{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:45:10Z","timestamp":1771472710886,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T00:00:00Z","timestamp":1161734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: In the rare inborn autosomal recessive disorder maple syrup urine disease (MSUD) the accumulation of the branched\u2010chain amino acids (BCAAs) and their metabolic products results in acute and chronic brain dysfunction. About 20% of the patients suffer from non\u2010classic variant forms of MSUD of different clinical severity. <jats:italic>Aim<\/jats:italic>: Up to now variant cases have mostly been published as individual case reports; the aim of this study was to give a comparative description of 16 individuals (aged 6\u201330 years) with different forms of variant MSUD. <jats:italic>Methods<\/jats:italic>: Laboratory data, information on clinical course and treatment as well as aspects of developmental, intellectual and social outcome were obtained retrospectively. Data from <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> methods measuring the degree of enzyme deficiency were included. <jats:italic>Results<\/jats:italic>: In addition to a mild phenotype, which fits well into the so\u2010called intermittent variant, and a more severe phenotype with a wider range from a mild variant to an almost classic form, which fits well into the so\u2010called intermediate variant, we assume the existence of an asymptomatic, non\u2010disease variant of MSUD. These clinical phenotypes are not unambiguously differentiable on the basis of biochemical parameters. <jats:italic>Conclusion<\/jats:italic>: A continuum of clinical severity from asymptomatic to very severe (border to classic) exists in variant MSUD. Apart from newborns with classic MSUD, also those with variant forms benefit from early diagnosis and start of adequate treatment.<\/jats:p>","DOI":"10.1007\/s10545-006-0276-1","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T16:34:41Z","timestamp":1161707681000},"page":"716-724","source":"Crossref","is-referenced-by-count":49,"title":["Variant maple syrup urine disease (MSUD)\u2014The entire spectrum"],"prefix":"10.1002","volume":"29","author":[{"given":"E.","family":"Simon","sequence":"first","affiliation":[{"name":"Department of General Paediatrics University Children's Hospital, Heinrich\u2010Heine University Moorenstr. 5 D\u00fcsseldorf D\u201040225 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Flaschker","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics University Children's Hospital, Heinrich\u2010Heine University Moorenstr. 5 D\u00fcsseldorf D\u201040225 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Schadewaldt","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics University Children's Hospital, Heinrich\u2010Heine University Moorenstr. 5 D\u00fcsseldorf D\u201040225 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Langenbeck","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Wendel","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics University Children's Hospital, Heinrich\u2010Heine University Moorenstr. 5 D\u00fcsseldorf D\u201040225 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(00)00105-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00735409"},{"key":"e_1_2_1_4_1","first-page":"1971","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Chuang DT","year":"2001"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005396823030"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/316950"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(89)90255-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885-4505(89)90015-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199111000-00007"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.10.1734"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200105000-00004"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970010402"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198901000-00003"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-006-0276-1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s10545-006-0276-1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-006-0276-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:19:15Z","timestamp":1694758755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-006-0276-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,25]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1007\/s10545-006-0276-1"],"URL":"https:\/\/doi.org\/10.1007\/s10545-006-0276-1","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,25]]}}}