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His lectures are perceived today as landmarks in the history of biochemistry, genetics and medicine. Garrod gave evidence for the dynamic nature of metabolism by showing involvement of normal metabolites in normal pathways made variant by Mendelian inheritance. His concepts and evidence were salient primarily among biochemists, controversial among geneticists because biometricians were dominant over Mendelists, and least salient among physicians who were not attracted to rare hereditary \u2018traits\u2019. In 2008, at the centennial of Garrod's Croonian Lectures, each charter inborn error of metabolism has acquired its own genomic locus, a cloned gene, a repertoire of annotated phenotype\u2010modifying alleles, a gene product with known structure and function, and altered function in the Mendelian variant.<\/jats:p>","DOI":"10.1007\/s10545-008-0984-9","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T06:01:10Z","timestamp":1223618470000},"page":"580-598","source":"Crossref","is-referenced-by-count":66,"title":["Garrod's Croonian Lectures (1908) and the charter \u2018Inborn Errors of Metabolism\u2019: Albinism, alkaptonuria, cystinuria, and pentosuria at age 100 in 2008"],"prefix":"10.1002","volume":"31","author":[{"given":"Charles R.","family":"Scriver","sequence":"first","affiliation":[{"name":"Departments of Human Genetics, Pediatrics, Biochemistry, and Biology McGill University  Montreal Canada"},{"name":"Department of Medical Genetics McGill University Health Centre  Montreal Canada"},{"name":"Montreal Children's Hospital Research Institute  2300 Tupper Street Montreal Quebec H3H 1P3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1905.14.1.54"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1826"},{"key":"e_1_2_1_4_1","first-page":"133","volume-title":"Report to the Evolution Committee of the Royal Society","author":"Bateson W","year":"1901"},{"key":"e_1_2_1_5_1","first-page":"587","volume-title":"Genes and Chemical Reactions in Neospora. 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