{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T19:08:24Z","timestamp":1778094504662,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa no Estado do Rio de Janeiro"},{"name":"Nelson Mandela University, PhosAgro\/UNESCO\/IUPAC"},{"name":"National Research Foundation (NRF) of South Africa","award":["129887"],"award-info":[{"award-number":["129887"]}]},{"name":"National Research Foundation (NRF) of South Africa","award":["129887"],"award-info":[{"award-number":["129887"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10534-024-00605-1","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:01:46Z","timestamp":1718348506000},"page":"1237-1253","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unveiling the antifungal mechanisms of CTP, a new copper(II)-theophylline\/1,10-phenanthroline complex, on drug-resistant non-albicans Candida species"],"prefix":"10.1007","volume":"37","author":[{"given":"Heloisa F.","family":"Frota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro F.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolline M. A.","family":"Lorentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena R. F.","family":"Affonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia S.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone S. C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucieri O. P.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunso O.","family":"Abosede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeniyi S.","family":"Ogunlaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta H.","family":"Branquinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 L. S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"605_CR1","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1128\/JCM.44.2.553-560.2006","volume":"44","author":"C Antachopoulos","year":"2006","unstructured":"Antachopoulos C, Meletiadis J, Roilides E, Sein T, Walsh TJ (2006) Rapid susceptibility testing of medically important zygomycetes by XTT assay. J Clin Microbiol 44:553\u2013560. https:\/\/doi.org\/10.1128\/JCM.44.2.553-560.2006","journal-title":"J Clin Microbiol"},{"key":"605_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s40097-020-00331-3","volume":"10","author":"M Ashrafi","year":"2020","unstructured":"Ashrafi M, Bayat M, Mortazavi P, Hashemi J, Meimandipour A (2020) Antimicrobial effect of chitosan\u2013silver\u2013copper nanocomposite on Candida albicans. J Nanostructure Chem 10:87\u201395. https:\/\/doi.org\/10.1007\/s40097-020-00331-3","journal-title":"J Nanostructure Chem"},{"key":"605_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ejmech.2018.02.077","volume":"150","author":"P Borowiecki","year":"2018","unstructured":"Borowiecki P, Wi\u0144ska P, Bretner M, Gizi\u0144ska M, Koronkiewicz M, Staniszewska M (2018) Synthesis of novel proxyphylline derivatives with dual anti-Candida albicans and anticancer activity. Eur J Med Chem 150:307\u2013333. https:\/\/doi.org\/10.1016\/j.ejmech.2018.02.077","journal-title":"Eur J Med Chem"},{"key":"605_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1126\/scitranslmed.3004404","volume":"4","author":"GD Brown","year":"2012","unstructured":"Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC (2012) Hidden killers: human fungal infections. Sci Transl Med 4:165. https:\/\/doi.org\/10.1126\/scitranslmed.3004404","journal-title":"Sci Transl Med"},{"key":"605_CR5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3855\/jidc.9698","volume":"12","author":"MK Calgin","year":"2018","unstructured":"Calgin MK, Cetinkol Y (2018) Distribution and antifungal susceptibility patterns of Candida species at a university hospital in Northern Turkey. J Infect Dev Ctries 12:97\u2013101. https:\/\/doi.org\/10.3855\/jidc.9698","journal-title":"J Infect Dev Ctries"},{"key":"605_CR6","doi-asserted-by":"publisher","first-page":"4470","DOI":"10.3390\/ijms22094470","volume":"22","author":"L \u010cern\u00e1kov\u00e1","year":"2021","unstructured":"\u010cern\u00e1kov\u00e1 L, Roudbary M, Br\u00e1s S, Tafaj S, Rodrigues CF (2021) Candida auris: a quick review on identification, current treatments, and challenges. Int J Mol Sci 22:4470. https:\/\/doi.org\/10.3390\/ijms22094470","journal-title":"Int J Mol Sci"},{"key":"605_CR7","unstructured":"CLSI. Clinical and Laboratory Standards Institute In: M27-Ed4E: Reference method for broth dilution antifungal susceptibility testing of yeasts, 4th Edition, 2017, (Wayne, PA, USA)"},{"key":"605_CR8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1023\/a:1020695923788","volume":"16","author":"B Coyle","year":"2003","unstructured":"Coyle B, Kavanagh K, McCann M, Devereux M, Geraghty M (2003) Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. Biometals 16:321\u2013329. https:\/\/doi.org\/10.1023\/a:1020695923788","journal-title":"Biometals"},{"issue":"11","key":"605_CR9","doi-asserted-by":"publisher","first-page":"e5128","DOI":"10.1002\/aoc.5128","volume":"33","author":"O Dar","year":"2019","unstructured":"Dar O, Lone S, Malik M, Wani M, Talukdar M, Al-Bogami A, Hashmi AA, Ahmad A (2019) Heteroleptic transition metal complexes of Schiff-base-derived ligands exert their antifungal activity by disrupting membrane integrity. Appl Organomet Chem 33(11):e5128. https:\/\/doi.org\/10.1002\/aoc.5128","journal-title":"Appl Organomet Chem"},{"key":"605_CR10","unstructured":"Denning DW\u00a0(2024) Global incidence and mortality of severe fungal disease. Lancet Infect Dis 12:S1473-3099(23)00692-8"},{"key":"605_CR11","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1021\/ja067294u","volume":"129","author":"S Dutta","year":"2007","unstructured":"Dutta S, Chowdhury G, Gates KS (2007) Interstrand cross-links generated by a basic sites in duplex DNA. J Am Chem Soc 129:1852\u20131853. https:\/\/doi.org\/10.1021\/ja067294u","journal-title":"J Am Chem Soc"},{"key":"605_CR12","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1021\/jacsau.2c00308","volume":"2","author":"A Frei","year":"2022","unstructured":"Frei A, Elliott AG, Kan A, Dinh H, Br\u00e4se S, Bruce AE, Bruce MR, Chen F, Humaidy D, Jung N, King AP, Lye PG, Maliszewska HK, Mansour AM, Matiadis D, Mu\u00f1oz MP, Pai TY, Pokhrel S, Sadler PJ, Sagnou M, Blaskovich MAT (2022) Metal complexes as antifungals? From a crowd-sourced compound library to the first in vivo experiments. JACS Au 2:2277\u20132294. https:\/\/doi.org\/10.1021\/jacsau.2c00308","journal-title":"JACS Au"},{"issue":"2","key":"605_CR13","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s10534-023-00549-y","volume":"37","author":"HF Frota","year":"2024","unstructured":"Frota HF, Lorentino CMA, Barbosa PF, Ramos LS, Barcellos IC, Giovanini L, Souza LOP, Oliveira SSC, Abosede OO, Ogunlaja AS, Pereira MM, Branquinha MH, Santos ALS (2024) Antifungal potential of the new copper(II)-theophylline\/1,10-phenanthroline complex against drug-resistant Candida species. Biometals 37(2):321\u2013336. https:\/\/doi.org\/10.1007\/s10534-023-00549-y","journal-title":"Biometals"},{"key":"605_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00775-021-01922-3","volume":"27","author":"ACM Galdino","year":"2022","unstructured":"Galdino ACM, Viganor L, Pereira MM, Devereux M, McCann M, Branquinha MH, Molphy Z, O\u2019Carroll S, Bain C, Menounou G, Kellett A, Santos ALS (2022) Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa. J Biol Inorg Chem 27:201\u2013213. https:\/\/doi.org\/10.1007\/s00775-021-01922-3","journal-title":"J Biol Inorg Chem"},{"key":"605_CR15","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3389\/fmicb.2017.01257","volume":"8","author":"RM Gandra","year":"2017","unstructured":"Gandra RM, Mc Carron P, Fernandes MF, Ramos LS, Mello TP, Aor AC, Branquinha MH, McCann M, Devereux M, Santos ALS (2017) Antifungal potential of copper(II), manganese(II) and silver(I) 1,10-phenanthroline chelates against multidrug-resistant fungal species forming the Candida haemulonii complex: Impact on the planktonic and biofilm lifestyles. Front Microbiol 8:1257. https:\/\/doi.org\/10.3389\/fmicb.2017.01257","journal-title":"Front Microbiol"},{"key":"605_CR16","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3389\/fmicb.2020.00470","volume":"11","author":"RM Gandra","year":"2020","unstructured":"Gandra RM, McCarron P, Viganor L, Fernandes MF, Kavanagh K, McCann M, Branquinha MH, Santos ALS, Howe O, Devereux M (2020) In vivo activity of copper(II), manganese(II), and silver(I) 1,10-phenanthroline chelates against Candida haemulonii using the Galleria mellonella model. Front Microbiol 11:470. https:\/\/doi.org\/10.3389\/fmicb.2020.00470","journal-title":"Front Microbiol"},{"key":"605_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/a:1009271221684","volume":"13","author":"M Geraghty","year":"2000","unstructured":"Geraghty M, Cronin JF, Devereux M, McCann M (2000) Synthesis and antimicrobial activity of copper(II) and manganese(II) alpha, omega-dicarboxylate complexes. Biometals 13:1\u20138. https:\/\/doi.org\/10.1023\/a:1009271221684","journal-title":"Biometals"},{"key":"605_CR18","doi-asserted-by":"publisher","first-page":"115649","DOI":"10.1016\/j.poly.2022.115649","volume":"214","author":"A Gordon","year":"2022","unstructured":"Gordon A, Abosede O, Ntsimango S, Hosten E, Myeza N, Eyk A, Harmse L, Ogunlaja A (2022) Synthesis and anticancer evaluation of copper(II)- and manganese(II)-theophylline mixed ligand complexes. Polyhedron 214:115649. https:\/\/doi.org\/10.1016\/j.poly.2022.115649","journal-title":"Polyhedron"},{"issue":"8","key":"605_CR19","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/s41564-022-01172-2","volume":"7","author":"M Hoenigl","year":"2022","unstructured":"Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, Ibrahim AS, Carvalho A (2022) COVID-19-associated fungal infections. Nat Microbiol 7(8):1127\u20131140. https:\/\/doi.org\/10.1038\/s41564-022-01172-2","journal-title":"Nat Microbiol"},{"key":"605_CR20","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.tim.2020.01.009","volume":"28","author":"JC Hoving","year":"2020","unstructured":"Hoving JC, Brown GD, G\u00f3mez BL, Govender NP, Limper AH, May RC, Meya DB (2020) AIDS-related mycoses: updated progress and future priorities. Trends Microbiol 28:425\u2013428. https:\/\/doi.org\/10.1016\/j.tim.2020.01.009","journal-title":"Trends Microbiol"},{"key":"605_CR21","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s00253-013-5422-8","volume":"98","author":"AP Ingle","year":"2014","unstructured":"Ingle AP, Duran N, Rai M (2014) Bioactivity, mechanism of action, and cytotoxicity of copper-based nanoparticles: a review. Appl Microbiol Biotechnol 98:1001\u20131009. https:\/\/doi.org\/10.1007\/s00253-013-5422-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"605_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/imj.15586","volume":"51","author":"A Khanina","year":"2021","unstructured":"Khanina A, Tio SY, Ananda-Rajah MR, Kidd SE, Williams E, Chee L, Urbancic K, Thursky KA, Australasian antifungal guidelines steering committee (2021) Consensus guidelines for antifungal stewardship, surveillance and infection prevention, 2021. Intern Med J 51:18\u201336. https:\/\/doi.org\/10.1111\/imj.15586","journal-title":"Intern Med J"},{"key":"605_CR23","doi-asserted-by":"publisher","first-page":"101215","DOI":"10.1016\/j.mam.2023.101215","volume":"94","author":"C Lass-Fl\u00f6rl","year":"2023","unstructured":"Lass-Fl\u00f6rl C, Steixner S (2023) The changing epidemiology of fungal infections. Mol Aspects Med 94:101215","journal-title":"Mol Aspects Med"},{"issue":"1","key":"605_CR24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrdp.2018.26","volume":"10","author":"C Lass-Fl\u00f6rl","year":"2024","unstructured":"Lass-Fl\u00f6rl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA (2024) Invasive Candidiasis. Nat Rev Dis Primers 10(1):20. https:\/\/doi.org\/10.1038\/nrdp.2018.26","journal-title":"Nat Rev Dis Primers"},{"issue":"11","key":"605_CR25","doi-asserted-by":"publisher","first-page":"e0243066","DOI":"10.1371\/journal.pone.0243066","volume":"15","author":"Y Li","year":"2020","unstructured":"Li Y, Shan M, Zhu Y, Yao H, Li H, Gu B, Zhu Z (2020) Kalopanaxsaponin A induces reactive oxygen species mediated mitochondrial dysfunction and cell membrane destruction in Candida albicans. PLoS ONE 15(11):e0243066. https:\/\/doi.org\/10.1371\/journal.pone.0243066","journal-title":"PLoS ONE"},{"key":"605_CR26","doi-asserted-by":"crossref","unstructured":"Liang J, Sun D, Yang Y, Li M, Li H, Chen L (2021) Discovery of\u00a0metal-based\u00a0complexes as promising antimicrobial agents. Eur J Med Chem 224:113696","DOI":"10.1016\/j.ejmech.2021.113696"},{"issue":"12","key":"605_CR27","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1093\/mmy\/myab053","volume":"59","author":"SJ Lim","year":"2021","unstructured":"Lim SJ, Mohamad Ali MS, Sabri S, Muhd Noor ND, Salleh AB, Oslan SN (2021) Opportunistic yeast pathogen Candida spp.: Secreted and membrane-bound virulence factors. Med Mycol 59(12):1127\u20131144","journal-title":"Med Mycol"},{"key":"605_CR28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.diagmicrobio.2015.03.019","volume":"82","author":"CD Mahl","year":"2015","unstructured":"Mahl CD, Behling CS, Hackenhaar FS, de Carvalho eSilva MN, Putti J, Salomon TB, Alves SH, Fuentefria A, Benfato MS (2015) Induction of ROS generation by fluconazole in Candida glabrata: activation of antioxidant enzymes and oxidative DNA damage. Diagn Microbiol Infect Dis 82:203\u2013208. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2015.03.019","journal-title":"Diagn Microbiol Infect Dis"},{"key":"605_CR29","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1039\/D0CE01387K","volume":"23","author":"S Majodina","year":"2020","unstructured":"Majodina S, Ndima L, Abosede O, Hosten E, Lorentino C, Frota H, Sangenito L, Branquinha MH, Santos ALS, Ogunlaja A (2020) Physical stability enhancement and antimicrobial properties of a sodium ionic cocrystal with theophylline. Cryst Eng Comm 23:335\u2013352. https:\/\/doi.org\/10.1039\/D0CE01387K","journal-title":"Cryst Eng Comm"},{"key":"605_CR30","doi-asserted-by":"publisher","first-page":"103771","DOI":"10.1016\/j.bioorg.2020.103771","volume":"98","author":"MA Malik","year":"2020","unstructured":"Malik MA, Lone SA, Wani MY, Talukdar MIA, Dar OA, Ahmad A, Hashmi AA (2020) S-benzyldithiocarbazate imine coordinated metal complexes kill Candida albicans by causing cellular apoptosis and necrosis. Bioorg Chem 98:103771. https:\/\/doi.org\/10.1016\/j.bioorg.2020.103771","journal-title":"Bioorg Chem"},{"key":"605_CR31","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.ejmech.2018.01.025","volume":"146","author":"SN Mangasuli","year":"2018","unstructured":"Mangasuli SN, Hosamani KM, Devarajegowda HC, Kurjogi MM, Joshi SD (2018) Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents. Eur J Med Chem 146:747\u2013756. https:\/\/doi.org\/10.1016\/j.ejmech.2018.01.025","journal-title":"Eur J Med Chem"},{"issue":"4","key":"605_CR32","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1155\/MBD.2000.185","volume":"7","author":"M McCann","year":"2000","unstructured":"McCann M, Geraghty M, Devereux M, O\u2019Shea D, Mason J, O\u2019Sullivan L (2000) Insights into the mode of action of the anti-Candida activity of 1,10-phenanthroline and its metal chelates. Met-Based Drugs 7(4):185\u2013193. https:\/\/doi.org\/10.1155\/MBD.2000.185","journal-title":"Met-Based Drugs"},{"issue":"2","key":"605_CR33","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.idc.2021.03.007","volume":"35","author":"TP McCarty","year":"2021","unstructured":"McCarty TP, White CM, Pappas PG (2021) Candidemia and invasive candidiasis. Infect Dis Clin North Am 35(2):389\u2013413. https:\/\/doi.org\/10.1016\/j.idc.2021.03.007","journal-title":"Infect Dis Clin North Am"},{"key":"605_CR34","doi-asserted-by":"publisher","first-page":"6627","DOI":"10.1128\/AAC.03570-14","volume":"58","author":"AC Mesa-Arango","year":"2014","unstructured":"Mesa-Arango AC, Trevijano-Contador N, Rom\u00e1n E, S\u00e1nchez-Fresneda R, Casas C, Herrero E, Arg\u00fcelles JC, Pla J, Cuenca-Estrella M, Zaragoza O (2014) The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug. Antimicrob Agents Chemother 58:6627\u20136638. https:\/\/doi.org\/10.1128\/AAC.03570-14","journal-title":"Antimicrob Agents Chemother"},{"key":"605_CR35","doi-asserted-by":"publisher","first-page":"5346","DOI":"10.1038\/s41467-018-07779-6","volume":"9","author":"JF Mu\u00f1oz","year":"2018","unstructured":"Mu\u00f1oz JF, Gade L, Chow NA, Loparev VN, Juieng P, Berkow EL, Farrer RA, Litvintseva AP, Cuomo CA (2018) Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species. Nat Commun 9:5346. https:\/\/doi.org\/10.1038\/s41467-018-07779-6","journal-title":"Nat Commun"},{"key":"605_CR36","first-page":"303","volume":"3","author":"MBM Nunes","year":"2022","unstructured":"Nunes MBM, Batista LM, Pessoa WFB (2022) Candida auris \u2013 a public health threat in Brazil: narrative review. Arch Health 3:303\u2013307","journal-title":"Arch Health"},{"key":"605_CR37","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/pathogens12010070","volume":"12","author":"SSC Oliveira","year":"2023","unstructured":"Oliveira SSC, Santos VS, Devereux M, McCann M, Santos ALS, Branquinha MH (2023) The anti-Leishmania amazonensis and anti-Leishmania chagasi action of copper(II) and silver(I) 1,10-phenanthroline-5,6-dione coordination compounds. Pathogens 12:70. https:\/\/doi.org\/10.3390\/pathogens12010070","journal-title":"Pathogens"},{"key":"605_CR38","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1128\/AAC.45.9.2475-2479.2001","volume":"45","author":"G Ramage","year":"2001","unstructured":"Ramage G, Vande Walle K, Wickes BL, L\u00f3pez-Ribot JL (2001) Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob Agents Chemother 45:2475\u20132479. https:\/\/doi.org\/10.1128\/AAC.45.9.2475-2479.2001","journal-title":"Antimicrob Agents Chemother"},{"key":"605_CR39","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/mmy\/myx005","volume":"55","author":"LS Ramos","year":"2017","unstructured":"Ramos LS, Oliveira SSC, Souto XM, Branquinha MH, Santos ALS (2017) Planktonic growth and biofilm formation profiles in Candida haemulonii species complex. Med Mycol 55:785\u2013789. https:\/\/doi.org\/10.1093\/mmy\/myx005","journal-title":"Med Mycol"},{"key":"605_CR40","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.2174\/1568026622666220520153748","volume":"22","author":"LS Ramos","year":"2022","unstructured":"Ramos LS, Silva LN, de Mello TP, Frota HF, Branquinha MH, Santos ALS (2022a) Prospective medicines against the widespread, emergent, and multidrug-resistant opportunistic fungal pathogen Candida auris: A breath of hope. Curr Top Med Chem 22:1297\u20131305. https:\/\/doi.org\/10.2174\/1568026622666220520153748","journal-title":"Curr Top Med Chem"},{"key":"605_CR41","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3390\/jof8060574","volume":"8","author":"LS Ramos","year":"2022","unstructured":"Ramos LS, Figueiredo-Carvalho MHG, Silva LN, Siqueira NLM, Lima JC, Oliveira SS, Almeida-Paes R, Zancop\u00e9-Oliveira RM, Azevedo FS, Ferreira ALP, Branquinha MH, Santos ALS (2022b) The threat called Candida haemulonii species complex in Rio de Janeiro State, Brazil: Focus on antifungal resistance and virulence attributes. J Fungi 8:574. https:\/\/doi.org\/10.3390\/jof8060574","journal-title":"J Fungi"},{"key":"605_CR42","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.micinf.2011.01.015","volume":"13","author":"F Sangalli-Leite","year":"2011","unstructured":"Sangalli-Leite F, Scorzoni L, Mesa-Arango AC, Casas C, Herrero E, Gianinni MJ, Rodr\u00edguez-Tudela JL, Cuenca-Estrella M, Zaragoza O (2011) Amphotericin B mediates killing in Cryptococcus neoformans through the induction of a strong oxidative burst. Microbes Infect 13:457\u2013467. https:\/\/doi.org\/10.1016\/j.micinf.2011.01.015","journal-title":"Microbes Infect"},{"key":"605_CR43","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.micron.2009.01.003","volume":"40","author":"S Sangetha","year":"2009","unstructured":"Sangetha S, Zuraini Z, Suryani S, Sasidharan S (2009) In situ TEM and SEM studies on the antimicrobial activity and prevention of Candida albicans biofilm by Cassia spectabilis extract. Micron 40:439\u2013443. https:\/\/doi.org\/10.1016\/j.micron.2009.01.003","journal-title":"Micron"},{"key":"605_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1099\/jmm.0.045054-0","volume":"62","author":"JCO Sardi","year":"2013","unstructured":"Sardi JCO, Scorzoni L, Bernardi T, Fusco-Almeida AM, Mendes Giannini MJS (2013) Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. Int J Med Microbiol 62:10\u201324. https:\/\/doi.org\/10.1099\/jmm.0.045054-0","journal-title":"Int J Med Microbiol"},{"key":"605_CR45","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.ejmech.2018.07.049","volume":"156","author":"ND Savi\u0107","year":"2018","unstructured":"Savi\u0107 ND, Vojnovic S, Gli\u0161i\u0107 B\u0110, Crochet A, Pavic A, Janji\u0107 GV, Pekmezovi\u0107 M, Opsenica IM, Fromm KM, Nikodinovic-Runic J, Djuran MI (2018) Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth. Eur J Med Chem 156:760\u2013773. https:\/\/doi.org\/10.1016\/j.ejmech.2018.07.049","journal-title":"Eur J Med Chem"},{"key":"605_CR46","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1093\/toxsci\/kfy307","volume":"168","author":"ZG Sheng","year":"2019","unstructured":"Sheng ZG, Shen C, Fan RM, Chao XJ, Liu YX, Zhu BZ (2019) The Critical Role of X Chromosome-linked inhibitor of apoptosis (XIAP) in differential synergism induced by pentachlorophenol and copper-1,10-phenanthroline complex in normal and cancer liver cells. Toxicol Sci 168:339\u2013348. https:\/\/doi.org\/10.1093\/toxsci\/kfy307","journal-title":"Toxicol Sci"},{"issue":"7","key":"605_CR47","doi-asserted-by":"publisher","first-page":"foy082","DOI":"10.1093\/femsyr\/foy082","volume":"18","author":"LN Silva","year":"2018","unstructured":"Silva LN, Campos-Silva R, Ramos LS, Trentin DS, Macedo AJ, Branquinha MH, Santos ALS (2018) Virulence of Candida haemulonii complex in Galleria mellonella and efficacy of classical antifungal drugs: a comparative study with other clinically relevant non-albicans Candida species. FEMS Yeast Res 18(7):foy082. https:\/\/doi.org\/10.1093\/femsyr\/foy082","journal-title":"FEMS Yeast Res"},{"issue":"5","key":"605_CR48","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1021\/acsinfecdis.0c00117","volume":"6","author":"LN Silva","year":"2020","unstructured":"Silva LN, Oliveira SSC, Magalh\u00e3es LB, Andrade Neto VV, Torres-Santos EC, Carvalho MDC, Pereira MD, Branquinha MH, Santos ALS (2020) Unmasking the amphotericin B resistance mechanisms in Candida haemulonii species complex. ACS Infect Dis 6(5):1273\u20131282. https:\/\/doi.org\/10.1021\/acsinfecdis.0c00117","journal-title":"ACS Infect Dis"},{"key":"605_CR49","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/jam.14669","volume":"129","author":"S Singh","year":"2020","unstructured":"Singh S, Fatima Z, Ahmad K, Hameed S (2020) Repurposing of respiratory drug theophylline against Candida albicans: mechanistic insights unveil alterations in membrane properties and metabolic fitness. J Appl Microbiol 129:860\u2013875. https:\/\/doi.org\/10.1111\/jam.14669","journal-title":"J Appl Microbiol"},{"key":"605_CR50","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1093\/jac\/dkv292","volume":"71","author":"L Viganor","year":"2016","unstructured":"Viganor L, Galdino AC, Nunes AP, Santos KR, Branquinha MH, Devereux M, Kellett A, McCann M, Santos ALS (2016) Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells. J Antimicrob Chemother 71:128\u2013134. https:\/\/doi.org\/10.1093\/jac\/dkv292","journal-title":"J Antimicrob Chemother"},{"key":"605_CR51","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1086\/421946","volume":"39","author":"H Wisplinghoff","year":"2004","unstructured":"Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39:309\u2013317. https:\/\/doi.org\/10.1086\/421946","journal-title":"Clin Infect Dis"},{"key":"605_CR52","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/nm.4141","volume":"22","author":"Y Xiao","year":"2016","unstructured":"Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, Zeng Q, Rappleye CA, Rajaram MV, Schlesinger LS, Tao L, Brown GD, Langdon WY, Li BT, Zhang J (2016) Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med 22:906\u2013914. https:\/\/doi.org\/10.1038\/nm.4141","journal-title":"Nat Med"},{"key":"605_CR53","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3390\/app12010260","volume":"12","author":"S Yang","year":"2021","unstructured":"Yang S, Veerana M, Yu N, Ketya W, Park G, Kim S, Kim Y (2021) Copper(II)-MOF containing glutarate and 4,4\u2032-azopyridine and its antifungal activity. Appl Sci 12:260. https:\/\/doi.org\/10.3390\/app12010260","journal-title":"Appl Sci"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-024-00605-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-024-00605-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-024-00605-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T15:05:39Z","timestamp":1728918339000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-024-00605-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["605"],"URL":"https:\/\/doi.org\/10.1007\/s10534-024-00605-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4087921\/v1","asserted-by":"object"}]},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"12 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}