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Some assays and analytes are particularly problematic. Over recent years, our laboratory tried to improve this situation by developing second\u2010tier tests to reduce false\u2010positive results in the screening for congenital adrenal hyperplasia (CAH), tyrosinaemia type I, methylmalonic acidaemias, homocystinuria, and maple syrup urine disease (MSUD). Beginning in 2004, this approach was applied to Mayo's newborn screening programme and resulted in a false\u2010positive rate of 0.09%, a positive predictive value of 41%, and a positive detection rate of 1 affected case in 1672 babies screened.<\/jats:p>","DOI":"10.1007\/s10545-007-0691-y","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T12:21:20Z","timestamp":1184934080000},"page":"585-592","source":"Crossref","is-referenced-by-count":186,"title":["Reduction of the false\u2010positive rate in newborn screening by implementation of MS\/MS\u2010based second\u2010tier tests: The Mayo Clinic experience (2004\u20132007)"],"prefix":"10.1002","volume":"30","author":[{"given":"D.","family":"Matern","sequence":"first","affiliation":[{"name":"Biochemical Genetics Laboratory Mayo Clinic College of Medicine Rochester Minnesota USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic College of Medicine, Biochemical Genetics Laboratory 200 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