{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:33:58Z","timestamp":1786980838349,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,12]],"date-time":"2006-08-12T00:00:00Z","timestamp":1155340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : Fabry disease is a lysosomal storage disorder due to deficient \u03b1\u2010galactosidase A activity, which leads to glycosphingolipid accumulation especially in vascular smooth\u2010muscle and endothelial cells. Little is known about the effects of Fabry disease on peripheral artery function and structure. Therefore, we aimed to further characterize the peripheral vascular structural and functional changes in Fabry disease.\n                    <jats:italic>Methods and results<\/jats:italic>\n                    : We measured structural and functional vascular parameters, including intima\u2010media thickness (IMT) of brachial and carotid arteries and abdominal aorta, carotid and aortic compliance, and brachial artery flow\u2010mediated dilatation (FMD) in 17 Fabry patients and 34 healthy controls matched for age, sex and smoking. Carotid IMT (0.64 \u00b1 0.15 vs 0.57 \u00b1 0.12 mm), brachial IMT (1.02 \u00b1 0.25 vs 0.74 \u00b1 0.18 mm), and aortic IMT (0.31 \u00b1 0.09 vs 0.26 \u00b1 0.04 mm) were significantly increased, and brachial FMD was significantly impaired (6.3 \u00b1 5.0 vs 9.7 \u00b1 3.9%) in Fabry patients compared to healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05 in all comparisons after adjustments for age, LDL\u2010cholesterol, and systolic blood pressure). No differences were observed in arterial compliance between the groups.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : These data suggest that Fabry disease affects arterial function and structure by disturbing peripheral endothelial function and promoting intima\u2010media thickening.\n                  <\/jats:p>","DOI":"10.1007\/s10545-006-0340-x","type":"journal-article","created":{"date-parts":[[2006,8,12]],"date-time":"2006-08-12T18:29:15Z","timestamp":1155407355000},"page":"660-666","source":"Crossref","is-referenced-by-count":54,"title":["Structural and functional changes in peripheral vasculature of Fabry patients"],"prefix":"10.1002","volume":"29","author":[{"given":"Riikka J.","family":"Kalliokoski","sequence":"first","affiliation":[{"name":"Turku PET Centre University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari 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S.","family":"Viikari","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Simell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"Nuutila","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku Turku Finland"},{"name":"Department of Medicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology University of Turku Turku 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