{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:26:12Z","timestamp":1789611972656,"version":"build-2803163510"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 32072811, 31872437"],"award-info":[{"award-number":["Grant No. 32072811, 31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 32072811, 31872437"],"award-info":[{"award-number":["Grant No. 32072811, 31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 32072811, 31872437"],"award-info":[{"award-number":["Grant No. 32072811, 31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 32072811, 31872437"],"award-info":[{"award-number":["Grant No. 32072811, 31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 32072811, 31872437"],"award-info":[{"award-number":["Grant No. 32072811, 31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 32072811, 31872437"],"award-info":[{"award-number":["Grant No. 32072811, 31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 32072811, 31872437"],"award-info":[{"award-number":["Grant No. 32072811, 31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s10534-022-00468-4","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T20:02:34Z","timestamp":1669406554000},"page":"137-152","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Selenium deficiency increased duodenal permeability and decreased expression of antimicrobial peptides by activating ROS\/NF-\u03baB signal pathway in chickens"],"prefix":"10.1007","volume":"36","author":[{"given":"He","family":"Yujiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang","family":"Xinyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Guangliang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"468_CR1","doi-asserted-by":"publisher","first-page":"666900","DOI":"10.3389\/fcimb.2021.666900","volume":"11","author":"F Alessandra","year":"2021","unstructured":"Alessandra F, Vittoria S, Maria D, Brunella P, Giovanna D (2021) Antimicrobial peptides human beta-defensin-2 and -3 protect the gut during candida albicans infections enhancing the intestinal barrier integrity. In Vitro Study Front Cell Infect Microbiol 11:666900","journal-title":"In Vitro Study Front Cell Infect Microbiol"},{"key":"468_CR2","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.3389\/fimmu.2019.02289","volume":"10","author":"L Berkowitz","year":"2019","unstructured":"Berkowitz L, Pardo-Roa C, Salazar GA, Salazar-Echegarai F, Miranda JP, Ram\u00edrez G, Ch\u00e1vez JL, Kalergis AM, Bueno SM, \u00c1lvarez-Lobos M (2019) Mucosal exposure to cigarette components induces intestinal inflammation and alters antimicrobial response in mice. Front Immunol 10:2289","journal-title":"Front Immunol"},{"issue":"5","key":"468_CR3","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.3382\/ps.0531870","volume":"53","author":"AH Cantor","year":"1974","unstructured":"Cantor AH, Scott ML (1974) The effect of selenium in the hen\u2019s diet on egg production, hatchability, performance of progeny and selenium concentration in eggs. Poult Sci 53(5):1870\u20131880","journal-title":"Poult Sci"},{"key":"468_CR4","doi-asserted-by":"publisher","first-page":"113880","DOI":"10.1016\/j.ecoenv.2022.113880","volume":"242","author":"D Chen","year":"2022","unstructured":"Chen D, Yao Y, Shi X, Li X, Cui W, Xu S (2022) Cadmium exposure causes mitochondrial fission and fusion disorder in the pig hypothalamus via the PI3K\/AKT pathway. Ecotoxicol Environ Saf 242:113880","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"468_CR5","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1053\/j.gastro.2020.04.077","volume":"159","author":"DM Chopyk","year":"2020","unstructured":"Chopyk DM, Grakoui A (2020) Contribution of the intestinal microbiome and gut barrier to hepatic disorders. Gastroenterology 159(3):849\u2013863","journal-title":"Gastroenterology"},{"issue":"2","key":"468_CR6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1017\/S0007114517001830","volume":"118","author":"YW Dong","year":"2017","unstructured":"Dong YW, Jiang WD, Liu Y, Wu P, Jiang J, Kuang SY, Tang L, Tang WN, Zhang YA, Zhou XQ, Feng L (2017) Threonine deficiency decreased intestinal immunity and aggravated inflammation associated with NF-\u03baB and target of rapamycin signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila. Br J Nutr 118(2):92\u2013108","journal-title":"Br J Nutr"},{"issue":"4","key":"468_CR7","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s10534-016-9953-1","volume":"29","author":"C Echeverr\u00eda","year":"2016","unstructured":"Echeverr\u00eda C, Romero V, Arancibia R, Klahn H, Montorfano I, Armisen R, Borgna V, Simon F, Ramirez-Tagle R (2016) The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release. Biometals 29(4):743\u2013749","journal-title":"Biometals"},{"key":"468_CR8","doi-asserted-by":"publisher","first-page":"153589","DOI":"10.1016\/j.phymed.2021.153589","volume":"88","author":"M Elbadawi","year":"2021","unstructured":"Elbadawi M, Ammar RM, Aziz-Kalbhenn H, Rabini S, Klauck SM, Dawood M, Saeed MEM, Kampf CJ, Efferth T (2021) Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids. Phytomedicine 88:153589","journal-title":"Phytomedicine"},{"key":"468_CR9","doi-asserted-by":"publisher","first-page":"106658","DOI":"10.1016\/j.intimp.2020.106658","volume":"85","author":"J Feng","year":"2020","unstructured":"Feng J, Wang L, Xie Y, Chen Y, Yi H, He D (2020) Effects of antimicrobial peptide cathelicidin-BF on diarrhea controlling, immune responses, intestinal inflammation and intestinal barrier function in piglets with postweaning diarrhea. Int Immunopharmacol 85:106658","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"468_CR10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s12011-011-9175-x","volume":"145","author":"X Gao","year":"2012","unstructured":"Gao X, Xing H, Li S, Li J, Ying T, Xu S (2012) Selenium regulates gene expression of selenoprotein W in chicken gastrointestinal tract. Biol Trace Elem Res 145(2):181\u2013188","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"468_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s12011-016-0651-1","volume":"173","author":"X Gao","year":"2016","unstructured":"Gao X, Zhang Z, Xing H, Yu J, Zhang N, Xu S (2016) Selenium deficiency-induced inflammation and increased expression of regulating inflammatory cytokines in the chicken gastrointestinal tract. Biol Trace Elem Res 173(1):210\u2013218","journal-title":"Biol Trace Elem Res"},{"key":"468_CR12","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.3389\/fphys.2018.01371","volume":"9","author":"H Guo","year":"2018","unstructured":"Guo H, Lin W, Hou J, Wang L, Zhang D, Wu X, Li L, Li D (2018) The protective roles of dietary selenium yeast and tea polyphenols on growth performance and ammonia tolerance of juvenile wuchang bream (megalobrama amblycephala). Front Physiol 9:1371","journal-title":"Front Physiol"},{"key":"468_CR13","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.fsi.2019.02.017","volume":"87","author":"X Gao","year":"2019","unstructured":"Gao X, Tang B, Liang H, Yi L, Wei Z (2019) Selenium deficiency induced an inflammatory response by the HSP60 - TLR2-MAPKs signalling pathway in the liver of carp. Fish Shellfish Immunol 87:688\u2013694","journal-title":"Fish Shellfish Immunol"},{"issue":"7","key":"468_CR14","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s00726-021-03001-y","volume":"53","author":"T Hasegawa","year":"2021","unstructured":"Hasegawa T, Mizugaki A, Inoue Y, Kato H, Murakami H (2021) Cystine reduces tight junction permeability and intestinal inflammation induced by oxidative stress in Caco-2 cells. Amino Acids 53(7):1021\u20131032","journal-title":"Amino Acids"},{"issue":"2","key":"468_CR15","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s12011-019-02017-6","volume":"197","author":"X He","year":"2020","unstructured":"He X, Lin Y, Lian S, Sun D, Guo D, Wang J, Wu R (2020) Selenium deficiency in chickens induces intestinal mucosal injury by affecting the mucosa morphology SIgA secretion, and GSH-Px activity. Biol Trace Elem Res 197(2):660\u2013666","journal-title":"Biol Trace Elem Res"},{"issue":"Pt 1","key":"468_CR16","doi-asserted-by":"publisher","first-page":"135662","DOI":"10.1016\/j.chemosphere.2022.135662","volume":"307","author":"Y He","year":"2022","unstructured":"He Y, Li Z, Xu T, Luo D, Chi Q, Zhang Y, Li S (2022) Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-\u03baB\/NLRP3 pathway. Chemosphere 307(Pt 1):135662","journal-title":"Chemosphere"},{"key":"468_CR17","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.3389\/fmicb.2017.02663","volume":"8","author":"L Hu","year":"2017","unstructured":"Hu L, Geng S, Li Y, Cheng S, Fu X, Yue X, Han X (2017) Exogenous fecal microbiota transplantation from local adult pigs to crossbred newborn piglets. Front Microbiol 8:2663","journal-title":"Front Microbiol"},{"issue":"6","key":"468_CR18","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s10534-021-00347-4","volume":"34","author":"Y Jia","year":"2021","unstructured":"Jia Y, Zhang L, Liu X, Zhang S, Dai J, Huang J, Chen J, Wang Y, Zhou J, Zeng Z (2021) Selenium can regulate the differentiation and immune function of human dendritic cells. Biometals 34(6):1365\u20131379","journal-title":"Biometals"},{"issue":"4","key":"468_CR19","doi-asserted-by":"publisher","first-page":"G648","DOI":"10.1152\/ajpgi.00342.2014","volume":"311","author":"AB Kohan","year":"2016","unstructured":"Kohan AB, Yang Q, Xu M, Lee D, Tso P (2016) Monosodium glutamate inhibits the lymphatic transport of lipids in the rat. Am J Physiol Gastrointest Liver Physiol 311(4):G648\u2013G654","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"468_CR20","doi-asserted-by":"publisher","first-page":"5514075","DOI":"10.1155\/2021\/5514075","volume":"2021","author":"H Lan","year":"2021","unstructured":"Lan H, Zhang LY, He W, Li WY, Zeng Z, Qian B, Wang C, Song JL (2021) Sinapic acid alleviated inflammation-induced intestinal epithelial barrier dysfunction in lipopolysaccharide- (LPS-) treated Caco-2 cells. Mediators Inflamm 2021:5514075","journal-title":"Mediators Inflamm"},{"issue":"11","key":"468_CR21","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1016\/j.bbagen.2018.03.029","volume":"1862","author":"S Li","year":"2018","unstructured":"Li S, Gao F, Huang J, Wu Y, Wu S, Lei XG (2018) Regulation and function of avian selenogenome. Biochim Biophys Acta Gen Subj 1862(11):2473\u20132479","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"468_CR22","doi-asserted-by":"publisher","first-page":"111127","DOI":"10.1016\/j.biopha.2020.111127","volume":"139","author":"S Lijun","year":"2021","unstructured":"Lijun S, Haitao Y, Hongbin L, Meixia C, Xiangfang Z, Shiyan Q (2021) Recombinant antimicrobial peptide microcin J25 alleviates DSS-induced colitis via regulating intestinal barrier function and modifying gut microbiota. Biomed Pharmacother 139:111127","journal-title":"Biomed Pharmacother"},{"issue":"Pt A","key":"468_CR23","doi-asserted-by":"publisher","first-page":"127318","DOI":"10.1016\/j.jhazmat.2021.127318","volume":"424","author":"Z Miao","year":"2022","unstructured":"Miao Z, Miao Z, Teng X, Xu S (2022) Chlorpyrifos triggers epithelioma papulosum cyprini cell pyroptosis via miR-124-3p\/CAPN1 axis. J Hazard Mater 424(Pt A):127318","journal-title":"J Hazard Mater"},{"issue":"7","key":"468_CR24","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1089\/ars.2009.2973","volume":"12","author":"LV Papp","year":"2010","unstructured":"Papp LV, Holmgren A, Khanna KK (2010) Selenium and selenoproteins in health and disease. Antioxid Redox Signal 12(7):793\u2013795","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"468_CR25","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3390\/ijms22010291","volume":"22","author":"A Parveen","year":"2020","unstructured":"Parveen A, Choi S, Kang JH, Oh SH, Kim SY (2020) Trifostigmanoside I, an active compound from sweet potato, restores the activity of MUC2 and protects the tight junctions through PKC\u03b1\/\u03b2 to maintain intestinal barrier function. Int J Mol Sci 22(1):291","journal-title":"Int J Mol Sci"},{"key":"468_CR26","doi-asserted-by":"publisher","first-page":"963520","DOI":"10.1155\/2013\/963520","volume":"2013","author":"A Popa-Wagner","year":"2013","unstructured":"Popa-Wagner A, Mitran S, Sivanesan S, Chang E, Buga AM (2013) ROS and brain diseases: the good, the bad, and the ugly. Oxid Med Cell Longev 2013:963520","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"468_CR27","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00210-013-0871-2","volume":"386","author":"O Prabhakar","year":"2013","unstructured":"Prabhakar O (2013) Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats. Naunyn Schmiedebergs Arch Pharmacol 386(8):705\u2013710","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"468_CR28","doi-asserted-by":"publisher","first-page":"111665","DOI":"10.1016\/j.jinorgbio.2021.111665","volume":"226","author":"Z Qing","year":"2022","unstructured":"Qing Z, Dongliu L, Xuedie G, Khoso PA, Xiaodan H, Shu L (2022) MiR-144-3p targets STC1 to activate PI3K\/AKT pathway to induce cell apoptosis and cell cycle arrest in selenium deficiency broilers. J Inorg Biochem 226:111665","journal-title":"J Inorg Biochem"},{"issue":"1","key":"468_CR29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s40104-021-00596-w","volume":"12","author":"Y Qiu","year":"2021","unstructured":"Qiu Y, Yang J, Wang L, Yang X, Gao K, Zhu C, Jiang Z (2021) Dietary resveratrol attenuation of intestinal inflammation and oxidative damage is linked to the alteration of gut microbiota and butyrate in piglets challenged with deoxynivalenol. J Anim Sci Biotechnol 12(1):71","journal-title":"J Anim Sci Biotechnol"},{"issue":"9822","key":"468_CR30","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","volume":"379","author":"MP Rayman","year":"2012","unstructured":"Rayman MP (2012) Selenium and human health. Lancet 379(9822):1256\u20131268","journal-title":"Lancet"},{"issue":"9","key":"468_CR31","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.5713\/ajas.17.0836","volume":"31","author":"D Rengaraj","year":"2018","unstructured":"Rengaraj D, Truong AD, Lillehoj HS, Han JY, Hong YH (2018) Expression and regulation of avian beta-defensin 8 protein in immune tissues and cell lines of chickens. Asian-Australas J Anim Sci 31(9):1516\u20131524","journal-title":"Asian-Australas J Anim Sci"},{"key":"468_CR32","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190515","author":"M Rexidamu","year":"2019","unstructured":"Rexidamu M, Li H, Jin H, Huang J (2019) Serum levels of trimethylamine-N-oxide in patients with ischemic stroke. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20190515"},{"issue":"20","key":"468_CR33","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.1007\/s00018-019-03195-1","volume":"76","author":"C Rocca","year":"2019","unstructured":"Rocca C, Pasqua T, Boukhzar L, Anouar Y, Angelone T (2019) Progress in the emerging role of selenoproteins in cardiovascular disease: focus on endoplasmic reticulum-resident selenoproteins. Cell Mol Life Sci 76(20):3969\u20133985","journal-title":"Cell Mol Life Sci"},{"issue":"19","key":"468_CR34","doi-asserted-by":"publisher","first-page":"10713","DOI":"10.3390\/ijms221910713","volume":"22","author":"BK Shimada","year":"2021","unstructured":"Shimada BK, Alfulaij N, Seale LA (2021) The impact of selenium deficiency on cardiovascular function. Int J Mol Sci 22(19):10713","journal-title":"Int J Mol Sci"},{"key":"468_CR35","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1016\/j.freeradbiomed.2013.07.016","volume":"65","author":"H Steinbrenner","year":"2013","unstructured":"Steinbrenner H (2013) Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radical Biol Med 65:1538\u20131547","journal-title":"Free Radical Biol Med"},{"issue":"10","key":"468_CR36","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1002\/tox.23618","volume":"37","author":"X Tang","year":"2022","unstructured":"Tang X, Fan X, Xu T, He Y, Chi Q, Li Z, Li S (2022) Polystyrene nanoplastics exacerbated lipopolysaccharide-induced necroptosis and inflammation via the ROS\/MAPK pathway in mice spleen. Environ Toxicol 37(10):2552\u20132565","journal-title":"Environ Toxicol"},{"key":"468_CR37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","volume":"524","author":"D Tsikas","year":"2017","unstructured":"Tsikas D (2017) Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem 524:13\u201330","journal-title":"Anal Biochem"},{"issue":"2","key":"468_CR38","first-page":"255","volume":"26","author":"K Verma","year":"2013","unstructured":"Verma K, Mehta SK, Shekhawat GS (2013) Nitric oxide (NO) counteracts cadmium induced cytotoxic processes mediated by reactive oxygen species (ROS) in Brassica juncea: cross-talk between ROS. NO and Antioxid Responses Biometals 26(2):255\u2013269","journal-title":"NO and Antioxid Responses Biometals"},{"issue":"4","key":"468_CR39","doi-asserted-by":"publisher","first-page":"e1009537","DOI":"10.1371\/journal.ppat.1009537","volume":"17","author":"J Vornhagen","year":"2021","unstructured":"Vornhagen J, Bassis CM, Ramakrishnan S, Hein R, Mason S, Bergman Y, Sunshine N, Fan Y, Holmes CL, Timp W, Schatz MC, Young VB, Simner PJ, Bachman MA (2021) A plasmid locus associated with klebsiella clinical infections encodes a microbiome-dependent gut fitness factor. PLoS Pathog 17(4):e1009537","journal-title":"PLoS Pathog"},{"key":"468_CR40","doi-asserted-by":"publisher","first-page":"112757","DOI":"10.1016\/j.ecoenv.2021.112757","volume":"225","author":"S Xu","year":"2021","unstructured":"Xu S, Xiaojing L, Xinyue S, Wei C, Honggui L, Shiwen X (2021) Pig lung fibrosis is active in the subacute CdCl(2) exposure model and exerts cumulative toxicity through the M1\/M2 imbalance. Ecotoxicol Environ Saf 225:112757","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"468_CR41","doi-asserted-by":"publisher","first-page":"100840","DOI":"10.1016\/j.psj.2020.10.073","volume":"100","author":"L Yan","year":"2021","unstructured":"Yan L, Lv ZZ, An S, Xing K, Wang ZG, Lv MB, Choct M, Guo YM, Zhou GL (2021) Effects of rearing system and narasin on growth performance, gastrointestinal development, and gut microbiota of broilers. Poult Sci 100(3):100840","journal-title":"Poult Sci"},{"key":"468_CR42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jinorgbio.2017.02.006","volume":"170","author":"J Yang","year":"2017","unstructured":"Yang J, Zhang Y, Hamid S, Cai J, Liu Q, Li H, Zhao R, Wang H, Xu S, Zhang Z (2017) Interplay between autophagy and apoptosis in selenium deficient cardiomyocytes in chicken. J Inorg Biochem 170:17\u201325","journal-title":"J Inorg Biochem"},{"issue":"1\u20132","key":"468_CR43","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s12011-014-0164-8","volume":"163","author":"J Yu","year":"2015","unstructured":"Yu J, Yao H, Gao X, Zhang Z, Wang JF, Xu SW (2015) The role of nitric oxide and oxidative stress in intestinal damage induced by selenium deficiency in chickens. Biol Trace Elem Res 163(1\u20132):144\u2013153","journal-title":"Biol Trace Elem Res"},{"issue":"43","key":"468_CR44","doi-asserted-by":"publisher","first-page":"11301","DOI":"10.1021\/acs.jafc.8b03405","volume":"66","author":"H Yu","year":"2018","unstructured":"Yu H, Shang L, Zeng X, Li N, Liu H, Cai S, Huang S, Wang G, Wang Y, Song Q (2018) Risks related to high-dosage recombinant antimicrobial peptide microcin J25 in mice model: intestinal microbiota, intestinal barrier function and immune regulation. J Agric Food Chem 66(43):11301\u201311310","journal-title":"J Agric Food Chem"},{"issue":"1","key":"468_CR45","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s12011-015-0512-3","volume":"171","author":"JL Zhang","year":"2016","unstructured":"Zhang JL, Xu B, Huang XD, Gao YH, Chen Y, Shan AS (2016) Selenium deficiency affects the mRNA expression of inflammatory factors and selenoprotein genes in the kidneys of broiler chicks. Biol Trace Elem Res 171(1):201\u2013207","journal-title":"Biol Trace Elem Res"},{"issue":"10","key":"468_CR46","doi-asserted-by":"publisher","first-page":"4392","DOI":"10.1039\/D1FO00424G","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Qi X, Chen X, Zhang J, Zhang W, Lin H (2021a) Dietary selenomethionine ameliorates lipopolysaccharide-induced renal inflammatory injury in broilers via regulating the PI3K\/AKT pathway to inhibit necroptosis. Food Funct 12(10):4392\u20134401","journal-title":"Food Funct"},{"issue":"1","key":"468_CR47","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/jcp.29836","volume":"236","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Zhang J, Bao J, Tang C, Zhang Z (2021b) Selenium deficiency induced necroptosis, Th1\/Th2 imbalance, and inflammatory responses in swine ileum. J Cell Physiol 236(1):222\u2013234","journal-title":"J Cell Physiol"},{"issue":"5","key":"468_CR48","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/biof.1762","volume":"47","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Zhang B, Guan H, Jiao X, Yang J, Cai J, Liu Q, Zhang Z (2021a) Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine. BioFactors 47(5):788\u2013800","journal-title":"BioFactors"},{"issue":"4","key":"468_CR49","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.aninu.2021.05.005","volume":"7","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Guan H, Yang J, Cai J, Liu Q, Zhang Z (2021b) Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine. Anim Nutr 7(4):997\u20131008","journal-title":"Anim Nutr"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-022-00468-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-022-00468-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-022-00468-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:38:39Z","timestamp":1676335119000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-022-00468-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["468"],"URL":"https:\/\/doi.org\/10.1007\/s10534-022-00468-4","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,25]]},"assertion":[{"value":"22 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures used in this study were approved by the Institutional Animal Care and Use Committee (SRM-11) of Northeast Agricultural University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors have read the manuscript and have agreed to submit the manuscript in its current form for consideration for publication in this journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}