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To ensure the best use of this costly ultra\u2010orphan agent, a systematic disease management approach has been proposed by an international panel; this includes the development, by consensus, of achievable treatment goals. Here we critically review these goals and monitoring guidelines and incorporate emerging experience of the disease in the therapeutic era, as well as contemporary clinical research. This review makes recommendations related specifically to the management of pregnancy; the appropriate use of splenectomy and bisphosphonate treatment; the relevance of biochemical markers to disease monitoring; and the use of semi\u2010quantitative methods for assessing bone marrow infiltration. In addition, we identify key areas for development, including the requirement for a validated index of disease severity; the need to correlate widely used biomarkers with long\u2010term disease outcomes, and the desirability of establishing agreed standards for monitoring of bone disease particularly in infants and children with Gaucher disease.<\/jats:p>","DOI":"10.1007\/s10545-008-0779-z","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T18:43:22Z","timestamp":1212000202000},"page":"319-336","source":"Crossref","is-referenced-by-count":107,"title":["Management of non\u2010neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring"],"prefix":"10.1002","volume":"31","author":[{"given":"T. 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