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Extraction using in-vitro methods (Unified BARGE Method\u2014UBM and INFOGEST) was evaluated allowing a comparison of protocols and using inductively coupled plasma optical emission spectrometry (ICP OES). Bioaccessibility values revealed differences among the elements in different types of food supplements. The limits of quantification (LOQs) obtained for some elements were relatively high for both methods due to the composition of the digests, which drastically impaired bioaccessibility assessment. As a result, most elements presented fractions lower than the LOQ, regardless of the sample. This is an important limitation promoted by interferences when analyzing these extracts by ICP-based techniques. A simple extraction using 1\u00a0mol\u00a0L\n                    <jats:sup>\u22121<\/jats:sup>\n                    HCl was evaluated, considering that HCl is present in the solutions used in both protocols. 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