{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:23:17Z","timestamp":1784204597950,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T00:00:00Z","timestamp":1208217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Deficiency of dihydropteridine reductase causes a variant form of phenylketonuria associated with a devastating neurological disease characterized by mental retardation, hypokinesis and other features relating to basal ganglia disorder. Hyperphenylalaninaemias with tetrahydrobiopterin deficiency make up about 1\u20133% of all hyperphenylalaninaemias. We describe three patients from Calabria, a southern region of Italy, who have a dihydropteridine reductase deficiency, caused by the same mutation (p.L14P) also found in the nearby region of Sicily. We report the evolution of clinical and biochemical data during the treatment of these patients where we used prolactin serum determination to adapt the specific therapy. This report suggests that serum prolactin levels can be a good biomarker for optimal dosage of hydroxylated precursors in long\u2010term treatment monitoring.<\/jats:p>","DOI":"10.1007\/s10545-007-0788-3","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T13:39:59Z","timestamp":1208525999000},"page":"193-197","source":"Crossref","is-referenced-by-count":13,"title":["Serum prolactin as a tool for the follow\u2010up of treated DHPR\u2010deficient patients"],"prefix":"10.1002","volume":"31","author":[{"given":"D.","family":"Concolino","sequence":"first","affiliation":[{"name":"Department of Pediatrics University \u2018Magna Graecia\u2019 of Catanzaro c\/o Ospedale Civile \u2018A. Pugliese\u2019, Viale Pio X Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Muzzi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University \u2018Magna Graecia\u2019 of Catanzaro c\/o Ospedale Civile \u2018A. Pugliese\u2019, Viale Pio X Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rapsomaniki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University \u2018Magna Graecia\u2019 of Catanzaro c\/o Ospedale Civile \u2018A. Pugliese\u2019, Viale Pio X Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Moricca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University \u2018Magna Graecia\u2019 of Catanzaro c\/o Ospedale Civile \u2018A. Pugliese\u2019, Viale Pio X Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Pascale","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University \u2018Magna Graecia\u2019 of Catanzaro c\/o Ospedale Civile \u2018A. Pugliese\u2019, Viale Pio X Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Strisciuglio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University \u2018Magna Graecia\u2019 of Catanzaro c\/o Ospedale Civile \u2018A. 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