{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:59:32Z","timestamp":1790254772632,"version":"4.1.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biometals"],"DOI":"10.1007\/s10534-026-00887-7","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:48:10Z","timestamp":1790246890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Duration-dependent mild heat stress attenuates mercury-induced Neuroreproductive and oxidative toxicity in Drosophila melanogaster via hormetic mechanisms"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4596-3348","authenticated-orcid":false,"given":"Oluwasegun Davis","family":"Olatomide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses Agbomhere","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolulope Timothy","family":"Arogundade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Olamilekan","family":"Ajayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelechi Emmanuella","family":"Adeyemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibukun Rebecca","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwanifemi Olasunkanmi","family":"Omodara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah Damilola","family":"Johnson-Dedeigbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Chibuike","family":"Emegoako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwaseun Samuel","family":"Karunwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayo Rotimi","family":"Omotoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"887_CR1","first-page":"33","volume":"1","author":"A Abolaji","year":"2013","unstructured":"Abolaji A, Kamdem J, Farombi E, Rocha J (2013) Drosophila melanogaster as a promising model organism in toxicological studies. Arch Bas App Med 1:33\u201338","journal-title":"Arch Bas App Med"},{"issue":"1","key":"887_CR2","doi-asserted-by":"publisher","first-page":"9039","DOI":"10.1038\/s41598-017-08324-z","volume":"7","author":"FA Aprile","year":"2017","unstructured":"Aprile FA, K\u00e4llstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C (2017) The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress \u03b1-synuclein aggregation. Sci Rep 7(1):9039","journal-title":"Sci Rep"},{"issue":"1","key":"887_CR3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/0003-2697(86)90513-0","volume":"154","author":"FC Ayers","year":"1986","unstructured":"Ayers FC, Warner GL, Smith KL, Lawrence DA (1986) Fluorometric quantitation of cellular and nonprotein thiols. Anal Biochem 154(1):186\u2013193","journal-title":"Anal Biochem"},{"key":"887_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2023.115192","volume":"673","author":"AM Azeez","year":"2023","unstructured":"Azeez AM, Hadwan MH (2023) Simple assay for quantifying xanthine oxidase activity. Anal Biochem 673:115192","journal-title":"Anal Biochem"},{"key":"887_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42696","author":"M Balali-Mood","year":"2025","unstructured":"Balali-Mood M, Eizadi-Mood N, Hassanian-Moghaddam H, Etemad L, Moshiri M, Vahabzadeh M, Sadeghi M (2025) Recent advances in the clinical management of intoxication by five heavy metals: mercury, lead, chromium, cadmium and arsenic. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2025.e42696","journal-title":"Heliyon"},{"issue":"1","key":"887_CR6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/toxsci\/kfaf018","volume":"205","author":"CR Beamish","year":"2025","unstructured":"Beamish CR, Becker J, Tam LM, Love T, Rand MD (2025) Transcriptomic analysis identifies muscle-specific mitochondrial and vesicular transport genes as methylmercury toxicity targets in a Drosophila model of congenital Minamata disease. Toxicol Sci 205(1):106\u2013123. https:\/\/doi.org\/10.1093\/toxsci\/kfaf018","journal-title":"Toxicol Sci"},{"issue":"1","key":"887_CR7","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.redox.2013.05.003","volume":"1","author":"F Bellanti","year":"2013","unstructured":"Bellanti F, Matteo M, Rollo T, De Rosario F, Greco P, Vendemiale G, Serviddio G (2013) Sex hormones modulate circulating antioxidant enzymes: impact of estrogen therapy. Redox Biol 1(1):340\u2013346","journal-title":"Redox Biol"},{"key":"887_CR8","first-page":"239","volume-title":"Advances in neurotoxicology","author":"V Branco","year":"2021","unstructured":"Branco V, Aschner M, Carvalho C (2021) Neurotoxicity of mercury: an old issue with contemporary significance. Advances in neurotoxicology. Elsevier, pp 239\u2013262"},{"issue":"10","key":"887_CR9","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3390\/ijerph14101108","volume":"14","author":"V Chauhan","year":"2017","unstructured":"Chauhan V, Srikumar S, Aamer S, Pandareesh MD, Chauhan A (2017) Methylmercury exposure induces sexual dysfunction in male and female Drosophila melanogaster. Int J Environ Res Public Health 14(10):1108","journal-title":"Int J Environ Res Public Health"},{"key":"887_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resourpol.2023.103370","volume":"81","author":"Y Cheng","year":"2023","unstructured":"Cheng Y, Watari T, Seccatore J, Nakajima K, Nansai K, Takaoka M (2023) A review of gold production, mercury consumption, and emission in artisanal and small-scale gold mining (ASGM). Resour Policy 81:103370. https:\/\/doi.org\/10.1016\/j.resourpol.2023.103370","journal-title":"Resour Policy"},{"key":"887_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2025.154277","author":"A Cyran","year":"2025","unstructured":"Cyran A, Ursu GM, Krawic C, Zhitkovich A (2025) Differential effects of mercury compounds on mutagenicity, genotoxicity and repair of UV-DNA damage. Toxicology. https:\/\/doi.org\/10.1016\/j.tox.2025.154277","journal-title":"Toxicology"},{"issue":"5","key":"887_CR12","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1046\/j.1365-2435.1998.00246.x","volume":"12","author":"J Dahlgaard","year":"1998","unstructured":"Dahlgaard J, Loeschcke V, Michalak P, Justesen J (1998) Induced thermotolerance and associated expression of the heat-shock protein Hsp70 in adult Drosophila melanogaster. Funct Ecol 12(5):786\u2013793","journal-title":"Funct Ecol"},{"issue":"1","key":"887_CR13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70\u201377","journal-title":"Arch Biochem Biophys"},{"issue":"27","key":"887_CR14","doi-asserted-by":"publisher","first-page":"6905","DOI":"10.1002\/chem.201704840","volume":"24","author":"LJ Esdaile","year":"2018","unstructured":"Esdaile LJ, Chalker JM (2018) The mercury problem in artisanal and small\u2010scale gold mining. Chem-Eur J 24(27):6905\u20136916","journal-title":"Chem-Eur J"},{"issue":"12","key":"887_CR15","doi-asserted-by":"publisher","first-page":"129285","DOI":"10.1016\/j.bbagen.2019.01.007","volume":"1863","author":"M Farina","year":"2019","unstructured":"Farina M, Aschner M (2019) Glutathione antioxidant system and methylmercury-induced neurotoxicity: an intriguing interplay. Biochimica Et Biophysica Acta (BBA)-Gen Subj 1863(12):129285","journal-title":"Biochimica Et Biophysica Acta (BBA)-Gen Subj"},{"issue":"1","key":"887_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0003-2697(83)90356-1","volume":"128","author":"B Forbush III","year":"1983","unstructured":"Forbush B III (1983) Assay of Na, K-ATPase in plasma membrane preparations: increasing the permeability of membrane vesicles using sodium dodecyl sulfate buffered with bovine serum albumin. Anal Biochem 128(1):159\u2013163","journal-title":"Anal Biochem"},{"issue":"13","key":"887_CR17","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00051-18","volume":"38","author":"M Fujimoto","year":"2018","unstructured":"Fujimoto M, Takii R, Katiyar A, Srivastava P, Nakai A (2018) Poly (ADP-Ribose) polymerase 1 promotes the human heat shock response by facilitating heat shock transcription factor 1 binding to DNA. Mol Cell Biol 38(13):e00051-18","journal-title":"Mol Cell Biol"},{"key":"887_CR18","first-page":"149","volume-title":"Methods in cell biology","author":"P Ghosh","year":"2024","unstructured":"Ghosh P, Mukherjee S, Ghosh S, Gangopadhyay A, Keswani T, Sengupta A, Sarkar S, Bhattacharyya A (2024) Estimating nitric oxide (NO) from MDSCs by Griess method. Methods in cell biology. Elsevier, pp 149\u2013158"},{"issue":"22","key":"887_CR19","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 249(22):7130\u20137139","journal-title":"J Biol Chem"},{"key":"887_CR20","doi-asserted-by":"publisher","DOI":"10.3791\/65029","author":"JM Holsopple","year":"2023","unstructured":"Holsopple JM, Smoot SR, Popodi EM, Colburne JK, Shaw JR, Oliver B, Kaufman TC, Tennessen JM (2023) Assessment of chemical toxicity in adult Drosophila melanogaster. J vis Exp: Jove. https:\/\/doi.org\/10.3791\/65029","journal-title":"J vis Exp: Jove"},{"issue":"3","key":"887_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.161","volume":"3","author":"C Hu","year":"2022","unstructured":"Hu C, Yang J, Qi Z, Wu H, Wang B, Zou F, Mei H, Liu J, Wang W, Liu Q (2022) Heat shock proteins: biological functions, pathological roles, and therapeutic opportunities. MedComm (2020) 3(3):e161","journal-title":"MedComm (2020)"},{"issue":"1","key":"887_CR22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/ph11010002","volume":"11","author":"PC Ikwegbue","year":"2017","unstructured":"Ikwegbue PC, Masamba P, Oyinloye BE, Kappo AP (2017) Roles of heat shock proteins in apoptosis, oxidative stress, human inflammatory diseases, and cancer. Pharmaceuticals (Basel) 11(1):2","journal-title":"Pharmaceuticals (Basel)"},{"key":"887_CR23","first-page":"64","volume":"28","author":"I Ilieva","year":"2021","unstructured":"Ilieva I, Sainova I, Yosifcheva K (2021) Toxic effects of heavy metals (mercury and arsenic) on the male fertility. Acta Morphol Anthropol 28:64\u201375","journal-title":"Acta Morphol Anthropol"},{"issue":"2","key":"887_CR24","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1006\/abio.1993.1368","volume":"212","author":"SL Jewett","year":"1993","unstructured":"Jewett SL, Rocklin AM (1993) Variation of one unit of activity with oxidation rate of organic substrate in indirect superoxide dismutase assays. Anal Biochem 212(2):555\u2013559","journal-title":"Anal Biochem"},{"issue":"1","key":"887_CR25","first-page":"924549","volume":"(2012)","author":"IJ Kade","year":"2012","unstructured":"Kade IJ (2012) (2012) \u2018Mercury toxicity on sodium pump and organoseleniums intervention: a paradox.\u2019 Biomed Res Int (2012)(1):924549","journal-title":"Biomed Res Int"},{"issue":"4","key":"887_CR26","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1007\/s11696-020-01401-0","volume":"75","author":"MA Kadhum","year":"2021","unstructured":"Kadhum MA, Hadwan MH (2021) A precise and simple method for measuring catalase activity in biological samples. Chem Pap 75(4):1669\u20131678","journal-title":"Chem Pap"},{"key":"887_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.173577","volume":"943","author":"B Kang","year":"2024","unstructured":"Kang B, Wang J, Guo S, Yang L (2024) Mercury-induced toxicity: mechanisms, molecular pathways, and gene regulation. Sci Total Environ 943:173577","journal-title":"Sci Total Environ"},{"key":"887_CR28","doi-asserted-by":"crossref","unstructured":"Kosk-Kosicka D (2012) Measurement of Ca2+-ATPase activity (in PMCA and SERCA1). Calcium Signal Protoc 343\u2013356.","DOI":"10.1007\/978-1-62703-086-1_21"},{"key":"887_CR29","doi-asserted-by":"publisher","DOI":"10.2307\/2390232","author":"R Krebs","year":"1994","unstructured":"Krebs R, Loeschcke V (1994) Costs and benefits of activation of the heat-shock response in Drosophila melanogaster. Funct Ecol. https:\/\/doi.org\/10.2307\/2390232","journal-title":"Funct Ecol"},{"issue":"3","key":"887_CR30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/BF02715811","volume":"82","author":"TN Kristensen","year":"2003","unstructured":"Kristensen TN, S\u00d8rensen JG, Loeschcke V (2003) Mild heat stress at a young age in Drosophila melanogaster leads to increased Hsp70 synthesis after stress exposure later in life. J Genet 82(3):89\u201394","journal-title":"J Genet"},{"issue":"2","key":"887_CR31","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10522-015-9629-1","volume":"17","author":"\u00c9 Le Bourg","year":"2016","unstructured":"Le Bourg \u00c9 (2016) Life-time protection against severe heat stress by exposing young Drosophila melanogaster flies to a mild cold stress. Biogerontology 17(2):409\u2013415","journal-title":"Biogerontology"},{"key":"887_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141320","volume":"306","author":"S Li","year":"2025","unstructured":"Li S, Yang H, Duan Y, Wu L, Hu C, Yu B, Zhao Y (2025) Role of heat shock proteins in response to temperature stress and their effect on apoptosis in Drosophila melanogaster. Int J Biol Macromol 306:141320. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.141320","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"887_CR33","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"key":"887_CR34","first-page":"1","volume-title":"Apoptosis methods and protocols","author":"D Matassov","year":"2004","unstructured":"Matassov D, Kagan T, Leblanc J, Sikorska M, Zakeri Z (2004) Measurement of apoptosis by DNA fragmentation. Apoptosis methods and protocols. Springer, pp 1\u201317"},{"issue":"31","key":"887_CR35","doi-asserted-by":"publisher","first-page":"32322","DOI":"10.1007\/s11356-019-06449-4","volume":"26","author":"LH Mojica-V\u00e1zquez","year":"2019","unstructured":"Mojica-V\u00e1zquez LH, Madrigal-Zarraga D, Garc\u00eda-Mart\u00ednez R, Boube M, Calder\u00f3n-Segura ME, Oyallon J (2019) Mercury chloride exposure induces DNA damage, reduces fertility, and alters somatic and germline cells in Drosophila melanogaster ovaries. Environ Sci Pollut Res 26(31):32322\u201332332","journal-title":"Environ Sci Pollut Res"},{"issue":"6","key":"887_CR36","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3109\/10715769809065821","volume":"28","author":"K Moore","year":"1998","unstructured":"Moore K, Roberts LJ (1998) Measurement of lipid peroxidation. Free Radic Res 28(6):659\u2013671","journal-title":"Free Radic Res"},{"key":"887_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.cbi.2016.10.018","volume":"260","author":"S Nesci","year":"2016","unstructured":"Nesci S, Trombetti F, Pirini M, Ventrella V, Pagliarani A (2016) Mercury and protein thiols: stimulation of mitochondrial F1FO-ATPase and inhibition of respiration. Chem Biol Interact 260:42\u201349","journal-title":"Chem Biol Interact"},{"key":"887_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.826193","volume":"16","author":"A Ni","year":"2022","unstructured":"Ni A, Ernst C (2022) Evidence that substantia nigra pars compacta dopaminergic neurons are selectively vulnerable to oxidative stress because they are highly metabolically active. Front Cell Neurosci 16:826193","journal-title":"Front Cell Neurosci"},{"key":"887_CR39","first-page":"3795","volume":"61","author":"CD Nichols","year":"2012","unstructured":"Nichols CD, Becnel J, Pandey UB (2012) Methods to assay Drosophila behavior. J vis Exp: Jove 61:3795","journal-title":"J vis Exp: Jove"},{"key":"887_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e41605","author":"OT Obafemi","year":"2025","unstructured":"Obafemi OT, Ayeleso AO, Adewale OB, Unuofin J, Ekundayo BE, Ntwasa M, Lebelo SL (2025) Animal models in biomedical research: relevance of Drosophila melanogaster. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e41605","journal-title":"Heliyon"},{"issue":"3","key":"887_CR41","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s11011-021-00871-9","volume":"37","author":"OB Ogunsuyi","year":"2022","unstructured":"Ogunsuyi OB, Olagoke OC, Afolabi BA, Loreto JS, Ademiluyi AO, Aschner M, Oboh G, Barbosa NV, da Rocha JBT (2022) Effect of Solanum vegetables on memory index, redox status, and expressions of critical neural genes in Drosophila melanogaster model of memory impairment. Metab Brain Dis 37(3):729\u2013741. https:\/\/doi.org\/10.1007\/s11011-021-00871-9","journal-title":"Metab Brain Dis"},{"key":"887_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/toxics13100896","author":"S Owumi","year":"2025","unstructured":"Owumi S, Otunla M, Akindipe P, Arunsi U, Babalola JO, Irozuru CE, Altayyar A, Oluwawibe B, Owoeye O, Oyelere AK (2025) Thymoquinone protective effect against mercury-induced reproductive derangement in rats: in vivo and in silico investigation. Toxics. https:\/\/doi.org\/10.3390\/toxics13100896","journal-title":"Toxics"},{"issue":"1","key":"887_CR43","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1152\/physrev.00029.2006","volume":"87","author":"P Pacher","year":"2007","unstructured":"Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87(1):315\u2013424","journal-title":"Physiol Rev"},{"issue":"1","key":"887_CR44","first-page":"01","volume":"70","author":"LA Pachla","year":"1987","unstructured":"Pachla LA, Reynolds DL, Wright DS, Kissinger PT (1987) Analytical methods for measuring uric acid in biological samples and food products. J Assoc off Anal Chem 70(1):01\u201314","journal-title":"J Assoc off Anal Chem"},{"issue":"2","key":"887_CR45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/0748233711427048","volume":"29","author":"H-J Park","year":"2013","unstructured":"Park H-J, Youn H-S (2013) Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase. Toxicol Ind Health 29(2):169\u2013174","journal-title":"Toxicol Ind Health"},{"issue":"34","key":"887_CR46","doi-asserted-by":"publisher","first-page":"17510","DOI":"10.1074\/jbc.M116.728782","volume":"291","author":"LA Parra","year":"2016","unstructured":"Parra LA, Baust TB, Smith AD, Jaumotte JD, Zigmond MJ, Torres S, Leak RK, Pino JA, Torres GE (2016) The molecular chaperone Hsc70 interacts with tyrosine hydroxylase to regulate enzyme activity and synaptic vesicle localization. J Biol Chem 291(34):17510\u201317522","journal-title":"J Biol Chem"},{"issue":"5","key":"887_CR47","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1095\/biolreprod.112.104018","volume":"87","author":"G Pennarossa","year":"2012","unstructured":"Pennarossa G, Maffei S, Rahman MM, Berruti G, Brevini TA, Gandolfi F (2012) Characterization of the constitutive pig ovary heat shock chaperone machinery and its response to acute thermal stress or to seasonal variations. Biol Reprod 87(5):119","journal-title":"Biol Reprod"},{"key":"887_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2025.101030","volume":"7","author":"P Perrone","year":"2025","unstructured":"Perrone P, D\u2019Angelo S (2025) Hormesis and health: molecular mechanisms and the key role of polyphenols. Food Chem Adv 7:101030","journal-title":"Food Chem Adv"},{"key":"887_CR49","volume":"150","author":"AL Rockwell","year":"2019","unstructured":"Rockwell AL, Beaver I, Hongay CF (2019) A direct and simple method to assess Drosophila melanogaster\u2019s viability from embryo to adult. J vis Exp 150:e59996","journal-title":"J vis Exp"},{"issue":"2","key":"887_CR50","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s12192-008-0021-9","volume":"13","author":"MC Ruete","year":"2008","unstructured":"Ruete MC, Carrizo LC, Vall\u00e9s PG (2008) Na+\/K+-ATPase stabilization by Hsp70 in the outer stripe of the outer medulla in rats during recovery from a low-protein diet. Cell Stress Chaperones 13(2):157\u2013167","journal-title":"Cell Stress Chaperones"},{"issue":"3","key":"887_CR51","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/toxres\/tfad039","volume":"12","author":"S Rupa","year":"2023","unstructured":"Rupa S, Patwary M, Matin M, Ghann W, Uddin J, Kazi M (2023) Interaction of mercury species with proteins: towards possible mechanism of mercurial toxicology. Toxicol Res 12(3):355\u2013368","journal-title":"Toxicol Res"},{"issue":"1","key":"887_CR52","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s13104-024-06945-y","volume":"17","author":"BJ Sanderson","year":"2024","unstructured":"Sanderson BJ, Sims-West DJ, Macdonald SJ (2024) Acute exposure to mercury drives changes in gene expression in Drosophila melanogaster. BMC Res Notes 17(1):279","journal-title":"BMC Res Notes"},{"issue":"1","key":"887_CR53","doi-asserted-by":"publisher","DOI":"10.1029\/2020GH000325","volume":"5","author":"FW Schwartz","year":"2021","unstructured":"Schwartz FW, Lee S, Darrah TH (2021) A review of the scope of artisanal and small\u2010scale mining worldwide, poverty, and the associated health impacts. Geohealth 5(1):e2020GH000325","journal-title":"Geohealth"},{"issue":"1","key":"887_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/219840","volume":"2013","author":"ME Sears","year":"2013","unstructured":"Sears ME (2013) Chelation: harnessing and enhancing heavy metal detoxification\u2014a review. Sci World J 2013(1):219840","journal-title":"Sci World J"},{"issue":"19","key":"887_CR55","doi-asserted-by":"publisher","first-page":"16853","DOI":"10.1074\/jbc.M200559200","volume":"277","author":"D Shenton","year":"2002","unstructured":"Shenton D, Perrone G, Quinn KA, Dawes IW, Grant CM (2002) Regulation of protein S-thiolation by glutaredoxin 5 in the yeast Saccharomyces cerevisiae. J Biol Chem 277(19):16853\u201316859","journal-title":"J Biol Chem"},{"key":"887_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.596729","volume":"11","author":"OM Strilbytska","year":"2020","unstructured":"Strilbytska OM, Zayachkivska A, Koliada A, Galeotti F, Volpi N, Storey KB, Vaiserman A, Lushchak O (2020) Anise hyssop Agastache foeniculum increases lifespan, stress resistance, and metabolism by affecting free radical processes in Drosophila. Front Physiol 11:596729","journal-title":"Front Physiol"},{"issue":"7","key":"887_CR57","first-page":"774","volume":"14","author":"Y Su","year":"2025","unstructured":"Su Y, Zheng X (2025) HSP70-mediated autophagy-apoptosis-inflammation network and neuroprotection induced by heat acclimatization. Biology (Basel) 14(7):774","journal-title":"Biology (Basel)"},{"key":"887_CR58","first-page":"54809","volume":"118","author":"ER Sunderhaus","year":"2016","unstructured":"Sunderhaus ER, Kretzschmar D (2016) Mass histology to quantify neurodegeneration in Drosophila. J vis Exp: Jove 118:54809","journal-title":"J vis Exp: Jove"},{"issue":"2","key":"887_CR59","first-page":"2777","volume":"61","author":"M Verderame","year":"2017","unstructured":"Verderame M, Limatola E, Scudiero R (2017) Metallothionein expression and synthesis in the testis of the lizard Podarcis sicula under natural conditions and following estrogenic exposure. Eur J Histochem 61(2):2777","journal-title":"Eur J Histochem"},{"issue":"1","key":"887_CR60","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nprot.2009.197","volume":"5","author":"CJ Weydert","year":"2010","unstructured":"Weydert CJ, Cullen JJ (2010) Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc 5(1):51\u201366","journal-title":"Nat Protoc"},{"key":"887_CR61","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.aquatox.2016.06.018","volume":"177","author":"Q-F Zhang","year":"2016","unstructured":"Zhang Q-F, Li Y-W, Liu Z-H, Chen Q-L (2016) Reproductive toxicity of inorganic mercury exposure in adult zebrafish: histological damage, oxidative stress, and alterations of sex hormone and gene expression in the hypothalamic-pituitary-gonadal axis. Aquat Toxicol 177:417\u2013424","journal-title":"Aquat Toxicol"},{"key":"887_CR62","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ecoenv.2017.04.058","volume":"143","author":"T Zhang","year":"2017","unstructured":"Zhang T, Lu Q, Su C, Yang Y, Hu D, Xu Q (2017) Mercury induced oxidative stress, DNA damage, and activation of antioxidative system and Hsp70 induction in duckweed (Lemna minor). Ecotoxicol Environ Saf 143:46\u201356","journal-title":"Ecotoxicol Environ Saf"},{"issue":"10","key":"887_CR63","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3390\/vetsci11100464","volume":"11","author":"Z Zhu","year":"2024","unstructured":"Zhu Z, Wu J, Wen Y, Wu X, Bao H, Wang M, Kang K (2024) Advances in the effects of heat stress on ovarian granulosa cells: unveiling novel ferroptosis pathways. Vet Sci 11(10):464","journal-title":"Vet Sci"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00887-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10534-026-00887-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-026-00887-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:02:37Z","timestamp":1790251357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10534-026-00887-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":63,"alternative-id":["887"],"URL":"https:\/\/doi.org\/10.1007\/s10534-026-00887-7","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors have no competing interests to declare.","order":1,"name":"Ethics","label":"Competing Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are currently no ethical restrictions to using\u00a0\n                      Drosophila melanogaster\n                      \u00a0as a research model. The \u201cuse of the fruit fly complies with the 3Rs protocol of the European Centre for the Validation of Alternative Methods on 3Rs\u2014refinement, replacement, and reduction\u201d.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}