{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:15:54Z","timestamp":1791062154839,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s10534-012-9521-2","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T06:24:48Z","timestamp":1327991088000},"page":"633-642","source":"Crossref","is-referenced-by-count":16,"title":["Copper deficiency has minimal impact on ferroportin expression or function"],"prefix":"10.1007","volume":"25","author":[{"given":"Joseph R.","family":"Prohaska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Broderius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"9521_CR1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S0007114507239960","volume":"97","author":"HS Andersen","year":"2007","unstructured":"Andersen HS, Gambling L, Holtrop G, McArdle HJ (2007) Effect of dietary copper deficiency on iron metabolism in the pregnant rat. Br J Nutr 97:239\u2013246","journal-title":"Br J Nutr"},{"key":"9521_CR2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3945\/jn.108.094052","volume":"139","author":"F Aydemir","year":"2009","unstructured":"Aydemir F, Jenkitkasemwong S, Gulec S, Knutson MD (2009) Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages. J Nutr 139:434\u2013438","journal-title":"J Nutr"},{"key":"9521_CR3","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1210\/en.2010-0252","volume":"151","author":"TW Bastian","year":"2010","unstructured":"Bastian TW, Prohaska JR, Georgieff MK, Anderson GW (2010) Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations. Endocrinology 151:4055\u20134065","journal-title":"Endocrinology"},{"key":"9521_CR4","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.jnutbio.2010.09.007","volume":"22","author":"TW Bastian","year":"2011","unstructured":"Bastian TW, Lassi KC, Anderson GW, Prohaska JR (2011) Maternal iron supplementation attenuates the impact of perinatal copper deficiency but does not eliminate hypotriiodothyroninemia nor impaired sensorimotor development. J Nutr Biochem 22:1084\u20131090","journal-title":"J Nutr Biochem"},{"key":"9521_CR5","first-page":"473","volume":"151","author":"M Broderius","year":"2010","unstructured":"Broderius M, Mostad E, Wendroth K, Prohaska JR (2010) Levels of plasma ceruloplasmin protein are markedly lower following dietary copper deficiency in rodents. Comp Biochem Physiol C 151:473\u2013479","journal-title":"Comp Biochem Physiol C"},{"key":"9521_CR6","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1182\/blood-2003-02-0347","volume":"102","author":"H Chen","year":"2003","unstructured":"Chen H, Su T, Attieh ZK, Fox TC, McKie AT, Anderson GJ, Vulpe CD (2003) Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency. Blood 102:1893\u20131899","journal-title":"Blood"},{"key":"9521_CR7","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/jn\/136.5.1236","volume":"136","author":"H Chen","year":"2006","unstructured":"Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD (2006) Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency. J Nutr 136:1236\u20131241","journal-title":"J Nutr"},{"key":"9521_CR8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10534-009-9229-0","volume":"22","author":"H Chen","year":"2009","unstructured":"Chen H, Attieh ZK, Gao H, Huang G, Su T, Ke W, Vulpe CD (2009) Age-related changes in iron homeostasis in mouse ferroxidase mutants. Biometals 22:827\u2013834","journal-title":"Biometals"},{"key":"9521_CR9","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3945\/jn.109.117531","volume":"140","author":"H Chen","year":"2010","unstructured":"Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD, McArdle HJ (2010) Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells. J Nutr 140:1728\u20131735","journal-title":"J Nutr"},{"key":"9521_CR10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/jn\/134.3.517","volume":"134","author":"J Chung","year":"2004","unstructured":"Chung J, Prohaska JR, Wessling-Resnick M (2004) Ferroportin-1 is not upregulated in copper-deficient mice. J Nutr 134:517\u2013521","journal-title":"J Nutr"},{"key":"9521_CR11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1753-4887.2010.00271.x","volume":"68","author":"JF Collins","year":"2010","unstructured":"Collins JF, Prohaska JR, Knutson MD (2010) Metabolic crossroads of iron and copper. Nutr Rev 68:133\u2013147","journal-title":"Nutr Rev"},{"key":"9521_CR12","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/sj.emboj.7601735","volume":"26","author":"I Domenico De","year":"2007","unstructured":"De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J (2007) Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J 26:2823\u20132831","journal-title":"EMBO J"},{"key":"9521_CR13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","volume":"1","author":"A Donovan","year":"2005","unstructured":"Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC (2005) The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis. Cell Metab 1:191\u2013200","journal-title":"Cell Metab"},{"key":"9521_CR14","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0271-5317(88)80006-X","volume":"8","author":"ML Failla","year":"1988","unstructured":"Failla ML, Seidel KE (1988) Total body content of copper and other essential metals in rats fed fructose or starch. Nutr Res 8:1379\u20131389","journal-title":"Nutr Res"},{"key":"9521_CR15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1020799512190","volume":"16","author":"PL Fox","year":"2003","unstructured":"Fox PL (2003) The copper-iron chronicles: the story of an intimate relationship. Biometals 16:9\u201340","journal-title":"Biometals"},{"key":"9521_CR16","doi-asserted-by":"crossref","unstructured":"Gletsu-Miller N, Broderius M, Frediani JK, Zhao VM, Griffith DP, Davis SSJ, Sweeney JF, Lin E, Prohaska JR, Ziegler TR (2012) Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. Int J Obesity (in press)","DOI":"10.1038\/ijo.2011.159"},{"key":"9521_CR17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1042\/BJ20081983","volume":"419","author":"LW Gray","year":"2009","unstructured":"Gray LW, Kidane TZ, Nguyen A, Akagi S, Petrasek K, Chu YL, Cabrera A, Kantardjieff K, Mason AZ, Linder MC (2009) Copper proteins and ferroxidases in human plasma and that of wild-type and ceruloplasmin knockout mice. Biochem J 419:237\u2013245","journal-title":"Biochem J"},{"key":"9521_CR18","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1074\/jbc.M709463200","volume":"283","author":"S Itoh","year":"2008","unstructured":"Itoh S, Kim HW, Nakagawa O, Ozumi K, Lessner SM, Aoki H, Akram K, McKinney RD, Ushio-Fukai M, Fukai T (2008) Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation. J Biol Chem 283:9157\u20139167","journal-title":"J Biol Chem"},{"key":"9521_CR19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3945\/jn.109.117077","volume":"140","author":"S Jenkitkasemwong","year":"2010","unstructured":"Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD (2010) Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels. J Nutr 140:723\u2013730","journal-title":"J Nutr"},{"key":"9521_CR20","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/jn\/128.11.1855","volume":"128","author":"J Karimbakas","year":"1998","unstructured":"Karimbakas J, Langkamp-Henken B, Percival SS (1998) Arrested maturation of granulocytes in copper deficient mice. J Nutr 128:1855\u20131860","journal-title":"J Nutr"},{"key":"9521_CR21","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1182\/blood-2008-03-143354","volume":"112","author":"L Kautz","year":"2008","unstructured":"Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, Deng C, Vaulont S, Mosser J, Coppin H, Roth MP (2008) Iron regulates phosphorylation of Smad1\/5\/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112:1503\u20131509","journal-title":"Blood"},{"key":"9521_CR22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.nutr.012809.104801","volume":"30","author":"MD Knutson","year":"2010","unstructured":"Knutson MD (2010) Iron-sensing proteins that regulate hepcidin and enteric iron absorption. Annu Rev Nutr 30:149\u2013171","journal-title":"Annu Rev Nutr"},{"key":"9521_CR23","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.bbamcr.2010.05.004","volume":"1802","author":"S Kono","year":"2010","unstructured":"Kono S, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H (2010) Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. Biochem Biophys Acta 1802:968\u2013975","journal-title":"Biochem Biophys Acta"},{"key":"9521_CR24","doi-asserted-by":"crossref","first-page":"6836","DOI":"10.1073\/pnas.111057298","volume":"98","author":"YM Kuo","year":"2001","unstructured":"Kuo YM, Zhou B, Cosco D, Gitschier J (2001) The copper transporter CTR1 provides an essential function in mammalian embryonic development. Proc Natl Acad Sci USA 98:6836\u20136841","journal-title":"Proc Natl Acad Sci USA"},{"key":"9521_CR25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-1119(00)00287-0","volume":"254","author":"J Lee","year":"2000","unstructured":"Lee J, Prohaska JR, Dagenais SL, Glover TW, Thiele DJ (2000) Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant. Gene 254:87\u201396","journal-title":"Gene"},{"key":"9521_CR26","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1073\/pnas.111058698","volume":"98","author":"J Lee","year":"2001","unstructured":"Lee J, Prohaska JR, Thiele DJ (2001) Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc Natl Acad Sci USA 98:6842\u20136847","journal-title":"Proc Natl Acad Sci USA"},{"key":"9521_CR27","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0168-8278(03)00408-2","volume":"39","author":"A Lymboussaki","year":"2003","unstructured":"Lymboussaki A, Pignatti E, Montosi G, Garuti C, Haile DJ, Pietrangelo A (2003) The role of the iron responsive element in the control of ferroportin1\/IREG1\/MTP1 gene expression. J Hepatol 39:710\u2013715","journal-title":"J Hepatol"},{"key":"9521_CR28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1258\/ebm.2010.010256","volume":"236","author":"EJ Mostad","year":"2011","unstructured":"Mostad EJ, Prohaska JR (2011) Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency. Exp Biol Med 236:298\u2013308","journal-title":"Exp Biol Med"},{"key":"9521_CR29","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/ng1152","volume":"34","author":"M Muckenthaler","year":"2003","unstructured":"Muckenthaler M, Roy CN, Custodio AO, Minana B, deGraaf J, Montross LK, Andrews NC, Hentze MW (2003) Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 34:102\u2013107","journal-title":"Nat Genet"},{"key":"9521_CR30","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","volume":"306","author":"E Nemeth","year":"2004","unstructured":"Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090\u20132093","journal-title":"Science"},{"key":"9521_CR31","doi-asserted-by":"crossref","first-page":"20185","DOI":"10.1074\/jbc.272.32.20185","volume":"272","author":"BN Patel","year":"1997","unstructured":"Patel BN, David S (1997) A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. J Biol Chem 272:20185\u201320190","journal-title":"J Biol Chem"},{"key":"9521_CR32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0271-5317(81)80098-X","volume":"1","author":"JR Prohaska","year":"1981","unstructured":"Prohaska JR (1981) Comparison between dietary and genetic copper deficiency in mice: copper-dependent anemia. Nutr Res 1:159\u2013167","journal-title":"Nutr Res"},{"key":"9521_CR33","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1093\/jn\/113.10.2048","volume":"113","author":"JR Prohaska","year":"1983","unstructured":"Prohaska JR (1983) Changes in tissue growth, concentrations of copper, iron, cytochrome oxidase and superoxide dismutase subsequent to dietary or genetic copper deficiency in mice. J Nutr 113:2048\u20132058","journal-title":"J Nutr"},{"key":"9521_CR34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0271-5317(89)80078-8","volume":"9","author":"JR Prohaska","year":"1989","unstructured":"Prohaska JR (1989) Effect of diet on milk copper and iron content of normal and heterozygous brindled mice. Nutr Res 9:353\u2013356","journal-title":"Nutr Res"},{"key":"9521_CR35","first-page":"458","volume-title":"Present knowledge in nutrition","author":"JR Prohaska","year":"2006","unstructured":"Prohaska JR (2006) Copper. In: Bowman BA, Russell RM (eds) Present knowledge in nutrition, vol 1. International Life Sciences Institute, Washington, pp 458\u2013470"},{"key":"9521_CR36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3945\/an.110.000208","volume":"2","author":"JR Prohaska","year":"2011","unstructured":"Prohaska JR (2011) Impact of copper limitation on expression and function of multicopper oxidases (ferroxidases). Adv Nutr 2:129\u2013137","journal-title":"Adv Nutr"},{"key":"9521_CR37","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1093\/jn\/129.12.2147","volume":"129","author":"JR Prohaska","year":"1999","unstructured":"Prohaska JR, Brokate B (1999) Copper deficiency alters rat dopamine \u03b2-monooxygenase mRNA and activity. J Nutr 129:2147\u20132153","journal-title":"J Nutr"},{"key":"9521_CR38","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1093\/jn\/112.9.1706","volume":"112","author":"JR Prohaska","year":"1982","unstructured":"Prohaska JR, Heller LJ (1982) Mechanical properties of the copper-deficient rat heart. J Nutr 112:2142\u20132150","journal-title":"J Nutr"},{"key":"9521_CR39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-4613-0553-8_11","volume":"262","author":"JR Prohaska","year":"1990","unstructured":"Prohaska JR, Lukasewycz OA (1990) Effects of copper deficiency on the immune system. Adv Exp Med Biol 262:123\u2013143","journal-title":"Adv Exp Med Biol"},{"key":"9521_CR40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1471-4159.1975.tb06956.x","volume":"25","author":"JR Prohaska","year":"1975","unstructured":"Prohaska JR, Wells WW (1975) Copper deficiency in the developing rat brain: evidence for abnormal mitochondria. J Neurochem 25:221\u2013228","journal-title":"J Neurochem"},{"key":"9521_CR41","first-page":"316","volume":"147","author":"JW Pyatskowit","year":"2008","unstructured":"Pyatskowit JW, Prohaska JR (2008a) Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels. Comp Biochem Physiol C 147:316\u2013323","journal-title":"Comp Biochem Physiol C"},{"key":"9521_CR42","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1093\/jn\/138.10.1880","volume":"138","author":"JW Pyatskowit","year":"2008","unstructured":"Pyatskowit JW, Prohaska JR (2008b) Iron injection restores brain iron and hemoglobin deficits in perinatal copper-deficient rats. J Nutr 138:1880\u20131886","journal-title":"J Nutr"},{"key":"9521_CR43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10534-007-9123-6","volume":"21","author":"JW Pyatskowit","year":"2008","unstructured":"Pyatskowit JW, Prohaska JR (2008c) Multiple mechanisms account for lower plasma iron in young copper deficient rats. Biometals 21:343\u2013352","journal-title":"Biometals"},{"key":"9521_CR44","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/jn\/134.8.1953","volume":"134","author":"PG Reeves","year":"2004","unstructured":"Reeves PG, DeMars LC (2004) Copper deficiency reduces iron absorption and biological half-life in male rats. J Nutr 134:1953\u20131957","journal-title":"J Nutr"},{"key":"9521_CR45","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1177\/153537020523000505","volume":"230","author":"PG Reeves","year":"2005","unstructured":"Reeves PG, Demars LC (2005) Repletion of copper-deficient rats with dietary copper restores duodenal hephaestin protein and iron absorption. Exp Biol Med 230:320\u2013325","journal-title":"Exp Biol Med"},{"key":"9521_CR46","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jnutbio.2006.04.004","volume":"17","author":"PG Reeves","year":"2006","unstructured":"Reeves PG, DeMars LC (2006) Signs of iron deficiency in copper-deficient rats are not affected by iron supplements administered by diet or by injection. J Nutr Biochem 17:635\u2013642","journal-title":"J Nutr Biochem"},{"key":"9521_CR47","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jn\/135.1.92","volume":"135","author":"PG Reeves","year":"2005","unstructured":"Reeves PG, Demars LC, Johnson WT, Lukaski HC (2005) Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. J Nutr 135:92\u201398","journal-title":"J Nutr"},{"key":"9521_CR48","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2010.08.003","volume":"12","author":"L Vanoaica","year":"2010","unstructured":"Vanoaica L, Darshan D, Richman L, Schumann K, Kuhn LC (2010) Intestinal ferritin H is required for an accurate control of iron absorption. Cell Metab 12:273\u2013282","journal-title":"Cell Metab"},{"key":"9521_CR49","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1182\/blood-2004-12-4608","volume":"105","author":"L Viatte","year":"2005","unstructured":"Viatte L, Lesbordes-Brion JC, Lou DQ, Bennoun M, Nicolas G, Kahn A, Canonne-Hergaux F, Vaulont S (2005) Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice. Blood 105:4861\u20134864","journal-title":"Blood"},{"key":"9521_CR50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/5979","volume":"21","author":"CD Vulpe","year":"1999","unstructured":"Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ (1999) Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 21:195\u2013199","journal-title":"Nat Genet"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-012-9521-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-012-9521-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-012-9521-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T22:30:36Z","timestamp":1561242636000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-012-9521-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,1]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["9521"],"URL":"https:\/\/doi.org\/10.1007\/s10534-012-9521-2","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,1]]}}}