{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:26:44Z","timestamp":1791217604388,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,10,22]],"date-time":"2007-10-22T00:00:00Z","timestamp":1193011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Spastic paraparesis is a general term describing progressive stiffness and weakness in the lower limbs caused by pyramidal tract lesions. This clinical situation is frequently encountered in adult neurology. The diagnostic survey is usually limited to searching for acquired causes (spinal cord compression, inflammatory, metabolic, infectious diseases) and the so\u2010called \u2018hereditary spastic paraparesis\u2019 Although poorly recognized by neurologists, spastic paraparesis is also one of the multiple presentations of inborn errors of metabolism (IEMs) in children and adults. Pyramidal signs are usually included in a diffuse neurological or systemic clinical picture; however, in some cases spastic paraparesis remains the only symptom for years. Since these metabolic causes are often treatable, it is essential to include them in the general diagnostic approach to spastic paraparesis. Here we review IEMs causing paraparesis in adults.<\/jats:p>","DOI":"10.1007\/s10545-007-0745-1","type":"journal-article","created":{"date-parts":[[2007,10,23]],"date-time":"2007-10-23T00:49:31Z","timestamp":1193100571000},"page":"855-864","source":"Crossref","is-referenced-by-count":48,"title":["Hereditary spastic paraparesis in adults associated with inborn errors of metabolism: A diagnostic approach"],"prefix":"10.1002","volume":"30","author":[{"given":"F.","family":"Sedel","sequence":"first","affiliation":[{"name":"Federation of Nervous System Diseases, The Salp\u00eatri\u00e8re Hospital Pierre et Marie Curie University Paris France"},{"name":"Reference Center for Lysosomal Diseases, The Salp\u00eatri\u00e8re Hospital Pierre et Marie Curie University Paris France"},{"name":"Federation of Nervous System Diseases Salp\u00eatri\u00e8re Hospital 47 Boulevard de l'H\u00f4pital Paris Cedex 13 75651 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Federation of Nervous System Diseases, The Salp\u00eatri\u00e8re Hospital Pierre et Marie Curie University Paris France"},{"name":"INSERM, UMR 546, The Salp\u00eatri\u00e8re Hospital Pierre et Marie Curie University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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