{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:44:49Z","timestamp":1789202689038,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomed Microdevices"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10544-020-00524-1","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T09:03:27Z","timestamp":1600679007000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Naringenin loaded multifunctional nanoparticles to enhance the chemotherapeutic efficacy in hepatic fibrosis"],"prefix":"10.1007","volume":"22","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"524_CR1","doi-asserted-by":"crossref","unstructured":"M. I. Amaro, H. V.-R. J. R., E.-F. M., M.-F. H., B. Sepodes, R. M.H., Food Res Int, 42(1010\u20131017 (2009)","DOI":"10.1016\/j.foodres.2009.04.016"},{"issue":"2","key":"524_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"R. Bataller, D.A. Brenner, J. Clin. Invest. 115(2), 209\u2013218 (2005)","journal-title":"J. Clin. Invest."},{"key":"524_CR3","first-page":"583","volume-title":"The liver: general aspects and epidemiology, liver pathophysiology: therapies & antioxidants","author":"S Casas-Grajales","year":"2017","unstructured":"S. Casas-Grajales, P. Muriel, The liver: general aspects and epidemiology, liver pathophysiology: therapies & antioxidants (Elsevier, Waltham, MA, 2017), pp. 583\u2013604"},{"issue":"11","key":"524_CR4","doi-asserted-by":"publisher","first-page":"14251","DOI":"10.3390\/ijms131114251","volume":"13","author":"L Cui","year":"2012","unstructured":"L. Cui, Z.H. Zhang, E. Sun, X.B. Jia, Int. J. Mol. Sci. 13(11), 14251\u201314261 (2012)","journal-title":"Int. J. Mol. Sci."},{"key":"524_CR5","doi-asserted-by":"crossref","unstructured":"S. Duarte, J. Baber, T. Fujii, A. J. Coito, Matrix Biol, 44\u201346(147\u2013156 (2015)","DOI":"10.1016\/j.matbio.2015.01.004"},{"issue":"2","key":"524_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/jn\/131.2.235","volume":"131","author":"I Erlund","year":"2001","unstructured":"I. Erlund, E. Meririnne, G. Alfthan, A. Aro, J. Nutr. 131(2), 235\u2013241 (2001)","journal-title":"J. Nutr."},{"issue":"24","key":"524_CR7","doi-asserted-by":"publisher","first-page":"4354","DOI":"10.3748\/wjg.v23.i24.4354","volume":"23","author":"E Hernandez-Aquino","year":"2017","unstructured":"E. Hernandez-Aquino, N. Zarco, S. Casas-Grajales, E. Ramos-Tovar, R.E. Flores-Beltran, J. Arauz, M. Shibayama, L. Favari, V. Tsutsumi, J. Segovia, P. Muriel, World J. Gastroenterol. 23(24), 4354\u20134368 (2017)","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"524_CR8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0378-5173(99)00191-X","volume":"187","author":"JY Jung","year":"1999","unstructured":"J.Y. Jung, S.D. Yoo, S.H. Lee, K.H. Kim, D.S. Yoon, K.H. Lee, Int. J. Pharm. 187(2), 209\u2013218 (1999)","journal-title":"Int. J. Pharm."},{"issue":"4","key":"524_CR9","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/sj.ejcn.1602543","volume":"61","author":"FI Kanaze","year":"2007","unstructured":"F.I. Kanaze, M.I. Bounartzi, M. Georgarakis, I. Niopas, Eur. J. Clin. Nutr. 61(4), 472\u2013477 (2007)","journal-title":"Eur. J. Clin. Nutr."},{"issue":"11","key":"524_CR10","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.3390\/ma5112403","volume":"5","author":"Y Li","year":"2012","unstructured":"Y. Li, X. Zhao, Y. Zu, X. Han, Y. Ge, W. Wang, X.A. Yu, Materials 5(11), 2403\u20132422 (2012)","journal-title":"Materials"},{"issue":"2\u20133","key":"524_CR11","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0169-409X(01)00105-3","volume":"47","author":"W Mehnert","year":"2001","unstructured":"W. Mehnert, K. Mader, Adv. Drug Deliv. Rev. 47(2\u20133), 165\u2013196 (2001)","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"524_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/02652040500286227","volume":"23","author":"E Memisoglu-Bilensoy","year":"2006","unstructured":"E. Memisoglu-Bilensoy, M. Sen, A.A. Hincal, J. Microencapsul. 23(1), 59\u201368 (2006)","journal-title":"J. Microencapsul."},{"issue":"3","key":"524_CR13","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1021\/mp100455h","volume":"8","author":"R Misra","year":"2011","unstructured":"R. Misra, S.K. Sahoo, Mol. Pharm. 8(3), 852\u2013866 (2011)","journal-title":"Mol. Pharm."},{"issue":"9","key":"524_CR14","first-page":"328","volume":"6","author":"AK Mohanty","year":"2014","unstructured":"A.K. Mohanty, G.P. Mohanta, Int J Pharm Pharm Sci 6(9), 328\u2013332 (2014)","journal-title":"Int J Pharm Pharm Sci"},{"issue":"3","key":"524_CR15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.2217\/nnm.10.9","volume":"5","author":"C Mohanty","year":"2010","unstructured":"C. Mohanty, S. Acharya, A.K. Mohanty, F. Dilnawaz, S.K. Sahoo, Nanomedicine (Lond) 5(3), 433\u2013449 (2010a)","journal-title":"Nanomedicine (Lond)"},{"issue":"5","key":"524_CR16","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3109\/10717541003720688","volume":"17","author":"AK Mohanty","year":"2010","unstructured":"A.K. Mohanty, F. Dilnawaz, C. Mohanty, S.K. Sahoo, Drug Deliv. 17(5), 330\u2013342 (2010b)","journal-title":"Drug Deliv."},{"issue":"3","key":"524_CR17","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/00007890-199508000-00010","volume":"60","author":"S Muthukkumar","year":"1995","unstructured":"S. Muthukkumar, T. Ramesh, S. Bondada, Transplantation 60(3), 264\u2013270 (1995)","journal-title":"Transplantation"},{"issue":"Suppl 1","key":"524_CR18","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1186\/1755-1536-5-S1-S26","volume":"5","author":"A Pellicoro","year":"2012","unstructured":"A. Pellicoro, P. Ramachandran, J.P. Iredale, Fibrogenesis Tissue Repair 5(Suppl 1), S26 (2012)","journal-title":"Fibrogenesis Tissue Repair"},{"key":"524_CR19","volume-title":"2014(7)","author":"S Purvin","year":"2014","unstructured":"S. Purvin, P. R. Vuddanda, S. K. Singh, A. Jain, S. Singh, J. Nanotechnol., 2014(7), (2014)"},{"key":"524_CR20","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/B978-0-12-804274-8.00049-7","volume-title":"Hepatoprotective properties of curcumin, liver pathophysiology: therapies & antioxidants","author":"K Reyes-Gordillo","year":"2017","unstructured":"K. Reyes-Gordillo, R.L. Shah, R.E. Flores-Beltran, P. Muriel, Hepatoprotective properties of curcumin, liver pathophysiology: therapies & antioxidants (Elsevier, Waltham, MA, 2017), pp. 687\u2013704"},{"issue":"24","key":"524_CR21","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/S1359-6446(03)02903-9","volume":"8","author":"SK Sahoo","year":"2003","unstructured":"S.K. Sahoo, V. Labhasetwar, Drug Discov. Today 8(24), 1112\u20131120 (2003)","journal-title":"Drug Discov. Today"},{"issue":"2","key":"524_CR22","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/ijc.20405","volume":"112","author":"SK Sahoo","year":"2004","unstructured":"S.K. Sahoo, W. Ma, V. Labhasetwar, Int. J. Cancer 112(2), 335\u2013340 (2004)","journal-title":"Int. J. Cancer"},{"issue":"2","key":"524_CR23","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3109\/07357900903179591","volume":"28","author":"MW Saif","year":"2010","unstructured":"M.W. Saif, N.A. Podoltsev, M.S. Rubin, J.A. Figueroa, M.Y. Lee, J. Kwon, E. Rowen, J. Yu, R.O. Kerr, Cancer Investig. 28(2), 186\u2013194 (2010)","journal-title":"Cancer Investig."},{"key":"524_CR24","doi-asserted-by":"crossref","unstructured":"A. Semalty, M. Semalty, D. Singh, M. S. M. Rawat, J InclPhenom Macrocycl Chem, 67(253\u2013260 (2010)","DOI":"10.1007\/s10847-009-9705-8"},{"issue":"49","key":"524_CR25","first-page":"42232","volume":"286","author":"GS Sen","year":"2011","unstructured":"G.S. Sen, S. Mohanty, D.M. Hossain, S. Bhattacharyya, S. Banerjee, J. Chakraborty, S. Saha, P. Ray, P. Bhattacharjee, D. Mandal, A. Bhattacharya, S. Chattopadhyay, T. Das, G. Sa, J. Biol, Chem. 286(49), 42232\u201342247 (2011)","journal-title":"Chem."},{"issue":"1","key":"524_CR26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.colsurfb.2009.03.010","volume":"72","author":"J Shao","year":"2009","unstructured":"J. Shao, X. Li, X. Lu, C. Jiang, Y. Hu, Q. Li, Y. You, Z. Fu, Colloids Surf B Biointerfaces 72(1), 40\u201347 (2009)","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"4","key":"524_CR27","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4062\/biomolther.2015.024","volume":"23","author":"HM Song","year":"2015","unstructured":"H.M. Song, G.H. Park, H.J. Eo, J.W. Lee, M.K. Kim, J.R. Lee, M.H. Lee, J.S. Koo, J.B. Jeong, Biomol Ther (Seoul) 23(4), 339\u2013344 (2015)","journal-title":"Biomol Ther (Seoul)"},{"key":"524_CR28","doi-asserted-by":"crossref","unstructured":"N. S. K. Srinivas, R. Verma, G. P. Kulyadi, L. Kumar, Int. J. Nanomedicine, 12(15), (2017)","DOI":"10.2147\/IJN.S122729"},{"issue":"2","key":"524_CR29","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1517\/17425247.5.2.155","volume":"5","author":"G Tosi","year":"2008","unstructured":"G. Tosi, L. Costantino, B. Ruozi, F. Forni, M.A. Vandelli, Expert Opin Drug Deliv 5(2), 155\u2013174 (2008)","journal-title":"Expert Opin Drug Deliv"},{"key":"524_CR30","first-page":"653","volume-title":"Antioxidant antiinflammatory and antifibrotic properties of quercetin in the liver, liver pathophysiology: therapies & and antioxidants","author":"LF V\u00e1zquez-Flores","year":"2017","unstructured":"L.F. V\u00e1zquez-Flores, S. Casas-Grajales, E. Hern\u00e1ndez-Aquino, E.E. Vargas-Pozada, P. Muriel, Antioxidant antiinflammatory and antifibrotic properties of quercetin in the liver, liver pathophysiology: therapies & and antioxidants (Elsevier, Waltham, MA, 2017), pp. 653\u2013674"},{"key":"524_CR31","doi-asserted-by":"crossref","unstructured":"J. A. Y\u00e1\u00f1ez, C. M. Remsberg, N. D. Miranda, K. R. Vega-Villa, P. K. Andrews, Biopharmaceutics & drug disposition, 29(63\u201382 (2008)","DOI":"10.1002\/bdd.588"},{"issue":"9","key":"524_CR32","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1089\/hum.2005.16.1075","volume":"16","author":"B Yao","year":"2005","unstructured":"B. Yao, Q.M. He, L. Tian, F. Xiao, Y. Jiang, R. Zhang, G. Li, L. Zhang, J.M. Hou, L. Wang, X.C. Cheng, Y.J. Wen, B. Kan, J. Li, X. Zhao, B. Hu, Q. Zhou, L. Zhang, Y.Q. Wei, Hum. Gene Ther. 16(9), 1075\u20131086 (2005)","journal-title":"Hum. Gene Ther."},{"issue":"4","key":"524_CR33","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s11095-008-9791-0","volume":"26","author":"FL Yen","year":"2009","unstructured":"F.L. Yen, T.H. Wu, L.T. Lin, T.M. Cham, C.C. Lin, Pharm. Res. 26(4), 893\u2013902 (2009)","journal-title":"Pharm. Res."},{"issue":"1","key":"524_CR34","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jconrel.2009.12.020","volume":"143","author":"C Zhan","year":"2010","unstructured":"C. Zhan, B. Gu, C. Xie, J. Li, Y. Liu, W. Lu, J. Control, Release 143(1), 136\u2013142 (2010)","journal-title":"Release"},{"issue":"1\u20132","key":"524_CR35","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ijpharm.2007.07.013","volume":"348","author":"HY Zhang","year":"2008","unstructured":"H.Y. Zhang, X. Tang, H.Y. Li, X.L. Liu, Int. J. Pharm. 348(1\u20132), 70\u201379 (2008)","journal-title":"Int. J. Pharm."},{"issue":"1","key":"524_CR36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ijpharm.2011.05.013","volume":"414","author":"H Zhang","year":"2011","unstructured":"H. Zhang, Z.-Y. Wang, W. Gong, Z.-P. Li, X.-G. Mei, W.-L. Lv, Int. J. Pharm. 414(1), 56\u201362 (2011)","journal-title":"Int. J. Pharm."},{"issue":"6","key":"524_CR37","first-page":"894","volume":"33","author":"F Zhang","year":"2012","unstructured":"F. Zhang, W. Shao, G. Lin, J. Dispers, Sci. Technol. 33(6), 894\u2013897 (2012)","journal-title":"Sci. Technol."}],"container-title":["Biomedical Microdevices"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10544-020-00524-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10544-020-00524-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10544-020-00524-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T01:17:05Z","timestamp":1632187025000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10544-020-00524-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["524"],"URL":"https:\/\/doi.org\/10.1007\/s10544-020-00524-1","relation":{},"ISSN":["1387-2176","1572-8781"],"issn-type":[{"value":"1387-2176","type":"print"},{"value":"1572-8781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"assertion":[{"value":"10 September 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal experiment study protocol was approved by the institute\u2019s committee on animal research, Kunming Medical University, Yunnan Province, China. The legal and ethical approval was obtained prior to initiation of the research work on animals, and the experiments were performed in accordance with the animal ethical committee guidelines and regulations of Republic of China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal rights"}}],"article-number":"68"}}