{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:53:05Z","timestamp":1790679185297,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T00:00:00Z","timestamp":1194825600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anderson\u2013Fabry disease (AFD), an X\u2010linked lysosomal storage disorder, leads to multi\u2010organ dysfunction and premature mortality. Depression in adults with AFD has been reported, but no large study has been done. We have examined the adult Fabry population in the United Kingdom to describe the prevalence, associated factors and frequency of diagnosis of depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Postal questionnaires were sent from four adult clinics to 296 AFD patients. A response rate of 62% (<jats:italic>n<\/jats:italic>=184; 74 male, 110 female) formed the data set. Questionnaires collected demographic and Fabry\u2010specific information. Depression status was assessed using the Centre for Epidemiological Studies depression scale (CES\u2010D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Responders were aged between 18 and 76 years (mean 44). The prevalence of depression was 46%, of which 28% were consistent with \u2018severe clinical depression\u2019 Unlike the normal population, males with AFD report a higher prevalence of severe depression than females (36% males; 22% females). Interference of AFD symptoms with individuals\u2010lives (particularly acroparaesthesiae or anhidrosis) showed the largest odds of association with depression. Relationship and financial status proved strong predictors of depression: 88% of those with mild\u2010moderate depression and 72% with severe depression were undiagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Depression is common and under\u2010diagnosed in AFD. Proper assessment of and treatment for depression could improve the quality of life of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10545-007-0708-6","type":"journal-article","created":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T10:03:04Z","timestamp":1194602584000},"page":"943-951","source":"Crossref","is-referenced-by-count":99,"title":["Depression in adults with Fabry disease: A common and under\u2010diagnosed problem"],"prefix":"10.1002","volume":"30","author":[{"given":"A. L.","family":"Cole","sequence":"first","affiliation":[{"name":"Charles Dent Metabolic Unit, Box 92 The National Hospital for Neurology and Neurosurgery Queen Square London WC1N3BG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Charles Dent Metabolic Unit, Box 92 The National Hospital for Neurology and Neurosurgery Queen Square London WC1N3BG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Lysosomal Storage Disorders Unit The Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. B.","family":"Deegan","sequence":"additional","affiliation":[{"name":"Lysosomal Disorders Centre Addenbrookes Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Waldek","sequence":"additional","affiliation":[{"name":"Department of Lysosomal Storage Disorders Hope Hospital Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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