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Previously, Emu Oil protected the intestine against experimentally-induced inflammatory intestinal disorders. Zinc monoglycerolate (ZMG) polymer, formed by heating zinc oxide with glycerol, demonstrated anti-inflammatory and wound healing properties. We aimed to determine whether ZMG, alone or in combination with Emu Oil, could reduce acute colitis severity in rats. Male Sprague Dawley rats (n\u2009=\u20098\/group) were orally-administered either vehicle, ZMG, Emu Oil (EO) or ZMG combined with EO (ZMG\/EO) daily. Rats were provided\n                    <jats:italic>ad libitum<\/jats:italic>\n                    access to drinking water (Groups 1\u20134) or dextran sulphate sodium (DSS; 2%w\/v; Groups 5\u20138) throughout the trial (days 0\u20135) before euthanasia on day 6. Disease activity index, crypt depth, degranulated mast cells (DMCs) and myeloperoxidase (MPO) activity were assessed. p\u2009&lt;\u20090.05 was considered significant. DSS increased disease severity (days 3\u20136) compared to normal controls (p\u2009&lt;\u20090.05). Importantly, in DSS-administered rats, ZMG\/EO (day 3) and ZMG (day 6) reduced disease activity index compared to controls (p\u2009&lt;\u20090.05). Following DSS consumption, distal colonic crypts lengthened (p\u2009&lt;\u20090.01), occurring to a greater extent with EO compared to ZMG and ZMG\/EO (p\u2009&lt;\u20090.001). DSS increased colonic DMC numbers compared to normal controls (p\u2009&lt;\u20090.001); an effect decreased only by EO (p\u2009&lt;\u20090.05). Colonic MPO activity increased following DSS consumption (p\u2009&lt;\u20090.05); notably, ZMG, EO and ZMG\/EO treatments decreased MPO activity compared to DSS controls (p\u2009&lt;\u20090.001). EO, ZMG and ZMG\/EO did not impact any parameter in normal animals. Emu Oil and ZMG independently decreased selected indicators of colitic disease severity in rats; however, the combination did not reveal any additional benefit.\n                  <\/jats:p>","DOI":"10.1007\/s10534-023-00521-w","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T19:02:19Z","timestamp":1688497339000},"page":"1331-1345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Emu Oil and zinc monoglycerolate independently reduce disease severity in a rat model of ulcerative colitis"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-8371","authenticated-orcid":false,"given":"Suzanne","family":"Mashtoub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon S","family":"Howarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"521_CR1","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s10620-011-1979-1","volume":"57","author":"SM Abimosleh","year":"2012","unstructured":"Abimosleh SM, Lindsay RJ, Butler RN, Cummins AG, Howarth GS (2012a) Emu oil increases colonic crypt depth in a rat model of ulcerative colitis. 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