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Current treatments require invasive shunt removal, reimplantation, or retrograde flush cleansing. We present a next-generation VP shunt system that actively removes blockages via external actuation. Our system, called CLogging Elimination ActuatoR Silicone (CLEARS), integrates a soft, expandable silicone tube within the catheter lumen. This soft robotic insert, capable of 900% strain, can inflate to dislodge blockages and then deflate to restore flow. To test CLEARS, we developed an ex vivo model simulating CSF flow and obstruction using a rapidly acting clogging agent. ICP upstream of the catheter was monitored to evaluate performance. When obstructed with 3\u00a0g of the clogging agent, ICP rose to 30\u00a0cmH<jats:inline-formula>\n              <jats:tex-math>$$_2$$<\/jats:tex-math>\n            <\/jats:inline-formula>O. Upon CLEARS activation, the silicone insert expanded through catheter ports and successfully removed the clog, restoring baseline ICP (<jats:inline-formula>\n              <jats:tex-math>$$\\sim$$<\/jats:tex-math>\n            <\/jats:inline-formula>0\u00a0cmH<jats:inline-formula>\n              <jats:tex-math>$$_2$$<\/jats:tex-math>\n            <\/jats:inline-formula>O) within approximately 40\u00a0s. Without the system, obstruction persisted and pressure remained elevated. Visual documentation confirmed the mechanism of action. The CLEARS system offers a promising solution to VP shunt occlusion by enabling non-invasive mechanical declogging. Our model replicates shunt obstruction and CSF dynamics, providing a testbed for device evaluation. The expandable insert maintained catheter flow and reduced ICP to normal levels after obstruction, representing a potential shift in how hydrocephalus is treated.<\/jats:p>","DOI":"10.1007\/s10544-025-00769-8","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:05:34Z","timestamp":1757588734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncloggable ventriculoperitoneal shunt system for hydrocephalus via an integrated soft robotic device: CLEARS device"],"prefix":"10.1007","volume":"27","author":[{"given":"Yau C.","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Santiago-Dieppa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Vasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Khalessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Friend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"769_CR1","doi-asserted-by":"publisher","first-page":"112649","DOI":"10.1016\/j.sna.2021.112649","volume":"323","author":"AB Bu\u00dfmann","year":"2021","unstructured":"A.B. 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