{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:40:20Z","timestamp":1770831620925,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s10534-015-9902-4","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T03:49:58Z","timestamp":1450237798000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sub-chronic iron overload triggers oxidative stress development in rat brain: implications for cell protection"],"prefix":"10.1007","volume":"29","author":[{"given":"Natacha E.","family":"Piloni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Perazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Videla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Puntarulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,12,16]]},"reference":[{"key":"9902_CR1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126","journal-title":"Methods Enzymol"},{"key":"9902_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0748-5514(85)90025-X","volume":"1","author":"SD Aust","year":"1985","unstructured":"Aust SD, Morehouse LA, Thomas CE (1985) Role of metals in oxygen radical reactions. J Free Radic Biol Med 1:3\u201325","journal-title":"J Free Radic Biol Med"},{"key":"9902_CR3","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.3748\/wjg.v16.i22.2720","volume":"16","author":"UD Bayraktar","year":"2010","unstructured":"Bayraktar UD, Bayraktar S (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. World J Gastroenterol 16:2720\u20132725","journal-title":"World J Gastroenterol"},{"key":"9902_CR4","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1471-4159.2008.05234.x","volume":"105","author":"A Brand","year":"2008","unstructured":"Brand A, Schonfeld E, Isharel I, Yavin E (2008) Docosahexaenoic acid\u2013dependent iron accumulation in oligodendroglia cells protects from hydrogen peroxide-induced damage. J Neurochem 105:1325\u20131335","journal-title":"J Neurochem"},{"key":"9902_CR5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0076-6879(67)10078-5","volume":"10","author":"PE Brumby","year":"1967","unstructured":"Brumby PE, Massey V (1967) Determination of nonheme iron, total iron and cooper. Methods Enzymol 10:463\u2013474","journal-title":"Methods Enzymol"},{"key":"9902_CR6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0891-5849(87)80033-3","volume":"3","author":"GR Buettner","year":"1987","unstructured":"Buettner GR (1987) Spin trapping: ESR parameters of spin adducts. Free Radic Biol Med 3:259\u2013303","journal-title":"Free Radic Biol Med"},{"key":"9902_CR7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.yjmcc.2008.08.011","volume":"45","author":"M Chevion","year":"2008","unstructured":"Chevion M, Leibowitz S, Aye NN, Novogrodsky O, Singer A, Avizemer O, Bulvik B, Konijn AM, Berenshtein E (2008) Heart protection by ischemic preconditioning: a novel pathway initiated by iron and mediated by ferritin. J Mol Cell Cardiol 45:839\u2013845","journal-title":"J Mol Cell Cardiol"},{"key":"9902_CR8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12011-014-9948-0","volume":"158","author":"Y Chtourou","year":"2014","unstructured":"Chtourou Y, Fetoui H, Gdoura R (2014) Protective Effects of naringenin on iron-overload-induced cerebral cortex neurotoxicity correlated with oxidative stress. Biol Trace Elem Res 158:376\u2013383","journal-title":"Biol Trace Elem Res"},{"key":"9902_CR9","first-page":"1397","volume":"46","author":"C Courderot-Masuyer","year":"2000","unstructured":"Courderot-Masuyer C, Lahet JJ, Verges B, Brun JM, Rochette L (2000) Ascorbyl free radical release in diabetic patients. Cell Mol Biol 46:1397\u20131401","journal-title":"Cell Mol Biol"},{"key":"9902_CR10","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.freeradbiomed.2011.06.034","volume":"51","author":"A Czerniczyniec","year":"2011","unstructured":"Czerniczyniec A, Karadayian AG, Bustamante J, Cutrera RA, Lores-Arnaiz S (2011) Paraquat induces behavioral changes and cortical and striatal mitochondrial dysfunction. Free Radic Biol Med 51:1428\u20131436","journal-title":"Free Radic Biol Med"},{"key":"9902_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00109-012-0937-5","volume":"91","author":"A Daba","year":"2013","unstructured":"Daba A, Gkouvatssos K, Sebastiani G, Pantopoulos K (2013) Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing. J Mol Med 91:95\u2013102","journal-title":"J Mol Med"},{"key":"9902_CR12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1182\/blood-2002-03-0914","volume":"102","author":"D Darbari","year":"2003","unstructured":"Darbari D, Loyevsky M, Gordeuk V, Kark JA, Castro O, Rana S (2003) Fluorescence measurements of the labile iron pool of sickle erythrocytes. Blood 102:357\u2013364","journal-title":"Blood"},{"key":"9902_CR60","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/iub.31","volume":"60","author":"M Das","year":"2008","unstructured":"Das M, Das DK (2008) Molecular mechanism of preconditioning. IUBMB Life 60:199\u2013203","journal-title":"IUBMB Life"},{"key":"9902_CR13","first-page":"405","volume":"16","author":"F Deryckere","year":"1994","unstructured":"Deryckere F, Gannon F (1994) A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. Biotechniques 16:405","journal-title":"Biotechniques"},{"key":"9902_CR14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0076-6879(84)05019-9","volume":"105","author":"I Desai","year":"1984","unstructured":"Desai I (1984) Vitamin E analysis methods for animal tissues. Methods Enzymol 105:138\u2013146","journal-title":"Methods Enzymol"},{"key":"9902_CR15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0005-2760(85)90285-1","volume":"835","author":"T Doba","year":"1985","unstructured":"Doba T, Burton GW, Ingold KU (1985) Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim Biophys Acta 835:298\u2013303","journal-title":"Biochim Biophys Acta"},{"key":"9902_CR16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","volume":"82","author":"W Dr\u00f6gue","year":"2002","unstructured":"Dr\u00f6gue W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82:47\u201395","journal-title":"Physiol Rev"},{"key":"9902_CR17","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1021\/bi9020378","volume":"49","author":"HJ Forman","year":"2010","unstructured":"Forman HJ, Maiorino M, Ursini F (2010) Signaling functions of reactive oxygen species. Biochemistry 49:835\u2013842","journal-title":"Biochemistry"},{"key":"9902_CR18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3945\/an.110.000190","volume":"2","author":"SJB Fretham","year":"2011","unstructured":"Fretham SJB, Carlson ES, Georgieff MK (2011) The role of iron in learning and memory. Adv Nutr 2:112\u2013121","journal-title":"Adv Nutr"},{"key":"9902_CR19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-4274(02)00196-0","volume":"133","author":"M Galleano","year":"2002","unstructured":"Galleano M, Aimo L, Puntarulo S (2002) Ascorbyl radical\/ascorbate ratio in plasma from iron overloaded rats as oxidative stress indicator. Toxicol Lett 133:193\u2013201","journal-title":"Toxicol Lett"},{"key":"9902_CR20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.lfs.2011.06.005","volume":"89","author":"M Galleano","year":"2011","unstructured":"Galleano M, Tapia G, Puntarulo S, Varela P, Videla LA, Fernandez V (2011) Liver preconditioning induced by iron in a rat model of ischemia\/reperfusion. Life Sci 89:221\u2013228","journal-title":"Life Sci"},{"key":"9902_CR21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.1987.tb23755.x","volume":"498","author":"KF Gey","year":"1987","unstructured":"Gey KF, St\u00e4helin HB, Puska P, Evans A (1987) Relationship of plasma level of vitamin C to mortality from ischemic heart disease. Ann N Y Acad Sci 498:110\u2013123","journal-title":"Ann N Y Acad Sci"},{"key":"9902_CR22","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","volume":"97","author":"B Halliwell","year":"2006","unstructured":"Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634\u20131658","journal-title":"J Neurochem"},{"key":"9902_CR23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/15216540701222906","volume":"59","author":"C Hidalgo","year":"2007","unstructured":"Hidalgo C, N\u00fa\u00f1ez MT (2007) Calcium, iron and neuronal function. IUBMB Life 59:280\u2013285","journal-title":"IUBMB Life"},{"key":"9902_CR24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuint.2007.03.006","volume":"51","author":"H Jiang","year":"2007","unstructured":"Jiang H, Song N, Wang J, Ren LY, Xie JX (2007) Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochem Int 51:32\u201336","journal-title":"Neurochem Int"},{"key":"9902_CR25","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0891-5849(02)01006-7","volume":"33","author":"O Kakhlon","year":"2002","unstructured":"Kakhlon O, Cabantchik ZI (2002) The labile iron pool: characterization, measurement, and participation in cellular processes. Free Radic Biol Med 33:1037\u20131046","journal-title":"Free Radic Biol Med"},{"key":"9902_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"TW Kensler","year":"2007","unstructured":"Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89\u2013116","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"9902_CR27","first-page":"95","volume":"53","author":"P Korantzopoulos","year":"2012","unstructured":"Korantzopoulos P, Vlachou C, Kotsia A, Kalantzi K, Barbouti A, Galaris D, Goudevenos JA (2012) Leukocyte labile iron pool in patients with systolic heart failure. Hellenic J Cardiol 53:95\u2013100","journal-title":"Hellenic J Cardiol"},{"key":"9902_CR28","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0304-4165(95)00172-7","volume":"1289","author":"Y Kotake","year":"1996","unstructured":"Kotake Y, Tanigawa T, Tanigawa M, Ueno I, Allen DR, Lai CS (1996) Continuous monitoring of cellular nitric oxide generation by spin trapping with an iron dithiocarbamate complex. Biochim Biophys Acta 1289:362\u2013368","journal-title":"Biochim Biophys Acta"},{"key":"9902_CR29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mrfmmm.2003.08.004","volume":"531","author":"M Kruszewski","year":"2003","unstructured":"Kruszewski M (2003) Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res 531:81\u201392","journal-title":"Mutat Res"},{"key":"9902_CR30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0003-2697(87)90594-X","volume":"166","author":"MA Kutnink","year":"1987","unstructured":"Kutnink MA, Hawkes WC, Schaus EE, Omaye ST (1987) An internal standard method for the unattended high-performance liquid chromatographic analysis of ascorbic acid in blood components. Anal Biochem 166:424\u2013430","journal-title":"Anal Biochem"},{"key":"9902_CR31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-9861(86)90104-9","volume":"244","author":"EK Lai","year":"1986","unstructured":"Lai EK, Crossley C, Sridhar R, Misra HP, Janzen EG, McCay PB (1986) In vivo spin trapping of free radicals generated in brain, spleen, and liver during \u03b3 radiation of mice. Arch Biochem Biophys 244:156\u2013160","journal-title":"Arch Biochem Biophys"},{"key":"9902_CR32","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/jxb\/42.4.509","volume":"42","author":"SH Laurie","year":"1991","unstructured":"Laurie SH, Tancock NP, McGrath SP, Sanders J (1991) Influence of complexation on the uptake by plants of iron, manganese, copper and zinc: I. Effect of EDTA in a multimetal and computer simulation study. Exp Bot 42:509\u2013513","journal-title":"Exp Bot"},{"key":"9902_CR33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"9902_CR34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1399-3054.1997.tb01023.x","volume":"101","author":"G Malanga","year":"1997","unstructured":"Malanga G, Calmanovici G, Puntarulo S (1997) Oxidative damage to chloroplasts from Chlorella vulgaris exposed to ultraviolet-B radiation. Physiol Plant 101:455\u2013462","journal-title":"Physiol Plant"},{"key":"9902_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","volume":"192","author":"JL Martindale","year":"2002","unstructured":"Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1\u201315","journal-title":"J Cell Physiol"},{"key":"9902_CR36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10534-006-9034-y","volume":"20","author":"B Metzler","year":"2007","unstructured":"Metzler B, Jehle J, Theurl I, Ludwiczek S, Obrist P, Pachinger O, Weiss G (2007) Short term protective effects of iron in a murine model if ischemia\/reperfusion. Biometals 20:205\u2013215","journal-title":"Biometals"},{"key":"9902_CR37","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF01973683","volume":"67","author":"K Minakata","year":"1993","unstructured":"Minakata K, Suzuki O, Saito S, Harada N (1993) Ascorbate radical levels in human sera and rat plasma intoxicated with paraquat and diquat. Arch Toxicol 67:126\u2013130","journal-title":"Arch Toxicol"},{"key":"9902_CR38","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/toxsci\/kfs193","volume":"129","author":"MS Moon","year":"2012","unstructured":"Moon MS, McDevitt EI, Zhu J, Stanley B, Krzeminskym J, Amin S, Aliaga C, Miller TG, Isom HC (2012) Elevated hepatic iron activates NF-E2-related factor2-regulated pathway in a dietary iron overload mouse model. Toxicol Sci 129:74\u201385","journal-title":"Toxicol Sci"},{"key":"9902_CR39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1039\/C3FO60265F","volume":"5","author":"P Morales","year":"2014","unstructured":"Morales P, Vargas R, Videla LA, Fern\u00e1ndez V (2014) Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol. Food Funct 5:243\u2013250","journal-title":"Food Funct"},{"key":"9902_CR40","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.freeradbiomed.2009.11.017","volume":"48","author":"JP Mu\u00f1oz","year":"2010","unstructured":"Mu\u00f1oz JP, Chiong M, Garc\u00eda L, Troncoso R, Toro B, Pedrozo A, D\u00edaz-Elizondo J, Salas D, Parra V, N\u00fa\u00f1ez MT, Hidalgo C, Lavandero S (2010) Iron induces protection and necrosis in cultured cardiomyocytes: role of reactive oxygen species and nitric oxide. Free Radic Biol Med 48:526\u2013534","journal-title":"Free Radic Biol Med"},{"key":"9902_CR41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/abio.1997.2372","volume":"254","author":"K Nakagawa","year":"1997","unstructured":"Nakagawa K, Kanno H, Miura Y (1997) Detection and analyses of ascorbyl radical in cerebrospinal fluid and serum of acute lymphoblastic leukemia. Anal Biochem 254:31\u201335","journal-title":"Anal Biochem"},{"key":"9902_CR42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0741-8329(03)00126-5","volume":"30","author":"A Pietrangelo","year":"2003","unstructured":"Pietrangelo A (2003) Iron-induced oxidant stress in alcoholic liver fibrogenesis. Alcohol 30:121\u2013129","journal-title":"Alcohol"},{"key":"9902_CR43","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/00007890-199409000-00023","volume":"58","author":"S Pietri","year":"1994","unstructured":"Pietri S, Culcasi M, Albat B, Alb\u00e9rici G, Menasch\u00e9 P (1994) Direct assessment of the antioxidant effects of a new heart preservation solution, Celsior. A hemodynamic and electron spin resonance study. Transplantation 58:739\u2013742","journal-title":"Transplantation"},{"key":"9902_CR44","first-page":"29","volume-title":"Metals in biology systems","author":"NE Piloni","year":"2010","unstructured":"Piloni NE, Puntarulo S (2010) Iron role in the oxidative metabolism of animal and plant cells. Effect of iron overload. In: Gimenez MS (ed) Metals in biology systems. Research Signpost, Transworld Research Network, Trivandrum, pp 29\u201350"},{"key":"9902_CR45","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tox.2013.09.015","volume":"314","author":"NE Piloni","year":"2013","unstructured":"Piloni NE, Fermandez V, Videla LA, Puntarulo S (2013) Acute iron overload and oxidative stress in brain. Toxicology 314:174\u2013182","journal-title":"Toxicology"},{"key":"9902_CR46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/cyto.a.20491","volume":"73A","author":"E Prus","year":"2008","unstructured":"Prus E, Fibach E (2008) Flow cytometry measurement of the labile iron pool in human hematopoietic cells. Cytometry 73A:22\u201327","journal-title":"Cytometry"},{"key":"9902_CR47","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.mam.2005.07.001","volume":"26","author":"S Puntarulo","year":"2005","unstructured":"Puntarulo S (2005) Iron, oxidative stress and human health. Mol Aspects Med 26:299\u2013312","journal-title":"Mol Aspects Med"},{"key":"9902_CR48","first-page":"402","volume":"47","author":"S Puntarulo","year":"1995","unstructured":"Puntarulo S, Simontacchi M, Galleano M, Caro A, Malanga G, Kozak RG (1995) Effect of oxidative stress on iron reduction rates in biological systems. J Braz Assoc Adv Sci 47:402\u2013406","journal-title":"J Braz Assoc Adv Sci"},{"key":"9902_CR49","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.plantsci.2007.01.003","volume":"172","author":"E Robello","year":"2007","unstructured":"Robello E, Galatro A, Puntarulo S (2007) Iron role in oxidative metabolism of soybean axes upon growth: effect of iron overload. Plant Sci 172:939\u2013947","journal-title":"Plant Sci"},{"key":"9902_CR50","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4254\/wjh.v1.i1.72","volume":"1","author":"LA Videla","year":"2009","unstructured":"Videla LA (2009) Oxidative stress signaling underlying liver disease and hepatoprotective mechanisms. World J Hepatol 1:72\u201378","journal-title":"World J Hepatol"},{"key":"9902_CR51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jinorgbio.2013.08.007","volume":"129","author":"A Walcourt","year":"2013","unstructured":"Walcourt A, Kurantsin-Mills J, Kwagyan J, Adenuga BB, Kalinowski DS, Lovejoy DB, Lane DJ, Richardson DR (2013) Anti-pasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool. J Inorg Biochem 129:43\u201351","journal-title":"J Inorg Biochem"},{"key":"9902_CR52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20101825","volume":"434","author":"J Wang","year":"2011","unstructured":"Wang J, Pantopoulos K (2011) Regulation of cellular iron metabolism. Biochem J 434:365\u2013381","journal-title":"Biochem J"},{"key":"9902_CR53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuro.2012.09.006","volume":"34","author":"J Wu","year":"2013","unstructured":"Wu J, Ding T, Sun J (2013) Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus. Neurotoxicology 34:243\u2013253","journal-title":"Neurotoxicology"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-015-9902-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-015-9902-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-015-9902-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T11:47:32Z","timestamp":1653824852000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-015-9902-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,16]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["9902"],"URL":"https:\/\/doi.org\/10.1007\/s10534-015-9902-4","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,16]]}}}