{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:35:08Z","timestamp":1793018108182,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"DOI":"10.1007\/s10534-026-00886-8","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:51:48Z","timestamp":1792763508000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supplemented acetylated whey comparing to N-acetylcysteine exerted promising chelation activity for overload iron-induction lung injury in rats"],"prefix":"10.1007","author":[{"given":"Sara A.","family":"Atta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Y.","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Y.","family":"Meligy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa Fares","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathy","family":"Fahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eslam","family":"Ekram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal A.Y.","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany Abdelrahman","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"886_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041031","author":"MM Abdel-Daim","year":"2020","unstructured":"Abdel-Daim MM et al (2020) Ethanolic extract of Moringa oleifera leaves influences NF-\u03baB signaling pathway to restore kidney tissue from cobalt-mediated oxidative injury and inflammation in rats. Nutrients. https:\/\/doi.org\/10.3390\/nu12041031","journal-title":"Nutrients"},{"issue":"10","key":"886_CR2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s13201-023-01988-1","volume":"13","author":"MA Akl","year":"2023","unstructured":"Akl MA, Al-Awadhi MMH, El-Zeny AS (2023) Divalent transition metal complexes of nitrogen, oxygen and sulfur containing ligand: design, structural, spectral, pH-metric, theoretical molecular modeling, analytical and mechanism studies. Appl Water Sci 13(10):195","journal-title":"Appl Water Sci"},{"issue":"3","key":"886_CR3","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1021\/acs.chemrev.7b00181","volume":"118","author":"I Ali","year":"2018","unstructured":"Ali I et al (2018) Lysine acetylation goes global: from epigenetics to metabolism and therapeutics. Chem Rev 118(3):1216\u20131252","journal-title":"Chem Rev"},{"issue":"1","key":"886_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/path.5401","volume":"251","author":"MK Ali","year":"2020","unstructured":"Ali MK et al (2020) Critical role for iron accumulation in the pathogenesis of fibrotic lung disease. J Pathol 251(1):49\u201362","journal-title":"J Pathol"},{"issue":"5","key":"886_CR5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41580-024-00723-1","volume":"25","author":"T Arnesen","year":"2024","unstructured":"Arnesen T, Kjos\u00e5s I, McTiernan N (2024) Protein N-terminal acetylation is entering the degradation end game. Nat Rev Mol Cell Biol 25(5):335\u2013336","journal-title":"Nat Rev Mol Cell Biol"},{"key":"886_CR6","first-page":"266","volume":"7","author":"C Beeton","year":"2007","unstructured":"Beeton C, Garcia A, Chandy KG (2007) Drawing blood from rats through the saphenous vein and by cardiac puncture. J vis Exp 7:266","journal-title":"J vis Exp"},{"issue":"9","key":"886_CR7","doi-asserted-by":"publisher","first-page":"e04691","DOI":"10.1016\/j.heliyon.2020.e04691","volume":"6","author":"J Briffa","year":"2020","unstructured":"Briffa J, Sinagra E, Blundell R (2020) Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon 6(9):e04691","journal-title":"Heliyon"},{"issue":"9","key":"886_CR8","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3346\/jkms.2015.30.9.1295","volume":"30","author":"CW Choi","year":"2015","unstructured":"Choi CW et al (2015) Deferoxamine improves alveolar and pulmonary vascular development by upregulating hypoxia-inducible factor-1\u03b1 in a rat model of bronchopulmonary dysplasia. J Korean Med Sci 30(9):1295\u20131301","journal-title":"J Korean Med Sci"},{"issue":"7","key":"886_CR9","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.3390\/ijerph7072745","volume":"7","author":"SJ Flora","year":"2010","unstructured":"Flora SJ, Pachauri V (2010) Chelation in metal intoxication. Int J Environ Res Public Health 7(7):2745\u20132788","journal-title":"Int J Environ Res Public Health"},{"issue":"12","key":"886_CR10","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1016\/j.bbagen.2016.05.026","volume":"1860","author":"AJ Ghio","year":"2016","unstructured":"Ghio AJ, Soukup JM, Dailey LA (2016) Air pollution particles and iron homeostasis. Biochim Biophys Acta - Gen Subj 1860(12):2816\u20132825","journal-title":"Biochim Biophys Acta - Gen Subj"},{"issue":"3","key":"886_CR11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","volume":"117","author":"MW Hentze","year":"2004","unstructured":"Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117(3):285\u2013297","journal-title":"Cell"},{"key":"886_CR12","doi-asserted-by":"publisher","DOI":"10.13140\/2.1.3903.9364","author":"AJM Jandal","year":"2013","unstructured":"Jandal AJM (2013) The effect of adding anhydrous acetic acid to prepare whey protein concentrates to improve its functional properties. Diyala Agric Sci J. https:\/\/doi.org\/10.13140\/2.1.3903.9364","journal-title":"Diyala Agric Sci J"},{"issue":"6","key":"886_CR13","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1185\/03007990802077442","volume":"24","author":"J Karnon","year":"2008","unstructured":"Karnon J et al (2008) Cost-utility analysis of deferasirox compared to standard therapy with desferrioxamine for patients requiring iron chelation therapy in the United Kingdom. Curr Med Res Opin 24(6):1609\u20131621","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"886_CR14","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1039\/an9952000845","volume":"120","author":"GJ Kontoghiorghes","year":"1995","unstructured":"Kontoghiorghes GJ (1995) New concepts of iron and aluminium chelation therapy with oral L1 (deferiprone) and other chelators a review. Analyst 120(3):845\u2013851","journal-title":"Analyst"},{"issue":"8","key":"886_CR15","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1002\/jctb.7695","volume":"99","author":"D Lee","year":"2024","unstructured":"Lee D, Bae, C, Ryu, S, Lee K (2024), N-Acetyl cysteine-loaded liposomes to reduce iron overload-induced toxicity in human kidney cells. J Chem Technol Biotechnol 99:1907\u20131913. https:\/\/doi.org\/10.1002\/jctb.7695","journal-title":"J Chem Technol Biotechnol"},{"issue":"11","key":"886_CR16","doi-asserted-by":"publisher","first-page":"20298","DOI":"10.1002\/jcp.28630","volume":"234","author":"Y Li","year":"2019","unstructured":"Li Y et al (2019) Immune effects of glycolysis or oxidative phosphorylation metabolic pathway in protecting against bacterial infection. J Cell Physiol 234(11):20298\u201320309","journal-title":"J Cell Physiol"},{"key":"886_CR17","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/B978-0-12-812124-5.00015-1","volume-title":"Whey proteins","author":"B Mann","year":"2019","unstructured":"Mann B et al (2019) Chapter 14 - bioactive peptides from whey proteins. In: Deeth HC, Bansal N (eds) Whey proteins. Academic Press, pp 519\u2013547"},{"issue":"1","key":"886_CR18","doi-asserted-by":"publisher","first-page":"1313676","DOI":"10.1080\/20010001.2017.1313676","volume":"7","author":"J Morton","year":"2017","unstructured":"Morton J, Snider TA (2017) Guidelines for collection and processing of lungs from aged mice for histological studies. Pathobiol Aging Age Relat Dis 7(1):1313676","journal-title":"Pathobiol Aging Age Relat Dis"},{"key":"886_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ph12010005","author":"J Neves","year":"2019","unstructured":"Neves J et al (2019) Iron homeostasis in the lungs-a balance between health and disease. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph12010005","journal-title":"Pharmaceuticals (Basel)"},{"key":"886_CR20","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.foodchem.2017.04.056","volume":"232","author":"SD Nielsen","year":"2017","unstructured":"Nielsen SD et al (2017) Milk bioactive peptide database: a comprehensive database of milk protein-derived bioactive peptides and novel visualization. Food Chem 232:673\u2013682","journal-title":"Food Chem"},{"issue":"6","key":"886_CR21","doi-asserted-by":"publisher","first-page":"831","DOI":"10.5851\/kosfa.2015.35.6.831","volume":"35","author":"YW Park","year":"2015","unstructured":"Park YW, Nam MS (2015) Bioactive peptides in milk and dairy products: a review. Korean J Food Sci Anim Resour 35(6):831\u2013840","journal-title":"Korean J Food Sci Anim Resour"},{"key":"886_CR22","doi-asserted-by":"publisher","first-page":"651552","DOI":"10.3389\/fmed.2021.651552","volume":"8","author":"M Qu","year":"2021","unstructured":"Qu M et al (2021) The role of ferroptosis in acute respiratory distress syndrome. Front Med (Lausanne) 8:651552","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"886_CR23","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1083\/jcb.17.1.208","volume":"17","author":"ES Reynolds","year":"1963","unstructured":"Reynolds ES (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 17(1):208\u2013212","journal-title":"J Cell Biol"},{"key":"886_CR24","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.redox.2017.05.022","volume":"13","author":"D Samanta","year":"2017","unstructured":"Samanta D, Semenza GL (2017) Maintenance of redox homeostasis by hypoxia-inducible factors. Redox Biol 13:331\u2013335","journal-title":"Redox Biol"},{"issue":"50","key":"886_CR25","doi-asserted-by":"publisher","first-page":"9940","DOI":"10.1523\/JNEUROSCI.1409-19.2019","volume":"39","author":"DA Santiago Gonz\u00e1lez","year":"2019","unstructured":"Santiago Gonz\u00e1lez DA et al (2019) Iron metabolism in the peripheral nervous system: the role of DMT1, ferritin, and transferrin receptor in schwann cell maturation and myelination. J Neurosci 39(50):9940\u20139953","journal-title":"J Neurosci"},{"issue":"3","key":"886_CR26","first-page":"152","volume":"35","author":"M Shindo","year":"2006","unstructured":"Shindo M et al (2006) Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF. Hepatol Res 35(3):152\u2013162","journal-title":"Hepatol Res"},{"key":"886_CR27","first-page":"385","volume":"25","author":"HM Sonpol","year":"2021","unstructured":"Sonpol HM, Bedeer RF, Ali LS, Baokbah TA, Farage AE, Elsisy RA, Abdelkareem MA (2021) Ameliorating effect of N-acetylcysteine on iron toxicity of the liver and pancreas in albino rats: histochemical and ultrastructural study. European J Anat 25:385\u2013396","journal-title":"European J Anat"},{"key":"886_CR28","doi-asserted-by":"publisher","first-page":"152289","DOI":"10.1016\/j.tox.2019.152289","volume":"427","author":"N Sumneang","year":"2019","unstructured":"Sumneang N et al (2019) Combined iron chelator with N-acetylcysteine exerts the greatest effect on improving cardiac calcium homeostasis in iron-overloaded thalassemic mice. Toxicology 427:152289","journal-title":"Toxicology"},{"key":"886_CR29","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.foodchem.2017.03.077","volume":"230","author":"N Sun","year":"2017","unstructured":"Sun N et al (2017) Contributions of molecular size, charge distribution, and specific amino acids to the iron-binding capacity of sea cucumber (Stichopus japonicus) ovum hydrolysates. Food Chem 230:627\u2013636","journal-title":"Food Chem"},{"key":"886_CR30","doi-asserted-by":"publisher","first-page":"116270","DOI":"10.1016\/j.biopha.2024.116270","volume":"172","author":"Y Sun","year":"2024","unstructured":"Sun Y et al (2024) Targeting iron-metabolism:a potential therapeutic strategy for pulmonary fibrosis. Biomed Pharmacother 172:116270","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"886_CR31","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0736-4679(99)00199-7","volume":"18","author":"T Tran","year":"2000","unstructured":"Tran T et al (2000) Intentional iron overdose in pregnancy--management and outcome. J Emerg Med 18(2):225\u2013228","journal-title":"J Emerg Med"},{"issue":"1","key":"886_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1139\/apnm-2020-0370","volume":"46","author":"QDJS Vasconcelos","year":"2021","unstructured":"Vasconcelos QDJS, Bachur TPR, Arag\u00e3o GF (2021) Whey protein supplementation and its potentially adverse effects on health: a systematic review. Appl Physiol Nutr Metab 46(1):27\u201333","journal-title":"Appl Physiol Nutr Metab"},{"issue":"1","key":"886_CR33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41392-022-00904-4","volume":"7","author":"L Wang","year":"2022","unstructured":"Wang L et al (2022) Therapeutic peptides: current applications and future directions. Signal Transduct Target Ther 7(1):48","journal-title":"Signal Transduct Target Ther"},{"key":"886_CR34","doi-asserted-by":"publisher","first-page":"103252","DOI":"10.1016\/j.redox.2024.103252","volume":"75","author":"F Yang","year":"2024","unstructured":"Yang F et al (2024) An active peptide from yak inhibits hypoxia-induced lung injury via suppressing VEGF\/MAPK\/inflammatory signaling. Redox Biol 75:103252","journal-title":"Redox Biol"},{"key":"886_CR35","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.freeradbiomed.2018.07.024","volume":"133","author":"WZ Zhang","year":"2019","unstructured":"Zhang WZ, Butler JJ, Cloonan SM (2019) Smoking-induced iron dysregulation in the lung. Free Radic Biol Med 133:238\u2013247","journal-title":"Free Radic Biol Med"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00886-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-026-00886-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00886-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:04:07Z","timestamp":1793016247000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-026-00886-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":35,"alternative-id":["886"],"URL":"https:\/\/doi.org\/10.1007\/s10534-026-00886-8","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"26 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}