{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T19:20:59Z","timestamp":1782328859054,"version":"3.54.5"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["15\/14360-4"],"award-info":[{"award-number":["15\/14360-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["16\/03709-9"],"award-info":[{"award-number":["16\/03709-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["18\/19684-0"],"award-info":[{"award-number":["18\/19684-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["88881.131918\/2016-01"],"award-info":[{"award-number":["88881.131918\/2016-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES07331"],"award-info":[{"award-number":["R01ES07331"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES10563"],"award-info":[{"award-number":["R01ES10563"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10534-020-00277-7","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T06:03:08Z","timestamp":1609653788000},"page":"259-275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Conjugates of desferrioxamine and aromatic amines improve markers of iron-dependent neurotoxicity"],"prefix":"10.1007","volume":"34","author":[{"given":"Rodrigo R. V.","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanara V.","family":"Peres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleber W.","family":"Liria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Teresa","family":"Machini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno P.","family":"Esp\u00f3sito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,3]]},"reference":[{"key":"277_CR1","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1007\/s10534-014-9795-7","volume":"27","author":"ECP Alta","year":"2014","unstructured":"Alta ECP, Goswami D, Machini MT, Silvestre DM, Nomura CS, Esp\u00f3sito BP (2014) Desferrioxamine-caffeine (DFCAF) as a cell permeant moderator of the oxidative stress caused by iron overload. Biometals 27:1351\u20131360","journal-title":"Biometals"},{"key":"277_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jinorgbio.2017.04.004","volume":"172","author":"A Arndt","year":"2017","unstructured":"Arndt A, Liria CW, Yokoyama-Yasunaka JKU, Machini MT, Uliana SRB, Esp\u00f3sito BP (2017) New iminodibenzyl derivatives with anti-leishmanial activity. J Inorg Biochem 172:9\u201315. https:\/\/doi.org\/10.1016\/j.jinorgbio.2017.04.004","journal-title":"J Inorg Biochem"},{"key":"277_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2174\/22133461114019990002","volume":"1","author":"D Balakrishna","year":"2014","unstructured":"Balakrishna D, Suryadevara V, Dandela R, Vegendla A, Mandava VBR, Manojit P (2014) Catalyst\/surfactant free chemoselective acylation of amines in water current. Green Chem 1:73\u201379. https:\/\/doi.org\/10.2174\/22133461114019990002","journal-title":"Green Chem"},{"key":"277_CR4","doi-asserted-by":"publisher","first-page":"e26039","DOI":"10.1371\/journal.pone.0026039","volume":"6","author":"L Berg","year":"2011","unstructured":"Berg L, Andersson CD, Artursson E, H\u00f6rnberg A, Tunemalm A-K, Linusson A, Ekstr\u00f6m F (2011) Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, struct determin mol modeling. PLoS ONE 6:e26039. https:\/\/doi.org\/10.1371\/journal.pone.0026039","journal-title":"PLoS ONE"},{"key":"277_CR5","doi-asserted-by":"publisher","unstructured":"Bianchi L, Driscoll M (2006) Culture of embryonic C. elegans cells for electrophysiological and pharmacological analyses WormBook, ed. The C. elegans Research Community, WormBook, https:\/\/doi.org\/10.1895\/wormbook.1.122.1, http:\/\/www.wormbook.org.","DOI":"10.1895\/wormbook.1.122.1"},{"key":"277_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","volume":"77","author":"S Brenner","year":"1974","unstructured":"Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71","journal-title":"Genetics"},{"key":"277_CR7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0955-3886(00)00087-4","volume":"23","author":"W Breuer","year":"2000","unstructured":"Breuer W, Hershko C, Cabantchik ZI (2000) The importance of non-transferrin bound iron in disorders of iron metabolism. Transfus Sci 23:185\u2013192. https:\/\/doi.org\/10.1016\/S0955-3886(00)00087-4","journal-title":"Transfus Sci"},{"key":"277_CR8","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.4081\/thal.2013.s1.e3","volume":"3","author":"ZIS Cabantchik","year":"2013","unstructured":"Cabantchik ZIS, Breuer W, Esp\u00f3sito BP (2013) The Molecular and cellular basis of iron toxicity in iron overload (io) disorders. Diagn Ther Approaches Thalassemia Rep 3:e3","journal-title":"Diagn Ther Approaches Thalassemia Rep"},{"key":"277_CR9","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1039\/C8MT00143J","volume":"10","author":"K Chand","year":"2018","unstructured":"Chand K, Rajeshwari CE, Cardoso SM, Chaves S, Santos MA (2018) Tacrine\u2013deferiprone hybrids as multi-target-directed metal chelators against Alzheimer\u2019s disease: a two-in-one drug. Metallomics 10:1460\u20131475. https:\/\/doi.org\/10.1039\/C8MT00143J","journal-title":"Metallomics"},{"key":"277_CR10","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/ajh.10348","volume":"73","author":"TB Chaston","year":"2003","unstructured":"Chaston TB, Richardson DR (2003) Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity. Am J Hematol 73:200\u2013210. https:\/\/doi.org\/10.1002\/ajh.10348","journal-title":"Am J Hematol"},{"key":"277_CR11","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1021\/acs.cgd.7b01503","volume":"18","author":"T Chen","year":"2018","unstructured":"Chen T, Li M, Liu J (2018a) \u03c0\u2013\u03c0 stacking interaction: a nondestructive and facile means in material engineering for bioapplications. Cryst Growth Des 18:2765\u20132783. https:\/\/doi.org\/10.1021\/acs.cgd.7b01503","journal-title":"Cryst Growth Des"},{"key":"277_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1080\/14756366.2017.1412314","volume":"33","author":"Y Chen","year":"2018","unstructured":"Chen Y et al (2018b) Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer\u2019s disease. J Enzyme Inhib Med Chem 33:290\u2013302. https:\/\/doi.org\/10.1080\/14756366.2017.1412314","journal-title":"J Enzyme Inhib Med Chem"},{"key":"277_CR13","doi-asserted-by":"publisher","first-page":"315","DOI":"10.2174\/1570159X11311030006","volume":"11","author":"MB Colovi\u0107","year":"2013","unstructured":"Colovi\u0107 MB, Krsti\u0107 DZ, Lazarevi\u0107-Pa\u0161ti TD, Bond\u017ei\u0107 AM, Vasi\u0107 VM (2013) Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol 11:315\u2013335. https:\/\/doi.org\/10.2174\/1570159X11311030006","journal-title":"Curr Neuropharmacol"},{"key":"277_CR14","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1042\/bst0300729","volume":"30","author":"BP Esp\u00f3sito","year":"2002","unstructured":"Esp\u00f3sito BP, Breuer W, Cabantchik ZI (2002a) Design and applications of methods for fluorescence detection of iron in biological systems. Biochem Soc Trans 30:729\u2013732","journal-title":"Biochem Soc Trans"},{"key":"277_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/abio.2002.5611","volume":"304","author":"BP Esp\u00f3sito","year":"2002","unstructured":"Esp\u00f3sito BP, Epsztejn S, Breuer W, Cabantchik ZI (2002b) A review of fluorescence methods for assessing labile iron in cells and biological fluids. Anal Biochem 304:1\u201318. https:\/\/doi.org\/10.1006\/abio.2002.5611","journal-title":"Anal Biochem"},{"key":"277_CR16","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1182\/blood-2003-03-0807","volume":"102","author":"BP Esp\u00f3sito","year":"2003","unstructured":"Esp\u00f3sito BP, Breuer W, Sirankapracha P, Pootrakul P, Hershko C, Cabantchik ZI (2003) Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood 102:2670\u20132677. https:\/\/doi.org\/10.1182\/blood-2003-03-0807","journal-title":"Blood"},{"key":"277_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10534-020-00250-4","volume":"33","author":"BP Esp\u00f3sito","year":"2020","unstructured":"Esp\u00f3sito BP, Martins AC, Carvalho RRV, Aschner M (2020) High throughput fluorimetric assessment of iron traffic and chelation in iron-overloaded Caenorhabditis elegans. Biometals 33:255\u2013327. https:\/\/doi.org\/10.1007\/s10534-020-00250-4","journal-title":"Biometals"},{"key":"277_CR18","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1039\/C4TX00120F","volume":"4","author":"DDA Fagundez","year":"2015","unstructured":"Fagundez DDA et al (2015) Behavioral and dopaminergic damage induced by acute iron toxicity in Caenorhabditis elegans. Toxicol Res 4:878\u2013884. https:\/\/doi.org\/10.1039\/C4TX00120F","journal-title":"Toxicol Res"},{"key":"277_CR19","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1093\/biosci\/biu058","volume":"64","author":"J Gjorgjieva","year":"2014","unstructured":"Gjorgjieva J, Biron D, Haspel G (2014) Neurobiology of Caenorhabditis elegans locomotion: where do we stand? Bioscience 64:476\u2013486. https:\/\/doi.org\/10.1093\/biosci\/biu058","journal-title":"Bioscience"},{"key":"277_CR20","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1021\/bc5004197","volume":"25","author":"D Goswami","year":"2014","unstructured":"Goswami D, Machini MT, Silvestre DM, Nomura CS, Esp\u00f3sito BP (2014) Cell Penetrating Peptide (CPP)-conjugated desferrioxamine for enhanced neuroprotection: synthesis and in vitro evaluation bioconjugate. Chemistry 25:2067\u20132080. https:\/\/doi.org\/10.1021\/bc5004197","journal-title":"Chemistry"},{"key":"277_CR21","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.bmc.2015.01.045","volume":"23","author":"N Guzior","year":"2015","unstructured":"Guzior N, Bajda M, Rakoczy J, Brus B, Gobec S, Malawska B (2015) Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer\u2019s agents. Bioorg Med Chem 23:1629\u20131637. https:\/\/doi.org\/10.1016\/j.bmc.2015.01.045","journal-title":"Bioorg Med Chem"},{"key":"277_CR22","doi-asserted-by":"crossref","unstructured":"Hart AC (2006) Behavior","DOI":"10.1895\/wormbook.1.87.1"},{"key":"277_CR23","doi-asserted-by":"publisher","first-page":"6701","DOI":"10.1039\/C4CS00026A","volume":"43","author":"DJ Hayne","year":"2014","unstructured":"Hayne DJ, Lim S, Donnelly PS (2014) Metal complexes designed to bind to amyloid-\u03b2 for the diagnosis and treatment of Alzheimer\u2019s disease. Chem Soc Rev 43:6701\u20136715. https:\/\/doi.org\/10.1039\/C4CS00026A","journal-title":"Chem Soc Rev"},{"key":"277_CR24","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1517\/13543776.2011.569493","volume":"21","author":"H Heli","year":"2011","unstructured":"Heli H, Mirtorabi S, Karimian K (2011) Advances in iron chelation: an update. Expert Opin Ther Pat 21:819\u2013856. https:\/\/doi.org\/10.1517\/13543776.2011.569493","journal-title":"Expert Opin Ther Pat"},{"key":"277_CR25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1039\/C0MT00087F","volume":"3","author":"RC Hider","year":"2011","unstructured":"Hider RC, Roy S, Ma YM, Le Kong X, Preston J (2011) The potential application of iron chelators for the treatment of neurodegenerative diseases. Metallomics 3:239\u2013249. https:\/\/doi.org\/10.1039\/C0MT00087F","journal-title":"Metallomics"},{"key":"277_CR26","doi-asserted-by":"publisher","first-page":"53519","DOI":"10.1039\/C6RA03455A","volume":"6","author":"A Hiremathad","year":"2016","unstructured":"Hiremathad A et al (2016) Tacrine-allyl\/propargylcysteine\u2013benzothiazole trihybrids as potential anti-Alzheimer\u2019s drug candidates. RSC Adv 6:53519\u201353532. https:\/\/doi.org\/10.1039\/C6RA03455A","journal-title":"RSC Adv"},{"key":"277_CR27","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0895-3988(09)60004-0","volume":"21","author":"Y-O Hu","year":"2008","unstructured":"Hu Y-O, Wang Y, Ye B-P, Wang D-Y (2008) Phenotypic and behavioral defects induced by iron exposure can be transferred to progeny in Caenorhabditis elegans. Biomed Environ Sci 21:467\u2013473. https:\/\/doi.org\/10.1016\/S0895-3988(09)60004-0","journal-title":"Biomed Environ Sci"},{"key":"277_CR28","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1002\/jps.10168","volume":"91","author":"PM Ihnat","year":"2002","unstructured":"Ihnat PM, Vennerstrom JL, Robinson DH (2002) Solution equilibria of deferoxamine amides. J Pharm Sci 91:1733\u20131741. https:\/\/doi.org\/10.1002\/jps.10168","journal-title":"J Pharm Sci"},{"key":"277_CR29","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1126\/science.3287621","volume":"240","author":"C Kenyon","year":"1988","unstructured":"Kenyon C (1988) The nematode Caenorhabditis elegans. Science 240:1448\u20131453. https:\/\/doi.org\/10.1126\/science.3287621","journal-title":"Science"},{"key":"277_CR30","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.1016\/j.bmc.2013.05.028","volume":"21","author":"RS Keri","year":"2013","unstructured":"Keri RS, Quintanova C, Marques SM, Esteves AR, Cardoso SM, Santos MA (2013) Design, synthesis and neuroprotective evaluation of novel tacrine\u2013benzothiazole hybrids as multi-targeted compounds against Alzheimer\u2019s disease. Bioorg Med Chem 21:4559\u20134569. https:\/\/doi.org\/10.1016\/j.bmc.2013.05.028","journal-title":"Bioorg Med Chem"},{"key":"277_CR31","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/cbdd.12633","volume":"87","author":"RS Keri","year":"2016","unstructured":"Keri RS, Quintanova C, Chaves S, Silva DF, Cardoso SM, Santos MA (2016) New tacrine hybrids with natural-based cysteine derivatives as multitargeted drugs for potential treatment of Alzheimer\u2019s disease. Chem Biol Drug Des 87:101\u2013111. https:\/\/doi.org\/10.1111\/cbdd.12633","journal-title":"Chem Biol Drug Des"},{"key":"277_CR32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2018.10.413","volume":"133","author":"MD Knutson","year":"2019","unstructured":"Knutson MD (2019) Non-transferrin-bound iron transporters. Free Radic Biol Med 133:101\u2013111. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.10.413","journal-title":"Free Radic Biol Med"},{"key":"277_CR33","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1016\/j.ccr.2012.03.013","volume":"256","author":"H Kozlowski","year":"2012","unstructured":"Kozlowski H, Luczkowski M, Remelli M, Valensin D (2012) Copper, zinc and iron in neurodegenerative diseases (Alzheimer\u2019s, Parkinson\u2019s and prion diseases) coordination. Chem Rev 256:2129\u20132141. https:\/\/doi.org\/10.1016\/j.ccr.2012.03.013","journal-title":"Chem Rev"},{"key":"277_CR34","doi-asserted-by":"publisher","first-page":"8212","DOI":"10.1039\/C6OB01400C","volume":"14","author":"C Kurth","year":"2016","unstructured":"Kurth C, Kage H, Nett M (2016) Siderophores as molecular tools in medical and environmental applications. Org Biomol Chem 14:8212\u20138227. https:\/\/doi.org\/10.1039\/C6OB01400C","journal-title":"Org Biomol Chem"},{"key":"277_CR35","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.2174\/0929867324666170705123509","volume":"24","author":"T Lazarevic-Pasti","year":"2017","unstructured":"Lazarevic-Pasti T, Leskovac A, Momic T, Petrovic S, Vasic V (2017) Modulators of acetylcholinesterase activity: from Alzheimer\u2019s disease to anti-cancer drugs. Curr Med Chem 24:3283\u20133309. https:\/\/doi.org\/10.2174\/0929867324666170705123509","journal-title":"Curr Med Chem"},{"key":"277_CR36","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1021\/jm9016703","volume":"53","author":"J Liu","year":"2010","unstructured":"Liu J et al (2010) Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload. J Med Chem 53:1370\u20131382. https:\/\/doi.org\/10.1021\/jm9016703","journal-title":"J Med Chem"},{"key":"277_CR37","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1080\/13880209.2020.1791192","volume":"58","author":"RVM Manalo","year":"2020","unstructured":"Manalo RVM, Medina PMB (2020) Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson\u2019s disease. J Pharm Bil 58:721\u2013731. https:\/\/doi.org\/10.1080\/13880209.2020.1791192","journal-title":"J Pharm Bil"},{"key":"277_CR38","doi-asserted-by":"publisher","first-page":"115640","DOI":"10.1016\/j.bmc.2020.115640","volume":"28","author":"M Maqbool","year":"2020","unstructured":"Maqbool M, Rajvansh R, Srividya K, Hoda N (2020) Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting \u03b1-synuclein in transgenic C. elegans model of Synucleinopathy. Bioorg Med Chem 28:115640","journal-title":"Bioorg Med Chem"},{"key":"277_CR39","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1039\/C2SC20045G","volume":"3","author":"CR Martinez","year":"2012","unstructured":"Martinez CR, Iverson BL (2012) Rethinking the term \u201cpi-stacking.\u201d Chem Sci 3:2191\u20132201. https:\/\/doi.org\/10.1039\/C2SC20045G","journal-title":"Chem Sci"},{"key":"277_CR40","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1021\/jm970150t","volume":"40","author":"MT McKenna","year":"1997","unstructured":"McKenna MT, Proctor GR, Young LC, Harvey AL (1997) Novel tacrine analogues for potential use against Alzheimer\u2019s disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. J Med Chem 40:3516\u20133523. https:\/\/doi.org\/10.1021\/jm970150t","journal-title":"J Med Chem"},{"key":"277_CR41","first-page":"212","volume":"26","author":"P Molyneux","year":"2004","unstructured":"Molyneux P (2004) The use of the stable radical Diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity Songklanakarin. J Sci Technol 26:212\u2013219","journal-title":"J Sci Technol"},{"key":"277_CR42","first-page":"601","volume":"18","author":"C Palleria","year":"2013","unstructured":"Palleria C, Di Paolo A, Giofr\u00e8 C, Caglioti C, Leuzzi G, Siniscalchi A, De Sarro G, Gallelli L (2013) Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci 18:601\u2013610","journal-title":"J Res Med Sci"},{"key":"277_CR43","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1080\/14756366.2018.1491564","volume":"33","author":"L Piemontese","year":"2018","unstructured":"Piemontese L et al (2018) Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer\u2019s drug candidates. J Enzyme Inhib Med Chem 33:1212\u20131224. https:\/\/doi.org\/10.1080\/14756366.2018.1491564","journal-title":"J Enzyme Inhib Med Chem"},{"key":"277_CR44","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1021\/acs.bioconjchem.8b00924","volume":"30","author":"S Pramanik","year":"2019","unstructured":"Pramanik S, Chakraborty S, Sivan M, Patro BS, Chatterjee S, Goswami D (2019) Cell permeable imidazole-desferrioxamine conjugates: synthesis and in vitro evaluation. Bioconjug Chem 30:841\u2013852. https:\/\/doi.org\/10.1021\/acs.bioconjchem.8b00924","journal-title":"Bioconjug Chem"},{"key":"277_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2015.06.008","author":"C Quintanova","year":"2015","unstructured":"Quintanova C, Keri R, Chaves S, Santos MA (2015a) Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles. J Inorg Biochem. https:\/\/doi.org\/10.1016\/j.jinorgbio.2015.06.008","journal-title":"J Inorg Biochem"},{"key":"277_CR46","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1039\/C5MD00236B","volume":"6","author":"C Quintanova","year":"2015","unstructured":"Quintanova C, Keri RS, Marques SM, Maria G, Cardoso SM, Serralheiro ML, Santos MA (2015b) Design, synthesis and bioevaluation of tacrine hybrids with cinnamate and cinnamylidene acetate derivatives as potential anti-Alzheimer drugs. MedChemComm 6:1969\u20131977. https:\/\/doi.org\/10.1039\/C5MD00236B","journal-title":"MedChemComm"},{"key":"277_CR47","doi-asserted-by":"publisher","unstructured":"Raines DJ, Sanderson TJ, Wilde EJ, Duhme-Klair AK (2015) Siderophores. In: Reference module in chemistry, molecular sciences and chemical engineering. Elsevier. https:\/\/doi.org\/10.1016\/B978-0-12-409547-2.11040-6","DOI":"10.1016\/B978-0-12-409547-2.11040-6"},{"key":"277_CR48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1749-6632.1967.tb34893.x","volume":"141","author":"DH Rammler","year":"1967","unstructured":"Rammler DH (1967) The effect of DMSO on several enzyme systems. Ann N Y Acad Sci 141:291\u2013299. https:\/\/doi.org\/10.1111\/j.1749-6632.1967.tb34893.x","journal-title":"Ann N Y Acad Sci"},{"key":"277_CR49","doi-asserted-by":"publisher","unstructured":"Rand JB (2007) Acetylcholine WormBook (ed) The C. elegans Research Community, WormBook, https:\/\/doi.org\/10.1895\/wormbook.1.131.1, http:\/\/www.wormbook.org.","DOI":"10.1895\/wormbook.1.131.1"},{"key":"277_CR50","doi-asserted-by":"publisher","first-page":"11252","DOI":"10.1002\/anie.201703744","volume":"56","author":"L-J Riwar","year":"2017","unstructured":"Riwar L-J, Trapp N, Kuhn B, Diederich F (2017) Substituent effects in parallel-displaced \u03c0\u2013\u03c0 stacking interactions: distance matters. Angew Chem Int Ed 56:11252\u201311257. https:\/\/doi.org\/10.1002\/anie.201703744","journal-title":"Angew Chem Int Ed"},{"key":"277_CR51","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1016\/j.ccr.2012.03.008","volume":"256","author":"C Rodr\u00edguez-Rodr\u00edguez","year":"2012","unstructured":"Rodr\u00edguez-Rodr\u00edguez C, Telpoukhovskaia M, Orvig C (2012) The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases. Coord Chem Rev 256:2308\u20132332. https:\/\/doi.org\/10.1016\/j.ccr.2012.03.008","journal-title":"Coord Chem Rev"},{"key":"277_CR52","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ejmech.2014.01.037","volume":"75","author":"WG Salgueiro","year":"2014","unstructured":"Salgueiro WG et al (2014) Direct synthesis of 4-organylsulfenyl-7-chloro quinolines and their toxicological and pharmacological activities in Caenorhabditis elegans. Eur J Med Chem 75:448\u2013459. https:\/\/doi.org\/10.1016\/j.ejmech.2014.01.037","journal-title":"Eur J Med Chem"},{"key":"277_CR53","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.freeradbiomed.2017.05.020","volume":"110","author":"WG Salgueiro","year":"2017","unstructured":"Salgueiro WG et al (2017) Insights into the differential toxicological and antioxidant effects of 4-phenylchalcogenil-7-chloroquinolines in Caenorhabditis elegans. Free Radic Biol Med 110:133\u2013141. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.05.020","journal-title":"Free Radic Biol Med"},{"key":"277_CR54","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ccr.2016.04.013","volume":"327\u2013328","author":"MA Santos","year":"2016","unstructured":"Santos MA, Chand K, Chaves S (2016) Recent progress in multifunctional metal chelators as potential drugs for Alzheimer\u2019s disease. Coord Chem Rev 327\u2013328:287\u2013303. https:\/\/doi.org\/10.1016\/j.ccr.2016.04.013","journal-title":"Coord Chem Rev"},{"key":"277_CR55","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1021\/ml500222g","volume":"5","author":"KV Sashidhara","year":"2014","unstructured":"Sashidhara KV, Modukuri RK, Jadiya P, Rao KB, Shjarma T, Haque R, Singh DK, Banerjee D, Siddiqi MI, Nazir A (2014a) Discovery of 3-arylcoumarin-tetracyclic tacrine hybrids as multifunctional agents against Parkinson\u2019s disease. ACS Med Chem Lett 5:1099\u20131103","journal-title":"ACS Med Chem Lett"},{"key":"277_CR56","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1002\/cmdc.201402291","volume":"9","author":"KV Sashidhara","year":"2014","unstructured":"Sashidhara KV et al (2014b) Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer\u2019s disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. ChemMedChem 9:2671\u20132684. https:\/\/doi.org\/10.1002\/cmdc.201402291","journal-title":"ChemMedChem"},{"key":"277_CR57","doi-asserted-by":"publisher","first-page":"111","DOI":"10.31887\/DCNS.2000.2.2\/lschneider","volume":"2","author":"L Schneider","year":"2000","unstructured":"Schneider L (2000) A critical review of cholinesterase inhibitors as a treatment modality in Alzheimer\u2019s disease. Dialogues Clin Neurosci 2:111\u2013128","journal-title":"Dialogues Clin Neurosci"},{"key":"277_CR58","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/moh.0000000000000031","volume":"21","author":"S Sheth","year":"2014","unstructured":"Sheth S (2014) Iron chelation: an update. Curr Opin Hematol 21:179\u2013185. https:\/\/doi.org\/10.1097\/moh.0000000000000031","journal-title":"Curr Opin Hematol"},{"key":"277_CR59","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1016\/j.bmcl.2013.03.026","volume":"23","author":"SK Sinha","year":"2013","unstructured":"Sinha SK, Shrivastava SK (2013) Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory. Bioorg Med Chem Lett 23:2984\u20132989. https:\/\/doi.org\/10.1016\/j.bmcl.2013.03.026","journal-title":"Bioorg Med Chem Lett"},{"key":"277_CR60","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1080\/10715762.2018.1492119","volume":"52","author":"MV Soares","year":"2018","unstructured":"Soares MV, Puntel RL, \u00c1vila DS (2018) Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans. Free Radic Res 52:939\u2013951. https:\/\/doi.org\/10.1080\/10715762.2018.1492119","journal-title":"Free Radic Res"},{"key":"277_CR61","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1021\/acs.cgd.8b01630","volume":"19","author":"R Thakuria","year":"2019","unstructured":"Thakuria R, Nath NK, Saha BK (2019) The nature and applications of \u03c0\u2013\u03c0 interactions: a perspective. Cryst Growth Des 19:523\u2013528. https:\/\/doi.org\/10.1021\/acs.cgd.8b01630","journal-title":"Cryst Growth Des"},{"key":"277_CR62","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.neuint.2013.01.023","volume":"62","author":"A Tiiman","year":"2013","unstructured":"Tiiman A, Palumaa P, T\u00f5ugu V (2013) The missing link in the amyloid cascade of Alzheimer\u2019s disease\u2014metal ions. Neurochem Int 62:367\u2013378. https:\/\/doi.org\/10.1016\/j.neuint.2013.01.023","journal-title":"Neurochem Int"},{"key":"277_CR63","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.apgeochem.2018.08.019","volume":"97","author":"M Walaszek","year":"2018","unstructured":"Walaszek M, Del Nero M, Bois P, Ribstein L, Courson O, Wanko A, Laurent J (2018) Sorption behavior of copper, lead and zinc by a constructed wetland treating urban stormwater. Appl Geochem 97:167\u2013180. https:\/\/doi.org\/10.1016\/j.apgeochem.2018.08.019","journal-title":"Appl Geochem"},{"key":"277_CR64","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.bbrc.2010.08.113","volume":"400","author":"X Wang","year":"2010","unstructured":"Wang X, Wang X, Li L, Wang D (2010) Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. Biochem Biophys Res Commun 400:613\u2013618. https:\/\/doi.org\/10.1016\/j.bbrc.2010.08.113","journal-title":"Biochem Biophys Res Commun"},{"key":"277_CR65","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jtemb.2014.12.012","volume":"31","author":"RJ Ward","year":"2015","unstructured":"Ward RJ, Dexter DT, Crichton RR (2015) Neurodegenerative diseases and therapeutic strategies using iron chelators. J Trace Elem Med Biol 31:267\u2013273. https:\/\/doi.org\/10.1016\/j.jtemb.2014.12.012","journal-title":"J Trace Elem Med Biol"},{"key":"277_CR66","doi-asserted-by":"publisher","first-page":"193","DOI":"10.5004\/dwt.2009.460","volume":"3","author":"RJ Xie","year":"2009","unstructured":"Xie RJ, Tan EK, Puah AN (2009) Oxidation-reduction potential in saline water reverse osmosis membrane desalination and its potential use for system control. Desalin Water Treat 3:193\u2013203. https:\/\/doi.org\/10.5004\/dwt.2009.460","journal-title":"Desalin Water Treat"},{"key":"277_CR67","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neuroscience.2014.07.068","volume":"278","author":"DC Zamberlan","year":"2014","unstructured":"Zamberlan DC, Arantes LP, Machado ML, Golombieski R, Soares FAA (2014) Diphenyl-diselenide suppresses amyloid-\u03b2 peptide in Caenorhabditis elegans model of Alzheimer\u2019s disease. Neuroscience 278:40\u201350. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.07.068","journal-title":"Neuroscience"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-020-00277-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-020-00277-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-020-00277-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T10:04:10Z","timestamp":1615197850000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-020-00277-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,3]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["277"],"URL":"https:\/\/doi.org\/10.1007\/s10534-020-00277-7","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,3]]},"assertion":[{"value":"27 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors do not report conflicting interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}