{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:09:50Z","timestamp":1791828590629,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T00:00:00Z","timestamp":1179532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine whether a new starch offers better short\u2010term metabolic control than uncooked cornstarch in patients with glycogen storage diseases (GSDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design:<\/jats:title>\n                    <jats:p>\n                      A short\u2010term double\u2010blind cross\u2010over pilot study comparing uncooked physically modified cornstarch (WMHM20) with uncooked cornstarch in patients with GSD types Ia, Ib and III. Twenty\u2010one patients (ages 3\u201347, 9 female) were given 2 g\/kg cornstarch or WMHM20 mixed in water. Blood glucose, lactate and insulin, and breath hydrogen and\n                      <jats:sup>13<\/jats:sup>\n                      CO\n                      <jats:sub>2<\/jats:sub>\n                      enrichment were measured, at baseline and after each load. The hourly biochemical evaluations terminated when blood glucose was \u22643.0 mmol\/L, when the study period had lasted 10 h or when the patient wished to end the test. The alternative starch was administered under similar trial conditions a median of 10 days later.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median starch load duration was 9 h for WMHM20 versus 7 h for cornstarch. Glucose decreased more slowly (\n                      <jats:italic>p<\/jats:italic>\n                      =0.05) and lactate was suppressed faster (\n                      <jats:italic>p<\/jats:italic>\n                      =0.17) for WMHM20 compared with cornstarch. Peak hydrogen excretion was increased (\n                      <jats:italic>p<\/jats:italic>\n                      =0.05) when cornstarch was taken.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These data indicate longer duration of euglycaemia and better short\u2010term metabolic control in the majority of GSD patients with WMHM20 compared to cornstarch.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10545-007-0479-0","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T12:08:20Z","timestamp":1179576500000},"page":"350-357","source":"Crossref","is-referenced-by-count":78,"title":["A novel starch for the treatment of glycogen storage diseases"],"prefix":"10.1002","volume":"30","author":[{"given":"K.","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Charles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery Queen Square London WC1N 3BG UK"},{"name":"Metabolic Unit Great Ormond Street Hospital London UK"},{"name":"Department of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Orton","sequence":"additional","affiliation":[{"name":"Metabolic Unit Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Qi","sequence":"additional","affiliation":[{"name":"Glycologic Ltd Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mundy","sequence":"additional","affiliation":[{"name":"Charles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery Queen Square London WC1N 3BG UK"},{"name":"Metabolic Unit Great Ormond Street Hospital London UK"},{"name":"Department of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Morley","sequence":"additional","affiliation":[{"name":"Environmental Change Research Centre University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Champion","sequence":"additional","affiliation":[{"name":"Department of Paediatric Metabolic Medicine Evelina Children's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Endocrinology and Metabolism, Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"Tester","sequence":"additional","affiliation":[{"name":"Glycologic Ltd Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Charles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery Queen Square London WC1N 3BG UK"},{"name":"Metabolic Unit Great Ormond Street Hospital London UK"},{"name":"Department of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200211000-00014"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200411000-00010"},{"key":"e_1_2_1_4_1","first-page":"1521","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Chen YT","year":"2001"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198401193100306"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02072090"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)38504-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/AN9941901497"},{"key":"e_1_2_1_9_1","first-page":"306","article-title":"Portacaval shunt for glycogen storage disease: value of prolonged intravenous hyperalimentation before surgery","volume":"72","author":"Folkman J","year":"1972","journal-title":"Surgery"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602192940805"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00710057"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02686.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02029361"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868717"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.6.546"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92187-6"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)93135-9"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02679988"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02679990"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02680007"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799948"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.146.2.370"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198409000-00015"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.1.95"},{"key":"e_1_2_1_25_1","first-page":"687","article-title":"The effect of portocaval transposition on carbohydrate metabolism: experimental and clinical observations","volume":"57","author":"Starzl TE","year":"1965","journal-title":"Surgery"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1079\/WPS20040014"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016572706488"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02679991"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.5.1507"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199908000-00008"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-007-0479-0","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s10545-007-0479-0","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-007-0479-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T20:40:38Z","timestamp":1694724038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-007-0479-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,19]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1007\/s10545-007-0479-0"],"URL":"https:\/\/doi.org\/10.1007\/s10545-007-0479-0","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,19]]}}}