{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T08:16:36Z","timestamp":1782634596548,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,11,8]],"date-time":"2008-11-08T00:00:00Z","timestamp":1226102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We used intravascular ultrasound (IVUS) to characterize coronary artery involvement in patients with Fabry disease (FD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine FD patients (5 women) were matched to 10 control patients (5 women) chosen from our IVUS database. Standard volumetric IVUS analyses were performed along with assessment of plaque echodensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plaques in FD patients were diffuse and hypoechogenic compared with more focal and more echogenic lesions in control patients. Echogenicity of plaques was significantly lower in FD patients (median 30.7\u2009 \u00b1\u2009 12.9 vs 55.9\u2009 \u00b1\u2009 15.7,<jats:italic>p<\/jats:italic>\u2009 = \u20090.0052, mean 37.2\u2009 \u00b1 \u200915.6 vs 66.2\u2009 \u00b1 \u200913.3,<jats:italic>p<\/jats:italic>\u2009 = \u20090.0014). Diffusiveness was assessed as differences between mean and median plaque burden versus the plaque burden in each of the analysed cross\u2010sections. These differences were lower in FD vs controls (5.8\u2009 \u00b1 \u20094.8 vs 8.7\u2009 \u00b1 \u20096.6,<jats:italic>p<\/jats:italic>\u2009 &lt; \u20090.001 for mean, and 5.8\u2009 \u00b1 \u20094.9 vs 8.8\u2009 \u00b1 \u20097.3,<jats:italic>p<\/jats:italic>\u2009 &lt; \u20090.001 for median) indicating a more diffuse involvement. The occurrence of lipid cores was significantly higher in FD patients than in controls (2.4\u2009 \u00b1 \u20091.5 vs 1.0\u2009 \u00b1 \u20090.94,<jats:italic>p<\/jats:italic>\u2009 = \u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IVUS showed diffuse hypoechogenic plaques in patients with FD. The explanation may be higher lipid content in plaques and accumulation of glycosphingolipid in smooth\u2010muscle and endothelial cells.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10545-008-0794-0","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T10:20:26Z","timestamp":1226053226000},"page":"753-760","source":"Crossref","is-referenced-by-count":15,"title":["Intravascular ultrasound assessment of coronary artery involvement in Fabry disease"],"prefix":"10.1002","volume":"31","author":[{"given":"T.","family":"Kovarnik","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, First Faculty of Medicine Charles University Prague Czech Republic"},{"name":"II.interni klinika VFN, U Nemocnice 2 Praha 2 128 08 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Karetova","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Horak","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bultas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Third Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Skulec","sequence":"additional","affiliation":[{"name":"Second Department of Internal 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