{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:28:06Z","timestamp":1793899686200,"version":"4.8.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Beijing Municipal Natural Science Foundation","award":["2242012"],"award-info":[{"award-number":["2242012"]}]},{"name":"the National Natural Science Foundation of China","award":["22171018, 22438007, 22288102, 21978023"],"award-info":[{"award-number":["22171018, 22438007, 22288102, 21978023"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Major Program of Qingyuan Innovation Laboratory","award":["001220005"],"award-info":[{"award-number":["001220005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10529-026-03792-8","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:12:45Z","timestamp":1790053965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Edible layered double hydroxide nanoparticles on 3D scaffolds for accelerated biological cell development"],"prefix":"10.1007","volume":"48","author":[{"given":"Mingyang","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianggui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"3792_CR1","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.ijbiomac.2022.07.140","volume":"218","author":"ZU Arif","year":"2022","unstructured":"Arif ZU, Khalid MY, Noroozi R, Sadehianmaryan A, Jalalvand M, Hossain M (2022) Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications. Int J Biol Macromol 218:930\u2013968. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.07.140","journal-title":"Int J Biol Macromol"},{"key":"3792_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/life9010019","volume":"9","author":"HS Bernhardt","year":"2019","unstructured":"Bernhardt HS (2019) Making molecules with clay: layered double hydroxides, pentopyranose nucleic acids and the origin of life. Life (Basel) 9:19. https:\/\/doi.org\/10.3390\/life9010019","journal-title":"Life (Basel)"},{"key":"3792_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cj.2025.06.003","volume":"14","author":"N Chai","year":"2026","unstructured":"Chai N, Xu J, Zhang RX, Li GZ, Wen J, Su LY, Xue Y, Li T, Liu JL, Zeng DC et al (2026) Synthetic metabolic engineering of functional crops: boosting nutrition and human health. Crop J 14:8\u201321. https:\/\/doi.org\/10.1016\/j.cj.2025.06.003","journal-title":"Crop J"},{"key":"3792_CR4","doi-asserted-by":"publisher","first-page":"24208","DOI":"10.1021\/acsanm.5c04898","volume":"8","author":"DK Chandra","year":"2025","unstructured":"Chandra DK, Kumar A, Mahapatra C (2025a) Ce-based MOFs coated with carbon nanotubes for pH-controlled release of antifungal agents. ACS Appl Nano Mater 8:24208\u201324226. https:\/\/doi.org\/10.1021\/acsanm.5c04898","journal-title":"ACS Appl Nano Mater"},{"key":"3792_CR5","doi-asserted-by":"publisher","first-page":"30994","DOI":"10.1021\/acs.langmuir.5c03023","volume":"41","author":"DK Chandra","year":"2025","unstructured":"Chandra DK, Kumar A, Mahapatra C (2025b) In silico and in vitro analysis of pH-responsive SLS delivery via CeBTC-modified CNT nanocarriers: molecular dynamic simulation to experimental assessment. Langmuir 41:30994\u201333103. https:\/\/doi.org\/10.1021\/acs.langmuir.5c03023","journal-title":"Langmuir"},{"key":"3792_CR6","doi-asserted-by":"publisher","first-page":"8423","DOI":"10.1007\/s42247-025-01231-4","volume":"8","author":"DK Chandra","year":"2025","unstructured":"Chandra DK, Kumar A, Mahapatra C (2025c) Antifungal inbuilt carbon nanotube based redox metal organic framework validated by transcriptomic analysis in aspergillus fumigatus. Emergent Mater 8:8423\u20138441. https:\/\/doi.org\/10.1007\/s42247-025-01231-4","journal-title":"Emergent Mater"},{"key":"3792_CR7","doi-asserted-by":"publisher","first-page":"10829","DOI":"10.1021\/acsnano.4c00557","volume":"18","author":"YT Cui","year":"2024","unstructured":"Cui YT, Wang K, Zhang CD (2024) Carbon nanomaterials for plant priming through mechanostimulation: emphasizing the role of shape. ACS Nano 18:10829\u201310839. https:\/\/doi.org\/10.1021\/acsnano.4c00557","journal-title":"ACS Nano"},{"key":"3792_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11892-4","volume":"12","author":"K Dox","year":"2022","unstructured":"Dox K, Martin T, Houot S, Merckx R, Smolders E (2022) Superior residual fertiliser value in soil with phosphorus recycled from urine in layered double hydroxides. Sci Rep 12:8092. https:\/\/doi.org\/10.1038\/s41598-022-11892-4","journal-title":"Sci Rep"},{"key":"3792_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.169160","volume":"912","author":"A Farhan","year":"2024","unstructured":"Farhan A, Khalid A, Maqsood N, Iftekhar S, Sharif HMA, Qi F, Sillanpaa M, Asif MB (2024) Progress in layered double hydroxides (LDHs): synthesis and application in adsorption, catalysis and photoreduction. Sci Total Environ 912:169160. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.169160","journal-title":"Sci Total Environ"},{"key":"3792_CR10","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1126\/sciadv.adx1576","volume":"11","author":"H Forgham","year":"2025","unstructured":"Forgham H, Chang YX, Wang Y, Zhu JY, Liu LW, Biggers H, Kakinen A, Jiang YH, You XR, Thurecht KJ et al (2025) The evolution of nanomedicine: The rise of next- generation nanomaterials in cancer nanomedicine. Sci Adv 11:2375\u20132548. https:\/\/doi.org\/10.1126\/sciadv.adx1576","journal-title":"Sci Adv"},{"key":"3792_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.plana.2024.100102","volume":"10","author":"MDKM Gunasena","year":"2024","unstructured":"Gunasena MDKM, Alahakoon AMPD, Polwaththa KPGDM, Galpaya GDCP, Priyanjani HASA, Koswattage KR, Senarath WTPSK (2024) Transforming plant tissue culture with nanoparticles: a review of current applications. Plant Nano Biol 10:100102. https:\/\/doi.org\/10.1016\/j.plana.2024.100102","journal-title":"Plant Nano Biol"},{"key":"3792_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202517103","volume":"64","author":"XH Guo","year":"2025","unstructured":"Guo XH, Jing YD, An NH, Cao YQ, Zhang J, Qian G, Zhou XG, Chen D, Yuan WK, Duan XZ (2025) Layered double hydroxides as building blocks for precise catalysis. Angew Chem Int Ed Engl 64:e202517103. https:\/\/doi.org\/10.1002\/anie.202517103","journal-title":"Angew Chem Int Ed Engl"},{"key":"3792_CR13","doi-asserted-by":"publisher","first-page":"28376","DOI":"10.1039\/d4ra04280h","volume":"14","author":"S Hashem","year":"2024","unstructured":"Hashem S, AbdElgawad H, Mohamed F, Hegab MM, AlGarawi A, Okla MK, Sayed M (2024) Zn\u2013Al and Mg\u2013Al layered double hydroxide nanoparticles improved primary and secondary metabolism of geranium plants. RSC Adv 14:28376\u201328389. https:\/\/doi.org\/10.1039\/d4ra04280h","journal-title":"RSC Adv"},{"key":"3792_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163891","volume":"519","author":"C Hu","year":"2025","unstructured":"Hu C, Wang YJ, Xu PC, Yu ZY (2025) Living materials revolutionizing biocatalysis with engineered whole-cell systems. Chem Eng J 519:163891. https:\/\/doi.org\/10.1016\/j.cej.2025.163891","journal-title":"Chem Eng J"},{"key":"3792_CR15","doi-asserted-by":"publisher","first-page":"19663","DOI":"10.1021\/acs.est.3c05686","volume":"57","author":"SJ Jeon","year":"2023","unstructured":"Jeon SJ, Hu PG, Kim K, Anastasia CM, Kim HI, Castillo C, Ahern CB, Pedersen JA, Fairbrother H, Giraldo JP (2023) Electrostatics control nanoparticle interactions with model and native cell walls of plants and algae. Environ Sci Technol 57:19663\u201319667. https:\/\/doi.org\/10.1021\/acs.est.3c05686","journal-title":"Environ Sci Technol"},{"key":"3792_CR16","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1039\/D3EN00733B","volume":"11","author":"RS Jimenez","year":"2024","unstructured":"Jimenez RS, Vera G, Tobar M, Moscote J, Acha G, Vasquez AH, Rivera DR, Vidal EA, Almeida AM, Ahumada M (2024) Mg-Al LDH nanosheets as a nanotechnological tool in agriculture: an exploratory toxicity evaluation study. Environ Sci Nano 11:2249\u20132261. https:\/\/doi.org\/10.1039\/D3EN00733B","journal-title":"Environ Sci Nano"},{"key":"3792_CR17","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1002\/jsfa.13994","volume":"105","author":"Y Khaled","year":"2025","unstructured":"Khaled Y, AbdElgawad H, Hegab MM, Okla M, AlGarawi AM, Tawfik WZ, Sayed M (2025) Priming with multiwalled carbon nanotubes improved biomass accumulation, biological activity and metabolism of four horticultural plants during the sprouting stage. J Sci Food Agric 105:2086\u20132100. https:\/\/doi.org\/10.1002\/jsfa.13994","journal-title":"J Sci Food Agric"},{"key":"3792_CR18","doi-asserted-by":"publisher","first-page":"2306035","DOI":"10.1002\/advs.202306035","volume":"11","author":"L Li","year":"2024","unstructured":"Li L, Soyhan I, Warszawik E, Rijn PV (2024a) Layered Double Hydroxides: Recent progress and promising perspectives toward biomedical applications. Adv Sci 11:2306035. https:\/\/doi.org\/10.1002\/advs.202306035","journal-title":"Adv Sci"},{"key":"3792_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128762","volume":"257","author":"XF Li","year":"2024","unstructured":"Li XF, Gao ZX, Zhou SS, Zhu L, Zhang Q, Wang S, You RC (2024b) Engineering biomimetic scaffolds by combining silk protein nanofibrils and hyaluronic acid. Int J Biol Macromol 257:128762. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.128762","journal-title":"Int J Biol Macromol"},{"key":"3792_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2024.103094","volume":"325","author":"SH Lim","year":"2024","unstructured":"Lim SH, Wong TW, Tay WX (2024) Overcoming colloidal nanoparticle aggregation in biological milieu for cancer therapeutic delivery: perspectives of materials and particle design. Adv Colloid Interface Sci 325:03094. https:\/\/doi.org\/10.1016\/j.cis.2024.103094","journal-title":"Adv Colloid Interface Sci"},{"key":"3792_CR21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12870-015-0581-7","volume":"15","author":"CJ Luo","year":"2015","unstructured":"Luo CJ, Wightman R, Meyerowitz E, Smoukov SK (2015) A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant cells. BMC Plant Biol 15:211. https:\/\/doi.org\/10.1186\/s12870-015-0581-7","journal-title":"BMC Plant Biol"},{"key":"3792_CR22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s42823-020-00195-1","volume":"31","author":"S Mathew","year":"2021","unstructured":"Mathew S, Tiwari DK, Tripathi D (2021) Interaction of carbon nanotubes with plant system: a review. Carbon Lett 31:167\u2013176. https:\/\/doi.org\/10.1007\/s42823-020-00195-1","journal-title":"Carbon Lett"},{"key":"3792_CR23","doi-asserted-by":"publisher","first-page":"148594","DOI":"10.1016\/j.cej.2024.148594","volume":"481","author":"JH Mou","year":"2024","unstructured":"Mou JH, Liu SF, Yang LL, Qin ZH, Yang YF, Wang ZY, Li HY, Lin Ki CS, Wang X (2024) Sustainable paramylon production from food waste by Euglena gracilis using a waste-based cell immobilisation technique. Chem Eng J 481:148594. https:\/\/doi.org\/10.1016\/j.cej.2024.148594","journal-title":"Chem Eng J"},{"key":"3792_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2025.144270","volume":"376","author":"RCP Ramachandran","year":"2025","unstructured":"Ramachandran RCP, Sreedevi GS, Edwin B, Palantavida S, Viswanathan M, Shereef A (2025) Unveiling the key toxicity indicators and mechanisms on phytotoxicity of cerium dioxide nanoparticles in rice (Oryza sativa). Chemosphere 376:144270. https:\/\/doi.org\/10.1016\/j.chemosphere.2025.144270","journal-title":"Chemosphere"},{"key":"3792_CR25","doi-asserted-by":"publisher","first-page":"20428","DOI":"10.1021\/acsomega.2c01405","volume":"7","author":"AS Roy","year":"2022","unstructured":"Roy AS, Pillai SK, Ray SS (2022) Layered double hydroxides for sustainable agriculture and environment: an overview. ACS Omega 7:20428\u201320440. https:\/\/doi.org\/10.1021\/acsomega.2c01405","journal-title":"ACS Omega"},{"key":"3792_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312084","volume":"36","author":"PG Saiz","year":"2024","unstructured":"Saiz PG, Reizabal A, Vilas-Vilela JL, Dalton PD, Lanceros-Mendez S (2024) Materials and strategies to enhance melt electro writing potential. Adv Mater 36:2312084. https:\/\/doi.org\/10.1002\/adma.202312084","journal-title":"Adv Mater"},{"key":"3792_CR28","doi-asserted-by":"publisher","first-page":"6088","DOI":"10.1039\/C1JM00073J","volume":"21","author":"WY Shi","year":"2011","unstructured":"Shi WY, Lin YJ, Kong XG, Zhang ST, Jia YK, Wei M, Evans DG, Duan X (2011) Fabrication of pyrenetetrasulfonate\/layered double hydroxide ultrathin films and their application in fluorescence chemosensors. J Mater Chem 21:6088\u20136094. https:\/\/doi.org\/10.1039\/C1JM00073J","journal-title":"J Mater Chem"},{"key":"3792_CR29","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1021\/acscentsci.4c00338","volume":"10","author":"YJ Wang","year":"2024","unstructured":"Wang YJ, Di ZG, Qin ML, Qu SM, Zhong WB, Yuan LF, Zhang J, Hibberd JM, Yu ZY (2024a) Advancing engineered plant living materials through tobaccoBY-2 cell growth and transfection within tailored granular hydrogel scaffolds. ACS Cent Sci 10:1094\u20131104. https:\/\/doi.org\/10.1021\/acscentsci.4c00338","journal-title":"ACS Cent Sci"},{"key":"3792_CR30","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/plcell\/koad308","volume":"36","author":"J Wang","year":"2024","unstructured":"Wang J, Bollier N, Buono RA, Vahldick H, Lin ZC, Feng QN, Hudecek R, Jiang QH, Mylie E, Damme DV et al (2024b) A developmentally controlled cellular decompartmentalization process executes programmed cell death in the Arabidopsis root cap. Plant Cell 36:678\u2013696. https:\/\/doi.org\/10.1093\/plcell\/koad308","journal-title":"Plant Cell"},{"key":"3792_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2025.113821","volume":"49","author":"YZ Wang","year":"2025","unstructured":"Wang YZ, Zhang W, Karamergenova A, Lin L (2025) Fabrication and application of polycaprolactone-based composite scaffolds in tissue engineering: a review. Mater Today Commun 49:113821. https:\/\/doi.org\/10.1016\/j.mtcomm.2025.113821","journal-title":"Mater Today Commun"},{"key":"3792_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2024.108628","volume":"210","author":"AK Wani","year":"2024","unstructured":"Wani AK, Khan Z, Sena S, Akhtar N, Alreshdi MA, Yadav KK, Alkahtani AM, Wani AW, Rahayu F, Tafakresnanto C et al (2024) Carbon nanotubes in plant dynamics: unravelling multifaceted roles and phytotoxic implications. Plant Physiol Biochem 210:108628. https:\/\/doi.org\/10.1016\/j.plaphy.2024.108628","journal-title":"Plant Physiol Biochem"},{"key":"3792_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51741-8","volume":"15","author":"LF Wei","year":"2024","unstructured":"Wei LF, Liu JY, Jiang GB (2024) Nanoparticle-specific transformations dictate nanoparticle effects associated with plants and implications for nanotechnology use in agriculture. Nat Commun 15:7389. https:\/\/doi.org\/10.1038\/s41467-024-51741-8","journal-title":"Nat Commun"},{"key":"3792_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2025.120747","volume":"245","author":"LY Wei","year":"2025","unstructured":"Wei LY, Wang BS, Cao SL, Tan H, Long TY, Bian CF, Peng LC, Wang HL, Cheng X, Zhu WB (2025) Single-cell insights into carbon dots interactions with plant cell walls for distinct internalization pathways via surface charge modulation. Carbon 245:120747. https:\/\/doi.org\/10.1016\/j.carbon.2025.120747","journal-title":"Carbon"},{"key":"3792_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.121031","volume":"271","author":"TT Zhang","year":"2025","unstructured":"Zhang TT, Xu ZH, Xu ZH, Ma Y, Niu ZH, Zhang M (2025a) Progress on layered double hydroxides as green materials in sustainable agricultural production. Environ Res 271:121031. https:\/\/doi.org\/10.1016\/j.envres.2025.121031","journal-title":"Environ Res"},{"key":"3792_CR36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00425-025-04633-0","volume":"261","author":"SN Zhang","year":"2025","unstructured":"Zhang SN, Wang SQ, Zhang B, Yang SH, Wang JH (2025b) Different concentrations of carbon nanotubes promote or inhibit organogenesis of Arabidopsis explants by regulating endogenous hormone homeostasis. Planta 261:55. https:\/\/doi.org\/10.1007\/s00425-025-04633-0","journal-title":"Planta"},{"key":"3792_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.121031","volume":"271","author":"TT Zhang","year":"2025","unstructured":"Zhang TT, Xu ZH, Xu ZH, Ma Y, Niu ZH, Chen JQ, Zhang M, Shi F (2025c) Progress on layered double hydroxides as green materials in sustainable agricultural production. Environ Res 271:121031. https:\/\/doi.org\/10.1016\/j.envres.2025.121031","journal-title":"Environ Res"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-026-03792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10529-026-03792-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-026-03792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:03:18Z","timestamp":1793898198000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10529-026-03792-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3792"],"URL":"https:\/\/doi.org\/10.1007\/s10529-026-03792-8","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"assertion":[{"value":"11 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests in this work.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"118"}}