{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:58:33Z","timestamp":1761058713347},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T00:00:00Z","timestamp":1187568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Increased risk of haematological malignancies has been described in Gaucher disease patients; however, high\u2010grade lymphoma has been rarely observed. We report two patients with Gaucher disease and sicca syndrome diagnosed with aggressive lymphoma involving the parotid gland. A 29\u2010year\u2010old woman with Gaucher disease developed tumour of the left parotid gland. She reported chronic arthralgias, xerostomia and xerophthalmia. Parotid gland biopsy disclosed diffuse large B\u2010cell lymphoma. No lymphadenopathy was found. Bone biopsy revealed focal lymphomatous infiltration consistent with stage IV disease. MACOP\u2010B chemotherapy regimen (cyclophosphamide, adriamycin, methotrexate, bleomycin, vincristine, prednisone) resulted in complete remission for 15 years. A 76\u2010year\u2010old patient with Gaucher disease suffered from dry\u2010mouth feeling. He developed a left parotid gland tumour. CT scan disclosed diffuse lymphadenopathy, pleural effusion and multiple lung nodules. A cervical lymph node biopsy revealed mantle cell lymphoma. Fine\u2010needle aspiration of the parotid gland showed lymphoma cells. Immunochemotherapy with fludarabine, cyclophosphamide and rituximab resulted in complete remission. Accumulation of the glucocerebroside in Gaucher disease activates macrophages, inducing release of pro\u2010inflammatory cytokines which may be involved in the pathogenesis of second malignancy. Patients with Gaucher disease bear an increased risk of haematological malignancies; however, aggressive lymphoma has been described only occasionally. In both our patients the presenting sign of lymphoma was tumour of the parotid gland. The patients suffered from sicca syndrome, which increases risk for developing lymphoma. The underlying Gaucher disease and sicca syndrome might be implicated as immunological triggers for lymphoma occurrence and its propensity for the parotid gland in these patients.<\/jats:p>","DOI":"10.1007\/s10545-007-0610-2","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T19:56:18Z","timestamp":1187294178000},"page":"825-825","source":"Crossref","is-referenced-by-count":8,"title":["Parotid gland involvement, the presenting sign of high grade non\u2010Hodgkin lymphoma in two patients with Gaucher disease and sicca syndrome"],"prefix":"10.1002","volume":"30","author":[{"given":"L.","family":"Shvidel","sequence":"first","affiliation":[{"name":"Hematology Institute Kaplan Medical Center #Affiliated to Hebrew University Rehovot 76100 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sigler","sequence":"additional","affiliation":[{"name":"Hematology Institute Kaplan Medical Center #Affiliated to Hebrew University Rehovot 76100 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shtalrid","sequence":"additional","affiliation":[{"name":"Hematology Institute Kaplan Medical Center #Affiliated to Hebrew University Rehovot 76100 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Feldberg","sequence":"additional","affiliation":[{"name":"Pathology Department Kaplan Medical Center Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Berrebi","sequence":"additional","affiliation":[{"name":"Hematology Institute Kaplan Medical Center #Affiliated to Hebrew University Rehovot 76100 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,20]]},"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-007-0610-2","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-007-0610-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:02:22Z","timestamp":1694754142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-007-0610-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,20]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1007\/s10545-007-0610-2"],"URL":"https:\/\/doi.org\/10.1007\/s10545-007-0610-2","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,20]]}}}