{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T12:32:31Z","timestamp":1719837151179},"reference-count":35,"publisher":"Portland Press Ltd.","issue":"4-5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8,10]]},"abstract":"<jats:p>This lecture outlines the early stages in the discovery of adrenaline \u03b2-receptor antagonists and of the histamine H2-receptor antagonists. It ends with a brief personal view about future research.<\/jats:p>","DOI":"10.1007\/s10540-005-2736-5","type":"journal-article","created":{"date-parts":[[2005,8,29]],"date-time":"2005-08-29T09:46:12Z","timestamp":1125308772000},"page":"302-322","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Drugs from Emasculated Hormones: The Principle of Syntopic Antagonism"],"prefix":"10.1042","volume":"24","author":[{"given":"James","family":"Black","sequence":"first","affiliation":[{"name":"Department of Analytical Pharmacology Rayne Institute, King's College School of Medicine & Dentistry, 123 Coldharbour Lane, SE5 9NU, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2005,8,17]]},"reference":[{"key":"2736_CR1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1152\/ajplegacy.1948.153.3.586","volume":"153","author":"R. P. Ahlquist","year":"1948","journal-title":"Am. J. Physiol"},{"key":"2736_CR2","first-page":"32","volume":"99","author":"E. J. Ariens","year":"1954","journal-title":"Archs. Int. Pharmacodyn. Ther"},{"key":"2736_CR3","first-page":"427","volume":"27","author":"A. S. F. Ash","year":"1966","journal-title":"Br. J. Pharmacol"},{"key":"2736_CR4","first-page":"219","volume-title":"Int. Symp. on Histamine H2-Receptor Antagonists","author":"J. W. Black","year":"1973"},{"key":"2736_CR5","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(64)91275-9","volume":"i","author":"J. W. Black","year":"1964","journal-title":"Lancet"},{"key":"2736_CR6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/236385a0","volume":"236","author":"J. W. Black","year":"1972","journal-title":"Nature"},{"key":"2736_CR7","first-page":"577","volume":"25","author":"J. W. Black","year":"1965","journal-title":"Br. J. Pharmacol"},{"key":"2736_CR8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1113\/jphysiol.1958.sp005952","volume":"141","author":"J. W. Black","year":"1958","journal-title":"J. Physiol"},{"key":"2736_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(80)90202-2","volume":"65","author":"J. W. Black","year":"1980","journal-title":"Eur. J. Pharmacol"},{"key":"2736_CR10","first-page":"141","volume":"220","author":"J. W. Black","year":"1983","journal-title":"Proc. Roy. Soc. B"},{"key":"2736_CR11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1476-5381.1985.tb12941.x","volume":"84","author":"J. W. Black","year":"1985a","journal-title":"Br. J. Pharmacol"},{"key":"2736_CR12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1476-5381.1985.tb08935.x","volume":"86","author":"J. W. Black","year":"1985b","journal-title":"Br. J. Pharmacol"},{"key":"2736_CR13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0140-6736(62)90103-4","volume":"ii","author":"J. W. Black","year":"1962","journal-title":"Lancet"},{"key":"2736_CR14","unstructured":"Cannon, W. B., and Rosenbleuth, A. (1939) in Autonomic Neuroeffector Mechanisms. The Macmillan Co., New York"},{"key":"2736_CR15","unstructured":"Clark, A. J. (1933) in The Mode of Action of Drugs in Cells. Edward Arnold Co., London"},{"key":"2736_CR16","first-page":"311","volume":"24","author":"C. F. Code","year":"1965","journal-title":"Fed. Proc"},{"key":"2736_CR17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1113\/jphysiol.1906.sp001148","volume":"34","author":"H. H. Dale","year":"1906","journal-title":"J. Physiol. London"},{"key":"2736_CR18","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0140-6736(62)90104-6","volume":"ii","author":"A. C. Dornhorst","year":"1962","journal-title":"Lancet"},{"key":"2736_CR19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.ne.07.030184.002011","volume":"7","author":"G. M. Edelman","year":"1984","journal-title":"Ann. Rev. Neurosci"},{"key":"2736_CR20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1748-1716.1948.tb00503.x","volume":"15","author":"B. Folkow","year":"1948","journal-title":"Acta Physiol. Scand"},{"key":"2736_CR21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1476-5381.1958.tb00190.x","volume":"13","author":"M. N. Ghosh","year":"1958","journal-title":"Br. J. Pharmacol. Chemother"},{"key":"2736_CR22","unstructured":"Grossman, S. P. (1967) In: Handbook of Physiology 1, Washington, USA, Sect. 6, pp. 287"},{"key":"2736_CR23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/BF01945354","volume":"43","author":"T. Hokfelt","year":"1987","journal-title":"Experientia"},{"key":"2736_CR24","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/BF01918636","volume":"28","author":"G. Kahlson","year":"1972","journal-title":"Experientia"},{"key":"2736_CR25","first-page":"406","volume":"213","author":"T. P. Kenakin","year":"1980","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2736_CR26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF01936304","volume":"197","author":"H Konzett","year":"1940","journal-title":"N. Arch. Exp. Path. Pharmak"},{"key":"2736_CR27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1476-5381.1985.tb10561.x","volume":"85","author":"P. Leff","year":"1985","journal-title":"Br. J. Pharmacol"},{"key":"2736_CR28","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1152\/physrev.1947.27.4.542","volume":"27","author":"E. R. Loew","year":"1947","journal-title":"Physiol. Rev"},{"key":"2736_CR29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/expphysiol.1938.sp000768","volume":"28","author":"F. C. MacIntosh","year":"1938","journal-title":"Quart. J. Exp. Physiol"},{"key":"2736_CR30","first-page":"223","volume":"124","author":"N. C. Moran","year":"1958","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2736_CR31","unstructured":"Parsons, M. E. (1969) Quantitative studies of drug-induced acid gastric secretion. PhD Thesis, University of London"},{"key":"2736_CR32","first-page":"480","volume":"122","author":"C. E. Powell","year":"1958","journal-title":"J. Pharmac. Exp. Ther"},{"key":"2736_CR33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1177\/003693305800300803","volume":"3","author":"G. Smith","year":"1958","journal-title":"Scot. Med. J"},{"key":"2736_CR34","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1073\/pnas.50.4.703","volume":"50","author":"R. W. Sperry","year":"1963","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2736_CR35","first-page":"379","volume":"11","author":"R. P. Stephenson","year":"1956","journal-title":"Br. J. Pharmacol"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/24\/4-5\/302\/472398\/bsr0240302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/24\/4-5\/302\/472398\/bsr0240302.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T17:56:14Z","timestamp":1637085374000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/24\/4-5\/302\/55051\/Drugs-from-Emasculated-Hormones-The-Principle-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,10]]},"references-count":35,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2004,8,10]]}},"URL":"https:\/\/doi.org\/10.1007\/s10540-005-2736-5","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,10]]}}}