bertrand","year":"2019","unstructured":"Bertrand RL (2019) Lag phase is a dynamic, organized, adaptive, and evolvable period that prepares bacteria for cell division. J Bacteriol 201:10.1128\/jb.00697-18. https:\/\/doi.org\/10.1128\/jb.00697-18","journal-title":"J Bacteriol"},{"key":"3765_CR4","doi-asserted-by":"publisher","first-page":"4173","DOI":"10.3390\/nu13114173","volume":"13","author":"S Bolsega","year":"2021","unstructured":"Bolsega S, Bleich A, Basic M (2021) Synthetic microbiomes on the rise\u2014application in deciphering the role of microbes in host health and disease. Nutrients 13:4173. https:\/\/doi.org\/10.3390\/nu13114173","journal-title":"Nutrients"},{"key":"3765_CR5","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1002\/ejp.621","volume":"19","author":"K Brune","year":"2015","unstructured":"Brune K, Renner B, Tiegs G (2015) Acetaminophen\/paracetamol: a history of errors, failures and false decisions. Eur J Pain 19:953\u2013965. https:\/\/doi.org\/10.1002\/ejp.621","journal-title":"Eur J Pain"},{"key":"3765_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1365-2672.1993.tb02792.x","volume":"75","author":"R Cachon","year":"1993","unstructured":"Cachon R, Divi\u00e8s C (1993) Kinetics of lactate fermentation and citrate bioconversion by Lactococcus lactis ssp. lactis in batch culture. J Appl Bacteriol 75:387\u2013392. https:\/\/doi.org\/10.1111\/j.1365-2672.1993.tb02792.x","journal-title":"J Appl Bacteriol"},{"issue":"Suppl 2","key":"3765_CR7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000354902","volume":"63","author":"YK Chan","year":"2013","unstructured":"Chan YK, Estaki M, Gibson DL (2013) Clinical consequences of diet-induced dysbiosis. Ann Nutr Metab 63(Suppl 2):28\u201340. https:\/\/doi.org\/10.1159\/000354902","journal-title":"Ann Nutr Metab"},{"key":"3765_CR8","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2231590","volume":"15","author":"S Cho","year":"2023","unstructured":"Cho S, Yang X, Won K-J et al (2023) Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity. Gut Microbes 15:2231590. https:\/\/doi.org\/10.1080\/19490976.2023.2231590","journal-title":"Gut Microbes"},{"key":"3765_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2023.102790","volume":"84","author":"M Fredua-Agyeman","year":"2023","unstructured":"Fredua-Agyeman M, Stapleton P, Gaisford S (2023) Growth assessment of mixed cultures of probiotics and common pathogens. Anaerobe 84:102790. https:\/\/doi.org\/10.1016\/j.anaerobe.2023.102790","journal-title":"Anaerobe"},{"key":"3765_CR10","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.semcancer.2021.12.013","volume":"86","author":"K Garbacz","year":"2022","unstructured":"Garbacz K (2022) Anticancer activity of lactic acid bacteria. Semin Cancer Biol 86:356\u2013366. https:\/\/doi.org\/10.1016\/j.semcancer.2021.12.013","journal-title":"Semin Cancer Biol"},{"key":"3765_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.biotechadv.2008.10.006","volume":"27","author":"F Garcia-Ochoa","year":"2009","unstructured":"Garcia-Ochoa F, Gomez E (2009) Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnol Adv 27:153\u2013176. https:\/\/doi.org\/10.1016\/j.biotechadv.2008.10.006","journal-title":"Biotechnol Adv"},{"key":"3765_CR12","doi-asserted-by":"publisher","unstructured":"Garc\u00eda-Gamboa R, Perfecto-Avalos Y, Gonzalez-Garcia J, et al (2024) In vitro analysis of postbiotic antimicrobial activity against Candida Species in a minimal synthetic model simulating the gut mycobiota in obesity. Sci Rep 14:16760. https:\/\/doi.org\/10.1038\/s41598-024-66806-3","DOI":"10.1038\/s41598-024-66806-3"},{"key":"3765_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40104-019-0402-1","volume":"11","author":"P Guo","year":"2020","unstructured":"Guo P, Zhang K, Ma X, He P (2020) Clostridium species as probiotics: potentials and challenges. J Anim Sci Biotechnol 11:24. https:\/\/doi.org\/10.1186\/s40104-019-0402-1","journal-title":"J Anim Sci Biotechnol"},{"key":"3765_CR14","doi-asserted-by":"publisher","unstructured":"Gutierrez-Vilchis A, Perfecto-Avalos Y, Garcia-Gonzalez A (2023) Modeling bacteria pairwise interactions in human microbiota by Sparse Identification of Nonlinear Dynamics (SINDy). Annu Int Conf IEEE Eng Med Biol Soc 2023:1\u20134.\nhttps:\/\/doi.org\/10.1109\/EMBC40787.2023.10341078","DOI":"10.1109\/EMBC40787.2023.10341078"},{"key":"3765_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03328","author":"S Iacob","year":"2019","unstructured":"Iacob S, Iacob DG, Luminos LM (2019) Intestinal microbiota as a host defense mechanism to infectious threats. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2018.03328","journal-title":"Front Microbiol"},{"key":"3765_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146916","volume":"782","author":"Y Jia","year":"2021","unstructured":"Jia Y, Wang Z, Fang D et al (2021) Acetaminophen promotes horizontal transfer of plasmid-borne multiple antibiotic resistance genes. Sci Total Environ 782:146916. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146916","journal-title":"Sci Total Environ"},{"key":"3765_CR17","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1007\/s00284-010-9819-7","volume":"62","author":"A Jim\u00e9nez-Serna","year":"2011","unstructured":"Jim\u00e9nez-Serna A, Hern\u00e1ndez-S\u00e1nchez H (2011) Effect of different antibiotics and non-steroidal anti-inflammatory drugs on the growth of Lactobacillus casei Shirota. Curr Microbiol 62:1028\u20131033. https:\/\/doi.org\/10.1007\/s00284-010-9819-7","journal-title":"Curr Microbiol"},{"key":"3765_CR18","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1472-765X.2006.01902.x","volume":"43","author":"Q Kong","year":"2006","unstructured":"Kong Q, He G, Chen F, Ruan H (2006) Studies on a kinetic model for butyric acid bioproduction by Clostridium butyricum. Lett Appl Microbiol 43:71\u201377. https:\/\/doi.org\/10.1111\/j.1472-765X.2006.01902.x","journal-title":"Lett Appl Microbiol"},{"key":"3765_CR19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.33073\/pjm-2023-038","volume":"72","author":"H Kruszewska","year":"2023","unstructured":"Kruszewska H, Zawistowska-Rojek A, Tyski S (2023) Do NSAIDs and other pain relief drugs can inhibit the growth of Lactobacillaceae? Pol J Microbiol 72:507\u2013513. https:\/\/doi.org\/10.33073\/pjm-2023-038","journal-title":"Pol J Microbiol"},{"key":"3765_CR20","unstructured":"R Core Team (2023) R: A Language and Environment for Statistical Computing"},{"key":"3765_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-2672.1997.tb03302.x","volume":"82","author":"P Loubiere","year":"1997","unstructured":"Loubiere P, Cocaign-Bousquet M, Matos J et al (1997) Influence of end-products inhibition and nutrient limitations on the growth of Lactococcus lactis subsp. lactis. J Appl Microbiol 82:95\u2013100. https:\/\/doi.org\/10.1111\/j.1365-2672.1997.tb03302.x","journal-title":"J Appl Microbiol"},{"key":"3765_CR22","doi-asserted-by":"publisher","unstructured":"Li M, Mao B, Tang X, et al (2024) Lactic acid bacteria derived extracellular vesicles: emerging bioactive nanoparticles in modulating host health. Gut Microbes 16:2427311. https:\/\/doi.org\/10.1080\/19490976.2024.2427311","DOI":"10.1080\/19490976.2024.2427311"},{"key":"3765_CR23","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nature25979","volume":"555","author":"L Maier","year":"2018","unstructured":"Maier L, Pruteanu M, Kuhn M et al (2018) Extensive impact of non-antibiotic drugs on human gut bacteria. Nature 555:623\u2013628. https:\/\/doi.org\/10.1038\/nature25979","journal-title":"Nature"},{"key":"3765_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60982-8","volume":"10","author":"MA Malfatti","year":"2020","unstructured":"Malfatti MA, Kuhn EA, Murugesh DK et al (2020) Manipulation of the gut microbiome alters acetaminophen biodisposition in mice. Sci Rep 10:4571. https:\/\/doi.org\/10.1038\/s41598-020-60982-8","journal-title":"Sci Rep"},{"key":"3765_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01153","author":"D Maseda","year":"2020","unstructured":"Maseda D, Ricciotti E (2020) NSAID\u2013gut microbiota interactions. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2020.01153","journal-title":"Front Pharmacol"},{"key":"3765_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2025.103642","volume":"15","author":"L Murphy","year":"2025","unstructured":"Murphy L, He Q, Wang J (2025a) A modified Gompertz model and its MATLAB implementation for microbial growth performance assessment. Methods X 15:103642. https:\/\/doi.org\/10.1016\/j.mex.2025.103642","journal-title":"Methods X"},{"key":"3765_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2025.125824","volume":"389","author":"LP Murphy","year":"2025","unstructured":"Murphy LP, He QP, Wang J (2025b) Expedited screening of methanotroph-microalgae cocultures for integrated biogas valorization and wastewater remediation. J Environ Manage 389:125824. https:\/\/doi.org\/10.1016\/j.jenvman.2025.125824","journal-title":"J Environ Manage"},{"key":"3765_CR28","doi-asserted-by":"publisher","first-page":"15979","DOI":"10.1073\/pnas.1906172116","volume":"116","author":"P Piccardi","year":"2019","unstructured":"Piccardi P, Vessman B, Mitri S (2019) Toxicity drives facilitation between 4 bacterial species. Proc Natl Acad Sci U S A 116:15979\u201315984. https:\/\/doi.org\/10.1073\/pnas.1906172116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3765_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114468","volume":"161","author":"C Purdel","year":"2023","unstructured":"Purdel C, Ungurianu A, Adam-Dima I, Margin\u0103 D (2023) Exploring the potential impact of probiotic use on drug metabolism and efficacy. Biomed Pharmacother 161:114468. https:\/\/doi.org\/10.1016\/j.biopha.2023.114468","journal-title":"Biomed Pharmacother"},{"key":"3765_CR30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1159\/000354449","volume":"32","author":"C Sch\u00e4fer","year":"2013","unstructured":"Sch\u00e4fer C, Schr\u00f6der KR, H\u00f6glinger O et al (2013) Acetaminophen changes intestinal epithelial cell membrane properties, subsequently affecting absorption processes. Cell Physiol Biochem 32:431\u2013447. https:\/\/doi.org\/10.1159\/000354449","journal-title":"Cell Physiol Biochem"},{"key":"3765_CR31","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1152\/physrev.00045.2009","volume":"90","author":"I Sekirov","year":"2010","unstructured":"Sekirov I, Russell SL, Antunes LCM, Finlay BB (2010) Gut microbiota in health and disease. Physiol Rev 90:859\u2013904. https:\/\/doi.org\/10.1152\/physrev.00045.2009","journal-title":"Physiol Rev"},{"key":"3765_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113746","volume":"43","author":"W Shi","year":"2024","unstructured":"Shi W, Cassmann TJ, Bhagwate AV et al (2024) Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation. Cell Rep 43:113746. https:\/\/doi.org\/10.1016\/j.celrep.2024.113746","journal-title":"Cell Rep"},{"key":"3765_CR33","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1136\/gutjnl-2023-330835","volume":"73","author":"ACY Su","year":"2024","unstructured":"Su ACY, Ding X, Lau HCH et al (2024) <em>Lactococcus lactis HkyuLL 10<\/em> suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase. Gut 73:1478. https:\/\/doi.org\/10.1136\/gutjnl-2023-330835","journal-title":"Gut"},{"key":"3765_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00544","author":"K Theophel","year":"2014","unstructured":"Theophel K, Schacht VJ, Schl\u00fcter M et al (2014) The importance of growth kinetic analysis in determining bacterial susceptibility against antibiotics and silver nanoparticles. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2014.00544","journal-title":"Front Microbiol"},{"key":"3765_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad012","volume":"47","author":"PT van Leeuwen","year":"2023","unstructured":"van Leeuwen PT, Brul S, Zhang J, Wortel MT (2023) Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications. FEMS Microbiol Rev 47:fuad012. https:\/\/doi.org\/10.1093\/femsre\/fuad012","journal-title":"FEMS Microbiol Rev"},{"key":"3765_CR36","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20178157","volume":"14","author":"OS Venturelli","year":"2018","unstructured":"Venturelli OS, Carr AV, Fisher G et al (2018) Deciphering microbial interactions in synthetic human gut microbiome communities. Mol Syst Biol 14:MSB178157. https:\/\/doi.org\/10.15252\/msb.20178157","journal-title":"Mol Syst Biol"},{"key":"3765_CR37","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/s41396-021-01153-z","volume":"16","author":"AS Weiss","year":"2022","unstructured":"Weiss AS, Burrichter AG, Durai Raj AC et al (2022) In vitro interaction network of a synthetic gut bacterial community. ISME J 16:1095\u20131109. https:\/\/doi.org\/10.1038\/s41396-021-01153-z","journal-title":"ISME J"},{"key":"3765_CR38","unstructured":"WHO VigiAccess. https:\/\/www.vigiaccess.org\/. Accessed 26 May 2026"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-026-03765-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10529-026-03765-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-026-03765-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:18:48Z","timestamp":1787998728000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10529-026-03765-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["3765"],"URL":"https:\/\/doi.org\/10.1007\/s10529-026-03765-x","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"12 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"99"}}