{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:05:49Z","timestamp":1773821149787,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T00:00:00Z","timestamp":1237939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with MPS II often present with limitations to functional mobility. With the advent of enzyme replacement therapy (ERT), robust assessment tools are important to assess response to treatment. The aim of this study was to see if the GAITRite\u2122 system (electronic pressure sensitive walkway) could identify any changes to gait pattern following commencement of ERT. Six boys with MPS type II were assessed at baseline and at intervals post commencing ERT. Four individual characteristics of gait were studied \u2013 velocity, cadence, step length and base of support. Changes in parameters for each individual could be analysed and be compared with age matched controls. The data generated from the GAITRite\u2122 indicated all six boys had changes to their gait pattern. The most notable changes were in velocity, step length and base of support. The GAITRite\u2122 was found to identify changes in gait parameters in this group of patients. It is an accessible way of providing both quantitative and qualitative analysis of gait in the clinical environment, and could potentially be used to monitor response to treatment. Larger studies are needed to corroborate our findings, as well as to establish the GAITRite\u2122 as a monitoring tool.<\/jats:p>","DOI":"10.1007\/s10545-009-1103-2","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T11:50:59Z","timestamp":1237895459000},"page":"127-135","source":"Crossref","is-referenced-by-count":5,"title":["Changes in gait pattern as assessed by the GAITRite\u2122 walkway system in MPS II patients undergoing enzyme replacement therapy"],"prefix":"10.1002","volume":"32","author":[{"given":"M.","family":"Wood","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Great Ormond Street Hospital for Children NHS Trust Great Ormond Street London WC1N 3JH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Cleary","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine Great Ormond Street Hospital for Children NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Alderson","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Great Ormond Street Hospital for Children NHS Trust Great Ormond Street London WC1N 3JH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vellodi","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine Great Ormond Street Hospital for Children NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Measuring Normal Impaired Walking in Children Using the GAITRite\u2122 Walkway","author":"Alderson LM","year":"2007"},{"key":"e_1_2_6_3_1","first-page":"438","volume-title":"Basic Biomechanics of the Musculoskeletal System","author":"Bart AE","year":"2001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-6362(02)00053-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01429.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.04.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.1.17"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2006.tb01318.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1350"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.19778"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.3.249"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2006.09.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-6362(99)00005-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2005.06.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0966-6362(95)01042-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2004.10.005"},{"key":"e_1_2_6_19_1","volume-title":"Gait Analysis: An Introduction","author":"Whittle MW","year":"2007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0b013e3181577d6d"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00661.x"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-009-1103-2","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s10545-009-1103-2","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-009-1103-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T03:17:24Z","timestamp":1694747844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-009-1103-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,25]]},"references-count":20,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1007\/s10545-009-1103-2"],"URL":"https:\/\/doi.org\/10.1007\/s10545-009-1103-2","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,25]]}}}