{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:18:47Z","timestamp":1787743127521,"version":"build-2784847793"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10534-026-00825-7","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:52:22Z","timestamp":1778251942000},"page":"1699-1712","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering the role of human peroxiredoxins for combating lead and zinc mediated cellular toxicity using a yeast model"],"prefix":"10.1007","volume":"39","author":[{"given":"Rahul","family":"Thakur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena V.","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasanka","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adesh K.","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"825_CR1","doi-asserted-by":"publisher","first-page":"e28357","DOI":"10.1016\/j.heliyon.2024.e28357","volume":"10","author":"PB Angon","year":"2024","unstructured":"Angon PB, Islam MS et al (2024) Sources, effects and present perspectives of heavy metals contamination: soil, plants and human food chain. Heliyon 10:e28357. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e28357","journal-title":"Heliyon"},{"key":"825_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/antiox11010093","volume":"11","author":"L Drago","year":"2021","unstructured":"Drago L, Ferro D, Bakiu R et al (2021) Typical 2-Cys peroxiredoxins as a defense mechanism against metal-induced oxidative stress in the solitary ascidian Ciona robusta. Antioxidants 11:93. https:\/\/doi.org\/10.3390\/antiox11010093","journal-title":"Antioxidants"},{"key":"825_CR3","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1089\/ars.2017.7272","volume":"28","author":"C Garza-Lomb\u00f3","year":"2018","unstructured":"Garza-Lomb\u00f3 C, Posadas Y, Quintanar L et al (2018) Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress. Antioxid Redox Signal 28:1669\u20131703. https:\/\/doi.org\/10.1089\/ars.2017.7272","journal-title":"Antioxid Redox Signal"},{"key":"825_CR4","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1158\/0008-5472.CAN-07-2683","volume":"68","author":"I Iraqui","year":"2008","unstructured":"Iraqui I, Faye G, Ragu S et al (2008) Human peroxiredoxin PrxI is an orthologue of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae. Cancer Res 68:1055\u20131063. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-2683","journal-title":"Cancer Res"},{"issue":"3","key":"825_CR5","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.3390\/ijms13033145","volume":"13","author":"M Jozefczak","year":"2012","unstructured":"Jozefczak M, Remans T, Vangronsveld J, Cuypers A (2012) Glutathione is a key player in metal-induced oxidative stress defenses. Int J Mol Sci 13(3):3145\u20133175. https:\/\/doi.org\/10.3390\/ijms13033145","journal-title":"Int J Mol Sci"},{"key":"825_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.freeradbiomed.2019.09.034","volume":"145","author":"R Kumar","year":"2019","unstructured":"Kumar R, Mohammad A, Saini RV et al (2019) Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast. Free Radic Biol Med 145:321\u2013329. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.09.034","journal-title":"Free Radic Biol Med"},{"key":"825_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2022.814678","volume":"10","author":"X Liu","year":"2022","unstructured":"Liu X, Zhang J, Huang X et al (2022) Heavy metal distribution and bioaccumulation combined with ecological and human health risk evaluation in a typical urban plateau lake, Southwest China. Front Environ Sci 10:814678. https:\/\/doi.org\/10.3389\/fenvs.2022.814678","journal-title":"Front Environ Sci"},{"key":"825_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/plants12163003","volume":"12","author":"S Mansoor","year":"2023","unstructured":"Mansoor S, Ali A, Kour N et al (2023) Heavy metal induced oxidative stress mitigation and ROS scavenging in plants. Plants 12:3003. https:\/\/doi.org\/10.3390\/plants12163003","journal-title":"Plants"},{"key":"825_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6235641","volume":"2016","author":"B Marengo","year":"2016","unstructured":"Marengo B, Nitti M, Furfaro AL et al (2016) Redox homeostasis and cellular antioxidant systems: crucial players in cancer growth and therapy. Oxid Med Cell Longev 2016:6235641. https:\/\/doi.org\/10.1155\/2016\/6235641","journal-title":"Oxid Med Cell Longev"},{"key":"825_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101738","volume":"37","author":"A Mohammad","year":"2020","unstructured":"Mohammad A, Saini RV, Kumar R et al (2020) A curious case of cysteines in human peroxiredoxin I. Redox Biol 37:101738. https:\/\/doi.org\/10.1016\/j.redox.2020.101738","journal-title":"Redox Biol"},{"key":"825_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e40370","volume":"10","author":"TE Oladimeji","year":"2024","unstructured":"Oladimeji TE, Oyedemi M, Emetere ME et al (2024) Review on the impact of heavy metals from industrial wastewater effluent and removal technologies. Heliyon 10:e40370. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e40370","journal-title":"Heliyon"},{"key":"825_CR12","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.tibs.2015.05.001","volume":"40","author":"A Perkins","year":"2015","unstructured":"Perkins A, Nelson KJ, Parsonage D et al (2015) Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci 40:435\u2013445. https:\/\/doi.org\/10.1016\/j.tibs.2015.05.001","journal-title":"Trends Biochem Sci"},{"key":"825_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175129","volume":"929","author":"S Singh","year":"2022","unstructured":"Singh S, Ganguly U, Pal S et al (2022) Protective effects of cyclosporine A on neurodegeneration and motor impairment in rotenone-induced experimental models of Parkinson\u2019s disease. Eur J Pharmacol 929:175129. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175129","journal-title":"Eur J Pharmacol"},{"key":"825_CR14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.5937\/scriptamed55-48730","volume":"55","author":"J Tiwana","year":"2024","unstructured":"Tiwana J, Shah A, Dhalla N (2024) The involvement of reactive oxygen species in causing chronic cardiovascular and neurodegenerative diseases and some cancers. Scr Med (Brno) 55:199\u2013217. https:\/\/doi.org\/10.5937\/scriptamed55-48730","journal-title":"Scr Med (Brno)"},{"key":"825_CR15","doi-asserted-by":"publisher","DOI":"10.3791\/63337","author":"MV Vaglienti","year":"2022","unstructured":"Vaglienti MV, Subirada PV, Barcelona PF et al (2022) Quantification of reactive oxygen species using 2\u20327\u2032-Dichlorofluorescein diacetate probe and flow-cytometry in M\u00fcller glial cells. J vis Exp. https:\/\/doi.org\/10.3791\/63337","journal-title":"J vis Exp"},{"key":"825_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2023.114723","volume":"189","author":"J Vald\u00e9s","year":"2023","unstructured":"Vald\u00e9s J, Ortlieb L, Sifeddine A, Castillo A (2023) Human-induced metals accumulation in sediments of an industrialized bay of northern Chile. An enrichment and ecological risk assessment based on preindustrial values. Mar Pollut Bull 189:114723. https:\/\/doi.org\/10.1016\/j.marpolbul.2023.114723","journal-title":"Mar Pollut Bull"},{"key":"825_CR17","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1074\/jbc.M106846200","volume":"277","author":"C-M Wong","year":"2002","unstructured":"Wong C-M, Zhou Y, Ng RWM et al (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J Biol Chem 277:5385\u20135394. https:\/\/doi.org\/10.1074\/jbc.M106846200","journal-title":"J Biol Chem"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00825-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-026-00825-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00825-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:26:31Z","timestamp":1787739991000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-026-00825-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["825"],"URL":"https:\/\/doi.org\/10.1007\/s10534-026-00825-7","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"23 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}