{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:52:35Z","timestamp":1776318755307,"version":"3.50.1"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Scientific research joint fund technology project of public hospital","award":["2024GLLH0411"],"award-info":[{"award-number":["2024GLLH0411"]}]},{"name":"General Program of Inner Mongolia Medical University","award":["YKD2025MS032"],"award-info":[{"award-number":["YKD2025MS032"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10534-026-00786-x","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:44:50Z","timestamp":1770270290000},"page":"517-537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of metal ions iron, copper, and zinc in the immune microenvironment of gastric cancer"],"prefix":"10.1007","volume":"39","author":[{"given":"Weiyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"issue":"2","key":"786_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2022.113452","volume":"422","author":"L An","year":"2023","unstructured":"An L, Liu Y (2023) ZNF460 mediates epithelial-mesenchymal transition to promote gastric cancer progression by transactivating APOC1 expression. Exp Cell Res 422(2):113452. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113452","journal-title":"Exp Cell Res"},{"issue":"3","key":"786_CR2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/s41590-018-0295-8","volume":"20","author":"C Anzilotti","year":"2019","unstructured":"Anzilotti C, Swan DJ, Boisson B et al (2019) An essential role for the Zn(2+) transporter ZIP7 in B cell development. Nat Immunol 20(3):350\u2013361. https:\/\/doi.org\/10.1038\/s41590-018-0295-8","journal-title":"Nat Immunol"},{"key":"786_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","volume":"640","author":"Y Aratani","year":"2018","unstructured":"Aratani Y (2018) Myeloperoxidase: its role for host defense, inflammation, and neutrophil function. Arch Biochem Biophys 640:47\u201352. https:\/\/doi.org\/10.1016\/j.abb.2018.01.004","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"786_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43725-3","volume":"13","author":"K Attri","year":"2023","unstructured":"Attri K, Chudasama B, Mahajan RL et al (2023) Therapeutic potential of lactoferrin-coated iron oxide nanospheres for targeted hyperthermia in gastric cancer. Sci Rep 13(1):17875. https:\/\/doi.org\/10.1038\/s41598-023-43725-3","journal-title":"Sci Rep"},{"issue":"12","key":"786_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13253","volume":"22","author":"S Banerjee","year":"2020","unstructured":"Banerjee S, Datta R (2020) Leishmania infection triggers hepcidin-mediated proteasomal degradation of Nramp1 to increase phagolysosomal iron availability. Cell Microbiol 22(12):e13253. https:\/\/doi.org\/10.1111\/cmi.13253","journal-title":"Cell Microbiol"},{"key":"786_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073642","author":"M Benvenuto","year":"2024","unstructured":"Benvenuto M, Focaccetti C (2024) Tumor microenvironment: cellular interaction and metabolic adaptations. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25073642","journal-title":"Int J Mol Sci"},{"issue":"6487","key":"786_CR7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1126\/science.aau6481","volume":"368","author":"NJ Bessman","year":"2020","unstructured":"Bessman NJ, Mathieu JRR, Renassia C et al (2020) Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science 368(6487):186\u2013189. https:\/\/doi.org\/10.1126\/science.aau6481","journal-title":"Science"},{"issue":"7831","key":"786_CR8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41586-020-2668-z","volume":"586","author":"CB Billesb\u00f8lle","year":"2020","unstructured":"Billesb\u00f8lle CB, Azumaya CM, Kretsch RC et al (2020) Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature 586(7831):807\u2013811. https:\/\/doi.org\/10.1038\/s41586-020-2668-z","journal-title":"Nature"},{"key":"786_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.147091","volume":"853","author":"I Bozgeyik","year":"2023","unstructured":"Bozgeyik I, Ege M, Temiz E et al (2023) Novel zinc oxide nanoparticles of Teucrium polium suppress the malignant progression of gastric cancer cells through modulating apoptotic signaling pathways and epithelial to mesenchymal transition. Gene 853:147091. https:\/\/doi.org\/10.1016\/j.gene.2022.147091","journal-title":"Gene"},{"key":"786_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-025-03593-3","author":"M Caforio","year":"2025","unstructured":"Caforio M, Iacovelli S, Locatelli F et al (2025) Inducing ferroptosis to improve cancer therapy: a promising tool for enhancing immunotherapy. J Exp Clin Cancer Res. https:\/\/doi.org\/10.1186\/s13046-025-03593-3","journal-title":"J Exp Clin Cancer Res"},{"key":"786_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101611","volume":"36","author":"G Camiolo","year":"2020","unstructured":"Camiolo G, Barbato A, Giallongo C et al (2020) Iron regulates myeloma cell\/macrophage interaction and drives resistance to bortezomib. Redox Biol 36:101611. https:\/\/doi.org\/10.1016\/j.redox.2020.101611","journal-title":"Redox Biol"},{"key":"786_CR12","doi-asserted-by":"publisher","DOI":"10.3892\/or.2021.8154","author":"CY Chang","year":"2021","unstructured":"Chang CY, Wu KL, Chang YY et al (2021) Amine oxidase, copper containing 3 exerts anti-mesenchymal transformation and enhances CD4(+) T-cell recruitment to prolong survival in lung cancer. Oncol Rep. https:\/\/doi.org\/10.3892\/or.2021.8154","journal-title":"Oncol Rep"},{"key":"786_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112441","author":"E Charlebois","year":"2023","unstructured":"Charlebois E, Pantopoulos K (2023) Nutritional aspects of iron in health and disease. Nutrients. https:\/\/doi.org\/10.3390\/nu15112441","journal-title":"Nutrients"},{"key":"786_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113631","volume":"155","author":"J Chen","year":"2022","unstructured":"Chen J, Zhang J, Chen T et al (2022) Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62\/Keap1\/Nrf2 signaling pathway to inhibit ferroptosis. Biomed Pharmacother 155:113631. https:\/\/doi.org\/10.1016\/j.biopha.2022.113631","journal-title":"Biomed Pharmacother"},{"key":"786_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109778","volume":"256","author":"Q Chen","year":"2023","unstructured":"Chen Q, Xiang M, Gao Z et al (2023) The role of B-cell ferroptosis in the pathogenesis of systemic lupus erythematosus. Clin Immunol 256:109778. https:\/\/doi.org\/10.1016\/j.clim.2023.109778","journal-title":"Clin Immunol"},{"issue":"1","key":"786_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01679-y","volume":"9","author":"B Chen","year":"2024","unstructured":"Chen B, Yu P, Chan WN et al (2024) Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal Transduct Target Ther 9(1):6. https:\/\/doi.org\/10.1038\/s41392-023-01679-y","journal-title":"Signal Transduct Target Ther"},{"key":"786_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1019153","volume":"12","author":"F Cheng","year":"2022","unstructured":"Cheng F, Peng G, Lu Y et al (2022) Relationship between copper and immunity: the potential role of copper in tumor immunity. Front Oncol 12:1019153. https:\/\/doi.org\/10.3389\/fonc.2022.1019153","journal-title":"Front Oncol"},{"key":"786_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400013","author":"J Cheng","year":"2024","unstructured":"Cheng J, Rink L, Wessels I (2024) Zinc supplementation reduces the formation of neutrophil extracellular traps by decreasing the expression of peptidyl arginine deiminase 4. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.202400013","journal-title":"Mol Nutr Food Res"},{"key":"786_CR19","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.3389\/fimmu.2019.03021","volume":"10","author":"I Cichon","year":"2019","unstructured":"Cichon I, Ortmann W, Bednarz A et al (2019) Reduced neutrophil extracellular trap (NET) formation during systemic inflammation in mice with menkes disease and wilson disease: copper requirement for NET release. Front Immunol 10:3021. https:\/\/doi.org\/10.3389\/fimmu.2019.03021","journal-title":"Front Immunol"},{"key":"786_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212333","author":"E Crescenzi","year":"2021","unstructured":"Crescenzi E, Leonardi A, Pacifico F (2021) NGAL as a potential target in tumor microenvironment. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms222212333","journal-title":"Int J Mol Sci"},{"key":"786_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118852","volume":"193","author":"A Darzi","year":"2025","unstructured":"Darzi A, Boroumandi S, Khajegi P et al (2025) Harnessing cuproptosis for pancreatic cancer therapy: from molecular insights to clinical prospects. Biomed Pharmacother 193:118852. https:\/\/doi.org\/10.1016\/j.biopha.2025.118852","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"786_CR22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2174\/1574892817666220524102403","volume":"18","author":"K Ding","year":"2023","unstructured":"Ding K, Zhang F, Qi G et al (2023) ZFP36L1 promotes gastric cancer progression via regulating JNK and p38 MAPK signaling pathways. Recent Pat Anticancer Drug Discov 18(1):80\u201391. https:\/\/doi.org\/10.2174\/1574892817666220524102403","journal-title":"Recent Pat Anticancer Drug Discov"},{"issue":"19","key":"786_CR23","doi-asserted-by":"publisher","first-page":"9503","DOI":"10.7150\/thno.63992","volume":"11","author":"P Feng","year":"2021","unstructured":"Feng P, Yang Q, Luo L et al (2021) The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis. Theranostics 11(19):9503\u20139518. https:\/\/doi.org\/10.7150\/thno.63992","journal-title":"Theranostics"},{"key":"786_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/biology12091163","author":"LM FERN\u00e1NDEZ-AGUILAR","year":"2023","unstructured":"FERN\u00e1NDEZ-AGUILAR LM, Vico-Barranco I, Arbulo-Echevarria MM et al (2023) A story of kinases and adaptors: the role of Lck, ZAP-70 and LAT in switch panel governing T-cell development and activation. Biol (Basel). https:\/\/doi.org\/10.3390\/biology12091163","journal-title":"Biol (Basel)"},{"issue":"1","key":"786_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-021-00271-y","volume":"26","author":"D Fu","year":"2021","unstructured":"Fu D, Wang C, Yu L et al (2021) Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2\/Keap1\/xCT signaling. Cell Mol Biol Lett 26(1):26. https:\/\/doi.org\/10.1186\/s11658-021-00271-y","journal-title":"Cell Mol Biol Lett"},{"issue":"49","key":"786_CR26","doi-asserted-by":"publisher","first-page":"12940","DOI":"10.1073\/pnas.1708018114","volume":"114","author":"H Gao","year":"2017","unstructured":"Gao H, Zhao L, Wang H et al (2017) Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. Proc Natl Acad Sci U S A 114(49):12940\u201312945. https:\/\/doi.org\/10.1073\/pnas.1708018114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"786_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6872621","volume":"2018","author":"H Gao","year":"2018","unstructured":"Gao H, Dai W, Zhao L et al (2018) The role of zinc and zinc homeostasis in macrophage function. J Immunol Res 2018:6872621. https:\/\/doi.org\/10.1155\/2018\/6872621","journal-title":"J Immunol Res"},{"key":"786_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1379365","volume":"15","author":"Y Gao","year":"2024","unstructured":"Gao Y, Liu S, Huang Y et al (2024) Regulation of anti-tumor immunity by metal ion in the tumor microenvironment. Front Immunol 15:1379365. https:\/\/doi.org\/10.3389\/fimmu.2024.1379365","journal-title":"Front Immunol"},{"issue":"5","key":"786_CR29","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.4049\/jimmunol.1600410","volume":"197","author":"MM George","year":"2016","unstructured":"George MM, Subramanian Vignesh K, Landero Figueroa JA et al (2016) Zinc induces dendritic cell tolerogenic phenotype and skews regulatory T cell-Th17 balance. J Invest Med 197(5):1864\u20131876. https:\/\/doi.org\/10.4049\/jimmunol.1600410","journal-title":"J Invest Med"},{"key":"786_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/cells7010008","author":"EA Golenkina","year":"2018","unstructured":"Golenkina EA, Viryasova GM, Galkina SI et al (2018) Fine regulation of neutrophil oxidative status and apoptosis by ceruloplasmin and its derivatives. Cells. https:\/\/doi.org\/10.3390\/cells7010008","journal-title":"Cells"},{"key":"786_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111413","volume":"218","author":"D Guan","year":"2021","unstructured":"Guan D, Li C, Li Y et al (2021) The DpdtbA induced emt inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2\/hif-1\u03b1 pathway. J Inorg Biochem 218:111413. https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111413","journal-title":"J Inorg Biochem"},{"key":"786_CR32","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3920664","volume":"2022","author":"D Guan","year":"2022","unstructured":"Guan D, Zhou W, Wei H et al (2022) Ferritinophagy-mediated ferroptosis and activation of Keap1\/Nrf2\/HO-1 pathway were conducive to emt inhibition of gastric cancer cells in action of 2,2\u2019-di-pyridineketone hydrazone dithiocarbamate butyric acid ester. Oxid Med Cell Longev 2022:3920664. https:\/\/doi.org\/10.1155\/2022\/3920664","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"786_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01451-3","volume":"16","author":"WL Guan","year":"2023","unstructured":"Guan WL, He Y, Xu RH (2023) Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol 16(1):57. https:\/\/doi.org\/10.1186\/s13045-023-01451-3","journal-title":"J Hematol Oncol"},{"issue":"22","key":"786_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212267","volume":"35","author":"B Guo","year":"2023","unstructured":"Guo B, Yang F, Zhang L et al (2023) Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with \u03b1PD-L1 for enhanced cancer immunotherapy. Adv Mater 35(22):e2212267. https:\/\/doi.org\/10.1002\/adma.202212267","journal-title":"Adv Mater"},{"issue":"1","key":"786_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-022-00467-w","volume":"19","author":"G Gupta","year":"2022","unstructured":"Gupta G, Cappellini F, Farcal L et al (2022) Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu\/Zn superoxide dismutase 1 (SOD1). Part Fibre Toxicol 19(1):33. https:\/\/doi.org\/10.1186\/s12989-022-00467-w","journal-title":"Part Fibre Toxicol"},{"key":"786_CR36","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jconrel.2022.06.002","volume":"348","author":"Y Han","year":"2022","unstructured":"Han Y, Dong Z, Wang C et al (2022) Ferrous ions doped calcium carbonate nanoparticles potentiate chemotherapy by inducing ferroptosis. J Controll Release\u202f: off J Controll Release Soc 348:346\u2013356. https:\/\/doi.org\/10.1016\/j.jconrel.2022.06.002","journal-title":"J Controll Release : off J Controll Release Soc"},{"issue":"32","key":"786_CR37","doi-asserted-by":"publisher","first-page":"11786","DOI":"10.1073\/pnas.1323557111","volume":"111","author":"S Hojyo","year":"2014","unstructured":"Hojyo S, Miyai T, Fujishiro H et al (2014) Zinc transporter SLC39A10\/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Proc Natl Acad Sci U S A 111(32):11786\u201311791. https:\/\/doi.org\/10.1073\/pnas.1323557111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"786_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00815-x","volume":"8","author":"J Hou","year":"2022","unstructured":"Hou J, Huang P, Lan C et al (2022) ZC3H15 promotes gastric cancer progression by targeting the FBXW7\/c-Myc pathway. Cell Death Discov 8(1):32. https:\/\/doi.org\/10.1038\/s41420-022-00815-x","journal-title":"Cell Death Discov"},{"issue":"16","key":"786_CR39","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.1039\/d3bm00627a","volume":"11","author":"X Hu","year":"2023","unstructured":"Hu X, Wang M, Shi S et al (2023) Polymer\/copper nanocomplex-induced lysosomal cell death promotes tumor lymphocyte infiltration and synergizes anti-PD-L1 immunotherapy for triple-negative breast cancer. Biomater Sci 11(16):5641\u20135652. https:\/\/doi.org\/10.1039\/d3bm00627a","journal-title":"Biomater Sci"},{"key":"786_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155220","volume":"123","author":"W Huang","year":"2024","unstructured":"Huang W, Wen F, Yang P et al (2024) Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT\/GSK3\u03b2\/NRF2\/GPX4 axis. Phytomedicine 123:155220. https:\/\/doi.org\/10.1016\/j.phymed.2023.155220","journal-title":"Phytomedicine"},{"issue":"3","key":"786_CR41","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10534-022-00453-x","volume":"36","author":"G Ianiro","year":"2023","unstructured":"Ianiro G, Rosa L, Bonaccorsi Di Patti MC et al (2023) Lactoferrin: from the structure to the functional orchestration of iron homeostasis. Biometals 36(3):391\u2013416. https:\/\/doi.org\/10.1007\/s10534-022-00453-x","journal-title":"Biometals"},{"issue":"1","key":"786_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05421-w","volume":"6","author":"T Iyoda","year":"2023","unstructured":"Iyoda T, Shimizu K, Endo T et al (2023) Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells. Commun Biol 6(1):1070. https:\/\/doi.org\/10.1038\/s42003-023-05421-w","journal-title":"Commun Biol"},{"issue":"1","key":"786_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11002-5","volume":"10","author":"Y Jiang","year":"2019","unstructured":"Jiang Y, Li C, Wu Q et al (2019) Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun 10(1):2935. https:\/\/doi.org\/10.1038\/s41467-019-11002-5","journal-title":"Nat Commun"},{"issue":"4","key":"786_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25721","volume":"10","author":"B Jiang","year":"2024","unstructured":"Jiang B, Zhou H, Xie X et al (2024) Down-regulation of zinc finger protein 335 undermines natural killer cell function in mouse colitis-associated colorectal carcinoma. Heliyon 10(4):e25721. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e25721","journal-title":"Heliyon"},{"issue":"3","key":"786_CR45","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/s41589-019-0462-8","volume":"16","author":"AA Kapralov","year":"2020","unstructured":"Kapralov AA, Yang Q, Dar HH et al (2020) Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol 16(3):278\u2013290. https:\/\/doi.org\/10.1038\/s41589-019-0462-8","journal-title":"Nat Chem Biol"},{"key":"786_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100866","volume":"75","author":"A Katsarou","year":"2020","unstructured":"Katsarou A, Pantopoulos K (2020) Basics and principles of cellular and systemic iron homeostasis. Mol Aspects Med 75:100866. https:\/\/doi.org\/10.1016\/j.mam.2020.100866","journal-title":"Mol Aspects Med"},{"issue":"9","key":"786_CR47","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/ni1373","volume":"7","author":"H Kitamura","year":"2006","unstructured":"Kitamura H, Morikawa H, Kamon H et al (2006) Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol 7(9):971\u2013977. https:\/\/doi.org\/10.1038\/ni1373","journal-title":"Nat Immunol"},{"issue":"1","key":"786_CR48","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","volume":"6","author":"VAN Kraft","year":"2020","unstructured":"Kraft VAN, Bezjian CT, Pfeiffer S et al (2020) GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci 6(1):41\u201353. https:\/\/doi.org\/10.1021\/acscentsci.9b01063","journal-title":"ACS Cent Sci"},{"key":"786_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.586578","volume":"8","author":"F Kuang","year":"2020","unstructured":"Kuang F, Liu J, Tang D et al (2020) Oxidative damage and antioxidant defense in ferroptosis. Front Cell Dev Biol 8:586578. https:\/\/doi.org\/10.3389\/fcell.2020.586578","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"786_CR50","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00394-020-02454-3","volume":"60","author":"V Kumar","year":"2021","unstructured":"Kumar V, Kumar A, Singh K et al (2021) Neurobiology of zinc and its role in neurogenesis. Eur J Nutr 60(1):55\u201364. https:\/\/doi.org\/10.1007\/s00394-020-02454-3","journal-title":"Eur J Nutr"},{"issue":"8","key":"786_CR51","doi-asserted-by":"publisher","first-page":"e999","DOI":"10.1002\/ctm2.999","volume":"12","author":"Y Lai","year":"2022","unstructured":"Lai Y, Zhao S, Chen B et al (2022) Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy. Clin Transl Med 12(8):e999. https:\/\/doi.org\/10.1002\/ctm2.999","journal-title":"Clin Transl Med"},{"issue":"1","key":"786_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09910-4","volume":"40","author":"Y Lai","year":"2024","unstructured":"Lai Y, Gao FF, Ge RT et al (2024) Metal ions overloading and cell death. Cell Biol Toxicol 40(1):72. https:\/\/doi.org\/10.1007\/s10565-024-09910-4","journal-title":"Cell Biol Toxicol"},{"issue":"10","key":"786_CR53","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18390","volume":"28","author":"L Lan","year":"2024","unstructured":"Lan L, Feng Z, Liu X et al (2024) The roles of essential trace elements in T cell biology. J Cell Mol Med 28(10):e18390. https:\/\/doi.org\/10.1111\/jcmm.18390","journal-title":"J Cell Mol Med"},{"issue":"12","key":"786_CR54","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1038\/s41418-024-01369-4","volume":"31","author":"EJ Lelliott","year":"2024","unstructured":"Lelliott EJ, Naddaf J, Ganio K et al (2024) Intracellular zinc protects tumours from T cell-mediated cytotoxicity. Cell Death Differ 31(12):1707\u20131716. https:\/\/doi.org\/10.1038\/s41418-024-01369-4","journal-title":"Cell Death Differ"},{"key":"786_CR55","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ceca.2018.08.004","volume":"75","author":"N Levaot","year":"2018","unstructured":"Levaot N, Hershfinkel M (2018) How cellular Zn(2+) signaling drives physiological functions. Cell Calcium 75:53\u201363. https:\/\/doi.org\/10.1016\/j.ceca.2018.08.004","journal-title":"Cell Calcium"},{"issue":"6","key":"786_CR56","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/jlb.3ma0821-015r","volume":"110","author":"L Li","year":"2021","unstructured":"Li L, Xia Y, Yuan S et al (2021) Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell. J Leukoc Biol 110(6):1057\u20131067. https:\/\/doi.org\/10.1002\/jlb.3ma0821-015r","journal-title":"J Leukoc Biol"},{"key":"786_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213010","volume":"139","author":"Y Li","year":"2022","unstructured":"Li Y, Lu Y, Qiu B et al (2022a) Copper-containing titanium alloys promote angiogenesis in irradiated bone through releasing copper ions and regulating immune microenvironment. Biomater Adv 139:213010. https:\/\/doi.org\/10.1016\/j.bioadv.2022.213010","journal-title":"Biomater Adv"},{"key":"786_CR58","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5288075","volume":"2022","author":"L Li","year":"2022","unstructured":"Li L, Liu ZH, Wang HJ et al (2022b) ZNF521 is correlated with tumor immune cell infiltration and act as a valuable prognostic biomarker in gastric cancer. Gastroenterol Res Pract 2022:5288075. https:\/\/doi.org\/10.1155\/2022\/5288075","journal-title":"Gastroenterol Res Pract"},{"key":"786_CR59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bbrc.2023.05.121","volume":"670","author":"K Li","year":"2023","unstructured":"Li K, Sun S, Lu Y et al (2023) MT1M regulates gastric cancer progression and stemness by modulating the Hedgehog pathway protein GLI1. Biochem Biophys Res Commun 670:63\u201372. https:\/\/doi.org\/10.1016\/j.bbrc.2023.05.121","journal-title":"Biochem Biophys Res Commun"},{"key":"786_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114210","author":"X Li","year":"2024","unstructured":"Li X, Qian J, Xu J et al (2024a) NRF2 inhibits RSL3 induced ferroptosis in gastric cancer through regulation of AKR1B1. Exp Cell Res. https:\/\/doi.org\/10.1016\/j.yexcr.2024.114210","journal-title":"Exp Cell Res"},{"issue":"6","key":"786_CR61","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-024-05838-8","volume":"150","author":"Y Li","year":"2024","unstructured":"Li Y, Zhou C, Wang G et al (2024b) Identification and validation of the role of ZNF281 in 5-fluorouracil chemotherapy of gastric cancer. J Cancer Res Clin Oncol 150(6):307. https:\/\/doi.org\/10.1007\/s00432-024-05838-8","journal-title":"J Cancer Res Clin Oncol"},{"issue":"12","key":"786_CR62","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82(12):2215\u20132227. https:\/\/doi.org\/10.1016\/j.molcel.2022.03.022","journal-title":"Mol Cell"},{"key":"786_CR63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1255443","volume":"14","author":"Z Lin","year":"2023","unstructured":"Lin Z, Zou S, Wen K (2023a) The crosstalk of CD8+ T cells and ferroptosis in cancer. Front Immunol 14:1255443. https:\/\/doi.org\/10.3389\/fimmu.2023.1255443","journal-title":"Front Immunol"},{"issue":"8","key":"786_CR64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0288091","volume":"18","author":"C Lin","year":"2023","unstructured":"Lin C, He J, Tong X et al (2023b) Copper homeostasis-associated gene PRNP regulates ferroptosis and immune infiltration in breast cancer. PLoS ONE 18(8):e0288091. https:\/\/doi.org\/10.1371\/journal.pone.0288091","journal-title":"PLoS ONE"},{"key":"786_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13010132","author":"W Lin","year":"2024","unstructured":"Lin W, Chen H, Chen X et al (2024) The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: the new progress. Antioxidants (Basel, Switzerland). https:\/\/doi.org\/10.3390\/antiox13010132","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"1","key":"786_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25715-z","volume":"12","author":"E Littwitz-Salomon","year":"2021","unstructured":"Littwitz-Salomon E, Moreira D, Frost JN et al (2021) Metabolic requirements of NK cells during the acute response against retroviral infection. Nat Commun 12(1):5376. https:\/\/doi.org\/10.1038\/s41467-021-25715-z","journal-title":"Nat Commun"},{"issue":"8","key":"786_CR67","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1158\/0008-5472.Can-18-3037","volume":"79","author":"T Liu","year":"2019","unstructured":"Liu T, Jiang L, Tavana O et al (2019) The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11. Cancer Res 79(8):1913\u20131924. https:\/\/doi.org\/10.1158\/0008-5472.Can-18-3037","journal-title":"Cancer Res"},{"key":"786_CR68","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2385406","volume":"2021","author":"SJ Liu","year":"2021","unstructured":"Liu SJ, Yang YB, Zhou JX et al (2021a) A novel ferroptosis-related gene risk signature for predicting prognosis and immunotherapy response in gastric cancer. Dis Markers 2021:2385406. https:\/\/doi.org\/10.1155\/2021\/2385406","journal-title":"Dis Markers"},{"issue":"12","key":"786_CR69","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.4251\/wjgo.v13.i12.2114","volume":"13","author":"YP Liu","year":"2021","unstructured":"Liu YP, Qiu ZZ, Li XH et al (2021b) Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p\/STAT3 axis. World J Gastrointest Oncol 13(12):2114\u20132128. https:\/\/doi.org\/10.4251\/wjgo.v13.i12.2114","journal-title":"World J Gastrointest Oncol"},{"issue":"22","key":"786_CR70","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.1111\/febs.16059","volume":"289","author":"J Liu","year":"2022","unstructured":"Liu J, Kang R, Tang D (2022a) Signaling pathways and defense mechanisms of ferroptosis. FEBS J 289(22):7038\u20137050. https:\/\/doi.org\/10.1111\/febs.16059","journal-title":"FEBS J"},{"issue":"3","key":"786_CR71","doi-asserted-by":"publisher","first-page":"6579","DOI":"10.1080\/21655979.2022.2038434","volume":"13","author":"Y Liu","year":"2022","unstructured":"Liu Y, Guan X, Wang M et al (2022b) Disulfiram\/Copper induces antitumor activity against gastric cancer via the ROS\/MAPK and NPL4 pathways. Bioengineered 13(3):6579\u20136589. https:\/\/doi.org\/10.1080\/21655979.2022.2038434","journal-title":"Bioengineered"},{"issue":"6","key":"786_CR72","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00432-024-05817-z","volume":"150","author":"X Liu","year":"2024","unstructured":"Liu X, Mao X, Zhu C et al (2024b) COMMD10 inhibited DNA damage to promote the progression of gastric cancer. J Cancer Res Clin Oncol 150(6):305. https:\/\/doi.org\/10.1007\/s00432-024-05817-z","journal-title":"J Cancer Res Clin Oncol"},{"key":"786_CR73","doi-asserted-by":"publisher","unstructured":"LIU Y M, XIAO S, YU D E, et al. 2024 [Effect of zinc oxide nanoparticles on hypoxia and pyroptosis of rat neutrophils. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 42(7): 481\u20136.https:\/\/doi.org\/10.3760\/cma.j.cn121094-20230710-00239.","DOI":"10.3760\/cma.j.cn121094-20230710-00239"},{"issue":"1","key":"786_CR74","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04719-2","volume":"9","author":"RM Loftus","year":"2018","unstructured":"Loftus RM, Assmann N, Kedia-Mehta N et al (2018) Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice. Nat Commun 9(1):2341. https:\/\/doi.org\/10.1038\/s41467-018-04719-2","journal-title":"Nat Commun"},{"key":"786_CR75","doi-asserted-by":"publisher","first-page":"128000","DOI":"10.1016\/j.talanta.2025.128000","volume":"292","author":"Z Long","year":"2025","unstructured":"Long Z, Bing T, Zhang N et al (2025) DNA aptamer targeting zinc transporters ZIP10 and ZIP6 on cancer cells. Talanta 292:128000. https:\/\/doi.org\/10.1016\/j.talanta.2025.128000","journal-title":"Talanta"},{"issue":"15","key":"786_CR76","doi-asserted-by":"publisher","first-page":"10542","DOI":"10.1021\/acsnano.3c12615","volume":"18","author":"Y Lu","year":"2024","unstructured":"Lu Y, Chen Y, Hou G et al (2024) Zinc-iron bimetallic peroxides modulate the tumor stromal microenvironment and enhance cell immunogenicity for enhanced breast cancer immunotherapy therapy. ACS Nano 18(15):10542\u201310556. https:\/\/doi.org\/10.1021\/acsnano.3c12615","journal-title":"ACS Nano"},{"key":"786_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116574","volume":"174","author":"M Luan","year":"2024","unstructured":"Luan M, Feng Z, Zhu W et al (2024) Mechanism of metal ion-induced cell death in gastrointestinal cancer. Biomed Pharmacother 174:116574. https:\/\/doi.org\/10.1016\/j.biopha.2024.116574","journal-title":"Biomed Pharmacother"},{"key":"786_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.681338","volume":"12","author":"SH Mao","year":"2021","unstructured":"Mao SH, Zhu CH, Nie Y et al (2021) Levobupivacaine induces ferroptosis by miR-489-3p\/SLC7A11 signaling in gastric cancer. Front Pharmacol 12:681338. https:\/\/doi.org\/10.3389\/fphar.2021.681338","journal-title":"Front Pharmacol"},{"key":"786_CR79","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jtemb.2018.02.004","volume":"50","author":"M Maywald","year":"2018","unstructured":"Maywald M, Wang F, Rink L (2018) Zinc supplementation plays a crucial role in T helper 9 differentiation in allogeneic immune reactions and non-activated T cells. J Trace Elem Med Biol\u202f: Org Soc Miner Trace Elem (GMS) 50:482\u2013488. https:\/\/doi.org\/10.1016\/j.jtemb.2018.02.004","journal-title":"J Trace Elem Med Biol : Org Soc Miner Trace Elem (GMS)"},{"issue":"15","key":"786_CR80","doi-asserted-by":"publisher","first-page":"5809","DOI":"10.7150\/ijbs.77734","volume":"18","author":"XJ Mi","year":"2022","unstructured":"Mi XJ, Park HR, Dhandapani S et al (2022) Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells. Int J Biol Sci 18(15):5809\u20135826. https:\/\/doi.org\/10.7150\/ijbs.77734","journal-title":"Int J Biol Sci"},{"issue":"25","key":"786_CR81","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.3748\/wjg.v27.i25.3851","volume":"27","author":"YH Miao","year":"2021","unstructured":"Miao YH, Mao LP, Cai XJ et al (2021) Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy. World J Gastroenterol 27(25):3851\u20133862. https:\/\/doi.org\/10.3748\/wjg.v27.i25.3851","journal-title":"World J Gastroenterol"},{"issue":"32","key":"786_CR82","doi-asserted-by":"publisher","first-page":"11780","DOI":"10.1073\/pnas.1323549111","volume":"111","author":"T Miyai","year":"2014","unstructured":"Miyai T, Hojyo S, Ikawa T et al (2014) Zinc transporter SLC39A10\/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A 111(32):11780\u201311785. https:\/\/doi.org\/10.1073\/pnas.1323549111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"786_CR83","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02394-7","volume":"12","author":"H Ni","year":"2021","unstructured":"Ni H, Qin H, Sun C et al (2021) MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis. Stem Cell Res Ther 12(1):325. https:\/\/doi.org\/10.1186\/s13287-021-02394-7","journal-title":"Stem Cell Res Ther"},{"key":"786_CR84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816282","volume":"13","author":"S Ni","year":"2022","unstructured":"Ni S, Yuan Y, Kuang Y et al (2022a) Iron metabolism and immune regulation. Front Immunol 13:816282. https:\/\/doi.org\/10.3389\/fimmu.2022.816282","journal-title":"Front Immunol"},{"issue":"11","key":"786_CR85","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.7150\/ijms.73701","volume":"19","author":"Z Ni","year":"2022","unstructured":"Ni Z, Nie X, Zhang H et al (2022b) Atranorin driven by nano materials SPION lead to ferroptosis of gastric cancer stem cells by weakening the mRNA 5-hydroxymethylcytidine modification of the Xc-\/GPX4 axis and its expression. Int J Med Sci 19(11):1680\u20131694. https:\/\/doi.org\/10.7150\/ijms.73701","journal-title":"Int J Med Sci"},{"key":"786_CR86","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jnutbio.2018.10.008","volume":"64","author":"J Ollig","year":"2019","unstructured":"Ollig J, Kloubert V, Taylor KM et al (2019) B cell activation and proliferation increase intracellular zinc levels. J Nutr Biochem 64:72\u201379. https:\/\/doi.org\/10.1016\/j.jnutbio.2018.10.008","journal-title":"J Nutr Biochem"},{"key":"786_CR87","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.773665","volume":"11","author":"Z Pang","year":"2021","unstructured":"Pang Z, Xu Y, Zhu Q (2021) Early growth response 1 suppresses macrophage phagocytosis by inhibiting NRF2 activation through upregulation of autophagy during Pseudomonas aeruginosa infection. Front Cell Infect Microbiol 11:773665. https:\/\/doi.org\/10.3389\/fcimb.2021.773665","journal-title":"Front Cell Infect Microbiol"},{"key":"786_CR88","doi-asserted-by":"publisher","DOI":"10.3390\/biom14010078","author":"MC PE\u00f1A-JU\u00e1REZ","year":"2024","unstructured":"PE\u00f1A-JU\u00e1REZ MC, Guadarrama-Escobar OR, SERRANO-CASTA\u00f1EDA P et al (2024) Synergistic effect of retinoic acid and lactoferrin in the maintenance of gut homeostasis. Biomolecules. https:\/\/doi.org\/10.3390\/biom14010078","journal-title":"Biomolecules"},{"issue":"14","key":"786_CR89","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70012","volume":"13","author":"Y Peng","year":"2024","unstructured":"Peng Y, Shi R, Yang S et al (2024) Cuproptosis-related gene DLAT is a biomarker of the prognosis and immune microenvironment of gastric cancer and affects the invasion and migration of cells. Cancer Med 13(14):e70012. https:\/\/doi.org\/10.1002\/cam4.70012","journal-title":"Cancer Med"},{"issue":"5","key":"786_CR90","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3892\/ijmm.2020.4535","volume":"45","author":"P Pietrangeli","year":"2020","unstructured":"Pietrangeli P, Capuozzo E, Mateescu MA et al (2020) Copper-containing amine oxidase purified from Lathyrus sativus as a modulator of human neutrophil functions. Int J Mol Med 45(5):1583\u20131590. https:\/\/doi.org\/10.3892\/ijmm.2020.4535","journal-title":"Int J Mol Med"},{"key":"786_CR91","doi-asserted-by":"publisher","DOI":"10.3390\/biology11040504","author":"EM Piskor","year":"2022","unstructured":"Piskor EM, Ross J, M\u00f6R\u00f6Y T et al (2022) Myc-interacting zinc finger protein 1 (Miz-1) is essential to maintain homeostasis and immunocompetence of the B cell lineage. Biology. https:\/\/doi.org\/10.3390\/biology11040504","journal-title":"Biology"},{"issue":"9","key":"786_CR92","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1158\/2326-6066.Cir-23-0739","volume":"12","author":"S Porte","year":"2024","unstructured":"Porte S, Audemard-Verger A, Wu C et al (2024) Iron boosts antitumor type 1 T-cell responses and anti-pd1 immunotherapy. Cancer Immunol Res 12(9):1252\u20131267. https:\/\/doi.org\/10.1158\/2326-6066.Cir-23-0739","journal-title":"Cancer Immunol Res"},{"issue":"1","key":"786_CR93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169531","volume":"12","author":"CJ Pyle","year":"2017","unstructured":"Pyle CJ, Akhter S, Bao S et al (2017) Zinc modulates endotoxin-induced human macrophage inflammation through ZIP8 induction and C\/EBP\u03b2 inhibition. PLoS ONE 12(1):e0169531. https:\/\/doi.org\/10.1371\/journal.pone.0169531","journal-title":"PLoS ONE"},{"key":"786_CR94","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202402308","author":"Q Qiu","year":"2024","unstructured":"Qiu Q, Li J, Ren H et al (2024) Zinc coordination lipid nanoparticles co-delivering calcium peroxide and chelating STING agonist for enhanced cancer metalloimmunotherapy. Small. https:\/\/doi.org\/10.1002\/smll.202402308","journal-title":"Small"},{"key":"786_CR95","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26010205","author":"Q RASC\u00f3N-CRUZ","year":"2021","unstructured":"RASC\u00f3N-CRUZ Q, ESPINOZA-S\u00e1NCHEZ EA, SIQUEIROS-CEND\u00f3N TS et al (2021) Lactoferrin: a glycoprotein involved in immunomodulation, anticancer, and antimicrobial processes. Molecules. https:\/\/doi.org\/10.3390\/molecules26010205","journal-title":"Molecules"},{"issue":"8","key":"786_CR96","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1038\/s12276-023-01062-5","volume":"55","author":"X Ren","year":"2023","unstructured":"Ren X, Feng C, Wang Y et al (2023) SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK\/ERK and PI3K\/AKT pathways. Exp Mol Med 55(8):1757\u20131769. https:\/\/doi.org\/10.1038\/s12276-023-01062-5","journal-title":"Exp Mol Med"},{"key":"786_CR97","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010449","author":"L Rochette","year":"2022","unstructured":"Rochette L, Dogon G, Rigal E et al (2022) Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24010449","journal-title":"Int J Mol Sci"},{"issue":"1","key":"786_CR98","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32751-w","volume":"13","author":"N Salustros","year":"2022","unstructured":"Salustros N, GR\u00f8NBERG C, Abeyrathna NS et al (2022) Structural basis of ion uptake in copper-transporting P(1B)-type ATPases. Nat Commun 13(1):5121. https:\/\/doi.org\/10.1038\/s41467-022-32751-w","journal-title":"Nat Commun"},{"issue":"1","key":"786_CR99","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-60920-y","volume":"14","author":"L Shao","year":"2024","unstructured":"Shao L, Zhu L, Su R et al (2024) Baicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis. Sci Rep 14(1):10745. https:\/\/doi.org\/10.1038\/s41598-024-60920-y","journal-title":"Sci Rep"},{"issue":"1","key":"786_CR100","doi-asserted-by":"publisher","first-page":"149257","DOI":"10.1016\/j.ijbiomac.2025.149257","volume":"335","author":"A Sharma","year":"2025","unstructured":"Sharma A, Srivastava Y, Prasad S et al (2025) SLC7A11 as a molecular nexus of prognosis, resistance, and therapeutic roadmap in cancer: a systematic review and meta-analysis. Int J Biol Macromol 335(1):149257. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149257","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"786_CR101","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70(1):7\u201330. https:\/\/doi.org\/10.3322\/caac.21590","journal-title":"CA Cancer J Clin"},{"key":"786_CR102","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102273","author":"D Skrajnowska","year":"2019","unstructured":"Skrajnowska D, Bobrowska-Korczak B (2019) Role of zinc in immune system and anti-cancer defense mechanisms. Nutrients. https:\/\/doi.org\/10.3390\/nu11102273","journal-title":"Nutrients"},{"issue":"35","key":"786_CR103","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301148","volume":"19","author":"WF Song","year":"2023","unstructured":"Song WF, Zeng JY, Ji P et al (2023) Self-assembled copper-based nanoparticles for glutathione activated and enzymatic cascade-enhanced ferroptosis and immunotherapy in cancer treatment. Small 19(35):e2301148. https:\/\/doi.org\/10.1002\/smll.202301148","journal-title":"Small"},{"issue":"6","key":"786_CR104","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2024.100238","volume":"15","author":"NU Stoffel","year":"2024","unstructured":"Stoffel NU, Drakesmith H (2024) Effects of iron status on adaptive immunity and vaccine efficacy: a review. Adv Nutr 15(6):100238. https:\/\/doi.org\/10.1016\/j.advnut.2024.100238","journal-title":"Adv Nutr"},{"issue":"9","key":"786_CR105","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1158\/1541-7786.Mcr-22-0056","volume":"20","author":"Y Su","year":"2022","unstructured":"Su Y, Zhang X, Li S et al (2022) Emerging roles of the copper-CTR1 axis in tumorigenesis. Mol Cancer Res 20(9):1339\u20131353. https:\/\/doi.org\/10.1158\/1541-7786.Mcr-22-0056","journal-title":"Mol Cancer Res"},{"issue":"12","key":"786_CR106","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1016\/j.celrep.2016.08.057","volume":"16","author":"K Subramanian Vignesh","year":"2016","unstructured":"Subramanian Vignesh K, Landero Figueroa JA, Porollo A et al (2016) IL-4 induces metallothionein 3- and SLC30A4-dependent increase in intracellular Zn(2+) that promotes pathogen persistence in macrophages. Cell Rep 16(12):3232\u20133246. https:\/\/doi.org\/10.1016\/j.celrep.2016.08.057","journal-title":"Cell Rep"},{"issue":"5","key":"786_CR107","doi-asserted-by":"publisher","first-page":"BSR20181023","DOI":"10.1042\/BSR20181023","volume":"38","author":"B Tan","year":"2018","unstructured":"Tan B, Li Y, Zhao Q, Fan L, Wang D (2018) ZNF139 increases multidrug resistance in gastric cancer cells by inhibiting miR-185. Biosci Rep 38(5):BSR20181023","journal-title":"Biosci Rep"},{"issue":"9","key":"786_CR108","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1084\/jem.20210009","volume":"218","author":"S Tan","year":"2021","unstructured":"Tan S, Guo X, Li M et al (2021) Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity. J Exp Med 218(9):5. https:\/\/doi.org\/10.1084\/jem.20210009","journal-title":"J Exp Med"},{"key":"786_CR109","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101459","author":"X Tang","year":"2022","unstructured":"Tang X, Guo T, Wu X et al (2022) Clinical significance and immune infiltration analyses of the cuproptosis-related human copper proteome in gastric cancer. Biomolecules. https:\/\/doi.org\/10.3390\/biom12101459","journal-title":"Biomolecules"},{"key":"786_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125134","volume":"411","author":"X Tao","year":"2021","unstructured":"Tao X, Wan X, Wu D et al (2021) A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage. J Hazard Mater 411:125134. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.125134","journal-title":"J Hazard Mater"},{"key":"786_CR111","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26178417","author":"VS Tseriotis","year":"2025","unstructured":"Tseriotis VS, Ampazis D, Karachrysafi S et al (2025) ZnO-based nanoparticles for targeted cancer chemotherapy and the role of tumor microenvironment: a systematic review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26178417","journal-title":"Int J Mol Sci"},{"key":"786_CR112","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.874253","volume":"13","author":"J Tulinska","year":"2022","unstructured":"Tulinska J, Mikusova ML, Liskova A et al (2022) Copper oxide nanoparticles stimulate the immune response and decrease antioxidant defense in mice after six-week inhalation. Front Immunol 13:874253. https:\/\/doi.org\/10.3389\/fimmu.2022.874253","journal-title":"Front Immunol"},{"issue":"7755","key":"786_CR113","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang W, Green M, Choi JE et al (2019) CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 569(7755):270\u2013274. https:\/\/doi.org\/10.1038\/s41586-019-1170-y","journal-title":"Nature"},{"issue":"8","key":"786_CR114","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202006231","volume":"17","author":"Y Wang","year":"2021","unstructured":"Wang Y, Ding Y, Yao D et al (2021a) Copper-based nanoscale coordination polymers augmented tumor radioimmunotherapy for immunogenic cell death induction and T-cell infiltration. Small 17(8):e2006231. https:\/\/doi.org\/10.1002\/smll.202006231","journal-title":"Small"},{"key":"786_CR115","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6014202","volume":"2021","author":"F Wang","year":"2021","unstructured":"Wang F, Chen C, Chen WP et al (2021b) Development and validation of a novel ferroptosis-related gene signature for predicting prognosis and the immune microenvironment in gastric cancer. BioMed Res Int 2021:6014202. https:\/\/doi.org\/10.1155\/2021\/6014202","journal-title":"BioMed Res Int"},{"issue":"8","key":"786_CR116","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s41423-022-00866-1","volume":"19","author":"Y Wang","year":"2022","unstructured":"Wang Y, Zhang L, Zhou F (2022a) Cuproptosis: a new form of programmed cell death. Cell Mol Immunol 19(8):867\u2013868. https:\/\/doi.org\/10.1038\/s41423-022-00866-1","journal-title":"Cell Mol Immunol"},{"key":"786_CR117","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6532253","volume":"2022","author":"T Wang","year":"2022","unstructured":"Wang T, Zhou Z, Wang C et al (2022b) LTBP2 knockdown promotes ferroptosis in gastric cancer cells through p62-Keap1-Nrf2 pathway. BioMed Res Int 2022:6532253. https:\/\/doi.org\/10.1155\/2022\/6532253","journal-title":"BioMed Res Int"},{"issue":"11","key":"786_CR118","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1038\/s41418-022-01008-w","volume":"29","author":"Y Wang","year":"2022","unstructured":"Wang Y, Zheng L, Shang W et al (2022c) Wnt\/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer. Cell Death Differ 29(11):2190\u20132202. https:\/\/doi.org\/10.1038\/s41418-022-01008-w","journal-title":"Cell Death Differ"},{"issue":"1","key":"786_CR119","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13046-023-02720-2","volume":"42","author":"W Wang","year":"2023","unstructured":"Wang W, Lu K, Jiang X et al (2023) Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer. J Exp Clin Cancer Res\u202f: CR 42(1):142. https:\/\/doi.org\/10.1186\/s13046-023-02720-2","journal-title":"J Exp Clin Cancer Res : CR"},{"issue":"1","key":"786_CR120","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09843-y","volume":"40","author":"J Wang","year":"2024","unstructured":"Wang J, Jia Q, Jiang S et al (2024) POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2\/SLC7A11 signaling in gastric cancer. Cell Biol Toxicol 40(1):3. https:\/\/doi.org\/10.1007\/s10565-024-09843-y","journal-title":"Cell Biol Toxicol"},{"issue":"1","key":"786_CR121","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.1038\/s41467-022-31218-2","volume":"13","author":"B Wiernicki","year":"2022","unstructured":"Wiernicki B, Maschalidi S, Pinney J et al (2022) Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity. Nat Commun 13(1):3676. https:\/\/doi.org\/10.1038\/s41467-022-31218-2","journal-title":"Nat Commun"},{"issue":"1","key":"786_CR122","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02520-6","volume":"24","author":"Y Wu","year":"2025","unstructured":"Wu Y, Li H, Yue K et al (2025) Ferroptosis in cancer: metabolism, mechanisms and therapeutic prospects. Mol Cancer 24(1):303. https:\/\/doi.org\/10.1186\/s12943-025-02520-6","journal-title":"Mol Cancer"},{"key":"786_CR123","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0801-6","volume":"19","author":"Y Xia","year":"2019","unstructured":"Xia Y, Liu X, Zhang L et al (2019) A new schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer. Cancer Cell Int 19:81. https:\/\/doi.org\/10.1186\/s12935-019-0801-6","journal-title":"Cancer Cell Int"},{"key":"786_CR124","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.2147\/cmar.S225229","volume":"12","author":"F Xu","year":"2020","unstructured":"Xu F, Xu Y, Xiong JH et al (2020a) AOC1 contributes to tumor progression by promoting the AKT and EMT pathways in gastric cancer. Cancer Manag Res 12:1789\u20131798. https:\/\/doi.org\/10.2147\/cmar.S225229","journal-title":"Cancer Manag Res"},{"key":"786_CR125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109196","volume":"328","author":"Z Xu","year":"2020","unstructured":"Xu Z, Feng J, Li Y et al (2020b) The vicious cycle between ferritinophagy and ROS production triggered emt inhibition of gastric cancer cells was through p53\/AKT\/mTor pathway. Chem Biol Interact 328:109196. https:\/\/doi.org\/10.1016\/j.cbi.2020.109196","journal-title":"Chem Biol Interact"},{"issue":"8","key":"786_CR126","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","volume":"19","author":"Q Xue","year":"2023","unstructured":"Xue Q, Kang R, Klionsky DJ et al (2023) Copper metabolism in cell death and autophagy. Autophagy 19(8):2175\u20132195. https:\/\/doi.org\/10.1080\/15548627.2023.2200554","journal-title":"Autophagy"},{"issue":"8","key":"786_CR127","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300918R","volume":"37","author":"I Yanatori","year":"2023","unstructured":"Yanatori I, Nishina S, Kishi F et al (2023) Newly uncovered biochemical and functional aspects of ferritin. FASEB J 37(8):e23095. https:\/\/doi.org\/10.1096\/fj.202300918R","journal-title":"FASEB J"},{"key":"786_CR128","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120739","volume":"271","author":"Y Yang","year":"2021","unstructured":"Yang Y, Tian Q, Wu S et al (2021) Blue light-triggered Fe(2+)-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy. Biomaterials 271:120739. https:\/\/doi.org\/10.1016\/j.biomaterials.2021.120739","journal-title":"Biomaterials"},{"issue":"5","key":"786_CR129","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00109-023-02311-w","volume":"101","author":"D Yang","year":"2023","unstructured":"Yang D, Xiao P, Qiu B et al (2023) Copper chaperone antioxidant 1: multiple roles and a potential therapeutic target. J Mol Med 101(5):527\u2013542. https:\/\/doi.org\/10.1007\/s00109-023-02311-w","journal-title":"J Mol Med"},{"key":"786_CR130","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.biopha.2019.01.018","volume":"111","author":"Y Yao","year":"2019","unstructured":"Yao Y, Zhou D, Shi D et al (2019) GLI1 overexpression promotes gastric cancer cell proliferation and migration and induces drug resistance by combining with the AKT-mTOR pathway. Biomed Pharmacother 111:993\u20131004. https:\/\/doi.org\/10.1016\/j.biopha.2019.01.018","journal-title":"Biomed Pharmacother"},{"key":"786_CR131","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102923","volume":"67","author":"L Yao","year":"2023","unstructured":"Yao L, Hou J, Wu X et al (2023) Cancer-associated fibroblasts impair the cytotoxic function of NK cells in gastric cancer by inducing ferroptosis via iron regulation. Redox Biol 67:102923. https:\/\/doi.org\/10.1016\/j.redox.2023.102923","journal-title":"Redox Biol"},{"issue":"7","key":"786_CR132","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.4049\/jimmunol.1901399","volume":"204","author":"EL Yarosz","year":"2020","unstructured":"Yarosz EL, Ye C, Kumar A et al (2020) Cutting edge: activation-induced iron flux controls CD4 T cell proliferation by promoting proper IL-2R signaling and mitochondrial function. J Immunol 204(7):1708\u20131713. https:\/\/doi.org\/10.4049\/jimmunol.1901399","journal-title":"J Immunol"},{"issue":"7","key":"786_CR133","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.trecan.2024.03.008","volume":"10","author":"T Yasuda","year":"2024","unstructured":"Yasuda T, Wang YA (2024) Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development. Trends Cancer 10(7):627\u2013642. https:\/\/doi.org\/10.1016\/j.trecan.2024.03.008","journal-title":"Trends Cancer"},{"key":"786_CR134","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2024.114948","author":"M You","year":"2024","unstructured":"You M, Huang Y, Chen Y et al (2024) ZnO nanoparticles induce melanoma-like lesions via recruiting dermal dendritic cells in barrier-damaged skin in mice. Food Chem Toxicol. https:\/\/doi.org\/10.1016\/j.fct.2024.114948","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"786_CR135","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/jcb.25002","volume":"116","author":"JR Zacherl","year":"2015","unstructured":"Zacherl JR, Tourkova I, St Croix CM et al (2015) Elaidate, an 18-carbon trans-monoenoic fatty acid, but not physiological fatty acids increases intracellular Zn(2+) in human macrophages. J Cell Biochem 116(4):524\u2013532. https:\/\/doi.org\/10.1002\/jcb.25002","journal-title":"J Cell Biochem"},{"issue":"2","key":"786_CR136","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.tips.2023.12.003","volume":"45","author":"YY Zhang","year":"2024","unstructured":"Zhang YY, Han Y, Li WN et al (2024a) Tumor iron homeostasis and immune regulation. Trends Pharmacol Sci 45(2):145\u2013156. https:\/\/doi.org\/10.1016\/j.tips.2023.12.003","journal-title":"Trends Pharmacol Sci"},{"key":"786_CR137","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116512","volume":"174","author":"W Zhang","year":"2024","unstructured":"Zhang W, Liu Y, Liao Y et al (2024b) GPX4, ferroptosis, and diseases. Biomed Pharmacother 174:116512. https:\/\/doi.org\/10.1016\/j.biopha.2024.116512","journal-title":"Biomed Pharmacother"},{"issue":"16","key":"786_CR138","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1021\/acs.biochem.4c00223","volume":"63","author":"B Zhang","year":"2024","unstructured":"Zhang B, Boyd SD, Zhabilov D et al (2024c) Pathogenic R(163)w variant of the copper chaperone for Sod1 (Ccs) functions as an anti-chaperone. Biochemistry 63(16):2051\u20132062. https:\/\/doi.org\/10.1021\/acs.biochem.4c00223","journal-title":"Biochemistry"},{"issue":"9","key":"786_CR139","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300801R","volume":"37","author":"J Zhao","year":"2023","unstructured":"Zhao J, Wen D, Zhang S et al (2023) The role of zinc finger proteins in malignant tumors. FASEB J 37(9):e23157. https:\/\/doi.org\/10.1096\/fj.202300801R","journal-title":"FASEB J"},{"issue":"12","key":"786_CR140","doi-asserted-by":"publisher","first-page":"e202213922","DOI":"10.1002\/anie.202213922","volume":"62","author":"J Zhou","year":"2023","unstructured":"Zhou J, Yu Q, Song J et al (2023) Photothermally triggered copper payload release for cuproptosis-promoted cancer synergistic therapy. Angew Chem Int Ed Engl 62(12):e202213922. https:\/\/doi.org\/10.1002\/anie.202213922","journal-title":"Angew Chem Int Ed Engl"},{"issue":"1","key":"786_CR141","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02224-x","volume":"41","author":"M Zhu","year":"2022","unstructured":"Zhu M, Zhang P, Yu S et al (2022) Targeting ZFP64\/GAL-1 axis promotes therapeutic effect of nab-paclitaxel and reverses immunosuppressive microenvironment in gastric cancer. J Exp Clin Cancer Res 41(1):14. https:\/\/doi.org\/10.1186\/s13046-021-02224-x","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"786_CR142","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.3892\/ol.2017.7574","volume":"15","author":"E Zuo","year":"2018","unstructured":"Zuo E, Lu Y, Yan M et al (2018) Increased expression of hepcidin and associated upregulation of JAK\/STAT3 signaling in human gastric cancer. Oncol Lett 15(2):2236\u20132244. https:\/\/doi.org\/10.3892\/ol.2017.7574","journal-title":"Oncol Lett"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00786-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-026-00786-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00786-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:16:33Z","timestamp":1776316593000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-026-00786-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":142,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["786"],"URL":"https:\/\/doi.org\/10.1007\/s10534-026-00786-x","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"27 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}