{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:43:01Z","timestamp":1784619781796,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,19]],"date-time":"2008-10-19T00:00:00Z","timestamp":1224374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Enzyme replacement therapy for lysosomal storage disorders has made an important contribution to improving the quality of life of affected patients. The treatment, however, is invasive and onerous, involving weekly or biweekly intravenous infusions of product over a 3\u20134 h period. Such therapy can be extremely disruptive of normal family life and the provision of a safe, home treatment regimen is greatly appreciated by affected families. In this report we demonstrate the safety of home treatment with Elaprase for mucopolysaccharidosis type II (17 patients) and Naglazyme for mucopolysaccharidosis type VI (6 patients). Careful patient selection, an experienced home care company and a detailed management plan for potential anaphylaxis and infusion\u2010associated reactions are important components in a successful home treatment programme.<\/jats:p>","DOI":"10.1007\/s10545-008-0980-0","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T08:37:14Z","timestamp":1224059834000},"page":"733-737","source":"Crossref","is-referenced-by-count":29,"title":["Home treatment with Elaprase\u00ae and Naglazyme\u00ae is safe in patients with mucopolysaccharidoses types II and VI, respectively"],"prefix":"10.1002","volume":"31","author":[{"given":"S.","family":"Bagewadi","sequence":"first","affiliation":[{"name":"Willink Biochemical Genetics Unit Royal Manchester Children's Hospital Manchester M27 4HA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Willink Biochemical Genetics Unit Royal Manchester Children's Hospital Manchester M27 4HA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mercer","sequence":"additional","affiliation":[{"name":"Willink Biochemical Genetics Unit Royal Manchester Children's Hospital Manchester M27 4HA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Willink Biochemical Genetics Unit Royal Manchester Children's Hospital Manchester M27 4HA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Healthcare at Home, Burton\u2010upon\u2010Trent Staffordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Wraith","sequence":"additional","affiliation":[{"name":"Willink Biochemical Genetics Unit Royal Manchester Children's Hospital Manchester M27 4HA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0686-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.014"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2007.16.22.27768"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2006.15.6.20681"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000232477.37660.fb"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-008-0980-0","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-008-0980-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T12:39:16Z","timestamp":1694781556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-008-0980-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,19]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1007\/s10545-008-0980-0"],"URL":"https:\/\/doi.org\/10.1007\/s10545-008-0980-0","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,19]]}}}