{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:18:44Z","timestamp":1787743124225,"version":"build-2784847793"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n (SECIHTI)."},{"name":"Instituto Polit\u00e9cnico Nacional, Mexico","award":["SIP-20250830"],"award-info":[{"award-number":["SIP-20250830"]}]},{"name":"Laboratorio de Investigaci\u00f3n, Tecnolog\u00eda, Innovaci\u00f3n Cient\u00edfica, Mexico","award":["FAI-2025"],"award-info":[{"award-number":["FAI-2025"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10534-026-00839-1","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T10:48:20Z","timestamp":1781347700000},"page":"1891-1902","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum zinc, copper status and Cu\/Zn ratio in overweight and obesity: associations with oxidative stress, adipokines, and cardiometabolic traits in adult women"],"prefix":"10.1007","volume":"39","author":[{"given":"Luis C\u00e9sar","family":"V\u00e1zquez-V\u00e1zquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Nava-Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Soto-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Ram\u00edrez-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Elizabeth","family":"Coss\u00edo-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Layseca-Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Vazquez-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Hern\u00e1ndez-Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Judith","family":"Rios-Lugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"issue":"2","key":"839_CR1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.dsx.2018.12.022","volume":"13","author":"MT Adnan","year":"2019","unstructured":"Adnan MT, Amin MN, Uddin MG, Hussain MS, Sarwar MS, Hossain MK et al (2019) Increased concentration of serum MDA, decreased antioxidants and altered trace elements and macro-minerals are linked to obesity among Bangladeshi population. Diabetes Metab Syndr 13(2):933\u2013938. https:\/\/doi.org\/10.1016\/j.dsx.2018.12.022","journal-title":"Diabetes Metab Syndr"},{"key":"839_CR2","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s42452-019-0825-5","volume":"1","author":"MF Al-Hakkani","year":"2019","unstructured":"Al-Hakkani MF (2019) Guideline of inductively coupled plasma mass spectrometry \u201cICP\u2013MS\u201d: fundamentals, practices, determination of the limits, quality control, and method validation parameters. SN Applied Sciences 1:791. https:\/\/doi.org\/10.1007\/s42452-019-0825-5","journal-title":"SN Applied Sciences"},{"issue":"2","key":"839_CR3","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s12011-019-02002-z","volume":"97","author":"MN Amin","year":"2020","unstructured":"Amin MN, Siddiqui SA, Uddin MG, Ibrahim M, Uddin SMN, Adnan MT et al (2020) Increased Oxidative Stress, Altered Trace Elements, and Macro-Minerals Are Associated with Female Obesity. Biol Trace Elem Res 97(2):384\u2013393. https:\/\/doi.org\/10.1007\/s12011-019-02002-z","journal-title":"Biol Trace Elem Res"},{"issue":"3","key":"839_CR4","doi-asserted-by":"publisher","first-page":"e163","DOI":"10.1016\/j.orcp.2010.02.003","volume":"4","author":"F Amirkhizi","year":"2010","unstructured":"Amirkhizi F, Siassi F, Djalali M, Foroushani AR (2010) Evaluation of oxidative stress and total antioxidant capacity in women with general and abdominal adiposity. Obes Res Clin Pract 4(3):e163-246. https:\/\/doi.org\/10.1016\/j.orcp.2010.02.003","journal-title":"Obes Res Clin Pract"},{"issue":"8","key":"839_CR5","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.3390\/antiox12081512","volume":"12","author":"W Anaya-Morua","year":"2023","unstructured":"Anaya-Morua W, Villafan-Bernal JR, Ram\u00edrez-Moreno E, Garc\u00eda-Ortiz H, Mart\u00ednez-Portilla RJ, Contreras-Cubas C et al (2023) Total Antioxidant Capacity in Obese and Non-Obese Subjects and Its Association with Anthropo-Metabolic Markers: Systematic Review and Meta-Analysis. Antioxidants 12(8):1512. https:\/\/doi.org\/10.3390\/antiox12081512","journal-title":"Antioxidants"},{"key":"839_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12011-009-8475-x","volume":"134","author":"M Arredondo","year":"2010","unstructured":"Arredondo M, N\u00fa\u00f1ez H, L\u00f3pez G, Pizarro F, Ayala M, Araya M (2010) Influence of estrogens on copper indicators: in vivo and in vitro studies. Biol Trace Elem Res 134:252\u2013264. https:\/\/doi.org\/10.1007\/s12011-009-8475-x","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"839_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12889-024-21061-z","volume":"25","author":"JP Bae","year":"2025","unstructured":"Bae JP, Nelson DR, Boye KS, Mather KJ (2025) Prevalence of complications and comorbidities associated with obesity: a health insurance claims analysis. BMC Public Health 25(1):273. https:\/\/doi.org\/10.1186\/s12889-024-21061-z","journal-title":"BMC Public Health"},{"issue":"4","key":"839_CR8","doi-asserted-by":"publisher","first-page":"414","DOI":"10.21149\/15863","volume":"66","author":"S Barquera","year":"2024","unstructured":"Barquera S, Hern\u00e1ndez-Barrera L, Oviedo-Sol\u00eds C, Rodr\u00edguez-Ram\u00edrez S, Monterrubio-Flores E, Trejo-Valdivia B et al (2024) Obesidad en adultos. Salud Publica Mex 66(4):414\u2013424","journal-title":"Salud Publica Mex"},{"issue":"2","key":"839_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.2337\/diab.34.2.179","volume":"34","author":"N Begin-Heick","year":"1985","unstructured":"Begin-Heick N, Dalpe-Scott M, Rowe J, Heick HM (1985) Zinc supplementation attenuates insulin secretory activity in pancreatic islets of the ob\/ob mouse. Diabetes 34(2):179\u2013184. https:\/\/doi.org\/10.2337\/diab.34.2.179","journal-title":"Diabetes"},{"issue":"10","key":"839_CR10","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/sj.ejcn.1600631","volume":"52","author":"G Berg","year":"1998","unstructured":"Berg G, Kohlmeier L, Brenner H (1998) Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 52(10):711\u2013715. https:\/\/doi.org\/10.1038\/sj.ejcn.1600631","journal-title":"Eur J Clin Nutr"},{"issue":"2","key":"839_CR12","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/jn\/138.2.305","volume":"138","author":"S Bo","year":"2008","unstructured":"Bo S, Durazzo M, Gambino R, Berutti C, Milanesio N, Caropreso A et al (2008) Associations of dietary and serum copper with inflammation, oxidative stress, and metabolic variables in adults. J Nutr 138(2):305\u2013310. https:\/\/doi.org\/10.1093\/jn\/138.2.305","journal-title":"J Nutr"},{"issue":"1","key":"839_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01679-y","volume":"9","author":"B Chen","year":"2024","unstructured":"Chen B, Yu P, Chan WN, Xie F, Zhang Y, Liang L et al (2024) Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal Transduct Target Ther 9(1):6. https:\/\/doi.org\/10.1038\/s41392-023-01679-y","journal-title":"Signal Transduct Target Ther"},{"key":"839_CR14","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2021.08.009","volume":"175","author":"B Choroma\u0144ska","year":"2021","unstructured":"Choroma\u0144ska B, My\u015bliwiec P, Dadan J, Maleckas A, Zalewska A, Maciejczyk M (2021) Effects of age and gender on the redox homeostasis of morbidly obese people. Free Radic Biol Med 175:108\u2013120. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.08.009","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"839_CR15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.numecd.2006.05.007","volume":"17","author":"C Chrysohoou","year":"2007","unstructured":"Chrysohoou C, Panagiotakos DB, Pitsavos C, Skoumas I, Papademetriou L, Economou M et al (2007) The implication of obesity on total antioxidant capacity in apparently healthy men and women: the ATTICA study. Nutr Metab Cardiovasc Dis 17(8):590\u2013597. https:\/\/doi.org\/10.1016\/j.numecd.2006.05.007","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"7","key":"839_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12071449","volume":"12","author":"S Cinti","year":"2023","unstructured":"Cinti S (2023) Obese adipocytes have altered redox homeostasis with metabolic consequences. Antioxidants 12(7):1449. https:\/\/doi.org\/10.3390\/antiox12071449","journal-title":"Antioxidants"},{"key":"839_CR17","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s13679-021-00453-x","volume":"10","author":"AJ Cooper","year":"2021","unstructured":"Cooper AJ, Gupta SR, Moustafa AF, Chao AM (2021) Sex\/gender differences in obesity prevalence, comorbidities, and treatment. Curr Obes Rep 10:458\u2013466. https:\/\/doi.org\/10.1007\/s13679-021-00453-x","journal-title":"Curr Obes Rep"},{"issue":"1","key":"839_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-25558-4","volume":"15","author":"Z Cui","year":"2025","unstructured":"Cui Z, Shao J, Zhu Z, Wang Y, Hu C, Yuan B (2025) Nonlinear association of serum copper-zinc ratio with overweight\/obesity in children and adolescents. Sci Rep 15(1):41690. https:\/\/doi.org\/10.1038\/s41598-025-25558-4","journal-title":"Sci Rep"},{"issue":"6","key":"839_CR19","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1161\/ATVBAHA.107.159228","volume":"28","author":"JP Despr\u00e9s","year":"2008","unstructured":"Despr\u00e9s JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rod\u00e9s-Cabau J, Bertrand OF, Poirier P (2008) Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 28(6):1039\u20131049. https:\/\/doi.org\/10.1161\/ATVBAHA.107.159228","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"839_CR20","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.3390\/ijms12053117","volume":"12","author":"A Fern\u00e1ndez-S\u00e1nchez","year":"2011","unstructured":"Fern\u00e1ndez-S\u00e1nchez A, Madrigal-Santill\u00e1n E, Bautista M, Esquivel-Soto J, Morales-Gonz\u00e1lez A, Esquivel-Chirino C et al (2011) Inflammation, oxidative stress, and obesity. Int J Mol Sci 12(5):3117\u20133132. https:\/\/doi.org\/10.3390\/ijms12053117","journal-title":"Int J Mol Sci"},{"issue":"6","key":"839_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306038","volume":"19","author":"N El Frakchi","year":"2024","unstructured":"El Frakchi N, El Kinany K, El Baldi M, Saoud Y, El Rhazi K (2024) Association of dietary total antioxidant capacity with general and abdominal obesity in type 2 diabetes mellitus patients. PLoS ONE 19(6):e0306038. https:\/\/doi.org\/10.1371\/journal.pone.0306038","journal-title":"PLoS ONE"},{"key":"839_CR22","doi-asserted-by":"publisher","first-page":"1273177","DOI":"10.3389\/fendo.2023.1273177","volume":"14","author":"C Franco","year":"2024","unstructured":"Franco C, Canzoniero LMT (2024) Zinc homeostasis and redox alterations in obesity. Front Endocrinol 14:1273177. https:\/\/doi.org\/10.3389\/fendo.2023.1273177","journal-title":"Front Endocrinol"},{"issue":"1","key":"839_CR23","doi-asserted-by":"publisher","first-page":"6619","DOI":"10.1038\/s41598-017-06997-0","volume":"7","author":"G Fr\u00fchbeck","year":"2017","unstructured":"Fr\u00fchbeck G, Catal\u00e1n V, Rodr\u00edguez A, Ram\u00edrez B, Becerril S, Salvador J et al (2017) Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome. Sci Rep 7(1):6619. https:\/\/doi.org\/10.1038\/s41598-017-06997-0","journal-title":"Sci Rep"},{"issue":"12","key":"839_CR24","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1172\/JCI21625","volume":"114","author":"S Furukawa","year":"2004","unstructured":"Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y et al (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114(12):1752\u20131761. https:\/\/doi.org\/10.1172\/JCI21625","journal-title":"J Clin Invest"},{"issue":"2","key":"839_CR25","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s12011-019-01803-6","volume":"194","author":"K Gu","year":"2020","unstructured":"Gu K, Li X, Xiang W, Jiang X (2020) The Relationship between serum copper and overweight\/obesity: a meta-analysis. Biol Trace Elem Res 194(2):336\u2013347. https:\/\/doi.org\/10.1007\/s12011-019-01803-6","journal-title":"Biol Trace Elem Res"},{"issue":"7","key":"839_CR26","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1210\/jc.2010-0288","volume":"95","author":"F Guerrero-Romero","year":"2010","unstructured":"Guerrero-Romero F, Simental-Mendia LE, Gonzalez-Ortiz M, Martinez-Abundis E, Ramos-Zavala MG, Hernandez-Gonzalez SO et al (2010) The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab 95(7):3347\u20133351. https:\/\/doi.org\/10.1210\/jc.2010-0288","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"839_CR27","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1194\/jlr.R066597","volume":"57","author":"AK Hauck","year":"2016","unstructured":"Hauck AK, Bernlohr DA (2016) Oxidative stress and lipotoxicity. J Lipid Res 57(11):1976\u20131986. https:\/\/doi.org\/10.1194\/jlr.R066597","journal-title":"J Lipid Res"},{"key":"839_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2022.127002","volume":"73","author":"H Hern\u00e1ndez-Mendoza","year":"2022","unstructured":"Hern\u00e1ndez-Mendoza H, Mart\u00ednez-Navarro I, Hern\u00e1ndez-Ochoa E, Espinoza-Ruiz M, Lugo-Trampe A, Trujillo-Murillo KDC et al (2022) Serum zinc levels are associated with obesity and low-density lipoprotein cholesterol in Mexican adults. J Trace Elem Med Biol 73:127002. https:\/\/doi.org\/10.1016\/j.jtemb.2022.127002","journal-title":"J Trace Elem Med Biol"},{"issue":"2","key":"839_CR29","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s12011-016-0785-1","volume":"175","author":"B Hosseini","year":"2017","unstructured":"Hosseini B, Saedisomeolia A, Allman-Farinelli M (2017) Association between antioxidant intake\/status and obesity: a systematic review of observational studies. Biol Trace Elem Res 175(2):287\u2013297. https:\/\/doi.org\/10.1007\/s12011-016-0785-1","journal-title":"Biol Trace Elem Res"},{"issue":"6","key":"839_CR30","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1021\/jf030723c","volume":"53","author":"D Huang","year":"2005","unstructured":"Huang D, Ou B, Prior RL (2005) The chemistry behind antioxidant capacity assays. J Agric Food Chem 53(6):1841\u20131856. https:\/\/doi.org\/10.1021\/jf030723c","journal-title":"J Agric Food Chem"},{"issue":"12","key":"839_CR31","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1007\/s12011-023-03609-z","volume":"201","author":"Y Huo","year":"2023","unstructured":"Huo Y, Ma F, Li L, Li Y, Zhong G, Liao J et al (2023) Effect of copper exposure on the cholesterol metabolism in broiler liver. Biol Trace Elem Res 201(12):5747\u20135755. https:\/\/doi.org\/10.1007\/s12011-023-03609-z","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"839_CR32","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0891-5849(95)02043-8","volume":"20","author":"AM Jentzsch","year":"1996","unstructured":"Jentzsch AM, Bachmann H, Furst P, Biesalski HK (1996) Improved analysis of malondialdehyde in human body fluids. Free Radic Biol Med 20(2):251\u2013256. https:\/\/doi.org\/10.1016\/0891-5849(95)02043-8","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"839_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094642","volume":"22","author":"CA Juan","year":"2021","unstructured":"Juan CA, P\u00e9rez de la Lastra JM, Plou FJ, P\u00e9rez-Lebe\u00f1a E (2021) The Chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, Lipids and Proteins) and induced pathologies. Int J Mol Sci 22(9):4642. https:\/\/doi.org\/10.3390\/ijms22094642","journal-title":"Int J Mol Sci"},{"issue":"2","key":"839_CR34","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22711","volume":"14","author":"D Khanna","year":"2022","unstructured":"Khanna D, Khanna S, Khanna P, Kahar P, Patel BM (2022) Obesity: a chronic low-grade inflammation and its markers. Cureus 14(2):e22711. https:\/\/doi.org\/10.7759\/cureus.22711","journal-title":"Cureus"},{"issue":"4","key":"839_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/life14040465","volume":"14","author":"Z Knazicka","year":"2024","unstructured":"Knazicka Z, Bihari M, Janco I, Harangozo L, Arvay J, Kovacik A et al (2024) Blood concentration of macro- and microelements in women who are overweight\/obesity and their associations with serum biochemistry. Life 14(4):465. https:\/\/doi.org\/10.3390\/life14040465","journal-title":"Life"},{"issue":"3","key":"839_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030690","volume":"11","author":"A Kury\u0142owicz","year":"2023","unstructured":"Kury\u0142owicz A (2023) Estrogens in adipose tissue physiology and obesity-related dysfunction. Biomedicines 11(3):690. https:\/\/doi.org\/10.3390\/biomedicines11030690","journal-title":"Biomedicines"},{"issue":"8","key":"839_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/cells12081137","volume":"12","author":"G Leanza","year":"2023","unstructured":"Leanza G, Conte C, Cannata F, Isgr\u00f2 C, Piccoli A, Strollo R et al (2023) Oxidative stress in postmenopausal women with or without obesity. Cells 12(8):1137. https:\/\/doi.org\/10.3390\/cells12081137","journal-title":"Cells"},{"key":"839_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2024.127436","volume":"84","author":"Y Lin","year":"2024","unstructured":"Lin Y, Yuan M, Wang G (2024) Copper homeostasis and cuproptosis in gynecological disorders: Pathogenic insights and therapeutic implications. J Trace Elem Med Biol 84:127436. https:\/\/doi.org\/10.1016\/j.jtemb.2024.127436","journal-title":"J Trace Elem Med Biol"},{"key":"839_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1368730","volume":"11","author":"M Luo","year":"2024","unstructured":"Luo M, Guo L, Wu C, Hao M, Gu J, Li X et al (2024) Effects of dietary copper intake on blood lipids in women of childbearing age and the potential role of gut microbiota. Front Nutr 11:1368730. https:\/\/doi.org\/10.3389\/fnut.2024.1368730","journal-title":"Front Nutr"},{"issue":"16","key":"839_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/nu15163605","volume":"15","author":"K Michalczyk","year":"2023","unstructured":"Michalczyk K, Kapczuk P, Kupnicka P, Witczak G, Michalczyk B, Bosiacki M et al (2023) Assessment of serum Zn, Cu, Mn, and Fe concentration in women with endometrial cancer and different endometrial pathologies. Nutrients 15(16):3605. https:\/\/doi.org\/10.3390\/nu15163605","journal-title":"Nutrients"},{"issue":"6","key":"839_CR41","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/S2213-8587(22)00076-6","volume":"10","author":"RE Nappi","year":"2022","unstructured":"Nappi RE, Chedraui P, Lambrinoudaki I, Simoncini T (2022) Menopause: a cardiometabolic transition. Lancet Diabetes Endocrinol 10(6):442\u2013456. https:\/\/doi.org\/10.1016\/S2213-8587(22)00076-6","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10481","key":"839_CR42","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","volume":"405","author":"M Ng","year":"2025","unstructured":"Ng M, Gakidou E, Lo J, Abate YH, Abbafati C, Abbas N et al (2025) Global, regional, and national prevalence of adult overweight and obesity, 1990\u20132021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet 405(10481):813\u2013838. https:\/\/doi.org\/10.1016\/S0140-6736(25)00355-1","journal-title":"Lancet"},{"issue":"6","key":"839_CR43","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s10534-024-00625-x","volume":"37","author":"ARS de Oliveira","year":"2024","unstructured":"de Oliveira ARS, Cruz KJC, Morais JBS, Dos Santos LR, de Sousa Melo SR, Fontenelle LC et al (2024) Magnesium, selenium and zinc deficiency compromises antioxidant defense in women with obesity. Biometals 37(6):1551\u20131563. https:\/\/doi.org\/10.1007\/s10534-024-00625-x","journal-title":"Biometals"},{"issue":"7-8","key":"839_CR44","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.clinbiochem.2016.01.003","volume":"49","author":"CE Ottobelli","year":"2016","unstructured":"Ottobelli CE, de Souza WM, da Silva TP, Moresco RN, Moretto MB (2016) Adipocytokines, inflammatory and oxidative stress markers of clinical relevance altered in young overweight\/obese subjects. Clin Biochem 49(7\u20138):548\u2013553. https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.01.003","journal-title":"Clin Biochem"},{"issue":"8","key":"839_CR45","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0009-9120(02)00363-6","volume":"35","author":"M Ozata","year":"2002","unstructured":"Ozata M, Mergen M, Oktenli C, Aydin A, Sanisoglu SY, Bolu E et al (2002) Increased oxidative stress and hypozincemia in male obesity. Clin Biochem 35(8):627\u2013631. https:\/\/doi.org\/10.1016\/S0009-9120(02)00363-6","journal-title":"Clin Biochem"},{"issue":"7","key":"839_CR46","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1007\/s12011-022-03407-z","volume":"201","author":"M de Paiva Sousa","year":"2023","unstructured":"de Paiva Sousa M, Fontenelle LC, de Sousa TGV, Dos Santos LR, Cruz KJC, da Cunha Soares T et al (2023) Relationship between markers of chronic inflammation and copper nutritional status in obese women. Biol Trace Elem Res 201(7):3133\u20133143. https:\/\/doi.org\/10.1007\/s12011-022-03407-z","journal-title":"Biol Trace Elem Res"},{"issue":"10","key":"839_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14101238","volume":"14","author":"K Pokorska-Niewiada","year":"2025","unstructured":"Pokorska-Niewiada K, Zi\u0119tek M, Szyd\u0142owska I, Ryterska K, Szczuko M (2025) The role of antioxidant minerals in the pathophysiology and treatment of endometriosis-systematic review. Antioxidants 14(10):1238. https:\/\/doi.org\/10.3390\/antiox14101238","journal-title":"Antioxidants"},{"issue":"1","key":"839_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12011-020-02060-8","volume":"198","author":"MJ Rios-Lugo","year":"2020","unstructured":"Rios-Lugo MJ, Madrigal-Arellano C, Gayt\u00e1n-Hern\u00e1ndez D, Hern\u00e1ndez-Mendoza H, Romero-Guzm\u00e1n ET (2020) Association of serum zinc levels in overweight and obesity. Biol Trace Elem Res 198(1):51\u201357. https:\/\/doi.org\/10.1007\/s12011-020-02060-8","journal-title":"Biol Trace Elem Res"},{"key":"839_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123470","volume":"233","author":"J Rumpf","year":"2023","unstructured":"Rumpf J, Burger R, Schulze M (2023) Statistical evaluation of DPPH, ABTS, FRAP, and Folin-Ciocalteu assays to assess the antioxidant capacity of lignins. Int J Biol Macromol 233:123470. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.123470","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"839_CR50","doi-asserted-by":"publisher","first-page":"10497","DOI":"10.3390\/ijms140510497","volume":"14","author":"I Savini","year":"2013","unstructured":"Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L (2013) Obesity-associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci 14(5):10497\u201310538. https:\/\/doi.org\/10.3390\/ijms140510497","journal-title":"Int J Mol Sci"},{"issue":"13","key":"839_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310978","volume":"24","author":"A Silvestrini","year":"2023","unstructured":"Silvestrini A, Meucci E, Ricerca BM, Mancini A (2023) Total antioxidant capacity: biochemical aspects and clinical significance. Int J Mol Sci 24(13):10978. https:\/\/doi.org\/10.3390\/ijms241310978","journal-title":"Int J Mol Sci"},{"issue":"4","key":"839_CR52","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1159\/000494032","volume":"73","author":"X Song","year":"2018","unstructured":"Song X, Wang W, Li Z, Zhang D (2018) Association between serum copper and serum lipids in adults. Ann Nutr Metab 73(4):282\u2013289. https:\/\/doi.org\/10.1159\/000494032","journal-title":"Ann Nutr Metab"},{"issue":"1","key":"839_CR53","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0021-9150(03)00145-X","volume":"169","author":"PA Svensson","year":"2003","unstructured":"Svensson PA, Englund MC, Markstr\u00f6m E, Ohlsson BG, Jern\u00e5s M, Billig H et al (2003) Copper induces the expression of cholesterogenic genes in human macrophages. Atherosclerosis 169(1):71\u201376. https:\/\/doi.org\/10.1016\/S0021-9150(03)00145-X","journal-title":"Atherosclerosis"},{"issue":"12","key":"839_CR54","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1097\/GME.0000000000002265","volume":"30","author":"L Todorova","year":"2023","unstructured":"Todorova L, Bonassi R, Guerrero Carre\u00f1o FJ, Hirschberg AL, Yuksel N, Rea C et al (2023) Prevalence and impact of vasomotor symptoms due to menopause among women in Brazil, Canada, Mexico, and Nordic Europe: a cross-sectional survey. Menopause 30(12):1179\u20131189. https:\/\/doi.org\/10.1097\/GME.0000000000002265","journal-title":"Menopause"},{"key":"839_CR55","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00125-019-05040-3","volume":"63","author":"B Tramunt","year":"2020","unstructured":"Tramunt B, Smati S, Grandgeorge N, Lenfant F, Arnal JF, Montagner A et al (2020) Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia 63:453\u2013461. https:\/\/doi.org\/10.1007\/s00125-019-05040-3","journal-title":"Diabetologia"},{"issue":"6","key":"839_CR56","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1007\/s12011-022-03383-4","volume":"201","author":"M Vazquez-Moreno","year":"2023","unstructured":"Vazquez-Moreno M, Sandoval-Castillo M, Rios-Lugo MJ, Kl\u00fcnder-Kl\u00fcnder M, Cruz M, Mart\u00ednez-Navarro I et al (2023) Overweight and Obesity Are Positively Associated with Serum Copper Levels in Mexican Schoolchildren. Biol Trace Elem Res 201(6):2744\u20132749. https:\/\/doi.org\/10.1007\/s12011-022-03383-4","journal-title":"Biol Trace Elem Res"},{"issue":"8","key":"839_CR57","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1039\/c9mt00148d","volume":"11","author":"H Yang","year":"2019","unstructured":"Yang H, Liu CN, Wolf RM, Ralle M, Dev S, Pierson H et al (2019) Obesity is associated with copper elevation in serum and tissues. Metallomics 11(8):1363\u20131371. https:\/\/doi.org\/10.1039\/c9mt00148d","journal-title":"Metallomics"},{"key":"839_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108883","volume":"100","author":"CC Zhong","year":"2022","unstructured":"Zhong CC, Zhao T, Hogstrand C, Chen F, Song CC, Luo Z (2022) Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2\/PPAR\u03b3 pathways. J Nutr Biochem 100:108883. https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108883","journal-title":"J Nutr Biochem"},{"key":"839_CR60","unstructured":"Ansar S, Alhefdhi T, Aleem AM (2015) Status of trace elements and antioxidants in premenopausal and postmenopausal phase of life: a comparative study. Int J Clin Exp Med 8(10):19486\u201319490. PMID: 26770597. Available at: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4694497\/pdf\/ijcem0008-19486.pdf"},{"key":"839_CR61","doi-asserted-by":"crossref","unstructured":"Flores-Luna L, Rojas-Mart\u00ednez R, Escamilla-N\u00fa\u00f1ez C, Castro-Porras L, Hern\u00e1ndez-Cadena L, Romero-Mart\u00ednez M, et al (2025) Prevalencia de factores de riesgo cardiometab\u00f3lico en M\u00e9xico, Ensanut 2021. Salud Publica de Mex 67(6): 644\u2013657. Available at: https:\/\/saludpublica.mx\/index.php\/spm\/article\/view\/17277","DOI":"10.21149\/17277"},{"key":"839_CR62","unstructured":"World Health Organization (2025) Obesity and overweight. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight. Accessed March 2026."}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00839-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-026-00839-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00839-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:26:17Z","timestamp":1787739977000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-026-00839-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["839"],"URL":"https:\/\/doi.org\/10.1007\/s10534-026-00839-1","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,13]]},"assertion":[{"value":"6 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This observational study was approved by the Bioethics Committee of the National School of Biological Sciences of the National Polytechnic Institute (approval registration: ENCB\/CEI\/064\/2021). The protocol was conducted according to the guidelines established in the Declaration of Helsinki and based on the Regulations of the General Health Law on Health Research in Mexico.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all participants before their inclusion.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}