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However, residual platinum can persist in the body long after treatment cessation, leading to progressive accumulation, chronic multi-system toxicity, and significant impairment of patients'\u00a0quality of life. The insidious onset and lack of specific monitoring methods often lead to the oversight of this treatment-related metal accumulation toxicity. This article reviews the environmental and occupational exposure risks of platinum, its unique pharmacokinetic properties, and elucidates how its irreversible binding to proteins and accumulation within mitochondria form the chemical basis for its long-term toxicity. It further elaborates on the core mechanisms underlying platinum accumulation-mediated multi-organ toxicity, including nephrotoxicity, neurotoxicity, and ototoxicity. 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