{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:58:12Z","timestamp":1792083492489,"version":"4.4.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T00:00:00Z","timestamp":1149638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2007,1,5]]},"DOI":"10.1007\/s10534-006-9015-1","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T08:16:51Z","timestamp":1149581811000},"page":"61-72","source":"Crossref","is-referenced-by-count":11,"title":["Characterization and in\u00a0vitro Cytotoxicity Testing of Ethanolamine-derived Cadmium Chelating Agents"],"prefix":"10.1007","volume":"20","author":[{"given":"Mikhail","family":"Zhukalin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan K.","family":"Blanksma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Dimitri","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Suyehira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Heggland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,6,7]]},"reference":[{"key":"9015_CR1","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1021\/cr980453a","volume":"99","author":"O Andersen","year":"1999","unstructured":"Andersen O (1999) Principles and recent developments in chelation treatment of metal intoxication. Chem Rev 99:2683\u20132710","journal-title":"Chem Rev"},{"key":"9015_CR2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/taap.1997.8125","volume":"144","author":"D Beyersmann","year":"1997","unstructured":"Beyersmann D, Hechtenberg S (1997) Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol Appl Pharmacol 144:247\u2013261","journal-title":"Toxicol Appl Pharmacol"},{"key":"9015_CR3","unstructured":"Centers for Disease Control and Prevention (CDC). 2005 Third National Report on Human Exposure to Environmental Chemicals (NCEH Pub. No. 05-0570). National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia 30341\u20133724."},{"key":"9015_CR4","first-page":"307","volume":"27","author":"H Cesur","year":"2003","unstructured":"Cesur H (2003) Determination of manganese, copper, cadmium and lead by FAAS after solid-phase extraction of their phenylpiperazine dithiocarbamate complexes on activated carbon. Turk J Chem 27:307\u2013314","journal-title":"Turk J Chem"},{"key":"9015_CR5","first-page":"27","volume":"17","author":"M Chatterjee","year":"2004","unstructured":"Chatterjee M, Dwivedi VK, Khandekar K, Tandon SK (2004) Chelation in metal intoxication XLVI: Synthesis of some \u03b1-mercapto-\u03b2-substituted aryl acrylic acids and their in\u00a0vitro cadmium chelating ability. Biomed Environ Sci 17: 27\u201332","journal-title":"Biomed Environ Sci"},{"key":"9015_CR6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/1568026013394831","volume":"1","author":"N Ercal","year":"2001","unstructured":"Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress Part I: Mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 1: 529\u2013539","journal-title":"Curr Top Med Chem"},{"key":"9015_CR7","unstructured":"Faggiani R, Gillespie RJ, Vekris JE. 1986 The cadmium(I) ion, Cd 2 2+ ; X-ray crystal structure of Cd2(AlCl4)2. J Chem Soc Chem Comm 517\u2013518."},{"key":"9015_CR8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1039\/an9952000975","volume":"120","author":"AB Fischer","year":"1995","unstructured":"Fischer AB (1995) Studies of cadmium chelator efficacy using mammalian cell cultures. Analyst 120: 975\u2013978","journal-title":"Analyst"},{"key":"9015_CR9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxlet.2005.07.001","volume":"160","author":"G Fotakis","year":"2006","unstructured":"Fotakis G, Timbrell JA (2006) In\u00a0vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 160: 171\u2013177","journal-title":"Toxicol Lett"},{"key":"9015_CR10","first-page":"474","volume":"13","author":"GR Gale","year":"1983","unstructured":"Gale GR, Atkins LM, Walker EM, Jr, Smith AB, Jones MM (1983) Mechanism of diethyldithiocarbamate, dihydroxyethyldithiocarbamate, and dicarboxymethyldithiocarbamate action of distribution and excretion of cadmium. Ann Clin Lab Sci 13: 474\u2013481","journal-title":"Ann Clin Lab Sci"},{"key":"9015_CR11","first-page":"137","volume":"14","author":"GR Gale","year":"1984","unstructured":"Gale GR, Atkins LM, Walker EM, Jr, Smith AB, Jones MM (1984) Dithiocarbamates and cadmium metabolism: Further correlations of cadmium chelate partition coefficients with pharmacologic activity. Ann Clin Lab Sci 14: 137\u2013145","journal-title":"Ann Clin Lab Sci"},{"key":"9015_CR12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0300-483X(02)00546-2","volume":"183","author":"A Gennari","year":"2003","unstructured":"Gennari A, Cortese E, Boveri M, Casado J, Prieto P (2003) Sensitive endpoints for evaluating cadmium-induced acute toxicity in LLC-PK1 cells. Toxicology 183: 211\u2013220","journal-title":"Toxicology"},{"key":"9015_CR13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/tera.1420420308","volume":"42","author":"A Hatori","year":"1990","unstructured":"Hatori A, Willhite CC, Jones MM, Sharma RP (1990) Dithiocarbamates and prevention of cadmium teratogenesis in the hamster. Teratology 42: 243\u2013251","journal-title":"Teratology"},{"key":"9015_CR14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1021\/cen-v084n001.p018","volume":"84","author":"B Hileman","year":"2006","unstructured":"Hileman B (2006) Electronic waste: States strive to solve burgeoning disposal problem as more waste ends up in developing countries. C&EN 84: 18\u201321","journal-title":"C&EN"},{"key":"9015_CR15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1023\/B:BIOM.0000045729.68774.a1","volume":"17","author":"L J\u00e4rup","year":"2004","unstructured":"J\u00e4rup L, Alfv\u00e9n T (2004) Low level cadmium exposure, renal and bone effects \u2013 the OSCAR study. Biometals 17: 505\u2013509","journal-title":"Biometals"},{"key":"9015_CR16","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/oem.55.11.755","volume":"55","author":"L J\u00e4rup","year":"1998a","unstructured":"J\u00e4rup L, Bellander T, Hogstedt C, Spang G (1998a) Mortality and cancer incidence in Swedish battery workers exposed to cadmium and nickel. Occup Environ Med 55: 755\u2013759","journal-title":"Occup Environ Med"},{"issue":"Suppl 1","key":"9015_CR17","first-page":"1","volume":"24","author":"L J\u00e4rup","year":"1998b","unstructured":"J\u00e4rup L, Berglund M, Elinder CG, Nordberg G, Vahter M (1998b) Health effects of cadmium exposure \u2013 a review of the literature and a risk estimate. Scand J Work Environ Health 24(Suppl 1): 1\u201351","journal-title":"Scand J Work Environ Health"},{"key":"9015_CR18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3390\/70700549","volume":"7","author":"XH Jiang","year":"2002","unstructured":"Jiang XH, Zhang WG, Zhong Y, Wang SL (2002) Synthesis and structure of the cadmium (II) complex: $$[\\hbox{Cd}(\\hbox{C}_{5}\\hbox{H}_{5}\\hbox{N})_{2}(\\hbox{S}_{2}\\hbox{CO-}n\\hbox{-C}_{4}\\hbox{H}_{9})_{2}]$$ . Molecules 7: 549\u2013553","journal-title":"Molecules"},{"key":"9015_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-483X(90)90027-E","volume":"62","author":"MM Jones","year":"1990","unstructured":"Jones MM, Cherian MG (1990) The search for chelate antagonists for chronic cadmium intoxication. Toxicology 62:1\u201325","journal-title":"Toxicology"},{"key":"9015_CR20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0041-008X(05)80006-7","volume":"110","author":"MM Jones","year":"1991a","unstructured":"Jones MM, Cherian MG, Singh PK, Basinger MA, Jones SG (1991a) A comparative study of the influence of vicinal dithiols and a dithiocarbamate on the biliary excretion of cadmium in rat. Toxicol Appl Pharmacol 110: 241\u2013250","journal-title":"Toxicol Appl Pharmacol"},{"key":"9015_CR21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1021\/tx00019a004","volume":"4","author":"MM Jones","year":"1991b","unstructured":"Jones MM, Singh PK, Jones SG, Mukundan CR, Banton JA, Gale GR, Atkins LM, Smith AB (1991b) Chirality, charge, and chain branching effects on dithiocarbamate-induced mobilization of cadmium from intracellular deposits in mice. Chem Res Toxicol 4: 27\u201334","journal-title":"Chem Res Toxicol"},{"key":"9015_CR22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1023\/B:BIOM.0000045727.76054.f3","volume":"17","author":"G Kazantzis","year":"2004","unstructured":"Kazantzis G (2004) Cadmium, osteoporosis, and calcium metabolism. BioMetals 17: 493\u2013498","journal-title":"BioMetals"},{"key":"9015_CR23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2174\/1381612805666230109212741","volume":"5","author":"C Kelley","year":"1999","unstructured":"Kelley C, Sargent DE, Uno JK (1999) Cadmium therapeutic agents. Curr Pharm Des 5: 229\u2013240","journal-title":"Curr Pharm Des"},{"key":"9015_CR24","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.freeradbiomed.2004.03.020","volume":"36","author":"A Lemari\u00e9","year":"2004","unstructured":"Lemari\u00e9 A, Lagadic-Gossmann D, Morzadec C, Allain N, Fardel O, Vernhet L (2004) Cadmium induces caspase-independent apoptosis in liver HEP3B cells: Role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Free Radic Biol Med 36:1517\u20131531","journal-title":"Free Radic Biol Med"},{"key":"9015_CR25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1246\/bcsj.55.809","volume":"55","author":"M Nakashima","year":"1982","unstructured":"Nakashima M, Kida S (1982) Photoreaction of tris(ethylenediamine)cobalt(III) ion with bis(2-hydroxyethyl)dithiocarbamate ion. Bull Chem Soc Jpn 55: 809\u2013812","journal-title":"Bull Chem Soc Jpn"},{"key":"9015_CR26","first-page":"349","volume":"4","author":"J Nerudov\u00e1","year":"1991","unstructured":"Nerudov\u00e1 J, Bl\u00e1ha K, Sokal A, Jehlickov\u00e1 H, Cikrt M (1991) Mobilization of aged cadmium from isolated rat hepatocytes by sulfhydryl chelators. Pol J Occup Med Environ Health 4:349\u2013357","journal-title":"Pol J Occup Med Environ Health"},{"key":"9015_CR27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1023\/B:BIOM.0000045726.75367.85","volume":"17","author":"GF Nordberg","year":"2004","unstructured":"Nordberg GF (2004) Cadmium and health in the 21st century \u2013 historical remarks and trends for the future. BioMetals 17: 485\u2013489","journal-title":"BioMetals"},{"key":"9015_CR28","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1103\/PhysRevB.44.5881","volume":"44","author":"G Ortiz","year":"1991","unstructured":"Ortiz G, Ballone P (1991) Metastability of doubly charged transition-metal dimers in density-functional theory. Phys Rev B 44: 5881\u20135884","journal-title":"Phys Rev B"},{"key":"9015_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0162-0134(85)83005-1","volume":"25","author":"A Pages","year":"1985","unstructured":"Pages A, Casas JS, Sanchez A, Sordo J, Bravo J, Gayoso M (1985) Dithiocarbamates in Heavy Metal Poisoning: Complexes of N,N-di(2-hidroxyethyl)dithiocarbamate with Zn(ll), Cd(ll), Hg(ll), CH3Hg(II), and C6H5Hg(II). J lnorg Biochem 25: 35\u201342","journal-title":"J lnorg Biochem"},{"key":"9015_CR30","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1126\/science.1101356","volume":"305","author":"I Resa","year":"2004","unstructured":"Resa I, Carmona E, Gutierrez-Puebla E, Monge A (2004) Decamethyldizincocene, a stable compound of Zn(I) with a Zn\u2013Zn bond. Science 305:1136\u20131138","journal-title":"Science"},{"key":"9015_CR31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0887-2333(03)00132-2","volume":"18","author":"K Ridd","year":"2004","unstructured":"Ridd K, Alexander DJ, Reed CJ (2004) Foetal rat lung epithelial (FRLE) cells: Partial characterisation and response to pneumotoxins. Toxicol In Vitro 18:79\u201388","journal-title":"Toxicol In Vitro"},{"key":"9015_CR32","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0140-6736(98)09356-8","volume":"353","author":"JA Staessen","year":"1999","unstructured":"Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R (1999) Environmental exposure to cadmium, forearm bone density, and risk of fractures: Prospective population study. Lancet 353:1140\u20131144","journal-title":"Lancet"},{"key":"9015_CR33","first-page":"205","volume":"13","author":"SK Tandon","year":"2000","unstructured":"Tandon SK, Prasad S, Singh S (2000) Chelation in metal intoxication. XLIV: Efficacy of \u03b1-mercapto-\u03b2-(5-substituted, 2-furyl) acrylic acids in mobilizing intracellularly bound cadmium in rat. Biomed Environ Sci 13: 205\u2013212","journal-title":"Biomed Environ Sci"},{"key":"9015_CR34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jat.723","volume":"21","author":"E T\u00e1trai","year":"2001a","unstructured":"T\u00e1trai E, Br\u00f3zik M, N\u00e1ray M, Adamis Z, Ungv\u00e1ry G (2001a) Combined pulmonary toxicity of cadmium chloride and sodium diethyldithiocarbamate. J Appl Toxicol 21:101\u2013105","journal-title":"J Appl Toxicol"},{"key":"9015_CR35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/009841001458316","volume":"62","author":"E T\u00e1trai","year":"2001b","unstructured":"T\u00e1trai E, Kov\u00e1cikov\u00e1 Z, Kar\u00e1csony G, Hud\u00e1k A, Adamis Z, Ungv\u00e1ry G (2001b) Effects of sodium diethyldithiocarbamate on type II pulmonary epithelial cells in\u00a0vitro. J Toxicol Environ Health, Part A 62:207\u2013216","journal-title":"J Toxicol Environ Health, Part A"},{"key":"9015_CR36","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1074\/jbc.275.3.1887","volume":"275","author":"F Th\u00e9venod","year":"2000","unstructured":"Th\u00e9venod F, Friedmann JM, Katsen AD, Hauser IA (2000) Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-\u03baB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J Biol Chem 275:1887\u20131896","journal-title":"J Biol Chem"},{"key":"9015_CR37","unstructured":"Van\u00a0Assche FJ. 1998 A stepwise model to quantify the relative contribution of different environmental sources to human cadmium exposure. NiCad \u201998, Prague, Czech Republic, September 21\u201322."},{"key":"9015_CR38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0300-483X(03)00305-6","volume":"192","author":"M Waisberg","year":"2003","unstructured":"Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192: 95\u2013117","journal-title":"Toxicology"},{"key":"9015_CR39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1024405119018","volume":"17","author":"W W\u00e4tjen","year":"2004","unstructured":"W\u00e4tjen W, Beyersmann D (2004) Cadmium-induced apoptosis in C6 glioma cells: Influence of oxidative stress. Biometals 17: 65\u201378","journal-title":"Biometals"},{"key":"9015_CR40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/00984109708984058","volume":"52","author":"H Yan","year":"1997","unstructured":"Yan H, Carter CE, Xu C, Singh PK, Jones MM, Johnson JE, Dietrich MS (1997) Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation. J Toxicol Environ Health 52: 149\u2013168","journal-title":"J Toxicol Environ Health"},{"key":"9015_CR41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/80500411","volume":"8","author":"W Zhang","year":"2003","unstructured":"Zhang W, Zhong Y, Tan M, Tang N, Yu K (2003) Synthesis and Structure of bis(Dibutyldithiocarbamate)zinc(II): $$\\hbox{Zn}_{2}[(n\\hbox{-Bu})_{2}\\hbox{NCSS}]_{4}$$ . Molecules 8: 411\u2013417","journal-title":"Molecules"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-006-9015-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-006-9015-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-006-9015-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T16:30:49Z","timestamp":1683477049000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-006-9015-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1,5]]}},"alternative-id":["9015"],"URL":"https:\/\/doi.org\/10.1007\/s10534-006-9015-1","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,7]]}}}