{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:33:20Z","timestamp":1786980800029,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T00:00:00Z","timestamp":1181779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite their unfavourable cardiovascular risk profile, patients with glycogen storage disease type Ia (GSD Ia) do not develop premature atherosclerosis. We hypothesized that this paradox might be related to a decreased formation of advanced glycation end products (AGEs) resulting from lifetime low plasma glucose levels and decreased oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 8 GSD Ia patients (age 20\u201324 years) and 30 matched controls we measured carotid intima\u2010media thickness (IMT), skin autofluorescence (AF; a non\u2010invasive index for AGEs), and specific AGEs (pentosidine,\n                      <jats:italic>N<\/jats:italic>\n                      \u2010(carboxymethyl)lysine (CML),\n                      <jats:italic>N<\/jats:italic>\n                      \u2010(carboxyethyl)lysine (CEL)) and collagen linked fluorescence (CLF, measured at excitation\/emission wavelength combinations of 328\/378 and 370\/440 nm) in skin samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Carotid IMT was significantly lower in GSD Ia patients. Skin AF did not differ between patients and controls. The skin samples showed higher CEL levels in the patient group (\n                      <jats:italic>p<\/jats:italic>\n                      =0.008), but similar levels of pentosidine, CML, and CLF. In the total group, skin AF correlated with CML (\n                      <jats:italic>r<\/jats:italic>\n                      =0.39,\n                      <jats:italic>p<\/jats:italic>\n                      =0.031), CLF 328\/378 nm (\n                      <jats:italic>r<\/jats:italic>\n                      =0.53;\n                      <jats:italic>p<\/jats:italic>\n                      =0.002) and CLF 370\/440 nm (\n                      <jats:italic>r<\/jats:italic>\n                      =0.60;\n                      <jats:italic>p<\/jats:italic>\n                      =0.001). In the control group, AF also correlated with the maximum carotid IMT (\n                      <jats:italic>r<\/jats:italic>\n                      =0.6;\n                      <jats:italic>p<\/jats:italic>\n                      =0.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although our data confirm that GSD Ia patients present with a reduced burden of atherosclerosis, this phenomenon cannot be explained by differences in AGE accumulation as measured in the skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10545-007-0507-0","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T19:58:32Z","timestamp":1181851112000},"page":"916-923","source":"Crossref","is-referenced-by-count":39,"title":["Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia"],"prefix":"10.1002","volume":"30","author":[{"given":"N. C.","family":"den Hollander","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University Medical Center Groningen PO Box 30.001 Hanzeplein 1 Groningen 9700 RB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Medical Center Groningen PO Box 30.001 Hanzeplein 1 Groningen 9700 RB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Graaff","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of South Carolina Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Baynes","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of South Carolina Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. P. A.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Medical Center Groningen PO Box 30.001 Hanzeplein 1 Groningen 9700 RB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3240565"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.133"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.09.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.3.746"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.1.57"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801073180102"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02170.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116481"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.22.12964"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.7.1813"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.5.676"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013996325720"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.1.87"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90072-8"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38543-6"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1451-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005020144"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1333.036"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1391"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00093.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602133140702"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.8.523"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(02)00199-8"},{"key":"e_1_2_5_25_1","first-page":"1649","article-title":"Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus","volume":"143","author":"Nakamura Y","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00214-2"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-0999-4"},{"key":"e_1_2_5_28_1","first-page":"688","article-title":"Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease","volume":"146","author":"Ritthaler U","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119180"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90186-4"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(67)90167-2"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-3-199402010-00008"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000125412.50839.b5"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-003-0017-9"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02679997"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00296.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00011a027"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119599"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15467-6"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00863-8"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2450243"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92657-8"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-007-0507-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:42:47Z","timestamp":1694738567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-007-0507-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,14]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1007\/s10545-007-0507-0"],"URL":"https:\/\/doi.org\/10.1007\/s10545-007-0507-0","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,14]]}}}