{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:08:34Z","timestamp":1760548114921},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T00:00:00Z","timestamp":1103673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Elevated concentrations of pipecolic acid have been reported in plasma and CSF of patients with pyridoxine\u2010dependent epilepsy, but its molecular background is unclear. To investigate any further association of pyridoxine and pipecolic acid metabolism, we have performed an animal trial and have measured the concentration of pipecolic acid in brain tissue of rats with nutritional pyridoxine deficiency and in control littermates. Concentrations of pyridoxal phosphate were significantly reduced in brain tissue of pyridoxine\u2010deficient rats (<jats:italic>p<\/jats:italic> &lt; 0.001), while concentrations of pipecolic acid were not significantly different from the normally nourished control group (<jats:italic>p<\/jats:italic> = 0.3). These data indicate that a direct association of pyridoxine and pipecolic acid metabolism is unlikely. We therefore assume that the characteristic elevation of pipecolic acid in pyridoxine\u2010dependent epilepsy could rather be a secondary phenomenon with the primary defect of pyridoxine\u2010dependent epilepsy being located outside the pipecolic acid pathway.<\/jats:p>","DOI":"10.1007\/s10545-005-0071-4","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T19:05:23Z","timestamp":1126119923000},"page":"689-693","source":"Crossref","is-referenced-by-count":4,"title":["Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine\u2010deficient rats"],"prefix":"10.1002","volume":"28","author":[{"given":"B.","family":"Plecko","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Hospital Graz  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hoeger","sequence":"additional","affiliation":[{"name":"Core Unit of Biomedical Research, Division of Laboratory and Animal Science and Genetics Medical University Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Jakobs","sequence":"additional","affiliation":[{"name":"Medical Center VU University  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Struys","sequence":"additional","affiliation":[{"name":"Medical Center VU University  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Stromberger","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Leschnik","sequence":"additional","affiliation":[{"name":"Clinical Department for Small Animals and Horses Veterinary University Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Muehl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Stoeckler\u2010Ipsiroglu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.2.309"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00965124"},{"key":"e_1_2_1_4_1","first-page":"1011","article-title":"Comparative rates of metabolism of pipecolic acid in several animal species","volume":"73","author":"Dancis J","year":"1982","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964820"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00354-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(87)90283-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200007)48:1<121::AID-ANA20>3.0.CO;2-V"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-005-0071-4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-005-0071-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T01:12:08Z","timestamp":1694740328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-005-0071-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,22]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1007\/s10545-005-0071-4"],"URL":"https:\/\/doi.org\/10.1007\/s10545-005-0071-4","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,22]]}}}