{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:49:28Z","timestamp":1790412568003,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T00:00:00Z","timestamp":1229904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK61518"],"award-info":[{"award-number":["DK61518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although genes and dietary habits are generally implicated in the aetiology of the prevailing obesity epidemic, the steep increase in the incidence of obesity within a relatively short span of time suggests that other contributing factors may be at play. The role of nutritional experience during the very early periods of life is increasingly being recognized as contributing to growth and metabolic changes in later life. Epidemiological data and studies from animal models have established a strong correlation between an aberrant intrauterine environment and adult\u2010onset disorders in offspring. The nutritional experience in the immediate postnatal life is another independent factor contributing to the development of metabolic diseases in adulthood. Although studies on the small\u2010litter rat model have shown that overnourishment during the suckling period results in adult\u2010onset metabolic disorders, our studies have shown that a change in the <jats:italic>quality<\/jats:italic> of calories\u2014specifically, increased carbohydrate intake by newborn rat pups in the immediate postnatal period\u2014results in chronic hyperinsulinaemia and adult\u2010onset obesity. Several functional alterations in islets and in the hypothalamic energy homeostatic mechanism appear to support this phenotype. Remarkably, female rats that underwent the high\u2010carbohydrate dietary modification as neonates spontaneously transmitted the obesity phenotype to their offspring, thus establishing a vicious generational effect. The high\u2010carbohydrate diet\u2010fed rat model has particular relevance in the context of the current human infant feeding practices: reduction in breast feeding and increase in formula feeding for infants, accompanied by early introduction of carbohydrate\u2010enriched baby foods.<\/jats:p>","DOI":"10.1007\/s10545-008-1033-4","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T13:52:58Z","timestamp":1229608378000},"page":"218-228","source":"Crossref","is-referenced-by-count":58,"title":["Metabolic programming: Role of nutrition in the immediate postnatal life"],"prefix":"10.1002","volume":"32","author":[{"given":"M. S.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Medicine and Biomedical Sciences State University of New York at Buffalo 140 Farber Hall, 3435 Main Street Buffalo NY 14214 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine and Biomedical Sciences State University of New York at Buffalo 140 Farber Hall, 3435 Main Street Buffalo NY 14214 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Laychock","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences State University of New York at Buffalo Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.6.E1061"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.3.E640"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802758"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1579"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38586.411273.E0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1995.tb01730.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0231"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200110290-00012"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32805dfb93"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02789.x"},{"key":"e_1_2_12_12_1","first-page":"29","article-title":"The main effect of cocaine\u2010 and amphetamine\u2010regulated transcript (CART) peptide on hypothalamic neuronal activity depends on the nutritional state of rats","volume":"26","author":"Davidowa H","year":"2005","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014016"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.648"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.05.039"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.1899"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.081"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050812"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051038"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318045bedb"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(03)00104-5"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(94)00342-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/60.1.5"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198116"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(86)90647-8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi222"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(92)90006-5"},{"key":"e_1_2_12_28_1","first-page":"495","article-title":"Long\u2010term effects of feeding high carbohydrate diet in pre\u2010weaning period by gastrostomy: a new rat model for obesity","volume":"17","author":"Hiremagalur BK","year":"1993","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_12_29_1","first-page":"225","article-title":"The composition of human milk","volume":"3","author":"Jenness R","year":"1979","journal-title":"Semin Perinatol"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002000208"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.06.069"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.055335"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00216.2005"},{"key":"e_1_2_12_34_1","first-page":"38","article-title":"Programming by early nutrition in man","volume":"156","author":"Lucas A","year":"1991","journal-title":"Ciba Found Symp"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.2.401S"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.2.602"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90499-3"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00053.2003"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00477.2006"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00672.2006"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2002000500016"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.47.1.73"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.1549"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.6.1298"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1176"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665199000804"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511544712.008"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082599"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200101000-00019"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0930147"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2004.055"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.08.065"},{"issue":"3","key":"e_1_2_12_53_1","first-page":"83","article-title":"Perinatal nutrition and hormone\u2010dependent programming of food intake","volume":"65","author":"Plagemann A","year":"2006","journal-title":"Horm Res"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.050"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.9.748"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16210-7"},{"key":"e_1_2_12_57_1","first-page":"23","article-title":"The contribution of infant food marketing to the obesogenic environment in Australia","volume":"15","author":"Smith J","year":"2007","journal-title":"Breastfeed Rev"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.9.2053"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.6.E1347"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(01)00176-0"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020322800102"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.4.984"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00248.2005"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.12.001"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0021"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90460.2008"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.194"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00355.2004"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.265.4.E565"},{"key":"e_1_2_12_70_1","first-page":"E731","article-title":"Persistence of metabolic consequences in the progeny of rats fed a HC formula in their early postnatal life","volume":"269","author":"Vadlamudi S","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.2.S116"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/60.1.173"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1276"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-008-1033-4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s10545-008-1033-4","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-008-1033-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T18:02:17Z","timestamp":1694800937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-008-1033-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,22]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1007\/s10545-008-1033-4"],"URL":"https:\/\/doi.org\/10.1007\/s10545-008-1033-4","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,22]]}}}