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ATP-binding cassette (ABC) transporters are ubiquitous in the human body\u2014usually in epithelia\u2014and are responsible for the transfer of indispensable physiological substrates\u00a0(e.g. lipids and heme), protection against potentially toxic substances, maintenance of fluid composition, and excretion of metabolic waste products. Derailed regulation and gene variants of ABC transporters culminate in a wide array of pathophysiological disease states, such as oncogenic multidrug resistance or cystic fibrosis. Cadmium (Cd) has no known physiological role in mammalians and poses a health risk due to its release into the environment as a result of industrial activities, and eventually passes into the food chain. Epithelial cells, especially within the liver, lungs, gastrointestinal tract and kidneys, are particularly susceptible to the multifaceted effects of Cd because of the plethora of uptake pathways available. Pertinent to their broad substrate spectra, ABC transporters represent a major cellular efflux pathway for Cd and Cd complexes. In this review, we summarize current knowledge concerning transport of Cd and its complexes (mainly Cd bound to glutathione) by the ABC transporters ABCB1 (P-glycoprotein, MDR1), ABCB6, ABCC1 (multidrug resistance related protein 1, MRP1), ABCC7 (cystic fibrosis transmembrane regulator, CFTR), and ABCG2 (breast cancer related protein, BCRP). Potential detoxification strategies underlying ABC transporter-mediated efflux of Cd and Cd complexes\u00a0are discussed.<\/jats:p>","DOI":"10.1007\/s10534-024-00582-5","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T14:02:26Z","timestamp":1707228146000},"page":"697-719","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cadmium transport by mammalian ATP-binding cassette transporters"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-3498","authenticated-orcid":false,"given":"Frank","family":"Th\u00e9venod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-4679","authenticated-orcid":false,"given":"Wing-Kee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"issue":"2","key":"582_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/oemed-2011-100111","volume":"69","author":"SV Adams","year":"2012","unstructured":"Adams SV, Passarelli MN, Newcomb PA (2012) Cadmium exposure and cancer mortality in the third national health and nutrition examination survey cohort. 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