{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:43:37Z","timestamp":1790905417901,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10534-025-00681-x","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T03:10:06Z","timestamp":1743909006000},"page":"863-871","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel native probiotics with protective effects against nickel-induced kidney injury: a strategy for heavy metal toxicity"],"prefix":"10.1007","volume":"38","author":[{"given":"Shokufeh","family":"Beglari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Rezaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Haririzadeh","family":"Jouriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham Haj Agha Gholizadeh","family":"Khiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Aghamohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Rohani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"681_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s13167-019-00184-z","volume":"10","author":"AG Abdelhamid","year":"2019","unstructured":"Abdelhamid AG, El-Masry SS, El-Dougdoug NK (2019) Probiotic lactobacillus and bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining. EPMA J 10:337\u2013350","journal-title":"EPMA J"},{"key":"681_CR2","doi-asserted-by":"publisher","first-page":"2344656","DOI":"10.1080\/0886022X.2024.2344656","volume":"46","author":"AI Alhazmi","year":"2024","unstructured":"Alhazmi AI, El-Refaei MF, Abdallah EA (2024) Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity. Ren Fail 46:2344656","journal-title":"Ren Fail"},{"key":"681_CR3","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1152\/physiolgenomics.00025.2005","volume":"21","author":"RD Barber","year":"2005","unstructured":"Barber RD, Harmer DW, Coleman RA, Clark BJ (2005) GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol Genomics 21:389\u2013395","journal-title":"Physiol Genomics"},{"key":"681_CR4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1080\/10889868.2022.2086529","volume":"27","author":"S Beglari","year":"2023","unstructured":"Beglari S, Khodagholi F, Gholami Pourbadie H, Iranbakhsh A, Rohani M (2023) Biosorption and bioaccumulation of nickel by probiotic lactic acid bacteria isolated from human feces. Bioremediat J 27:453\u2013464","journal-title":"Bioremediat J"},{"key":"681_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2478\/intox-2019-0010","volume":"12","author":"S Bhattacharya","year":"2019","unstructured":"Bhattacharya S (2019) Probiotics against alleviation of lead toxicity: recent advances. Interdiscip Toxicol 12:89\u201392","journal-title":"Interdiscip Toxicol"},{"key":"681_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1515\/jbcpp-2017-0171","volume":"30","author":"KK Das","year":"2019","unstructured":"Das KK, Reddy RC, Bagoji IB, Das S, Bagali S, Mullur L et al (2019) Primary concept of nickel toxicity\u2013an overview. J Basic Clin Physiol Pharmacol 30:141\u2013152","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"681_CR7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/s12602-022-09946-0","volume":"15","author":"S Dashtbanei","year":"2023","unstructured":"Dashtbanei S, Keshtmand Z (2023) A mixture of multi-strain probiotics (lactobacillus rhamnosus, lactobacillus helveticus, and lactobacillus casei) had anti-inflammatory, anti-apoptotic, and anti-oxidative effects in oxidative injuries induced by cadmium in small intestine and lung. Probiotics and Antimicrob Proteins 15:226\u2013238","journal-title":"Probiotics and Antimicrob Proteins"},{"key":"681_CR8","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3390\/antiox13080980","volume":"13","author":"J Du","year":"2024","unstructured":"Du J, Li Z, Cao X, Qi Q, Wang L, Liu P et al (2024) Mechanism of mitochondrial kinetic imbalance and Nrf2 Signaling pathway-mediated oxidative stress in nickel and\/or chromium-induced kidney injury in mice. Antioxidants 13:980","journal-title":"Antioxidants"},{"key":"681_CR9","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.micpath.2017.08.014","volume":"111","author":"M Eshaghi","year":"2017","unstructured":"Eshaghi M, Bibalan MH, Rohani M, Esghaei M, Douraghi M, Talebi M et al (2017) Bifidobacterium obtained from mother\u2019s milk and their infant stool: a comparative genotyping and antibacterial analysis. Microb Pathog 111:94\u201398","journal-title":"Microb Pathog"},{"key":"681_CR10","doi-asserted-by":"publisher","first-page":"1801944","DOI":"10.1080\/19490976.2020.1801944","volume":"12","author":"T Feng","year":"2020","unstructured":"Feng T, Wang J (2020) Oxidative stress tolerance and antioxidant capacity of lactic acid bacteria as probiotic: a systematic review. Gut Microbes 12:1801944","journal-title":"Gut Microbes"},{"key":"681_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41522-022-00326-8","volume":"8","author":"P Feng","year":"2022","unstructured":"Feng P, Yang J, Zhao S, Ling Z, Han R, Wu Y et al (2022) Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome. NPJ Biofilms and Microbiomes 8:63","journal-title":"NPJ Biofilms and Microbiomes"},{"key":"681_CR12","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1007\/s11164-012-0780-x","volume":"39","author":"KH Gathwan","year":"2013","unstructured":"Gathwan KH, Al-Karkhi IHT, Jaffar AL-Mulla EA (2013) Hepatic toxicity of nickel chloride in mice. Res Chem Intermed 39:2537\u20132542","journal-title":"Res Chem Intermed"},{"key":"681_CR13","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3390\/ijerph17030679","volume":"17","author":"G Genchi","year":"2020","unstructured":"Genchi G, Carocci A, Lauria G, Sinicropi MS, Catalano A (2020) Nickel: human health and environmental toxicology. Int J Environ Res Public Health 17:679","journal-title":"Int J Environ Res Public Health"},{"key":"681_CR14","doi-asserted-by":"publisher","first-page":"01","DOI":"10.13005\/bbra\/2714","volume":"16","author":"P Goyal","year":"2019","unstructured":"Goyal P, Belapurkar P, Kar A (2019) A review on in vitro and in vivo bioremediation potential of environmental and probiotic species of Bacillus and other probiotic microorganisms for two heavy metals, cadmium and nickel. Biosci, Biotechnol Res Asia 16:01\u201313","journal-title":"Biosci, Biotechnol Res Asia"},{"key":"681_CR15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1161\/CIRCRESAHA.121.318063","volume":"128","author":"KK Griendling","year":"2021","unstructured":"Griendling KK, Camargo LL, Rios FJ, Alves-Lopes R, Montezano AC, Touyz RM (2021) Oxidative stress and hypertension. Circ Res 128:993\u20131020","journal-title":"Circ Res"},{"key":"681_CR16","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","volume":"94","author":"\u0130 Gulcin","year":"2020","unstructured":"Gulcin \u0130 (2020) Antioxidants and antioxidant methods: an updated overview. Archives Toxicol 94:651","journal-title":"Archives Toxicol"},{"key":"681_CR17","doi-asserted-by":"publisher","first-page":"5478708","DOI":"10.1155\/2020\/5478708","volume":"2020","author":"M Gyur\u00e1szov\u00e1","year":"2020","unstructured":"Gyur\u00e1szov\u00e1 M, Gureck\u00e1 R, B\u00e1b\u00ed\u010dkov\u00e1 J, T\u00f3thov\u00e1 \u013d (2020) Oxidative stress in the pathophysiology of kidney disease: implications for noninvasive monitoring and identification of biomarkers. Oxid Med Cell Longev 2020:5478708","journal-title":"Oxid Med Cell Longev"},{"key":"681_CR18","doi-asserted-by":"publisher","first-page":"792","DOI":"10.5114\/aoms.2019.89894","volume":"17","author":"A Hoffmann","year":"2021","unstructured":"Hoffmann A, Kleniewska P, Pawliczak R (2021) Antioxidative activity of probiotics. Archives Med Sci: AMS 17:792","journal-title":"Archives Med Sci: AMS"},{"key":"681_CR19","doi-asserted-by":"publisher","first-page":"lxad061","DOI":"10.1093\/jambio\/lxad061","volume":"134","author":"L Hu","year":"2023","unstructured":"Hu L, Zhao Y, You T, Xu H (2023) Lactiplantibacillus plantarum P101 alleviated lead-induced more severe hepatic injury in obese mice, by promoting fecal lead excretion and enhancing antioxidative defense system. J Appl Microbiol 134:lxad061","journal-title":"J Appl Microbiol"},{"key":"681_CR20","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1177\/07482337211034711","volume":"37","author":"S Iqbal","year":"2021","unstructured":"Iqbal S, Jabeen F, Peng C, Shah MA, Ijaz MU, Rasul A et al (2021) Nickel nanoparticles induce hepatotoxicity via oxidative and nitrative stress-mediated apoptosis and inflammation. Toxicol Ind Health 37:619\u2013634","journal-title":"Toxicol Ind Health"},{"key":"681_CR21","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3390\/biom12050729","volume":"12","author":"B Karaca","year":"2022","unstructured":"Karaca B, Yilmaz M, Gursoy UK (2022) Targeting Nrf2 with probiotics and postbiotics in the treatment of periodontitis. Biomolecules 12:729","journal-title":"Biomolecules"},{"key":"681_CR22","doi-asserted-by":"publisher","first-page":"012062","DOI":"10.1088\/1755-1315\/889\/1\/012062","volume":"889","author":"M Kaur","year":"2021","unstructured":"Kaur M, Sharma A (2021) A review on heavy metal accumulation and toxicity in biotic and abiotic components. IOP Conf Ser: Earth Environ Sci 889:012062","journal-title":"IOP Conf Ser: Earth Environ Sci"},{"key":"681_CR23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"681_CR24","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/cells12010184","volume":"12","author":"C Mazziotta","year":"2023","unstructured":"Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC (2023) Probiotics mechanism of action on immune cells and beneficial effects on human health. Cells 12:184","journal-title":"Cells"},{"key":"681_CR25","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.3390\/ma14081984","volume":"14","author":"M Parcheta","year":"2021","unstructured":"Parcheta M, \u015awis\u0142ocka R, Orzechowska S, Akimowicz M, Choi\u0144ska R, Lewandowski W (2021) Recent developments in effective antioxidants: the structure and antioxidant properties. Materials 14:1984","journal-title":"Materials"},{"key":"681_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144467","volume":"10","author":"M Rohani","year":"2015","unstructured":"Rohani M, Noohi N, Talebi M, Katouli M, Pourshafie MR (2015) Highly heterogeneous probiotic Lactobacillus species in healthy Iranians with low functional activities. PLoS ONE 10:e0144467","journal-title":"PLoS ONE"},{"key":"681_CR27","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00424-020-02352-x","volume":"472","author":"NL Rukavina Mikusic","year":"2020","unstructured":"Rukavina Mikusic NL, Kouyoumdzian NM, Choi MR (2020) Gut microbiota and chronic kidney disease: evidences and mechanisms that mediate a new communication in the gastrointestinal-renal axis. Pfl\u00fcgers Archiv-Eur J Physiol 472:303\u2013320","journal-title":"Pfl\u00fcgers Archiv-Eur J Physiol"},{"key":"681_CR28","doi-asserted-by":"publisher","first-page":"e15610","DOI":"10.1016\/j.heliyon.2023.e15610","volume":"9","author":"R Rwubuzizi","year":"2023","unstructured":"Rwubuzizi R, Kim H, Holzapfel WH, Todorov SD (2023) Beneficial, safety, and antioxidant properties of lactic acid bacteria: a next step in their evaluation as potential probiotics. Heliyon 9:e15610","journal-title":"Heliyon"},{"key":"681_CR29","doi-asserted-by":"publisher","first-page":"136013","DOI":"10.1016\/j.scitotenv.2019.136013","volume":"706","author":"SR Saleh","year":"2020","unstructured":"Saleh SR, Kandeel MM, Ghareeb D, Ghoneim TM, Talha NI, Alaoui-Soss\u00e9 B et al (2020) Wheat biological responses to stress caused by cadmium, nickel and lead. Sci Total Environ 706:136013","journal-title":"Sci Total Environ"},{"key":"681_CR30","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3390\/life13102023","volume":"13","author":"G Saxami","year":"2023","unstructured":"Saxami G, Kerezoudi EN, Eliopoulos C, Arapoglou D, Kyriacou A (2023) The gut-organ axis within the human body: gut dysbiosis and the role of prebiotics. Life 13:2023","journal-title":"Life"},{"key":"681_CR31","doi-asserted-by":"publisher","DOI":"10.15171\/ipp.2017.03","volume":"3","author":"FD Shahreza","year":"2016","unstructured":"Shahreza FD (2016) Oxidative stress, free radicals, kidney disease and plant antioxidants. Immunopathologia Persa 3:e11","journal-title":"Immunopathologia Persa"},{"key":"681_CR32","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1556\/2060.106.2019.19","volume":"106","author":"K Sumida","year":"2019","unstructured":"Sumida K, Kovesdy C (2019) The gut\u2013kidney\u2013heart axis in chronic kidney disease. Physiol Int 106:195\u2013206","journal-title":"Physiol Int"},{"key":"681_CR33","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s12011-012-9462-1","volume":"150","author":"F Tian","year":"2012","unstructured":"Tian F, Zhai Q, Zhao J, Liu X, Wang G, Zhang H et al (2012) Lactobacillus plantarum CCFM8661 alleviates lead toxicity in mice. Biol Trace Elem Res 150:264\u2013271","journal-title":"Biol Trace Elem Res"},{"key":"681_CR34","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/806358","volume":"2015","author":"PS Tucker","year":"2015","unstructured":"Tucker PS, Scanlan AT, Dalbo VJ (2015) Chronic kidney disease influences multiple systems: describing the relationship between oxidative stress, inflammation, kidney damage, and concomitant disease. Oxid Med Cell Longev 2015:806358","journal-title":"Oxid Med Cell Longev"},{"key":"681_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114037","volume":"244","author":"B Wu","year":"2022","unstructured":"Wu B, Liu Y, Zhen J, Mou P, Li J, Xu Z et al (2022) Protective effect of methionine on the intestinal oxidative stress and microbiota change induced by nickel. Ecotoxicol Environ Saf 244:114037","journal-title":"Ecotoxicol Environ Saf"},{"key":"681_CR36","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1021\/acs.chemrestox.6b00265","volume":"29","author":"Y Yu","year":"2016","unstructured":"Yu Y, Cui Y, Niedernhofer LJ, Wang Y (2016) Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage. Chem Res Toxicol 29:2008\u20132039","journal-title":"Chem Res Toxicol"},{"key":"681_CR37","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3390\/antiox12030769","volume":"12","author":"T Zhao","year":"2023","unstructured":"Zhao T, Wang H, Liu Z, Liu Y, DeJi BL et al (2023) Recent perspective of Lactobacillus in reducing oxidative stress to prevent disease. Antioxidants 12:769","journal-title":"Antioxidants"},{"key":"681_CR38","doi-asserted-by":"publisher","first-page":"1448388","DOI":"10.3389\/fnut.2024.1448388","volume":"11","author":"Q Zhu","year":"2024","unstructured":"Zhu Q, Chen B, Zhang F, Zhang B, Guo Y, Pang M et al (2024) Toxic and essential metals: metabolic interactions with the gut microbiota and health implications. Front Nutr 11:1448388","journal-title":"Front Nutr"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-025-00681-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-025-00681-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-025-00681-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T08:58:10Z","timestamp":1748422690000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-025-00681-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,5]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["681"],"URL":"https:\/\/doi.org\/10.1007\/s10534-025-00681-x","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,5]]},"assertion":[{"value":"15 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental protocols were established following the Declaration of Helsinki and approved by the ethics committee of the Islamic Azad University of Tehran, Iran, (IR.IAU.SRB.REC.1399.106). All methods were carried out in accordance with relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The purpose of this study is to investigate the anti-oxidative effect of probiotics in Nickel-induced oxidative stress in the kidneys. The participation of authors in this study is entirely voluntary. All information collected during this study will be kept confidential. Our data will be used solely for the research purposes outlined and will be reported in aggregate form.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have actively contributed to the manuscript as detailed above and hereby consent to its submission and publication. They acknowledge that upon publication, their contributions will be accessible to the public and affirm that this work is original, free from any copyright infringements. Additionally, if applicable, the authors confirm that consent has been obtained from all participants whose data is included in this study for the purpose of publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}