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Treatment often cannot prevent severe brain injury and neurological sequelae. The causes of the brain oedema in hyperammonaemic encephalopathy (HAE) have been subject of intense controversy among physicians and scientists working in this field. Currently favoured hypotheses are astrocyte swelling due to increased intracellular glutamine content and neuronal cell death due to excitotoxicity caused by elevated extracellular glutamate levels. While many researchers focus on these mechanisms of cytotoxicity, others emphasize vascular causes of brain oedema. New data gleaned from expression profiling of astrocytes acutely isolated from hyperammonaemic mouse brains point to disturbed water and potassium homeostasis as regulated by astrocytes at the brain microvasculature and in the perisynaptic space as a potential mechanism of brain oedema development in hyperammonaemia.<\/jats:p>","DOI":"10.1007\/s10545-008-0834-9","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T10:37:29Z","timestamp":1217932649000},"page":"492-502","source":"Crossref","is-referenced-by-count":28,"title":["Profiling of astrocyte properties in the hyperammonaemic brain: Shedding new light on the pathophysiology of the brain damage in hyperammonaemia"],"prefix":"10.1002","volume":"31","author":[{"given":"U.","family":"Lichter\u2010Konecki","sequence":"first","affiliation":[{"name":"Center for Neuroscience Research  Washington DC USA"},{"name":"Division of Genetics &amp; Metabolism Children's National Medical Center  111 Michigan Ave., 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