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However, commonly used supplements, including those based on ferrous iron salts, are associated with gastrointestinal side effects and unfavorable changes in the intestinal microbiome. Sucrosomial\u00ae iron is a novel iron formulation that is effective at treating iron deficiency, and with fewer gastrointestinal side effects, yet its effect on the gut microbiome has not been examined previously. Thus, we treated mice for two weeks with diets containing either Sucrosomial\u00ae iron or ferrous sulfate as the sole iron source and examined bacterial communities in the intestine using 16S Microbial Profiling of DNA extracted from feces collected both prior to and following dietary treatment. Mice treated with Sucrosomial\u00ae iron showed an increase in Shannon diversity over the course of the study. This was associated with a decrease in the abundance of the phylum Proteobacteria, which contains many pathogenic species, and an increase in short chain fatty acid producing bacteria such as<jats:italic>Lachnospiraceae<\/jats:italic>,<jats:italic>Oscillibacter<\/jats:italic>and<jats:italic>Faecalibaculum<\/jats:italic>. None of these changes were observed in mice treated with ferrous sulfate. These results suggest that Sucrosomial\u00ae iron may have a beneficial effect on the intestinal microbiome when compared to ferrous sulfate and that this form of iron is a promising alternative to ferrous iron salts for the treatment of iron deficiency.<\/jats:p>","DOI":"10.1007\/s10534-021-00348-3","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T16:02:55Z","timestamp":1635177775000},"page":"27-38","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Supplementation with Sucrosomial\u00ae iron leads to favourable changes in the intestinal microbiome when compared to ferrous sulfate in mice"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-5070","authenticated-orcid":false,"given":"Martha","family":"Zakrzewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-4173","authenticated-orcid":false,"given":"Sarah J.","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-2988","authenticated-orcid":false,"given":"Sheridan L.","family":"Helman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-5164","authenticated-orcid":false,"given":"Elisa","family":"Brilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-1614","authenticated-orcid":false,"given":"Germano","family":"Tarantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-5866","authenticated-orcid":false,"given":"Gregory J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-1379","authenticated-orcid":false,"given":"David M.","family":"Frazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"348_CR1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s11739-018-1993-9","volume":"14","author":"G Abbati","year":"2019","unstructured":"Abbati G, Incerti F, Boarini C, Pileri F, Bocchi D, Ventura P, Buzzetti E, Pietrangelo A (2019) Safety and efficacy of sucrosomial iron in inflammatory bowel disease patients with iron deficiency anemia. 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