{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:17:47Z","timestamp":1790713067958,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES \u2013 Finance code 001"],"award-info":[{"award-number":["CAPES \u2013 Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES \u2013 Finance code 001"],"award-info":[{"award-number":["CAPES \u2013 Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES \u2013 Finance code 001"],"award-info":[{"award-number":["CAPES \u2013 Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES \u2013 Finance code 001"],"award-info":[{"award-number":["CAPES \u2013 Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES \u2013 Finance code 001"],"award-info":[{"award-number":["CAPES \u2013 Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307749\/2021-5 MCTIC\/CNPq 04\/2021"],"award-info":[{"award-number":["307749\/2021-5 MCTIC\/CNPq 04\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307749\/2021-5 MCTIC\/CNPq 04\/2021"],"award-info":[{"award-number":["307749\/2021-5 MCTIC\/CNPq 04\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["2022-DRN29 Edital PROFIX FAPES 15\/2022"],"award-info":[{"award-number":["2022-DRN29 Edital PROFIX FAPES 15\/2022"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["2020-HMC0S Edital PRONEM FAPES 06\/2019"],"award-info":[{"award-number":["2020-HMC0S Edital PRONEM FAPES 06\/2019"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["2022-DRN29 Edital PROFIX FAPES 15\/2022"],"award-info":[{"award-number":["2022-DRN29 Edital PROFIX FAPES 15\/2022"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10534-025-00705-6","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T05:44:33Z","timestamp":1750139073000},"page":"1265-1280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute exposure to iron (II) impairs the vascular endothelial structure and function"],"prefix":"10.1007","volume":"38","author":[{"given":"Anderson Ramiro Rangel","family":"Carnelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza Mageste","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Giuseppe Rossi Bai\u00e3o","family":"Passamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar Mendes Souza Wan","family":"Der Maas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jones Bernardes","family":"Graceli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Andrade","family":"\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Bermond","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"705_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.07.003","author":"RA \u00c1vila","year":"2016","unstructured":"\u00c1vila RA, Silva MASC, Peixoto JV et al (2016) Mechanisms involved in the in vitro contractile dysfunction induced by different concentrations of ferrous iron in the rat myocardium. Toxicol Vitro. https:\/\/doi.org\/10.1016\/j.tiv.2016.07.003","journal-title":"Toxicol Vitro"},{"key":"705_CR2","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1113\/EP089429","volume":"106","author":"RA \u00c1vila","year":"2021","unstructured":"\u00c1vila RA, Rossi EM, Carvalho GM et al (2021) Moderate-intensity aerobic training reduces cardiac damage attributable to experimental iron overload in rats. Exp Physiol 106:1772\u20131784. https:\/\/doi.org\/10.1113\/EP089429","journal-title":"Exp Physiol"},{"key":"705_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110122","author":"BR Bacon","year":"1990","unstructured":"Bacon BR, Britton RS (1990) The pathology of hepatic iron overload: a free radical-mediated process? Hepatology. https:\/\/doi.org\/10.1002\/hep.1840110122","journal-title":"Hepatology"},{"key":"705_CR4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.toxlet.2018.07.010","volume":"295","author":"SR Bertoli","year":"2018","unstructured":"Bertoli SR, Marques VB, Rossi EM et al (2018) Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats. Toxicol Lett 295:296\u2013306. https:\/\/doi.org\/10.1016\/j.toxlet.2018.07.010","journal-title":"Toxicol Lett"},{"key":"705_CR5","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.biocel.2003.08.006","volume":"36","author":"CL Bos","year":"2004","unstructured":"Bos CL, Richel DJ, Ritsema T et al (2004) Prostanoids and prostanoid receptors in signal transduction. Int J Biochem Cell Biol 36:1187\u20131205. https:\/\/doi.org\/10.1016\/j.biocel.2003.08.006","journal-title":"Int J Biochem Cell Biol"},{"key":"705_CR6","doi-asserted-by":"publisher","first-page":"8440","DOI":"10.1073\/pnas.88.19.8440","volume":"88","author":"MJ Burkitt","year":"1991","unstructured":"Burkitt MJ, Mason RP (1991) Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation. Proc Natl Acad Sci 88:8440\u20138444. https:\/\/doi.org\/10.1073\/pnas.88.19.8440","journal-title":"Proc Natl Acad Sci"},{"key":"705_CR7","doi-asserted-by":"publisher","first-page":"H121","DOI":"10.1152\/ajpheart.1994.266.1.h121","volume":"266","author":"RM Byler","year":"2017","unstructured":"Byler RM, Sherman NA, Wallner JS, Horwitz LD (2017) Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent. Am J Physiol-Heart Circul Physiol 266:H121\u2013H127. https:\/\/doi.org\/10.1152\/ajpheart.1994.266.1.h121","journal-title":"Am J Physiol-Heart Circul Physiol"},{"key":"705_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cardiores.2005.06.021","volume":"68","author":"H Cai","year":"2005","unstructured":"Cai H (2005) Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences. Cardiovasc Res 68:26\u201336. https:\/\/doi.org\/10.1016\/j.cardiores.2005.06.021","journal-title":"Cardiovasc Res"},{"key":"705_CR9","first-page":"523","volume":"145","author":"LP Candeias","year":"2013","unstructured":"Candeias LP, Wardman P (2013) Introduction to fenton chemistry. Radiat Res 145:523\u2013531","journal-title":"Radiat Res"},{"key":"705_CR10","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1097\/PEC.0b013e3182302604","volume":"27","author":"TP-Y Chang","year":"2011","unstructured":"Chang TP-Y, Rangan C (2011) Iron poisoning. Pediatr Emerg Care 27:978\u2013985. https:\/\/doi.org\/10.1097\/PEC.0b013e3182302604","journal-title":"Pediatr Emerg Care"},{"key":"705_CR11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3390\/metabo14040228","volume":"14","author":"M Correnti","year":"2024","unstructured":"Correnti M, Gammella E, Cairo G, Recalcati S (2024) Iron absorption: molecular and pathophysiological aspects. Metabolites 14:228. https:\/\/doi.org\/10.3390\/metabo14040228","journal-title":"Metabolites"},{"key":"705_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1161\/JAHA.116.003456","volume":"6","author":"SK Das","year":"2017","unstructured":"Das SK, Patel VB, Basu R et al (2017) Females are protected from iron-overload cardiomyopathy independent of iron metabolism: key role of oxidative stress. J Am Heart Assoc 6:11\u201313. https:\/\/doi.org\/10.1161\/JAHA.116.003456","journal-title":"J Am Heart Assoc"},{"key":"705_CR13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066910.02844.D0","author":"SM Day","year":"2003","unstructured":"Day SM, Duquaine D, Mundada LV et al (2003) Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis. Circulation. https:\/\/doi.org\/10.1161\/01.CIR.0000066910.02844.D0","journal-title":"Circulation"},{"key":"705_CR14","doi-asserted-by":"publisher","first-page":"130172","DOI":"10.1016\/j.bbagen.2022.130172","volume":"1866","author":"L dos Santos","year":"2022","unstructured":"dos Santos L, Bertoli SR, \u00c1vila RA, Marques VB (2022) Iron overload, oxidative stress and vascular dysfunction: evidences from clinical studies and animal models. Biochimica Et Biophysica Acta BBA General Subjects 1866:130172. https:\/\/doi.org\/10.1016\/j.bbagen.2022.130172","journal-title":"Biochimica Et Biophysica Acta BBA General Subjects"},{"key":"705_CR15","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.tcb.2006.12.003","volume":"17","author":"LL Dunn","year":"2007","unstructured":"Dunn LL, Rahmanto YS, Richardson DR (2007) Iron uptake and metabolism in the new millennium. Trends Cell Biol 17:93\u2013100. https:\/\/doi.org\/10.1016\/j.tcb.2006.12.003","journal-title":"Trends Cell Biol"},{"key":"705_CR16","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/bph.14904","volume":"177","author":"HG Fidelis","year":"2020","unstructured":"Fidelis HG, Mageski JGA, Goes SCE et al (2020) Blockade of angiotensin AT1 receptors prevents arterial remodelling and stiffening in iron-overloaded rats. Br J Pharmacol 177:1119\u20131130. https:\/\/doi.org\/10.1111\/bph.14904","journal-title":"Br J Pharmacol"},{"key":"705_CR17","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1016\/S0735-1097(02)02611-6","volume":"40","author":"H Gaenzer","year":"2002","unstructured":"Gaenzer H, Marschang P, Sturm W et al (2002) Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol 40:2189\u20132194. https:\/\/doi.org\/10.1016\/S0735-1097(02)02611-6","journal-title":"J Am Coll Cardiol"},{"key":"705_CR18","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","volume":"93","author":"T Ganz","year":"2013","unstructured":"Ganz T (2013) Systemic iron homeostasis. Physiol Rev 93:1721\u20131741. https:\/\/doi.org\/10.1152\/physrev.00008.2013","journal-title":"Physiol Rev"},{"key":"705_CR19","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1002\/mnfr.201400036","volume":"58","author":"A Gudjoncik","year":"2014","unstructured":"Gudjoncik A, Guenancia C, Zeller M et al (2014) Iron, oxidative stress, and redox signaling in the cardiovascular system. Mol Nutr Food Res 58:1721\u20131738. https:\/\/doi.org\/10.1002\/mnfr.201400036","journal-title":"Mol Nutr Food Res"},{"key":"705_CR20","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1093\/JN\/NXZ166","volume":"149","author":"PB Ji","year":"2019","unstructured":"Ji PB, Nonnecke E, Doan N et al (2019) Excess iron enhances purine catabolism through activation of xanthine oxidase and impairs myelination in the hippocampus of nursing piglets. J Nutr 149:1911\u20131919. https:\/\/doi.org\/10.1093\/JN\/NXZ166","journal-title":"J Nutr"},{"key":"705_CR21","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/IUB.2656","volume":"74","author":"Z Jiang","year":"2022","unstructured":"Jiang Z, Wang H, Qi G et al (2022) Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study. IUBMB Life 74:1052\u20131069. https:\/\/doi.org\/10.1002\/IUB.2656","journal-title":"IUBMB Life"},{"key":"705_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS11142152","author":"T Kawabata","year":"2022","unstructured":"Kawabata T (2022) Iron-induced oxidative stress in human diseases. Cells. https:\/\/doi.org\/10.3390\/CELLS11142152","journal-title":"Cells"},{"key":"705_CR23","doi-asserted-by":"crossref","unstructured":"Kehrer JP (2000) The Haber-Weiss reaction and mechanisms of toxicity. Toxicology","DOI":"10.1016\/S0300-483X(00)00231-6"},{"key":"705_CR24","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/S00246-007-9107-X\/TABLES\/3","volume":"29","author":"V Kukongviriyapan","year":"2008","unstructured":"Kukongviriyapan V, Somparn N, Senggunprai L et al (2008) Endothelial dysfunction and oxidant status in pediatric patients with hemoglobin E-\u03b2 thalassemia. Pediatr Cardiol 29:130\u2013135. https:\/\/doi.org\/10.1007\/S00246-007-9107-X\/TABLES\/3","journal-title":"Pediatr Cardiol"},{"key":"705_CR25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/1358836X9900400305","volume":"4","author":"J Lekakis","year":"1999","unstructured":"Lekakis J, Papamichael C, Stamatelopoulos K et al (1999) Hemochromatosis associated with endothelial dysfunction: evidence for the role of iron stores in early atherogenesis. Vasc Med 4:147\u2013148. https:\/\/doi.org\/10.1177\/1358836X9900400305","journal-title":"Vasc Med"},{"key":"705_CR26","doi-asserted-by":"publisher","first-page":"269","DOI":"10.2174\/15672026113109990016","volume":"10","author":"B Lipinski","year":"2013","unstructured":"Lipinski B, Pretorius E (2013) Iron-induced fibrin in cardiovascular disease. Curr Neurovasc Res 10:269\u2013274. https:\/\/doi.org\/10.2174\/15672026113109990016","journal-title":"Curr Neurovasc Res"},{"key":"705_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/J.PEPTIDES.2022.170863","author":"PdasD Lopes","year":"2022","unstructured":"Lopes PdasD, de Assis N, de Ara\u00fajo NF et al (2022) COX\/iNOS dependence for angiotensin-II-induced endothelial dysfunction. Peptides (NY). https:\/\/doi.org\/10.1016\/J.PEPTIDES.2022.170863","journal-title":"Peptides (NY)"},{"key":"705_CR28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.lfs.2015.10.034","volume":"15","author":"VB Marques","year":"2015","unstructured":"Marques VB, Nascimento TB, Ribeiro RF et al (2015) Chronic iron overload in rats increases vascular reactivity by increasing oxidative stress and reducing nitric oxide bioavailability. Life Sci 15:89\u201397. https:\/\/doi.org\/10.1016\/j.lfs.2015.10.034","journal-title":"Life Sci"},{"key":"705_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116702","author":"VB Marques","year":"2019","unstructured":"Marques VB, Leal MAS, Mageski JGA et al (2019) Chronic iron overload intensifies atherosclerosis in apolipoprotein E deficient mice: Role of oxidative stress and endothelial dysfunction. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2019.116702","journal-title":"Life Sci"},{"key":"705_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/8416763","volume":"2017","author":"G Pizzino","year":"2017","unstructured":"Pizzino G, Irrera N, Cucinotta M et al (2017) Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev 2017:1\u201313. https:\/\/doi.org\/10.1155\/2017\/8416763","journal-title":"Oxid Med Cell Longev"},{"key":"705_CR31","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1093\/BIOLRE\/IOAB040","volume":"104","author":"X Qin","year":"2021","unstructured":"Qin X, Liang D, Hu M et al (2021) Chronic overload of concentration-dependent iron exerts different effects on ovarian function in C57BL\/6J mice\u2020. Biol Reprod 104:1347\u20131359. https:\/\/doi.org\/10.1093\/BIOLRE\/IOAB040","journal-title":"Biol Reprod"},{"key":"705_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.toxlet.2017.07.497","volume":"279","author":"RF Ribeiro J\u00fanior","year":"2017","unstructured":"Ribeiro J\u00fanior RF, Marques VB, Nunes DO et al (2017) Chronic iron overload induces functional and structural vascular changes in small resistance arteries via NADPH oxidase-dependent O2[rad]\u2212 production. Toxicol Lett 279:43\u201352. https:\/\/doi.org\/10.1016\/j.toxlet.2017.07.497","journal-title":"Toxicol Lett"},{"key":"705_CR33","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1042\/BCJ20190873","volume":"477","author":"B Ristic","year":"2020","unstructured":"Ristic B, Sivaprakasam S, Narayanan M, Ganapathy V (2020) Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression\/activity of xanthine oxidase and ABCG2. Biochem J 477:1499\u20131513. https:\/\/doi.org\/10.1042\/BCJ20190873","journal-title":"Biochem J"},{"key":"705_CR34","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/J.TIPS.2021.05.001","volume":"42","author":"K Roemhild","year":"2021","unstructured":"Roemhild K, von Maltzahn F, Weiskirchen R et al (2021) Iron metabolism: pathophysiology and pharmacology. Trends Pharmacol Sci 42:640\u2013656. https:\/\/doi.org\/10.1016\/J.TIPS.2021.05.001","journal-title":"Trends Pharmacol Sci"},{"key":"705_CR35","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.toxlet.2015.10.027","volume":"240","author":"EM Rossi","year":"2016","unstructured":"Rossi EM, Marques VB, Nunes DdeO et al (2016) Acute iron overload leads to hypothalamic-pituitary-gonadal axis abnormalities in female rats. Toxicol Lett 240:196\u2013213. https:\/\/doi.org\/10.1016\/j.toxlet.2015.10.027","journal-title":"Toxicol Lett"},{"key":"705_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02078-y","author":"EM Rossi","year":"2020","unstructured":"Rossi EM, \u00c1vila RA, Carneiro MTWD et al (2020) Chronic iron overload restrains the benefits of aerobic exercise to the vasculature. Biol Trace Elem Res. https:\/\/doi.org\/10.1007\/s12011-020-02078-y","journal-title":"Biol Trace Elem Res"},{"key":"705_CR37","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/j.1365-2036.2012.05051.x","volume":"35","author":"A Siddique","year":"2012","unstructured":"Siddique A, Kowdley KV (2012) Review article: the iron overload syndromes. Aliment Pharmacol Ther 35:876\u2013893. https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05051.x","journal-title":"Aliment Pharmacol Ther"},{"key":"705_CR38","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000201540.91234.8f","author":"K Thakali","year":"2006","unstructured":"Thakali K, Davenport L, Fink GD, Watts SW (2006) Pleiotropic effects of hydrogen peroxide in arteries and veins from normotensive and hypertensive rats. Hypertension. https:\/\/doi.org\/10.1161\/01.HYP.0000201540.91234.8f","journal-title":"Hypertension"},{"key":"705_CR39","doi-asserted-by":"publisher","DOI":"10.7717\/PEERJ.2611","author":"Q Tian","year":"2016","unstructured":"Tian Q, Wu S, Dai Z et al (2016) Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway. PeerJ. https:\/\/doi.org\/10.7717\/PEERJ.2611","journal-title":"PeerJ"},{"key":"705_CR40","doi-asserted-by":"publisher","DOI":"10.1201\/9781351071529","author":"TG Tong","year":"2018","unstructured":"Tong TG, William B (2018) Iron poisoning. Drug Toxic Metabol Pediatr. https:\/\/doi.org\/10.1201\/9781351071529","journal-title":"Drug Toxic Metabol Pediatr"},{"key":"705_CR41","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/0002-8703(83)90242-9","volume":"105","author":"R Virmani","year":"1983","unstructured":"Virmani R, Roberts WC (1983) Extravasated erythrocytes, iron, and fibrin in atherosclerotic plaques of coronary arteries in fatal coronary heart disease and their relation to luminal thrombus: Frequency and significance in 57 necropsy patients and in 2958 five mm segments of 224 major epicardial coronary arteries. Am Heart J 105:788\u2013797. https:\/\/doi.org\/10.1016\/0002-8703(83)90242-9","journal-title":"Am Heart J"},{"key":"705_CR42","doi-asserted-by":"publisher","DOI":"10.2307\/3579270","author":"P Wardman","year":"1996","unstructured":"Wardman P, Candeias LP (1996) Fenton chemistry: an introduction. Radiat Res. https:\/\/doi.org\/10.2307\/3579270","journal-title":"Radiat Res"},{"key":"705_CR43","doi-asserted-by":"publisher","first-page":"24509","DOI":"10.1007\/S11356-017-0061-8","volume":"24","author":"CF Ximenes","year":"2017","unstructured":"Ximenes CF, Rodrigues SML, Podratz PL et al (2017) Tributyltin chloride disrupts aortic vascular reactivity and increases reactive oxygen species production in female rats. Environ Sci Pollut Res Int 24:24509\u201324520. https:\/\/doi.org\/10.1007\/S11356-017-0061-8","journal-title":"Environ Sci Pollut Res Int"},{"key":"705_CR44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/J.MOLIMM.2021.10.020","volume":"141","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Ma X, Zha Z et al (2022) The protective effects of allopurinol against IL-17A-induced inflammatory response in mast cells. Mol Immunol 141:53\u201359. https:\/\/doi.org\/10.1016\/J.MOLIMM.2021.10.020","journal-title":"Mol Immunol"},{"key":"705_CR45","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.prostaglandins.2006.05.005","volume":"82","author":"M-H Zou","year":"2007","unstructured":"Zou M-H (2007) Peroxynitrite and protein tyrosine nitration of prostacyclin synthase. Prostaglandins Other Lipid Mediat 82:119\u2013127. https:\/\/doi.org\/10.1016\/j.prostaglandins.2006.05.005","journal-title":"Prostaglandins Other Lipid Mediat"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-025-00705-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-025-00705-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-025-00705-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T02:05:01Z","timestamp":1753927501000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-025-00705-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["705"],"URL":"https:\/\/doi.org\/10.1007\/s10534-025-00705-6","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"14 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}