{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:53:49Z","timestamp":1761807229489},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The Minnesota Multiphasic Personality Inventory (MMPI\u20102) is commonly used in chronic illness and chronic pain populations to assess psychological functioning. We report the results of the first study employing the MMPI\u20102 to assess psychological aspects of patients with Gaucher disease, type I (GD) is an inborn error of metabolism with unique features as a chronic illness: the disorder often presents with mild symptoms, and is frequently diagnosed in later childhood or adulthood; the treatment is highly efficacious, but, that same treatment is intrusive and expensive and requires that patients restructure their work and personal schedules. In this study, 28 patients with GD completed the MMPI\u20102 and a background questionnaire. GD patients scored significantly higher than the MMPI\u20102 normative sample on MMPI\u20102 scales of Validity (<jats:italic>K<\/jats:italic>)<jats:italic>,<\/jats:italic> Hypochondriasis (<jats:italic>Hs<\/jats:italic>), Depression (<jats:italic>D<\/jats:italic>), Hysteria (<jats:italic>Hy<\/jats:italic>), Psychasthenia (<jats:italic>Pt<\/jats:italic>) and Schizophrenia (<jats:italic>Sc<\/jats:italic>). Individuals with elevated scores on the <jats:italic>Hs<\/jats:italic>, <jats:italic>D<\/jats:italic> and <jats:italic>Hy<\/jats:italic> scales tend to have somatic concerns and depressed mood. Under stress, they are likely to report physical symptoms. Elevated <jats:italic>Pt<\/jats:italic> and <jats:italic>Sc<\/jats:italic> scales suggest psychological turmoil and, possibly feelings of isolation. An elevated <jats:italic>K<\/jats:italic> scale indicates a tendency for individuals to deny psychopathology. The length of time the patient with GD had been on enzyme replacement therapy was not significantly related to any of the 13 MMPI\u20102 scales. Cohorts of patients with chronic heart disease (CRHD) and cohorts of patients with chronic pain were utilized as comparative populations in this investigation. The elevated scores of the GD patients on MMPI\u20102 scales <jats:italic>Hs<\/jats:italic>, <jats:italic>D<\/jats:italic> and <jats:italic>Hy<\/jats:italic> were similar to those of the CRHD population. The chronic pain patients also showed elevations on MMPI\u20102 scales <jats:italic>Hs<\/jats:italic>, <jats:italic>D<\/jats:italic> and <jats:italic>Hy<\/jats:italic>, which were elevated in the GD patients; the elevations in the chronic pain patients were higher than those shown by the GD patients. We conclude that patients with GD exhibit moderate to severe psychological complications, similar to patients with other long\u2010term chronic illnesses.<\/jats:p>","DOI":"10.1007\/s10545-006-0154-x","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T21:48:10Z","timestamp":1144360090000},"page":"99-105","source":"Crossref","is-referenced-by-count":35,"title":["Psychological complications of patients with Gaucher disease"],"prefix":"10.1002","volume":"29","author":[{"given":"W.","family":"Packman","sequence":"first","affiliation":[{"name":"Pacific Graduate School of Psychology 935 E. Meadow Drive Palo Alto CA 94303 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Wilson","family":"Crosbie","sequence":"additional","affiliation":[{"name":"Pacific Graduate School of Psychology 935 E. Meadow Drive Palo Alto CA 94303 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Riesner","sequence":"additional","affiliation":[{"name":"University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Fairley","sequence":"additional","affiliation":[{"name":"University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Packman","sequence":"additional","affiliation":[{"name":"University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105233242104"},{"key":"e_1_2_1_3_1","first-page":"1354","article-title":"Gaucher's disease","volume":"19","author":"Beutler E","year":"1991","journal-title":"N Engl J Med"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(65)90743-6"},{"key":"e_1_2_1_5_1","volume-title":"MMPI\u20102: Manual for Administration and Scoring","author":"Butcher JN","year":"1989"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.16.1754"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008814105603"},{"key":"e_1_2_1_8_1","first-page":"640","volume-title":"Handbook of Coping: Theory, Research, Applications","author":"Devins GM","year":"1996"},{"issue":"2","key":"e_1_2_1_9_1","first-page":"315","article-title":"The adolescent with an inborn error of metabolism: medical issues and transition to adulthood [Review]","volume":"13","author":"Enns G","year":"2002","journal-title":"Adolesc. 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