{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:54:51Z","timestamp":1769846091722,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T00:00:00Z","timestamp":1276041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s10534-010-9349-6","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T08:50:22Z","timestamp":1275987022000},"page":"1043-1051","source":"Crossref","is-referenced-by-count":24,"title":["A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder"],"prefix":"10.1007","volume":"23","author":[{"given":"Janet K.","family":"Kern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Geier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Geier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,9]]},"reference":[{"issue":"12","key":"9349_CR1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1080\/15287390601172080","volume":"70","author":"JB Adams","year":"2007","unstructured":"Adams JB, Romdalvik J, Ramanujam VM, Legator MS (2007) Mercury, lead, and zinc in baby teeth of children with autism versus controls. J Toxicol Environ Health A 70(12):1046\u20131051","journal-title":"J Toxicol Environ Health A"},{"key":"9349_CR2","doi-asserted-by":"crossref","unstructured":"Adams JB, Baral M, Geis E, Mitchel JL, Ingram J, Hensley A, Zappia I, Newmark S, Gehn E, Rubin R.A, Mitchell K, Bradstreet J, El-Dahr JJM (2009) The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels. J Toxicol. doi: 10.1155\/2009\/532640","DOI":"10.1155\/2009\/532640"},{"key":"9349_CR3","unstructured":"American Psychiatric Association (2000) Diagnostic criteria for autistic disorder. In Diagnostic and statistical manual of mental disorders (Fourth edition\u2014text revision (DSM-IV-TR). American Psychiatric Association, Washington, DC, p 75"},{"issue":"6","key":"9349_CR4","first-page":"46","volume":"14","author":"RL Blaylock","year":"2008","unstructured":"Blaylock RL (2008) A possible central mechanism in autism spectrum disorders, part 1. Altern Ther in Health Med 14(6):46\u201353","journal-title":"Altern Ther in Health Med"},{"key":"9349_CR5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/092986709787002745","volume":"16","author":"RL Blaylock","year":"2009","unstructured":"Blaylock RL, Struneka A (2009) Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Curr Med Chem 16:157\u2013170","journal-title":"Curr Med Chem"},{"issue":"3","key":"9349_CR6","first-page":"76","volume":"8","author":"J Bradstreet","year":"2003","unstructured":"Bradstreet J, Geier DA, Kartzinel JJ, Adams JB, Geier MR (2003) A case-control study of mercury burden in children with autistic spectrum disorders. J Am Phys Surg 8(3):76\u201379","journal-title":"J Am Phys Surg"},{"key":"9349_CR7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-4800(90)90070-T","volume":"52","author":"G Danscher","year":"1990","unstructured":"Danscher G, Horsted-Bindslev P, Rungby J (1990) Traces of mercury in organs from primates with amalgam fillings. Exp Mol Pathol 52:291\u2013299","journal-title":"Exp Mol Pathol"},{"issue":"11","key":"9349_CR8","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1177\/0883073807307111","volume":"22","author":"MC DeSoto","year":"2007","unstructured":"DeSoto MC, Hitlan RT (2007) Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set. J Child Neurol 22(11):1308\u20131311","journal-title":"J Child Neurol"},{"issue":"2","key":"9349_CR9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0892-0362(94)00049-J","volume":"17","author":"D Echeverria","year":"1995","unstructured":"Echeverria D, Heyer NJ, Martin MD, Naleway CA, Woods JS, Bittner AC (1995) Behavioral effects of low-level exposure to Hg0 among dentists. Neurotoxicol Teratol 17(2):161\u2013168","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"9349_CR10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jnr.20375","volume":"79","author":"E Fonfria","year":"2005","unstructured":"Fonfria E, Vilaro MT, Babot Z, Rodriguez-Farre E, Sunol C (2005) Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells. J Neurosci Res 79(4):545\u2013553","journal-title":"J Neurosci Res"},{"issue":"5","key":"9349_CR11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/ije\/dyp258","volume":"38","author":"I Hertz-Picciotto","year":"2009","unstructured":"Hertz-Picciotto I (2009) Commentary: diagnostic change and the increase prevalence of autism. Int J Epidemiol 38(5):1239\u20131241","journal-title":"Int J Epidemiol"},{"issue":"1","key":"9349_CR12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/EDE.0b013e3181902d15","volume":"20","author":"I Hertz-Picciotto","year":"2009","unstructured":"Hertz-Picciotto I, Delwiche L (2009) The rise in autism and the role of age at diagnosis. Epidemiology 20(1):84\u201390","journal-title":"Epidemiology"},{"issue":"3","key":"9349_CR13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxlet.2007.11.004","volume":"176","author":"CF Huang","year":"2008","unstructured":"Huang CF, Hsu CJ, Liu SH, Lin-Shiau SY (2008) Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: oxidative stress and down-regulated Na+\/K(+)-ATPase involved. Toxicol Lett 176(3):188\u2013197","journal-title":"Toxicol Lett"},{"key":"9349_CR14","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.metabol.2008.07.009","volume":"57 Suppl 2","author":"M Kalia","year":"2008","unstructured":"Kalia M (2008) Brain development: anatomy, connectivity, adaptive plasticity, and toxicity. Metabolism 57 Suppl 2:S2\u2013S5","journal-title":"Metabolism"},{"issue":"6","key":"9349_CR15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0387-7604(03)00056-1","volume":"25","author":"JK Kern","year":"2003","unstructured":"Kern JK (2003) Purkinje cell vulnerability and autism: a possible etiological connection. Brain Dev 25(6):377\u2013382","journal-title":"Brain Dev"},{"issue":"6","key":"9349_CR16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/10937400600882079","volume":"9","author":"JK Kern","year":"2006","unstructured":"Kern JK, Jones AM (2006) Evidence of toxicity, oxidative stress, and neuronal insult in autism. J Toxicol Environ Health B 9(6):485\u2013499","journal-title":"J Toxicol Environ Health B"},{"issue":"6","key":"9349_CR17","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s10534-009-9261-0","volume":"22","author":"DR Laks","year":"2009","unstructured":"Laks DR (2009) Assessment of chronic mercury exposure within the U.S. population, National Health and Nutrition Examination Survey, 1999\u20132006. Biometals 22(6):1103","journal-title":"Biometals"},{"key":"9349_CR18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3844\/ajbbsp.2008.130.145","volume":"4","author":"E Lopez-Hurtado","year":"2008","unstructured":"Lopez-Hurtado E, Prieto JJ (2008) A microsopic study of language-related cortex in autism. Am J Biochem Biotechnol 4:130\u2013145","journal-title":"Am J Biochem Biotechnol"},{"key":"9349_CR19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.taap.2006.04.008","volume":"214","author":"R Nataf","year":"2006","unstructured":"Nataf R, Skorupka C, Amet L, Lam A, Springbett A, Lathe R (2006) Porphyinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol Appl Pharmcol 214:99\u2013108","journal-title":"Toxicol Appl Pharmcol"},{"key":"9349_CR20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00019052-199412000-00013","volume":"7","author":"CW Olanow","year":"1994","unstructured":"Olanow CW, Arendash GW (1994) Metals and free radicals in neurodegeneration. Curr Opin Neurol 7:548\u2013558","journal-title":"Curr Opin Neurol"},{"issue":"2","key":"9349_CR21","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/toxsci\/61.2.234","volume":"61","author":"SD Pingree","year":"2001","unstructured":"Pingree SD, Simmonds PL, Rummel KT, Woods JS (2001) Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats. Toxicol Sci 61(2):234\u2013240","journal-title":"Toxicol Sci"},{"key":"9349_CR22","doi-asserted-by":"crossref","unstructured":"Rimland B, Edelson M (1999) Autism Treatment Evaluation Checklist. Autism Research Institute, 4812 Adams Ave, San Diego, CA 92116. www.ARI-ATEC.com and https:\/\/www.autismeval.com\/ari-atec\/report1.html","DOI":"10.1037\/t03995-000"},{"key":"9349_CR23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/08035250410023124","volume":"94","author":"M Rutter","year":"2005","unstructured":"Rutter M (2005) Incidence of autism spectrum disorders: changes over time and their meaning. Acta Pediatr 94:2\u201315","journal-title":"Acta Pediatr"},{"key":"9349_CR24","unstructured":"Schopler E, Reichler RJ, Renner BR (1994) The Childhood Autism Rating Scale. Western Psychological Services, 12031 Wilshire Boulevard, Los Angeles, California, 90025-91251"},{"issue":"11","key":"9349_CR25","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1021\/es0157503","volume":"36","author":"PF Schuster","year":"2002","unstructured":"Schuster PF, Krabbenhoft DP, Naftz DL, Cecil LD, Olson ML, Dewild JF, Susong DD, Green JR, Abbott ML (2002) Atmospherc mercury deposition during the last 270\u00a0years: a glacial ice core record of natural and anthropogenic sources. Environ Sci Technol 36(11):2303\u20132310","journal-title":"Environ Sci Technol"},{"issue":"1","key":"9349_CR26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.taap.2007.10.010","volume":"227","author":"J Stringari","year":"2008","unstructured":"Stringari J, Nunes AK, Franco JL, Bohrer D, Garcia SC, Dafre AL, Milatovic D, Souza DO, Rocha JB, Aschner M, Farina M (2008) Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol Appl Pharmacol 227(1):147\u2013154","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"9349_CR27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.taap.2003.11.002","volume":"195","author":"T Toimela","year":"2004","unstructured":"Toimela T, Maenpaa H, Mannerstrom M, Tahti H (2004) Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicol Appl Pharmacol 195(1):73\u201382","journal-title":"Toxicol Appl Pharmacol"},{"key":"9349_CR28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.mp.4001476","volume":"9","author":"M Waly","year":"2004","unstructured":"Waly M, Olteanu H, Banjeree R, Choi SW, Manson JB, Parker BS, Sukumar S, Shim S, Sharma A, Benzecry JM, Power-Charnitsky VA, Deth RC (2004) Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Mol Psychiatry 9:358\u2013370","journal-title":"Mol Psychiatry"},{"key":"9349_CR29","first-page":"210","volume":"74","author":"JS Woods","year":"1996","unstructured":"Woods JS (1996) Altered prophyrin metabolism as a biomarker of mercury exposure and toxicity. Can J Physiol Pharmacol 74:210\u2013215","journal-title":"Can J Physiol Pharmacol"},{"issue":"14","key":"9349_CR30","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/15287390902959557","volume":"72","author":"JS Woods","year":"2009","unstructured":"Woods JS, Martin MD, Leroux BG, DeRouen TA, Bernardo MF, Luis HS, Leitao JG, Simmonds PL, Echeverria D, Rue TC (2009) Urinary porphyrins excretion in children with mercury amalgam treatment: findings from the Casa Pia Children\u2019s Dental Amalgam Trial. J Toxicol Environ Health A 72(14):891\u2013896","journal-title":"J Toxicol Environ Health A"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-010-9349-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-010-9349-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-010-9349-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T02:24:59Z","timestamp":1635474299000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-010-9349-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,9]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["9349"],"URL":"https:\/\/doi.org\/10.1007\/s10534-010-9349-6","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,9]]}}}