{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:56:31Z","timestamp":1755694591222,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Dutch Ministry of Defence","award":["V1036"],"award-info":[{"award-number":["V1036"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s10534-018-0136-0","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T07:13:15Z","timestamp":1534921995000},"page":"941-950","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["LFchimera protects HeLa cells from invasion by Yersinia spp. in vitro"],"prefix":"10.1007","volume":"31","author":[{"given":"Tjitske","family":"Sijbrandij","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoon J.","family":"Ligtenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Nazmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra A. M.","family":"van den Keijbus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno C. I.","family":"Veerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G. M.","family":"Bolscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-4630","authenticated-orcid":false,"given":"Floris J.","family":"Bikker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"136_CR1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bios.2015.11.032","volume":"78","author":"BA Adducci","year":"2016","unstructured":"Adducci BA, Gruszewski HA, Khatibi PA, Schmale DG (2016) Differential detection of a surrogate biological threat agent (Bacillus globigii) with a portable surface plasmon resonance biosensor. Biosens Bioelectron 78:160\u2013166","journal-title":"Biosens Bioelectron"},{"key":"136_CR2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8466.1","author":"S Atkinson","year":"2016","unstructured":"Atkinson S, Williams P (2016) Yersinia virulence factors\u2014a sophisticated arsenal for combating host defences. F1000Research. https:\/\/doi.org\/10.12688\/f1000research.8466.1","journal-title":"F1000Research"},{"key":"136_CR3","doi-asserted-by":"publisher","first-page":"397","DOI":"10.5604\/12321966.1167700","volume":"22","author":"A Bancerz-Kisiel","year":"2015","unstructured":"Bancerz-Kisiel A, Szweda W (2015) Yersiniosis\u2014a zoonotic foodborne disease of relevance to public health. Ann Agric Environ Med 22:397\u2013402","journal-title":"Ann Agric Environ Med"},{"key":"136_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/j.1747-0285.2006.00424.x","volume":"68","author":"FJ Bikker","year":"2006","unstructured":"Bikker FJ, Kaman-van Zanten WE, de Vries-van de Ruit AM, Voskamp-Visser I, van Hooft PA, Mars-Groenendijk RH, de Visser PC, Noort D (2006) Evaluation of the antibacterial spectrum of drosocin analogues. Chem Biol Drug Des 68:148\u2013153","journal-title":"Chem Biol Drug Des"},{"key":"136_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.biochi.2008.05.019","volume":"91","author":"JGM Bolscher","year":"2009","unstructured":"Bolscher JGM, Ad\u00e3o R, Nazmi K, van den Keybus PAM, van \u2018t Hof W, Nieuw Amerongen AV, Bastos M, Veerman ECI (2009) Bactericidal activity of LFchimera is stronger and less sensitive to ionic strength than its constituent lactoferricin and lactoferrampin peptides. Biochimie 91:123\u2013132","journal-title":"Biochimie"},{"key":"136_CR6","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1139\/o11-085","volume":"90","author":"J Bolscher","year":"2012","unstructured":"Bolscher J, Nazmi K, van Marle J, van \u2018t Hof W, Veerman E (2012) Chimerization of lactoferricin and lactoferrampin peptides strongly potentiates the killing activity against Candida albicans. Biochem Cell Biol 90:378\u2013388","journal-title":"Biochem Cell Biol"},{"key":"136_CR7","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/prca.201600012","volume":"10","author":"N Chauhan","year":"2016","unstructured":"Chauhan N, Wrobel A, Skurnik M, Leo JC (2016) Yersinia adhesins: an arsenal for infection. Proteom Clin Appl 10:949\u2013963","journal-title":"Proteom Clin Appl"},{"key":"136_CR8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/10408410802143808","volume":"34","author":"RM Dawson","year":"2008","unstructured":"Dawson RM, Liu CQ (2008) Properties and applications of antimicrobial peptides in biodefense against biological warfare threat agents. Crit Rev Microbiol 34:89\u2013107","journal-title":"Crit Rev Microbiol"},{"key":"136_CR9","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1093\/emboj\/18.5.1199","volume":"18","author":"P Dersch","year":"1999","unstructured":"Dersch P, Isberg RR (1999) A region of the Yersinia pseudotuberculosis invasin protein enhances integrin-mediated uptake into mammalian cells and promotes self-association. EMBO J 18:1199\u20131213","journal-title":"EMBO J"},{"key":"136_CR10","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1099\/jmm.0.05410-0","volume":"53","author":"AM Biase Di","year":"2004","unstructured":"Di Biase AM, Tinari A, Pietrantoni A, Antonini G, Valenti P, Conte MP, Superti F (2004) Effect of bovine lactoferricin on enteropathogenic Yersinia adhesion and invasion in HEp-2 cells. J Med Microbiol 53:407\u2013412","journal-title":"J Med Microbiol"},{"key":"136_CR11","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s10534-010-9306-4","volume":"23","author":"H Flores-Villase\u00f1or","year":"2010","unstructured":"Flores-Villase\u00f1or H, Canizalez-Rom\u00e1n A, Reyes-Lopez M, Nazmi K, de la Garza M, Zazueta-Beltr\u00e1n J, Le\u00f3n-Sicairos N, Bolscher JGM (2010) Bactericidal effect of bovine lactoferrin, LFcin, LFampin and LFchimera on antibiotic-resistant Staphylococcus aureus and Escherichia coli. Biometals 23:569\u2013578","journal-title":"Biometals"},{"key":"136_CR12","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1016\/j.biochi.2012.05.011","volume":"94","author":"H Flores-Villase\u00f1or","year":"2012","unstructured":"Flores-Villase\u00f1or H, Canizalez-Rom\u00e1n A, de la Garza M, Nazmi K, Bolscher JGM, Le\u00f3n-Sicairos N (2012a) Lactoferrin and lactoferrin chimera inhibit damage caused by enteropathogenic Escherichia coli in HEp-2 cells. Biochimie 94:1935\u20131942","journal-title":"Biochimie"},{"key":"136_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1139\/o11-089","volume":"90","author":"H Flores-Villase\u00f1or","year":"2012","unstructured":"Flores-Villase\u00f1or H, Canizalez-Rom\u00e1n A, Velazquez-Roman J, Nazmi K, Bolscher JGM, Leon-Sicairos N (2012b) Protective effects of lactoferrin chimera and bovine lactoferrin in a mouse model of enterohaemorrhagic Escherichia coli O157:H7 infection. Biochem Cell Biol 90:405\u2013411","journal-title":"Biochem Cell Biol"},{"key":"136_CR14","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s10534-014-9740-9","volume":"27","author":"A Frioni","year":"2014","unstructured":"Frioni A, Conte MP, Cutone A, Longhi C, Natalizi T, Marazzato M, Lepanto MS, Valenti P, Berlutti F (2014) Lactoferrin differently modulates the inflammatory response in epithelial models mimicking human inflammatory and infectious diseases. Biometals 27:843\u2013856","journal-title":"Biometals"},{"key":"136_CR15","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/182051","author":"CL Galindo","year":"2011","unstructured":"Galindo CL, Rosenzweig JA, Kirtley ML, Chopra AK (2011) Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in human Yersiniosis. J Pathog. https:\/\/doi.org\/10.4061\/2011\/182051","journal-title":"J Pathog"},{"key":"136_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.micinf.2014.12.014","volume":"17","author":"E Gillenius","year":"2015","unstructured":"Gillenius E, Urban CF (2015) The adhesive protein invasin of Yersinia pseudotuberculosis induces neutrophil extracellular traps via \u03b21 integrins. Microbes Infect 17:327\u2013336","journal-title":"Microbes Infect"},{"key":"136_CR17","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1128\/JCM.35.11.2826-2833.1997","volume":"35","author":"A Guiyoule","year":"1997","unstructured":"Guiyoule A, Rasoamanana B, Buchrieser C, Michel P, Chanteau S, Carniel E (1997) Recent emergence of new variants of Yersinia pestis in Madagascar. J Clin Microbiol 35:2826\u20132833","journal-title":"J Clin Microbiol"},{"key":"136_CR18","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3201\/eid0701.010106","volume":"7","author":"A Guiyoule","year":"2001","unstructured":"Guiyoule A, Gerbaud G, Buchrieser C, Galimand M, Rahalison L, Chanteau S, Courvalin P, Carniel E (2001) Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis. Emerg Infect Dis 7:43\u201348","journal-title":"Emerg Infect Dis"},{"key":"136_CR19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.bbamem.2011.11.023","volume":"1818","author":"EF Haney","year":"2012","unstructured":"Haney EF, Nazmi K, Bolscher JGM, Vogel HJ (2012) Structural and biophysical characterization of an antimicrobial peptide chimera comprised of lactoferricin and lactoferrampin. BBA 1818:762\u2013775","journal-title":"BBA"},{"key":"136_CR20","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1093\/jac\/dkg484","volume":"52","author":"E Hernandez","year":"2003","unstructured":"Hernandez E, Girardet M, Ramisse F, Vidal D, Cavallo JD (2003) Antibiotic susceptibilities of 94 isolates of Yersinia pestis to 24 antimicrobial agents. J Antimicrob Chemother 52:1029\u20131031","journal-title":"J Antimicrob Chemother"},{"key":"136_CR21","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1046\/j.1365-2958.2002.03159.x","volume":"46","author":"BJ Hinnebusch","year":"2002","unstructured":"Hinnebusch BJ, Rosso ML, Schwan TG, Carniel E (2002) High-frequency conjugative transfer of antibiotic resistance genes to Yersinia pestis in the flea midgut. Mol Microbiol 46:349\u2013354","journal-title":"Mol Microbiol"},{"key":"136_CR22","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1021\/bi972323m","volume":"37","author":"PM Hwang","year":"1998","unstructured":"Hwang PM, Zhou N, Shan X, Arrowsmith CH, Vogel HJ (1998) Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. Biochem 37:4288\u20134298","journal-title":"Biochem"},{"key":"136_CR23","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/1469-0691.12699","volume":"20","author":"HJ Jansen","year":"2014","unstructured":"Jansen HJ, Breeveld FJ, Stijnis C, Grobusch MP (2014) Biological warfare, bioterrorism, and biocrime. Clin Microbiol Infect 20:488\u2013496","journal-title":"Clin Microbiol Infect"},{"key":"136_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s12223-011-0027-z","volume":"56","author":"WE Kaman","year":"2011","unstructured":"Kaman WE, Hawkey S, van der Kleij D, Broekhuijsen MP, Silman NJ, Bikker FJ (2011) A comprehensive study on the role of the Yersinia pestis virulence markers in an animal model of pneumonic plague. Folia Microbiol 56:95\u2013102","journal-title":"Folia Microbiol"},{"key":"136_CR25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ijantimicag.2009.05.012","volume":"34","author":"S Kanthawong","year":"2009","unstructured":"Kanthawong S, Nazmi K, Wongratanacheewin S, Bolscher JGM, Wuthiekanun V, Taweechaisupapong S (2009) In vitro susceptibility of Burkholderia pseudomallei to antimicrobial peptides. Int J Antimicrob Agents 34:309\u2013314","journal-title":"Int J Antimicrob Agents"},{"key":"136_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.febslet.2011.12.011","volume":"586","author":"CW Kim","year":"2012","unstructured":"Kim CW, Lee TH, Park KH, Choi SY, Kim J (2012) Human lactoferrin suppresses TNF-\u03b1-induced intercellular adhesion molecule-1 expression via competition with NF-\u03baB in endothelial cells. FEBS Lett 586:229\u2013234","journal-title":"FEBS Lett"},{"key":"136_CR27","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s10534-014-9775-y","volume":"27","author":"N Le\u00f3n-Sicairos","year":"2014","unstructured":"Le\u00f3n-Sicairos N, Angulo-Zamudio UA, Vidal JE, L\u00f3pez-Torres CA, Bolscher JGM, Nazmi K, Reyes-Cortes R, Reyes-L\u00f3pez M, de la Garza M, Canizalez-Rom\u00e1n A (2014) Bactericidal effect of bovine lactoferrin and synthetic peptide lactoferrin chimera in Streptococcus pneumoniae and the decrease in luxS gene expression by lactoferrin. Biometals 27:969\u2013980","journal-title":"Biometals"},{"key":"136_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/BF00277158","volume":"183","author":"C Longhi","year":"1994","unstructured":"Longhi C, Conte MP, Bellamy W, Seganti L, Valenti P (1994) Effect of lactoferricin B, a pepsin-generated peptide of bovine lactoferrin, on Escherichia coli HB101 (pRI203) entry into HeLa cells. Med Microbiol Immunol 183:77\u201385","journal-title":"Med Microbiol Immunol"},{"key":"136_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.micinf.2003.11.001","volume":"6","author":"HH Niemann","year":"2004","unstructured":"Niemann HH, Schubert WD, Heinz DW (2004) Adhesins and invasins of pathogenic bacteria: a structural view. Microbes Infect 6:101\u2013112","journal-title":"Microbes Infect"},{"key":"136_CR30","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1586\/14787210.2013.814432","volume":"11","author":"PC Oyston","year":"2013","unstructured":"Oyston PC, Williamson ED (2013) Prophylaxis and therapy of plague. Expert Rev Anti Infect Ther 11:817\u2013829","journal-title":"Expert Rev Anti Infect Ther"},{"key":"136_CR31","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1007\/s11274-013-1284-6","volume":"29","author":"A Puknun","year":"2013","unstructured":"Puknun A, Bolscher JGM, Nazmi K, Veerman EC, Tungpradabkul S, Wongratanacheewin S, Kanthawong S, Taweechaisupapong S (2013) A heterodimer comprised of two bovine lactoferrin antimicrobial peptides exhibits powerful bactericidal activity against Burkholderia pseudomallei. World J Microbiol Biotechnol 29:1217\u20131224","journal-title":"World J Microbiol Biotechnol"},{"key":"136_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11274-015-1988-x","volume":"32","author":"A Puknun","year":"2016","unstructured":"Puknun A, Kanthawong S, Anutrakunchai C, Nazmi K, Tigchelaar W, Hoeben KA, Veerman ECI, Bolscher JGM, Taweechaisupapong S (2016) Ultrastructural effects and antibiofilm activity of LFchimera against Burkholderia pseudomallei. World J Microbiol Biotechnol 32:33","journal-title":"World J Microbiol Biotechnol"},{"key":"136_CR33","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3201\/eid0802.010164","volume":"8","author":"LD Rotz","year":"2002","unstructured":"Rotz LD, Khan AS, Lillibridge SR, Ostroff SM, Hughes JM (2002) Public health assessment of potential biological terrorism agents. Emerg Infect Dis 8:225\u2013230","journal-title":"Emerg Infect Dis"},{"key":"136_CR34","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1128\/IAI.64.6.2106-2113.1996","volume":"64","author":"R Schulte","year":"1996","unstructured":"Schulte R, Wattiau P, Hartland EL, Robins-Browne RM, Cornelis GR (1996) Differential secretion of interleukin-8 by human epithelial cell lines upon entry of virulent or nonvirulent Yersinia enterocolitica. Infect Immun 64:2106\u20132113","journal-title":"Infect Immun"},{"key":"136_CR35","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1096\/fj.99-0847com","volume":"14","author":"R Schulte","year":"2000","unstructured":"Schulte R, Grass GA, Preger S, Fessele S, Jacobi CA, Schaller M, Nelson PJ, Autenrieth IB (2000) Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J 14:1471\u20131484","journal-title":"FASEB J"},{"key":"136_CR36","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1139\/bcb-2016-0049","volume":"95","author":"R Sessa","year":"2017","unstructured":"Sessa R, Di Pietro M, Filardo S, Bressan A, Rosa L, Curone A, Frioni A, Berlutti F, Paesano R, Valenti P (2017) Effect of bovine lactoferrin on Chlamydia trachomatis infection and inflammation. Biochem Cell Biol 95:34\u201340","journal-title":"Biochem Cell Biol"},{"key":"136_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11274-016-2171-8","volume":"33","author":"T Sijbrandij","year":"2017","unstructured":"Sijbrandij T, Ligtenberg AJM, Nazmi K, Veerman ECI, Bolscher JGM, Bikker FJ (2017) Effects of lactoferrin derived peptides on simulants of biological warfare agents. World J Microbiol Biotechnol 33:3","journal-title":"World J Microbiol Biotechnol"},{"key":"136_CR38","first-page":"85","volume":"19","author":"Y Tan","year":"2017","unstructured":"Tan Y, Liu W, Zhang Q, Cao S, Zhao H, Wang T, Qi Z, Han Y, Song Y, Wang X, Yang R, Du Z (2017) Yersinia pestis YopK inhibits bacterial adhesion to host cells by binding to the extracellular matrix adaptor protein Matrilin-2. Infect Immun 19:85","journal-title":"Infect Immun"},{"key":"136_CR39","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/j.1460-2075.1993.tb05837.x","volume":"12","author":"G Tran Van Nhieu","year":"1993","unstructured":"Tran Van Nhieu G, Isberg RR (1993) Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density. EMBO J 12:1887\u20131895","journal-title":"EMBO J"},{"key":"136_CR40","first-page":"602","volume":"14","author":"SK Verma","year":"2016","unstructured":"Verma SK, Tuteja U (2016) Plague vaccine development: current research and future trends. Front Immunol 14:602","journal-title":"Front Immunol"},{"key":"136_CR41","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ijfoodmicro.2008.04.016","volume":"125","author":"X Wang","year":"2008","unstructured":"Wang X, Qiu H, Jin D, Cui Z, Kan B, Xiao Y, Xu Y, Xia S, Wang H, Yang J, Wang X, Hu W, Xu J, Jing H (2008) O:8 serotype Yersinia enterocolitica strains in China. Int J Food Microbiol 125:259\u2013266","journal-title":"Int J Food Microbiol"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-018-0136-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-018-0136-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-018-0136-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T02:47:01Z","timestamp":1604803621000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-018-0136-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,22]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["136"],"URL":"https:\/\/doi.org\/10.1007\/s10534-018-0136-0","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"type":"print","value":"0966-0844"},{"type":"electronic","value":"1572-8773"}],"subject":[],"published":{"date-parts":[[2018,8,22]]},"assertion":[{"value":"30 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}