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There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human neurodegenerative disorders in animal models of the disease. However, there are similarly several identifiable environmental influences on outcomes of the genetic defects; and the course of a progressive neurodegenerative disorder can be greatly modified by environmental elements. In this review we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene\u2013environment interplay including, where implicated, mitochondrial genes.<\/jats:p>","DOI":"10.1007\/s10540-006-9028-6","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T20:24:35Z","timestamp":1160166275000},"page":"341-367","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Genes and the Environment in Neurodegeneration"],"prefix":"10.1042","volume":"26","author":[{"given":"Fabio","family":"Copped\u00e8","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of Pisa, Via Roma 67, Pisa, 56126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangelo","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Pisa, Via Roma 67, Pisa, 56126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Pisa, Via Roma 67, Pisa, 56126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Migliore","sequence":"additional","affiliation":[{"name":"Department of Human and Environmental Sciences, University of Pisa, Via S. 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